Ron L Shanderson, PhD 🦀
@theshanderson.bsky.social
Postdoc
Stanford Bioengineering
Interested in how signaling networks regulate transcription
Stanford Bioengineering
Interested in how signaling networks regulate transcription
Reposted by Ron L Shanderson, PhD 🦀
As instruments and approaches emerge for single-molecule protein analysis, some developers and early users share their first impressions with Nature Methods. 🧪
Is single-molecule protein sequencing here yet?
Nature Methods
go.nature.com
August 10, 2025 at 1:38 PM
As instruments and approaches emerge for single-molecule protein analysis, some developers and early users share their first impressions with Nature Methods. 🧪
Reposted by Ron L Shanderson, PhD 🦀
Cool paper using LLM to discover a protein sequence code for subcellular localization 👏
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Protein codes promote selective subcellular compartmentalization
Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...
www.science.org
February 9, 2025 at 12:46 AM
Cool paper using LLM to discover a protein sequence code for subcellular localization 👏
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Ron L Shanderson, PhD 🦀
Timescales in Cell Biology
December 1, 2024 at 1:35 PM
Timescales in Cell Biology
Reposted by Ron L Shanderson, PhD 🦀
Beautiful single-molecule footprinting study from the Greenleaf and Bintu labs www.nature.com/articles/s41...
Single-molecule states link transcription factor binding to gene expression - Nature
A study uses single-molecule footprinting to measure protein occupancy at regulatory elements on individual molecules in human cells and describes how different properties of transcription factor bind...
www.nature.com
November 21, 2024 at 1:01 AM
Beautiful single-molecule footprinting study from the Greenleaf and Bintu labs www.nature.com/articles/s41...
Reposted by Ron L Shanderson, PhD 🦀
Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. We reported in Nature last week that collectives of ecDNAs are inherited together by dividing cancer cells. 1/
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Coordinated inheritance of extrachromosomal DNAs in cancer cells - Nature
Cooperative species of extrachromosomal DNAs are coordinately inherited through mitotic co-segregation.
www.nature.com
November 18, 2024 at 5:37 PM
Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. We reported in Nature last week that collectives of ecDNAs are inherited together by dividing cancer cells. 1/
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ron L Shanderson, PhD 🦀
Too often we spend only two weeks choosing a problem and then many years trying solving it, but this limits our potential impact.
A must read for PhD students: Problem choice and decision trees in science and engineering.
pubmed.ncbi.nlm.nih.gov/38608651/
A must read for PhD students: Problem choice and decision trees in science and engineering.
pubmed.ncbi.nlm.nih.gov/38608651/
November 17, 2024 at 5:35 PM
Too often we spend only two weeks choosing a problem and then many years trying solving it, but this limits our potential impact.
A must read for PhD students: Problem choice and decision trees in science and engineering.
pubmed.ncbi.nlm.nih.gov/38608651/
A must read for PhD students: Problem choice and decision trees in science and engineering.
pubmed.ncbi.nlm.nih.gov/38608651/
Reposted by Ron L Shanderson, PhD 🦀
Republicizing my preprint from earlier this year! We found that mitochondrial Raf1 upregulates glutamine catabolism in cancer cells.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Mitochondrial Raf1 Regulates Glutamine Catabolism
Raf1 is present within the mitochondrial matrix, where it binds GLS to regulate glutamine catabolism and tumorigenesis.
In cancer, Raf1 activation occurs via mechanisms that include mutation of upstr...
www.biorxiv.org
November 12, 2024 at 5:16 PM
Republicizing my preprint from earlier this year! We found that mitochondrial Raf1 upregulates glutamine catabolism in cancer cells.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...