Martin King
@thecarrierking.bsky.social
Reposted by Martin King
CRISPR-based tools can’t easily access the DNA in mitochondria, but researchers are finding other ways in
go.nature.com/46WbLQL
go.nature.com/46WbLQL
Faulty mitochondria cause deadly diseases: fixing them is about to get a lot easier
Nature - CRISPR-based tools can’t easily access the DNA in these organelles, but researchers are finding other ways in.
go.nature.com
October 19, 2025 at 11:49 AM
CRISPR-based tools can’t easily access the DNA in mitochondria, but researchers are finding other ways in
go.nature.com/46WbLQL
go.nature.com/46WbLQL
Reposted by Martin King
A brilliant new paper by @Marilia Meira Dias and @Thomas MacVicar and others is out! It has discovered that a mitochondrial carrier SLC25A45 is involved in the uptake of methylated lysine and arginine, a key step in carnitine biosynthesis!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis
Methylated amino acids accumulate upon the degradation of methylated proteins and are implicated in diverse metabolic and signaling pathways. Disturbe…
www.sciencedirect.com
October 11, 2025 at 1:42 PM
A brilliant new paper by @Marilia Meira Dias and @Thomas MacVicar and others is out! It has discovered that a mitochondrial carrier SLC25A45 is involved in the uptake of methylated lysine and arginine, a key step in carnitine biosynthesis!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Martin King
Our review on the peculiar properties of mitochondrial carriers of the SLC25 family out: portlandpress.com/biochemj/art...
July 25, 2025 at 11:29 AM
Our review on the peculiar properties of mitochondrial carriers of the SLC25 family out: portlandpress.com/biochemj/art...
Reposted by Martin King
Reposted by Martin King
In space, Venus flanks Earth on the left, with a hellfire greenhouse effect. Mars on the right, which long ago had running water. Today, it's bone dry. Something bad happened on each planet.
Seems like the wrong time to limit the Nation’s capacity to conduct climate research.
Seems like the wrong time to limit the Nation’s capacity to conduct climate research.
May 5, 2025 at 7:25 PM
In space, Venus flanks Earth on the left, with a hellfire greenhouse effect. Mars on the right, which long ago had running water. Today, it's bone dry. Something bad happened on each planet.
Seems like the wrong time to limit the Nation’s capacity to conduct climate research.
Seems like the wrong time to limit the Nation’s capacity to conduct climate research.
Reposted by Martin King
Ever wondered why eating something sugary gives you such an energy boost? 🍰
April 25, 2025 at 10:14 AM
Ever wondered why eating something sugary gives you such an energy boost? 🍰
Reposted by Martin King
It is believed that proton conductance by the mitochondrial uncoupling protein (UCP1) is inhibited specifically by purine nucleotides, but we show that pyrimidine nucleotides also inhibit UCP1 with similar affinities in a pH-dependent manner. #mitochondria
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
February 28, 2025 at 4:59 PM
It is believed that proton conductance by the mitochondrial uncoupling protein (UCP1) is inhibited specifically by purine nucleotides, but we show that pyrimidine nucleotides also inhibit UCP1 with similar affinities in a pH-dependent manner. #mitochondria
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Martin King
Thought that only purine nucleotides could inhibit mitochondrial thermogenesis in brown adipose tissue? Edmund Kunji and coworkers @mitocarriers.bsky.social @mrc-mbu.bsky.social show that pyrimidines bind and inhibit UCP1 in similar manner
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
March 3, 2025 at 5:25 PM
Thought that only purine nucleotides could inhibit mitochondrial thermogenesis in brown adipose tissue? Edmund Kunji and coworkers @mitocarriers.bsky.social @mrc-mbu.bsky.social show that pyrimidines bind and inhibit UCP1 in similar manner
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Martin King
Our paper is finally out: Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier | Science Advances www.science.org/doi/10.1126/...
#mitochondria #cryo-EM
#mitochondria #cryo-EM
Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier
The mitochondrial pyruvate carrier transport mechanism is ΔpH driven and is inhibited competitively by distinct compound classes.
www.science.org
April 18, 2025 at 6:16 PM
Our paper is finally out: Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier | Science Advances www.science.org/doi/10.1126/...
#mitochondria #cryo-EM
#mitochondria #cryo-EM