Taylor Mighell
@taylor-mighell.bsky.social
Postdoc @crg.eu Barcelona
GPCRs | synthetic biology | genomics
GPCRs | synthetic biology | genomics
Reposted by Taylor Mighell
🎙️ Next up Dec 2 in VESS!
Thea Schulze (Lindorff-Larsen Lab): Predicting mutated protein abundance @tkschulze.bsky.social
Taylor Mighell (Lehner Lab): Massive mutagenesis to understand GPCRs @taylor-mighell.bsky.social
🔗 More info at varianteffect.org/seminar-series
@varianteffect.bsky.social
Thea Schulze (Lindorff-Larsen Lab): Predicting mutated protein abundance @tkschulze.bsky.social
Taylor Mighell (Lehner Lab): Massive mutagenesis to understand GPCRs @taylor-mighell.bsky.social
🔗 More info at varianteffect.org/seminar-series
@varianteffect.bsky.social
November 4, 2025 at 6:31 PM
🎙️ Next up Dec 2 in VESS!
Thea Schulze (Lindorff-Larsen Lab): Predicting mutated protein abundance @tkschulze.bsky.social
Taylor Mighell (Lehner Lab): Massive mutagenesis to understand GPCRs @taylor-mighell.bsky.social
🔗 More info at varianteffect.org/seminar-series
@varianteffect.bsky.social
Thea Schulze (Lindorff-Larsen Lab): Predicting mutated protein abundance @tkschulze.bsky.social
Taylor Mighell (Lehner Lab): Massive mutagenesis to understand GPCRs @taylor-mighell.bsky.social
🔗 More info at varianteffect.org/seminar-series
@varianteffect.bsky.social
Reposted by Taylor Mighell
New online: A small molecule stabilizer rescues the surface expression of nearly all missense variants in a GPCR
A small molecule stabilizer rescues the surface expression of nearly all missense variants in a GPCR
Nature Structural & Molecular Biology, Published online: 22 September 2025; doi:10.1038/s41594-025-01659-6Many mutations cause disease because they destabilize proteins. Here, Mighell and Lehner show that a single small molecule can correct the destabilization caused by nearly all pathogenic mutations in a human GPCR.
go.nature.com
September 22, 2025 at 11:29 AM
New online: A small molecule stabilizer rescues the surface expression of nearly all missense variants in a GPCR
GPCR-MAPS is now live! www.biorxiv.org/content/10.1...
A new platform for high resolution functional mapping of GPCRs with massive mutagenesis. We identify the core activation network, residues involved in biased signaling, and generate >7,000 full dose response curves. With @benlehner.bsky.social
A new platform for high resolution functional mapping of GPCRs with massive mutagenesis. We identify the core activation network, residues involved in biased signaling, and generate >7,000 full dose response curves. With @benlehner.bsky.social
The genetic architecture of G-protein coupled receptor signaling
G-protein coupled receptors (GPCRs) are the most abundant class of human receptors and drug targets. The vast majority of GPCR drugs bind the conserved orthosteric pocket, which can lead to non-specif...
www.biorxiv.org
June 1, 2025 at 7:48 AM
GPCR-MAPS is now live! www.biorxiv.org/content/10.1...
A new platform for high resolution functional mapping of GPCRs with massive mutagenesis. We identify the core activation network, residues involved in biased signaling, and generate >7,000 full dose response curves. With @benlehner.bsky.social
A new platform for high resolution functional mapping of GPCRs with massive mutagenesis. We identify the core activation network, residues involved in biased signaling, and generate >7,000 full dose response curves. With @benlehner.bsky.social
Reposted by Taylor Mighell
The genetic architecture of G-protein coupled receptor signaling https://www.biorxiv.org/content/10.1101/2025.05.30.656974v1
May 31, 2025 at 7:04 AM
The genetic architecture of G-protein coupled receptor signaling https://www.biorxiv.org/content/10.1101/2025.05.30.656974v1
Reposted by Taylor Mighell
Another local hero! Up next at #VariantEffect25:
@taylor-mighell.bsky.social from @benlehner.bsky.social lab presents: Two wrongs make a right: can GPCR antagonists rescue mutant receptors? 🧬🧪🔁
@taylor-mighell.bsky.social from @benlehner.bsky.social lab presents: Two wrongs make a right: can GPCR antagonists rescue mutant receptors? 🧬🧪🔁
May 23, 2025 at 10:05 AM
Another local hero! Up next at #VariantEffect25:
@taylor-mighell.bsky.social from @benlehner.bsky.social lab presents: Two wrongs make a right: can GPCR antagonists rescue mutant receptors? 🧬🧪🔁
@taylor-mighell.bsky.social from @benlehner.bsky.social lab presents: Two wrongs make a right: can GPCR antagonists rescue mutant receptors? 🧬🧪🔁
Reposted by Taylor Mighell
May 23, 2025 at 10:17 AM
Reposted by Taylor Mighell
Introducing Human Domainome v1, the largest and most comprehensive library of human protein variants to date, which maps the effects of +500K mutations across 522 domains. The study by @benlehner.bsky.social and Toni Beltran is out now in @nature.com. Illustration by @queralttolosa.bsky.social.
January 8, 2025 at 4:09 PM
Introducing Human Domainome v1, the largest and most comprehensive library of human protein variants to date, which maps the effects of +500K mutations across 522 domains. The study by @benlehner.bsky.social and Toni Beltran is out now in @nature.com. Illustration by @queralttolosa.bsky.social.
Reposted by Taylor Mighell
Nice highlighting of @taylor-mighell.bsky.social's GPCR pharmacochaperone preprint by @dereklowe.bsky.social @science.org www.biorxiv.org/content/10.1...
January 19, 2025 at 2:05 PM
Nice highlighting of @taylor-mighell.bsky.social's GPCR pharmacochaperone preprint by @dereklowe.bsky.social @science.org www.biorxiv.org/content/10.1...
Reposted by Taylor Mighell
Missense mutations are responsible for many heritable genetic disorders. Researchers led by @benlehner.bsky.social are carrying out large-scale experiments to understand why. Unstable proteins are emerging as a clear mechanism of action. Today in @elpais.com by @manuelansede.bsky.social.
The first ‘human domainome’ reveals the cause of a multitude of diseases
An ingenious large-scale experiment in Barcelona has led to the creation of a catalog detailing the effects of half a million DNA mutations
english.elpais.com
January 9, 2025 at 6:34 AM
Missense mutations are responsible for many heritable genetic disorders. Researchers led by @benlehner.bsky.social are carrying out large-scale experiments to understand why. Unstable proteins are emerging as a clear mechanism of action. Today in @elpais.com by @manuelansede.bsky.social.