Sohail Zahid
@szahid.bsky.social
Physician scientist interested in obesity, cardiology, genomics, and artificial intelligence.
Reposted by Sohail Zahid
.@who.int published a guideline in JAMA on the use and indications of #GLP-1 therapies for the management of #obesity in adults. The guideline offers two conditional recommendations to inform clinical practice and health policy.
Read the guideline: ja.ma/4oNCLHN
Read the guideline: ja.ma/4oNCLHN
December 14, 2025 at 2:00 PM
.@who.int published a guideline in JAMA on the use and indications of #GLP-1 therapies for the management of #obesity in adults. The guideline offers two conditional recommendations to inform clinical practice and health policy.
Read the guideline: ja.ma/4oNCLHN
Read the guideline: ja.ma/4oNCLHN
Reposted by Sohail Zahid
Normalization of glucose in people with prediabetes, i.e. achieving remission, is linked to halving of major cardiovascular adverse events over ensuing decades
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Prediabetes remission and cardiovascular morbidity and mortality: post-hoc analyses from the Diabetes Prevention Program Outcome study and the DaQing Diabetes Prevention Outcome study
Reaching prediatbetes remission is linked to a decades-long benefit, halving the risk
of cardiovascular death or hospitalisation for heart failure in diverse populations.
Targeting remission might rep...
www.thelancet.com
December 13, 2025 at 12:43 AM
Normalization of glucose in people with prediabetes, i.e. achieving remission, is linked to halving of major cardiovascular adverse events over ensuing decades
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
We are starting to integrate these polygenic risk scores into clinical workflows and these are great ways to start. This did not significantly change biopsy rates but accurately assessed risk, which is important especially when someone may not know their family history or true inherited risk.
Important new, large (N>28,000 women) randomized clinical trial of breast cancer screening: age-based vs risk-based by polygenic risk score, genomics
"opportunity to modernize screening"
jamanetwork.com/journals/jam...
"opportunity to modernize screening"
jamanetwork.com/journals/jam...
Risk-Based vs Annual Breast Cancer Screening
This randomized clinical trial examines whether risk-based screening is a safe and effective alternative to annual mammography for detecting breast cancer in women 40 years and older.
jamanetwork.com
December 12, 2025 at 9:44 PM
We are starting to integrate these polygenic risk scores into clinical workflows and these are great ways to start. This did not significantly change biopsy rates but accurately assessed risk, which is important especially when someone may not know their family history or true inherited risk.
Reposted by Sohail Zahid
29% weight loss, 71 pounds!
That what the triple receptor GLP-1 drug retatrutide achieved in a placebo-controlled trial
Plus 3-fold complete relief of knee osteoarthritis pain
www.nytimes.com/2025/12/11/h...
That what the triple receptor GLP-1 drug retatrutide achieved in a placebo-controlled trial
Plus 3-fold complete relief of knee osteoarthritis pain
www.nytimes.com/2025/12/11/h...
Major Weight Loss and Knee-Pain Relief Seen With New Eli Lilly Drug
www.nytimes.com
December 11, 2025 at 7:16 PM
29% weight loss, 71 pounds!
That what the triple receptor GLP-1 drug retatrutide achieved in a placebo-controlled trial
Plus 3-fold complete relief of knee osteoarthritis pain
www.nytimes.com/2025/12/11/h...
That what the triple receptor GLP-1 drug retatrutide achieved in a placebo-controlled trial
Plus 3-fold complete relief of knee osteoarthritis pain
www.nytimes.com/2025/12/11/h...
Reposted by Sohail Zahid
Nature research paper: Gut micro-organisms associated with health, nutrition and dietary interventions
go.nature.com/4a6NYQd
go.nature.com/4a6NYQd
Gut micro-organisms associated with health, nutrition and dietary interventions - Nature
Comprehensive large-scale studies of multi-national populations identified microbiome species consistently associated with favourable and unfavourable health markers, informing future studies of the human gut microbiome and its association with diet and cardiometabolic conditions.
go.nature.com
December 11, 2025 at 1:57 PM
Nature research paper: Gut micro-organisms associated with health, nutrition and dietary interventions
go.nature.com/4a6NYQd
go.nature.com/4a6NYQd
Reposted by Sohail Zahid
Scientists have characterized the broad genetic patterns that are shared across 14 psychiatric disorders. Could it reframe how mental-health conditions are diagnosed?
go.nature.com/48AooC4
go.nature.com/48AooC4
Shared genetic risk in psychiatric disorders
Scientists have characterized the broad genetic patterns that are shared across 14 psychiatric disorders. Could it reframe how mental-health conditions are diagnosed?
go.nature.com
December 12, 2025 at 9:14 AM
Scientists have characterized the broad genetic patterns that are shared across 14 psychiatric disorders. Could it reframe how mental-health conditions are diagnosed?
go.nature.com/48AooC4
go.nature.com/48AooC4
Reposted by Sohail Zahid
💬 Viewpoint: New #Obesity guidelines recommend direct adiposity measures, staging by obesity-related complications, explicit weight loss goals, and guidance on pharmacotherapy to advance personalized, risk-based care.
ja.ma/3KqL8Lz
ja.ma/3KqL8Lz
December 11, 2025 at 4:15 PM
💬 Viewpoint: New #Obesity guidelines recommend direct adiposity measures, staging by obesity-related complications, explicit weight loss goals, and guidance on pharmacotherapy to advance personalized, risk-based care.
ja.ma/3KqL8Lz
ja.ma/3KqL8Lz
Reposted by Sohail Zahid
How sugary drinks loaded with fructose and glucose may promote colon cancer metastatic potential
www.nature.com/articles/s42...
www.nature.com/articles/s42...
September 19, 2025 at 4:57 PM
How sugary drinks loaded with fructose and glucose may promote colon cancer metastatic potential
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Sohail Zahid
Does A.I. support of physicians lead to their deskilling?
A new report of gastroenterologists doing colonoscopy for polyp detection, with and without A.I., raises the possibility www.thelancet.com/journals/lan...
A new report of gastroenterologists doing colonoscopy for polyp detection, with and without A.I., raises the possibility www.thelancet.com/journals/lan...
August 12, 2025 at 10:39 PM
Does A.I. support of physicians lead to their deskilling?
A new report of gastroenterologists doing colonoscopy for polyp detection, with and without A.I., raises the possibility www.thelancet.com/journals/lan...
A new report of gastroenterologists doing colonoscopy for polyp detection, with and without A.I., raises the possibility www.thelancet.com/journals/lan...
Reposted by Sohail Zahid
Among patients with IgA nephropathy, treatment with iptacopan, which inhibits the alternative complement pathway, resulted in a significant reduction in proteinuria as compared with placebo. Full APPLAUSE-IgAN trial results and Research Summary: nej.md/3UmrOkh
#MedSky #Nephrology
#MedSky #Nephrology
February 10, 2025 at 8:45 PM
Among patients with IgA nephropathy, treatment with iptacopan, which inhibits the alternative complement pathway, resulted in a significant reduction in proteinuria as compared with placebo. Full APPLAUSE-IgAN trial results and Research Summary: nej.md/3UmrOkh
#MedSky #Nephrology
#MedSky #Nephrology