Terukazu Nogi
@t-nogi.bsky.social
Protein science, Crystallography, Structure and dynamics, Molecular recognition
Reposted by Terukazu Nogi
Interested in crystallizing your favorite biomolecule for structural studies?
Join the #IUCr2026 Biomolecular Crystallization Workshop for
- Sample prep/characterization
- Optimization and seeding
- Ways to ‘see’ your crystals
- Ultrasmall to large crystals
- AI/ML advances
event.fourwaves.com/...
Join the #IUCr2026 Biomolecular Crystallization Workshop for
- Sample prep/characterization
- Optimization and seeding
- Ways to ‘see’ your crystals
- Ultrasmall to large crystals
- AI/ML advances
event.fourwaves.com/...
January 8, 2026 at 4:05 PM
Interested in crystallizing your favorite biomolecule for structural studies?
Join the #IUCr2026 Biomolecular Crystallization Workshop for
- Sample prep/characterization
- Optimization and seeding
- Ways to ‘see’ your crystals
- Ultrasmall to large crystals
- AI/ML advances
event.fourwaves.com/...
Join the #IUCr2026 Biomolecular Crystallization Workshop for
- Sample prep/characterization
- Optimization and seeding
- Ways to ‘see’ your crystals
- Ultrasmall to large crystals
- AI/ML advances
event.fourwaves.com/...
Reposted by Terukazu Nogi
No, seriously. Go get your flu shot. I’m not kidding.
November 12, 2025 at 8:29 PM
No, seriously. Go get your flu shot. I’m not kidding.
Reposted by Terukazu Nogi
SNDing proteins into the membrane! Our new publication from @melaniemcdowell.bsky.social ’s group identifies the SND3 protein as a new route for membrane protein insertion! 🍄 📘 Read more here: www.mpg.de/25599408/102... Image: Louise Duever.
October 30, 2025 at 8:55 AM
SNDing proteins into the membrane! Our new publication from @melaniemcdowell.bsky.social ’s group identifies the SND3 protein as a new route for membrane protein insertion! 🍄 📘 Read more here: www.mpg.de/25599408/102... Image: Louise Duever.
Reposted by Terukazu Nogi
#IUCr2026 Housing is Open!
Delegates have access to a variety of housing options, from convenient university dormitories to modern downtown hotels, making IUCr2026 accessible for every budget and preference
event.fourwaves.com/...
Delegates have access to a variety of housing options, from convenient university dormitories to modern downtown hotels, making IUCr2026 accessible for every budget and preference
event.fourwaves.com/...
October 22, 2025 at 3:50 PM
#IUCr2026 Housing is Open!
Delegates have access to a variety of housing options, from convenient university dormitories to modern downtown hotels, making IUCr2026 accessible for every budget and preference
event.fourwaves.com/...
Delegates have access to a variety of housing options, from convenient university dormitories to modern downtown hotels, making IUCr2026 accessible for every budget and preference
event.fourwaves.com/...
Reposted by Terukazu Nogi
BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"
Stay tuned for more.
#NobelPrize
Stay tuned for more.
#NobelPrize
October 6, 2025 at 9:34 AM
BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"
Stay tuned for more.
#NobelPrize
Stay tuned for more.
#NobelPrize
Scalable emulation of protein equilibrium ensembles with generative deep learning | Science www.science.org/doi/10.1126/...
Scalable emulation of protein equilibrium ensembles with generative deep learning
Following the sequence and structure revolutions, predicting functionally relevant protein structure changes at scale remains an outstanding challenge. We introduce BioEmu, a deep learning system that...
www.science.org
July 23, 2025 at 9:20 AM
Scalable emulation of protein equilibrium ensembles with generative deep learning | Science www.science.org/doi/10.1126/...
Reposted by Terukazu Nogi
Researchers funded by the NIH will be required to make their scientific papers available to read for free as soon as they are published
https://go.nature.com/3I0dtXr
https://go.nature.com/3I0dtXr
NIH-funded science must now be free to read instantly: what you should know
Nature - US biomedical agency’s public-access policy kicks in on 1 July. Nature talks to specialists about how to comply.
go.nature.com
June 28, 2025 at 4:22 PM
Researchers funded by the NIH will be required to make their scientific papers available to read for free as soon as they are published
https://go.nature.com/3I0dtXr
https://go.nature.com/3I0dtXr
Reposted by Terukazu Nogi
The minimal #IronSulfurCluster [Fe-S] biogenesis systems MIS & SMS are ancestral to modern ones. This study shows that the ancestral SMS system from M. jannaschii assembles [Fe-S] clusters via unique ATP-regulated mechanisms & uses sulfide as a #sulfur source @plosbiology.org 🧪 plos.io/46l0BoC
![Overall architecture of the SmsC2B2 complex. Top left: AMP-PNP-loaded SmsC2B2 crystal structure. Top right: Close-up on the binding site of the AMP-PNP/Mg2+ showing residues surrounding the binding site of AMP-PNP. Bottom left: Cryo-EM structure of the [Fe-S]-bound SmsC2B2 complex. Bottom right: Close-up on the binding site of the [Fe-S] cluster showing the C218, C239, and C242 coordinating the [Fe-S] cluster. The cluster binding site lies in a solvent-exposed hydrophobic pocket consisting of residues P40, L216, I223, Y235, F234, and P247.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:5522ztebtekoor5efelihqhb/bafkreigq7fsftcqadfcu2msy5pmyxf6fgce3eelb6fe7xrijsvazsc64va@jpeg)
June 26, 2025 at 4:38 PM
The minimal #IronSulfurCluster [Fe-S] biogenesis systems MIS & SMS are ancestral to modern ones. This study shows that the ancestral SMS system from M. jannaschii assembles [Fe-S] clusters via unique ATP-regulated mechanisms & uses sulfide as a #sulfur source @plosbiology.org 🧪 plos.io/46l0BoC
Reposted by Terukazu Nogi
The Na+-pumping mechanism driven by redox reactions in the NADH-quinone oxidoreductase from Vibrio cholerae relies on dynamic conformational changes www.biorxiv.org/content/10.1101/2025.06.01.656757v1 #cryoem
June 2, 2025 at 7:10 AM
The Na+-pumping mechanism driven by redox reactions in the NADH-quinone oxidoreductase from Vibrio cholerae relies on dynamic conformational changes www.biorxiv.org/content/10.1101/2025.06.01.656757v1 #cryoem
Reposted by Terukazu Nogi
Structure and organization of full-length epidermal growth factor receptor in extracellular vesicles by cryo-electron tomography pubmed.ncbi.nlm.nih.gov/40455995/ #cryoem
June 3, 2025 at 1:44 PM
Structure and organization of full-length epidermal growth factor receptor in extracellular vesicles by cryo-electron tomography pubmed.ncbi.nlm.nih.gov/40455995/ #cryoem
Reposted by Terukazu Nogi
A strain of bacterium that often causes infections in hospital can break down plastic
https://go.nature.com/434BcfX
https://go.nature.com/434BcfX
Microbe that infests hospitals can digest medical-grade plastic ― a first
The bacterium Pseudomonas aeruginosa produces an enzyme that breaks down biodegradable plastics.
go.nature.com
May 8, 2025 at 11:52 AM
A strain of bacterium that often causes infections in hospital can break down plastic
https://go.nature.com/434BcfX
https://go.nature.com/434BcfX
Reposted by Terukazu Nogi
Instrumentation and methods for efficient time-resolved X-ray crystallography of biomolecular systems with sub-10 ms time resolution pubmed.ncbi.nlm.nih.gov/40277177/ #cryoem
April 26, 2025 at 6:40 PM
Instrumentation and methods for efficient time-resolved X-ray crystallography of biomolecular systems with sub-10 ms time resolution pubmed.ncbi.nlm.nih.gov/40277177/ #cryoem
Reposted by Terukazu Nogi
Structural basis of urate transport by glucose transporter 9
Structural basis of urate transport by glucose transporter 9
Matsushita et al. report cryo-EM structures of a urate transporter, GLUT9, in apo and urate-bound states, revealing a unique recognition manner as compared to conventional GLUTs. Functional analysis revealed the importance of collective action by several residues in the urate pocket.
dlvr.it
April 7, 2025 at 7:50 PM
Structural basis of urate transport by glucose transporter 9
Our new paper on the cryo-EM SPA of intramembrane protease RseP has been oublished online. www.science.org/doi/10.1126/...
Cryo-EM structure of the bacterial intramembrane metalloprotease RseP in the substrate-bound state
Cryo-EM analysis suggests that bacterial group I site-2 proteases accommodate substrates into an occluded transmembrane cavity.
www.science.org
February 27, 2025 at 12:38 AM
Our new paper on the cryo-EM SPA of intramembrane protease RseP has been oublished online. www.science.org/doi/10.1126/...
Reposted by Terukazu Nogi
Watch the neutrophil response in zebrafish larvae to salmonella infection from this January paper. #12DaysOfeLife
https://buff.ly/4gKVws2
https://buff.ly/4gKVws2
December 27, 2024 at 4:44 PM
Watch the neutrophil response in zebrafish larvae to salmonella infection from this January paper. #12DaysOfeLife
https://buff.ly/4gKVws2
https://buff.ly/4gKVws2
Reposted by Terukazu Nogi
A fun journey of full-length EGFR with Dan Leahy and
@edwardmarcotte.bsky.social at UT Austin @utaustin.bsky.social. See below:
Structure and organization of full-length Epidermal Growth Factor Receptor in extracellular vesicles by cryo-electron tomography www.biorxiv.org/content/10.1...
@edwardmarcotte.bsky.social at UT Austin @utaustin.bsky.social. See below:
Structure and organization of full-length Epidermal Growth Factor Receptor in extracellular vesicles by cryo-electron tomography www.biorxiv.org/content/10.1...
November 29, 2024 at 6:15 AM
A fun journey of full-length EGFR with Dan Leahy and
@edwardmarcotte.bsky.social at UT Austin @utaustin.bsky.social. See below:
Structure and organization of full-length Epidermal Growth Factor Receptor in extracellular vesicles by cryo-electron tomography www.biorxiv.org/content/10.1...
@edwardmarcotte.bsky.social at UT Austin @utaustin.bsky.social. See below:
Structure and organization of full-length Epidermal Growth Factor Receptor in extracellular vesicles by cryo-electron tomography www.biorxiv.org/content/10.1...