Ron L Shanderson, PhD 🦀
@theshanderson.bsky.social
Postdoc
Stanford Bioengineering
Interested in how signaling networks regulate transcription
Stanford Bioengineering
Interested in how signaling networks regulate transcription
There's a lot that I'm proud of in this paper, but my favorite experiment is knocking out Raf1 and rescuing the phenotype with mitochondrial-localized Raf1 or plasma-membrane localized Raf1 and being able to separate Raf1's typical signaling function from our novel mitochondrial function.
November 12, 2024 at 6:04 PM
There's a lot that I'm proud of in this paper, but my favorite experiment is knocking out Raf1 and rescuing the phenotype with mitochondrial-localized Raf1 or plasma-membrane localized Raf1 and being able to separate Raf1's typical signaling function from our novel mitochondrial function.
Almost 20 years ago, Galmiche and Fueller published a review describing the role of outer-mitochondrial Raf1 in regulating apoptosis and they speculate that Raf1 may also exist inside of the mitochondria to regulate metabolism. They were right!
November 12, 2024 at 5:28 PM
Almost 20 years ago, Galmiche and Fueller published a review describing the role of outer-mitochondrial Raf1 in regulating apoptosis and they speculate that Raf1 may also exist inside of the mitochondria to regulate metabolism. They were right!