Tyler Ekins
@tylerekins.bsky.social
(Psychedelic) neurophysiology researcher (postdoc) at University of Michigan (https://www.omarlab.org)
Pinned
Tyler Ekins
@tylerekins.bsky.social
· Sep 16
Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors - Molecular Psychiatry
Molecular Psychiatry - Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors
www.nature.com
Excited to share our latest publication -- psychedelic drugs can enhance synaptic connectivity of neurons not expressing 5-HT2ARs (but requiring 5-HT2AR expression in the input neurons -- lots in the supplementals too!)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Excited to share our latest publication -- psychedelic drugs can enhance synaptic connectivity of neurons not expressing 5-HT2ARs (but requiring 5-HT2AR expression in the input neurons -- lots in the supplementals too!)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors - Molecular Psychiatry
Molecular Psychiatry - Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors
www.nature.com
September 16, 2025 at 8:33 PM
Excited to share our latest publication -- psychedelic drugs can enhance synaptic connectivity of neurons not expressing 5-HT2ARs (but requiring 5-HT2AR expression in the input neurons -- lots in the supplementals too!)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Our latest manuscript (from www.omarlab.org) is now published and available online --
Long lasting enhancement in reversal learning after a single psychedelic dose
pmc.ncbi.nlm.nih.gov/articles/PMC...
Long lasting enhancement in reversal learning after a single psychedelic dose
pmc.ncbi.nlm.nih.gov/articles/PMC...
Single-dose psychedelic enhances cognitive flexibility and reversal learning in mice weeks after administration
Psychedelic compounds have demonstrated remarkable therapeutic potential for treating neuropsychiatric disorders by promoting sustained neuroplasticity in the prefrontal cortex (PFC). Cognitive flexib...
pmc.ncbi.nlm.nih.gov
August 13, 2025 at 1:32 PM
Our latest manuscript (from www.omarlab.org) is now published and available online --
Long lasting enhancement in reversal learning after a single psychedelic dose
pmc.ncbi.nlm.nih.gov/articles/PMC...
Long lasting enhancement in reversal learning after a single psychedelic dose
pmc.ncbi.nlm.nih.gov/articles/PMC...
Reposted by Tyler Ekins
Did you go to #GRCpsychedelics and not get soap? Don't worry, our themed soap will be ready in 2-3 weeks. Mouse brain toppers, rainbow swirl, dendrite+spine embed. Happy to send a free bar to ~10 people/ attendees.
These are handmade by an amateur, so expect imperfections.
These are handmade by an amateur, so expect imperfections.
July 20, 2025 at 7:44 PM
Did you go to #GRCpsychedelics and not get soap? Don't worry, our themed soap will be ready in 2-3 weeks. Mouse brain toppers, rainbow swirl, dendrite+spine embed. Happy to send a free bar to ~10 people/ attendees.
These are handmade by an amateur, so expect imperfections.
These are handmade by an amateur, so expect imperfections.
Reposted by Tyler Ekins
Somehow we got almost all the students and postdocs in one photo!!
Until next time #GRCPsychedelics 🫡
Until next time #GRCPsychedelics 🫡
July 18, 2025 at 6:51 PM
Somehow we got almost all the students and postdocs in one photo!!
Until next time #GRCPsychedelics 🫡
Until next time #GRCPsychedelics 🫡
Reposted by Tyler Ekins
#GRCPsychedelics is squad goals !!
I learned so much, laughed even more, and slept even less
Grateful for the new connections, strengthening of old ones and for the opportunity to view my favorite topics from a different lens.
I learned so much, laughed even more, and slept even less
Grateful for the new connections, strengthening of old ones and for the opportunity to view my favorite topics from a different lens.
July 18, 2025 at 6:51 PM
#GRCPsychedelics is squad goals !!
I learned so much, laughed even more, and slept even less
Grateful for the new connections, strengthening of old ones and for the opportunity to view my favorite topics from a different lens.
I learned so much, laughed even more, and slept even less
Grateful for the new connections, strengthening of old ones and for the opportunity to view my favorite topics from a different lens.
Reposted by Tyler Ekins
A starter pack including all attendees (that I can find for now)
Please let me know if I missed anyone!
#GRCPsychedelics
go.bsky.app/2ExXJcr
Please let me know if I missed anyone!
#GRCPsychedelics
go.bsky.app/2ExXJcr
July 8, 2025 at 4:28 PM
A starter pack including all attendees (that I can find for now)
Please let me know if I missed anyone!
#GRCPsychedelics
go.bsky.app/2ExXJcr
Please let me know if I missed anyone!
#GRCPsychedelics
go.bsky.app/2ExXJcr
Reposted by Tyler Ekins
Awhile back we started a Slack group for psychedelic science.
Researchers used it to organize meetups and panels at conferences. We discuss papers, including a lively discussion now of the Lu et al. preprint.
DM @mikaelpalner.bsky.social or I if you work in academia and want to join
Researchers used it to organize meetups and panels at conferences. We discuss papers, including a lively discussion now of the Lu et al. preprint.
DM @mikaelpalner.bsky.social or I if you work in academia and want to join
April 10, 2025 at 7:18 PM
Awhile back we started a Slack group for psychedelic science.
Researchers used it to organize meetups and panels at conferences. We discuss papers, including a lively discussion now of the Lu et al. preprint.
DM @mikaelpalner.bsky.social or I if you work in academia and want to join
Researchers used it to organize meetups and panels at conferences. We discuss papers, including a lively discussion now of the Lu et al. preprint.
DM @mikaelpalner.bsky.social or I if you work in academia and want to join
Reposted by Tyler Ekins
Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🧪
Led by Ling-Xiao Shao and @ItsClaraLiao
Funded by @NIH @NIMHgov
📄 Read in @nature.com - www.nature.com/articles/s41...
1/12
Led by Ling-Xiao Shao and @ItsClaraLiao
Funded by @NIH @NIMHgov
📄 Read in @nature.com - www.nature.com/articles/s41...
1/12
Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors - Nature
A pyramidal cell type and the 5-HT2A receptor in the medial frontal cortex have essential roles in psilocybin’s long-term drug action.
www.nature.com
April 2, 2025 at 4:09 PM
Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🧪
Led by Ling-Xiao Shao and @ItsClaraLiao
Funded by @NIH @NIMHgov
📄 Read in @nature.com - www.nature.com/articles/s41...
1/12
Led by Ling-Xiao Shao and @ItsClaraLiao
Funded by @NIH @NIMHgov
📄 Read in @nature.com - www.nature.com/articles/s41...
1/12
Our latest preprint -- a single psychedelic dose induces a long-lasting improvement in reversal learning ability
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Psychedelic enhancement of flexible learning weeks after a single dose
Psychedelic drugs have shown therapeutic potential for the treatment of multiple neuropsychiatric disorders chiefly by promoting long-lasting plasticity in the prefrontal cortex (PFC). A critical func...
www.biorxiv.org
January 8, 2025 at 5:56 PM
Our latest preprint -- a single psychedelic dose induces a long-lasting improvement in reversal learning ability
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Tyler Ekins
Our latest work led by @claraliao.bsky.social is a collaboration with the other Kwan lab @kwanlab.bsky.social
We used single-nucleus RNA sequencing to measure transcriptional responses in the mouse medial frontal cortex following a single dose of psilocybin. 🍄 🧠 🧬
www.biorxiv.org/content/10.1...
We used single-nucleus RNA sequencing to measure transcriptional responses in the mouse medial frontal cortex following a single dose of psilocybin. 🍄 🧠 🧬
www.biorxiv.org/content/10.1...
January 6, 2025 at 12:49 PM
Our latest work led by @claraliao.bsky.social is a collaboration with the other Kwan lab @kwanlab.bsky.social
We used single-nucleus RNA sequencing to measure transcriptional responses in the mouse medial frontal cortex following a single dose of psilocybin. 🍄 🧠 🧬
www.biorxiv.org/content/10.1...
We used single-nucleus RNA sequencing to measure transcriptional responses in the mouse medial frontal cortex following a single dose of psilocybin. 🍄 🧠 🧬
www.biorxiv.org/content/10.1...
Reposted by Tyler Ekins
Psilocybin slows and reduces complexity of neural dynamics in medial prefrontal cortex.
New paper with Ross Purple, Rahul Gupta, Matt Jones & Co.
New paper with Ross Purple, Rahul Gupta, Matt Jones & Co.
Short- and long-term reconfiguration of rat prefrontal cortical networks following single doses of psilocybin https://www.biorxiv.org/content/10.1101/2024.12.10.627734v1
December 17, 2024 at 10:51 AM
Psilocybin slows and reduces complexity of neural dynamics in medial prefrontal cortex.
New paper with Ross Purple, Rahul Gupta, Matt Jones & Co.
New paper with Ross Purple, Rahul Gupta, Matt Jones & Co.
Reposted by Tyler Ekins
Short- and long-term reconfiguration of rat prefrontal cortical networks following single doses of psilocybin https://www.biorxiv.org/content/10.1101/2024.12.10.627734v1
December 14, 2024 at 9:15 AM
Short- and long-term reconfiguration of rat prefrontal cortical networks following single doses of psilocybin https://www.biorxiv.org/content/10.1101/2024.12.10.627734v1
Our preprint on psychedelic control of prefrontal cortex pyramidal neurons! (from www.omarlab.org)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Cellular rules underlying psychedelic control of prefrontal pyramidal neurons
Classical psychedelic drugs are thought to increase excitability of pyramidal cells in prefrontal cortex via activation of serotonin 2A receptors (5-HT2ARs). Here, we instead find that multiple classe...
www.biorxiv.org
November 16, 2024 at 2:31 PM
Our preprint on psychedelic control of prefrontal cortex pyramidal neurons! (from www.omarlab.org)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...