Boris D Heifets
@theborislab.bsky.social
Anesthesiologist, neuroscientist, amateur psychiatrist. Mouse rave DJ. Legendary dancer.
Reposted by Boris D Heifets
🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging.
👇🧵
nature.com/articles/s41...
#Neuroscience #Psychedelics #BrainImaging
👇🧵
nature.com/articles/s41...
#Neuroscience #Psychedelics #BrainImaging
Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function
Nature Neuroscience - Padawer-Curry et al. show that the hallucinogenic 5-HT2A receptor agonist DOI alters neurovascular coupling in mice, with implications for the interpretation of human fMRI...
nature.com
October 15, 2025 at 8:18 PM
🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging.
👇🧵
nature.com/articles/s41...
#Neuroscience #Psychedelics #BrainImaging
👇🧵
nature.com/articles/s41...
#Neuroscience #Psychedelics #BrainImaging
Reposted by Boris D Heifets
And I want to thank the wonderful reviewers (among them was @theborislab.bsky.social )who made the paper all that much stronger
October 15, 2025 at 8:18 PM
And I want to thank the wonderful reviewers (among them was @theborislab.bsky.social )who made the paper all that much stronger
Reposted by Boris D Heifets
Interested in bridging the translatability gap between mice and humans, specifically with regard to psychedelics? Have I got an opportunity for you! Join us for an interactive and stimulating pre-meeting before #SfN2025. @theborislab.bsky.social @bita37.bsky.social @fredbarrettphd.bsky.social
September 30, 2025 at 8:11 PM
Interested in bridging the translatability gap between mice and humans, specifically with regard to psychedelics? Have I got an opportunity for you! Join us for an interactive and stimulating pre-meeting before #SfN2025. @theborislab.bsky.social @bita37.bsky.social @fredbarrettphd.bsky.social
Reposted by Boris D Heifets
Interested in bridging the translatability gap between mice and humans, specifically with regard to psychedelics? Have I got an opportunity for you! Join us for an interactive and stimulating pre-meeting before #SfN2025. @theborislab.bsky.social @bita37.bsky.social @fredbarrett.bsky.social
September 29, 2025 at 5:11 PM
Interested in bridging the translatability gap between mice and humans, specifically with regard to psychedelics? Have I got an opportunity for you! Join us for an interactive and stimulating pre-meeting before #SfN2025. @theborislab.bsky.social @bita37.bsky.social @fredbarrett.bsky.social
Amazing lineup! And I promise we won’t just bash forced swim tests
🚨 Limited spots!
👉 🌈🧠 SfN Psychedelic Research Event 🌈🧠
Join us before #SfN2025 (Friday, Nov 14) for a deep dive into cross-species psychedelic neuroscience.
Register + speaker profiles: 👉 hopkinspsychedelic.org/sfn2025
Posters, 🎤 panels, 🔑 keynotes,🍸 cocktails + 🥟 bites.
#psychedelicresearch
👉 🌈🧠 SfN Psychedelic Research Event 🌈🧠
Join us before #SfN2025 (Friday, Nov 14) for a deep dive into cross-species psychedelic neuroscience.
Register + speaker profiles: 👉 hopkinspsychedelic.org/sfn2025
Posters, 🎤 panels, 🔑 keynotes,🍸 cocktails + 🥟 bites.
#psychedelicresearch
September 29, 2025 at 5:27 PM
Amazing lineup! And I promise we won’t just bash forced swim tests
Reposted by Boris D Heifets
Excited to share our latest publication -- psychedelic drugs can enhance synaptic connectivity of neurons not expressing 5-HT2ARs (but requiring 5-HT2AR expression in the input neurons -- lots in the supplementals too!)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors - Molecular Psychiatry
Molecular Psychiatry - Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors
www.nature.com
September 16, 2025 at 8:33 PM
Excited to share our latest publication -- psychedelic drugs can enhance synaptic connectivity of neurons not expressing 5-HT2ARs (but requiring 5-HT2AR expression in the input neurons -- lots in the supplementals too!)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Boris D Heifets
Meet one of the winning teams of our MapMySections challenge! 🧠📈
Daniel Rijsketic, Austen Casey, and @theborislab.bsky.social developed UNRAVEL, a tool that precisely maps fluorescent labels across the mouse brain.
Join us on 8/27 for a webinar and live demo: alleninstitute.org/events/mapmy...
Daniel Rijsketic, Austen Casey, and @theborislab.bsky.social developed UNRAVEL, a tool that precisely maps fluorescent labels across the mouse brain.
Join us on 8/27 for a webinar and live demo: alleninstitute.org/events/mapmy...
August 11, 2025 at 10:05 PM
Meet one of the winning teams of our MapMySections challenge! 🧠📈
Daniel Rijsketic, Austen Casey, and @theborislab.bsky.social developed UNRAVEL, a tool that precisely maps fluorescent labels across the mouse brain.
Join us on 8/27 for a webinar and live demo: alleninstitute.org/events/mapmy...
Daniel Rijsketic, Austen Casey, and @theborislab.bsky.social developed UNRAVEL, a tool that precisely maps fluorescent labels across the mouse brain.
Join us on 8/27 for a webinar and live demo: alleninstitute.org/events/mapmy...
Reposted by Boris D Heifets
🎯 Algorithm Accuracy Award 🎯
Daniel Ryskamp Rijsketic, Austen Casey, and @theborislab.bsky.social (StanfordMedicine.bsky.social) created UNRAVEL, a Python library for whole-brain fluorescent label mapping: b-heifets.github.io/UNRAVEL/
Daniel Ryskamp Rijsketic, Austen Casey, and @theborislab.bsky.social (StanfordMedicine.bsky.social) created UNRAVEL, a Python library for whole-brain fluorescent label mapping: b-heifets.github.io/UNRAVEL/
August 4, 2025 at 4:46 PM
🎯 Algorithm Accuracy Award 🎯
Daniel Ryskamp Rijsketic, Austen Casey, and @theborislab.bsky.social (StanfordMedicine.bsky.social) created UNRAVEL, a Python library for whole-brain fluorescent label mapping: b-heifets.github.io/UNRAVEL/
Daniel Ryskamp Rijsketic, Austen Casey, and @theborislab.bsky.social (StanfordMedicine.bsky.social) created UNRAVEL, a Python library for whole-brain fluorescent label mapping: b-heifets.github.io/UNRAVEL/
Reposted by Boris D Heifets
Hope this paper gets some recognition.
www.biorxiv.org/content/10.1...
Basic pharmacological principles are kinda important for experimental design.
www.biorxiv.org/content/10.1...
Basic pharmacological principles are kinda important for experimental design.
Off-target effects of PLX5622 revealed: mixing microglial function in anesthesia and addiction withdrawal
Microglia have gained increasing attention as important regulators in the brain. Acute microglial depletion using the colony-stimulating factor 1 receptor (CSF1R) inhibitor, PLX5622, has become a popu...
www.biorxiv.org
July 24, 2025 at 3:33 AM
Hope this paper gets some recognition.
www.biorxiv.org/content/10.1...
Basic pharmacological principles are kinda important for experimental design.
www.biorxiv.org/content/10.1...
Basic pharmacological principles are kinda important for experimental design.
Reposted by Boris D Heifets
#GRCPsychedelics - What a blast! It was great to talk science with so many incredible people in the field. Can't wait to do it all over again!
July 19, 2025 at 4:32 PM
#GRCPsychedelics - What a blast! It was great to talk science with so many incredible people in the field. Can't wait to do it all over again!
Reposted by Boris D Heifets
So happy the first #GRCPsychedelics was such a success. It was great to see everyone and share all the amazing science and community. Thank you to all the speakers and congratulations to the travel awardees!!
July 18, 2025 at 8:33 PM
So happy the first #GRCPsychedelics was such a success. It was great to see everyone and share all the amazing science and community. Thank you to all the speakers and congratulations to the travel awardees!!
Reposted by Boris D Heifets
So grateful to @alexkwan.bsky.social and @vyazovskiy.bsky.social for such a great program. Excited to plan for 2027 with @viditavaidya.bsky.social and new vice chairs @theborislab.bsky.social and @mikaelpalner.bsky.social
July 18, 2025 at 8:40 PM
So grateful to @alexkwan.bsky.social and @vyazovskiy.bsky.social for such a great program. Excited to plan for 2027 with @viditavaidya.bsky.social and new vice chairs @theborislab.bsky.social and @mikaelpalner.bsky.social
Reposted by Boris D Heifets
I’ve been really feeling down recently, feeling a lot of stress around my job situation + coming to terms with identity shift.
Being at the GRC has filled me with such love, such a sense of community and reminded me of my hard work and that I can continue to inspire people.
Thank you ❤️
Being at the GRC has filled me with such love, such a sense of community and reminded me of my hard work and that I can continue to inspire people.
Thank you ❤️
July 17, 2025 at 12:57 AM
I’ve been really feeling down recently, feeling a lot of stress around my job situation + coming to terms with identity shift.
Being at the GRC has filled me with such love, such a sense of community and reminded me of my hard work and that I can continue to inspire people.
Thank you ❤️
Being at the GRC has filled me with such love, such a sense of community and reminded me of my hard work and that I can continue to inspire people.
Thank you ❤️
Reposted by Boris D Heifets
We’ve got some with psilocybin and nicotine withdrawal that we really should publish!
July 9, 2025 at 10:22 PM
We’ve got some with psilocybin and nicotine withdrawal that we really should publish!
How much is the psychedelic experience influenced by what we see, hear and read? We made a way to measure it: The Psychedelic Media Exposure Questionnaire - developed by Audrey Evers, Chris Kelly, @shaylalove.bsky.social , @tehseennoorani.bsky.social, validated on >600 respondents. Link below:
The Psychedelic Media Exposure Questionnaire: The development and validation of a new scale assessing psychedelic-related media exposure
Rationale: A reliable and valid instrument is needed to measure exposure to psychedelic-related media to examine the impact of media and expectations on outcomes in psychedelic clinical trials. Object...
www.medrxiv.org
July 9, 2025 at 8:29 PM
How much is the psychedelic experience influenced by what we see, hear and read? We made a way to measure it: The Psychedelic Media Exposure Questionnaire - developed by Audrey Evers, Chris Kelly, @shaylalove.bsky.social , @tehseennoorani.bsky.social, validated on >600 respondents. Link below:
Reposted by Boris D Heifets
This seems relevant to psychedelic research, where expectancy is still often viewed only as a baseline variable. We should also consider its dynamic changes, how (psychedelic & other) treatment experiences influence them, and their impact on outcomes.
@psybalazs.bsky.social
@theborislab.bsky.social
@psybalazs.bsky.social
@theborislab.bsky.social
In psychotherapy, treatment expectations matter. But even more powerful? ➡️ How they change over time. Our new paper shows that updating expectations during psychotherapy for MDD predicts depression outcomes. 🔗 www.tandfonline.com/eprint/WRBWU...
#depression #psychotherapy #beliefupdating
#depression #psychotherapy #beliefupdating
Dynamic expectancies: The independent role of within-person change in outcome expectancy in predicting overall treatment outcomes in psychotherapy for depression
Dynamic changes in patients’ outcome expectancy have been increasingly recognized as important for psychotherapy success. However, whether expectancy change predicts treatment outcomes independentl...
www.tandfonline.com
June 30, 2025 at 4:30 AM
This seems relevant to psychedelic research, where expectancy is still often viewed only as a baseline variable. We should also consider its dynamic changes, how (psychedelic & other) treatment experiences influence them, and their impact on outcomes.
@psybalazs.bsky.social
@theborislab.bsky.social
@psybalazs.bsky.social
@theborislab.bsky.social
Reposted by Boris D Heifets
Great lineup of speakers from preclinical to clinical, drug discovery to plasticity, and animals to human research. 🔥
@argelaguilarvalles.bsky.social @rcbagot.bsky.social @fredbarrettphd.bsky.social @theborislab.bsky.social @kepecslab.bsky.social @nuro-science.bsky.social @amykooz.bsky.social ...
@argelaguilarvalles.bsky.social @rcbagot.bsky.social @fredbarrettphd.bsky.social @theborislab.bsky.social @kepecslab.bsky.social @nuro-science.bsky.social @amykooz.bsky.social ...
June 26, 2025 at 6:38 PM
Great lineup of speakers from preclinical to clinical, drug discovery to plasticity, and animals to human research. 🔥
@argelaguilarvalles.bsky.social @rcbagot.bsky.social @fredbarrettphd.bsky.social @theborislab.bsky.social @kepecslab.bsky.social @nuro-science.bsky.social @amykooz.bsky.social ...
@argelaguilarvalles.bsky.social @rcbagot.bsky.social @fredbarrettphd.bsky.social @theborislab.bsky.social @kepecslab.bsky.social @nuro-science.bsky.social @amykooz.bsky.social ...
Reposted by Boris D Heifets
The final episode of Season 4 of Psychedelic Brain Science discusses a recent preprint that gets at the heart of reproducibility in science.
This body of work titled "A multi-institutional investigation of psilocybin's effects on mouse behavior" can be found on BioRxiv!
This body of work titled "A multi-institutional investigation of psilocybin's effects on mouse behavior" can be found on BioRxiv!
bioRxiv
www.biorxiv.org
May 5, 2025 at 3:19 PM
The final episode of Season 4 of Psychedelic Brain Science discusses a recent preprint that gets at the heart of reproducibility in science.
This body of work titled "A multi-institutional investigation of psilocybin's effects on mouse behavior" can be found on BioRxiv!
This body of work titled "A multi-institutional investigation of psilocybin's effects on mouse behavior" can be found on BioRxiv!
Does ketamine reset the placebo response? Some interesting links emerging between opioids, placebo antidepressant responses, and maybe a ketamine mechanism to links them. Thx PsyPost for the writeup, lead author Theresa Lii. PsyPost write up here:
Unexpected results from a ketamine study might reshape depression research
A new study suggests chronic opioid use may interfere with the brain’s natural ability to respond to placebo antidepressants. Surprisingly, ketamine’s antidepressant effects remained intact—raising in...
www.psypost.org
May 5, 2025 at 10:18 AM
Does ketamine reset the placebo response? Some interesting links emerging between opioids, placebo antidepressant responses, and maybe a ketamine mechanism to links them. Thx PsyPost for the writeup, lead author Theresa Lii. PsyPost write up here:
What an afternoon! Never quite expected to have a serious conversation about drugs and dreaming, recorded no less - thank you Heather and Christof!
Can altering cognitive states under anesthesia impact trauma?
@theborislab.bsky.social, Dr. Berlin, and Meritorious Investigator Dr. Christof Koch explore the latest research on Ketamine, the placebo effect, and the potential impact of anesthesia-induced dreams. 🧠✨
📺 youtu.be/ssbz0nKVw5Q
🧠📈
@theborislab.bsky.social, Dr. Berlin, and Meritorious Investigator Dr. Christof Koch explore the latest research on Ketamine, the placebo effect, and the potential impact of anesthesia-induced dreams. 🧠✨
📺 youtu.be/ssbz0nKVw5Q
🧠📈
The Placebo Effect with Dr. Boris Heifets
YouTube video by Unlikely Collaborators
youtu.be
April 26, 2025 at 12:15 AM
What an afternoon! Never quite expected to have a serious conversation about drugs and dreaming, recorded no less - thank you Heather and Christof!
Reposted by Boris D Heifets
Can altering cognitive states under anesthesia impact trauma?
@theborislab.bsky.social, Dr. Berlin, and Meritorious Investigator Dr. Christof Koch explore the latest research on Ketamine, the placebo effect, and the potential impact of anesthesia-induced dreams. 🧠✨
📺 youtu.be/ssbz0nKVw5Q
🧠📈
@theborislab.bsky.social, Dr. Berlin, and Meritorious Investigator Dr. Christof Koch explore the latest research on Ketamine, the placebo effect, and the potential impact of anesthesia-induced dreams. 🧠✨
📺 youtu.be/ssbz0nKVw5Q
🧠📈
The Placebo Effect with Dr. Boris Heifets
YouTube video by Unlikely Collaborators
youtu.be
April 25, 2025 at 8:25 PM
Can altering cognitive states under anesthesia impact trauma?
@theborislab.bsky.social, Dr. Berlin, and Meritorious Investigator Dr. Christof Koch explore the latest research on Ketamine, the placebo effect, and the potential impact of anesthesia-induced dreams. 🧠✨
📺 youtu.be/ssbz0nKVw5Q
🧠📈
@theborislab.bsky.social, Dr. Berlin, and Meritorious Investigator Dr. Christof Koch explore the latest research on Ketamine, the placebo effect, and the potential impact of anesthesia-induced dreams. 🧠✨
📺 youtu.be/ssbz0nKVw5Q
🧠📈
Reposted by Boris D Heifets
I spoke to @theborislab.bsky.social & @alexkwan.bsky.social about a new preprint that has caused lots of discussion among psychedelics researchers.
The 5-lab study failed to replicate many of the more exciting persistent effects of psilocybin in mice.
Preprint: www.biorxiv.org/content/10.1...
The 5-lab study failed to replicate many of the more exciting persistent effects of psilocybin in mice.
Preprint: www.biorxiv.org/content/10.1...
April 11, 2025 at 1:11 PM
I spoke to @theborislab.bsky.social & @alexkwan.bsky.social about a new preprint that has caused lots of discussion among psychedelics researchers.
The 5-lab study failed to replicate many of the more exciting persistent effects of psilocybin in mice.
Preprint: www.biorxiv.org/content/10.1...
The 5-lab study failed to replicate many of the more exciting persistent effects of psilocybin in mice.
Preprint: www.biorxiv.org/content/10.1...
Reposted by Boris D Heifets
This is a very important paper
That will be discussed for many years
That will be discussed for many years
A much-needed joint effort from five labs to see which behavioral effects of psilocybin in mice are reliable, and which may be spurious 🐁🍄
@theborislab.bsky.social @mazenkheirbek.bsky.social @indigenerd.bsky.social Vikaas Sohal and Stephan Lammel 👏
www.biorxiv.org/content/10.1...
@theborislab.bsky.social @mazenkheirbek.bsky.social @indigenerd.bsky.social Vikaas Sohal and Stephan Lammel 👏
www.biorxiv.org/content/10.1...
A multi-institutional investigation of psilocybin's effects on mouse behavior
Studies reporting novel therapeutic effects of psychedelic drugs are rapidly emerging. However, the reproducibility and reliability of these findings could remain uncertain for years. Here, we impleme...
www.biorxiv.org
April 10, 2025 at 6:56 AM
This is a very important paper
That will be discussed for many years
That will be discussed for many years
Reposted by Boris D Heifets
A much-needed joint effort from five labs to see which behavioral effects of psilocybin in mice are reliable, and which may be spurious 🐁🍄
@theborislab.bsky.social @mazenkheirbek.bsky.social @indigenerd.bsky.social Vikaas Sohal and Stephan Lammel 👏
www.biorxiv.org/content/10.1...
@theborislab.bsky.social @mazenkheirbek.bsky.social @indigenerd.bsky.social Vikaas Sohal and Stephan Lammel 👏
www.biorxiv.org/content/10.1...
A multi-institutional investigation of psilocybin's effects on mouse behavior
Studies reporting novel therapeutic effects of psychedelic drugs are rapidly emerging. However, the reproducibility and reliability of these findings could remain uncertain for years. Here, we impleme...
www.biorxiv.org
April 9, 2025 at 7:11 PM
A much-needed joint effort from five labs to see which behavioral effects of psilocybin in mice are reliable, and which may be spurious 🐁🍄
@theborislab.bsky.social @mazenkheirbek.bsky.social @indigenerd.bsky.social Vikaas Sohal and Stephan Lammel 👏
www.biorxiv.org/content/10.1...
@theborislab.bsky.social @mazenkheirbek.bsky.social @indigenerd.bsky.social Vikaas Sohal and Stephan Lammel 👏
www.biorxiv.org/content/10.1...
Sleep people- any experience w home sleep staging via wearable that allows access to raw data? Thinking re Oura, Fitbit or Whoop.
jigglypuff is sitting on the ground with its eyes closed and says `` good night , sleep well '' .
ALT: jigglypuff is sitting on the ground with its eyes closed and says `` good night , sleep well '' .
media.tenor.com
January 9, 2025 at 9:19 PM
Sleep people- any experience w home sleep staging via wearable that allows access to raw data? Thinking re Oura, Fitbit or Whoop.