Soumen Basak
@systems-immunol.bsky.social
Systems Immunology Lab
National Institute of Immunology Delhi
posting on personal capacity
National Institute of Immunology Delhi
posting on personal capacity
Pinned
Soumen Basak
@systems-immunol.bsky.social
· May 26
Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense
Enteric nervous system (ENS)–derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is conside...
www.science.org
www.science.org/doi/10.1126/...
Completing the circuit? Enteric neurons produce immunomodulatory neuropeptides. It seems that they also express cytokine receptors and that cytokine signals promote neuropeptide production by them. The study shows the importance of this crosstalk in helminth control.
Completing the circuit? Enteric neurons produce immunomodulatory neuropeptides. It seems that they also express cytokine receptors and that cytokine signals promote neuropeptide production by them. The study shows the importance of this crosstalk in helminth control.
Reposted by Soumen Basak
A species of lungfish found in South America has claimed the title of the animal with the biggest genome sequenced so far.
Learn more on #WorldAnimalDay: https://scim.ag/46OMl6v
Learn more on #WorldAnimalDay: https://scim.ag/46OMl6v
October 4, 2025 at 8:54 PM
A species of lungfish found in South America has claimed the title of the animal with the biggest genome sequenced so far.
Learn more on #WorldAnimalDay: https://scim.ag/46OMl6v
Learn more on #WorldAnimalDay: https://scim.ag/46OMl6v
Reposted by Soumen Basak
Is seeing the northern lights on your bucket list? With the fall equinox approaching, now is the best time to catch aurorae. Learn more and discover how you can see (and photograph) the aurorae at skyandtelescope.org/how-to-see-t....
.
.
#astronomy #stargazing #aurora #northernlights #auroraborialis
.
.
#astronomy #stargazing #aurora #northernlights #auroraborialis
September 8, 2025 at 7:27 PM
Is seeing the northern lights on your bucket list? With the fall equinox approaching, now is the best time to catch aurorae. Learn more and discover how you can see (and photograph) the aurorae at skyandtelescope.org/how-to-see-t....
.
.
#astronomy #stargazing #aurora #northernlights #auroraborialis
.
.
#astronomy #stargazing #aurora #northernlights #auroraborialis
Reposted by Soumen Basak
Between 800,000 and 900,000 years ago, the population of human ancestors crashed, a 2023 Science study finds.
The results suggest there were only ~1280 breeding individuals during the transition between the early and middle Pleistocene. https://scim.ag/3K4hcnC #ScienceMagArchives
The results suggest there were only ~1280 breeding individuals during the transition between the early and middle Pleistocene. https://scim.ag/3K4hcnC #ScienceMagArchives
Genomic inference of a severe human bottleneck during the Early to Middle Pleistocene transition
A severe bottleneck that brought human ancestors close to extinction occurred between about 930 and 813 thousand years ago.
scim.ag
September 8, 2025 at 7:56 PM
Between 800,000 and 900,000 years ago, the population of human ancestors crashed, a 2023 Science study finds.
The results suggest there were only ~1280 breeding individuals during the transition between the early and middle Pleistocene. https://scim.ag/3K4hcnC #ScienceMagArchives
The results suggest there were only ~1280 breeding individuals during the transition between the early and middle Pleistocene. https://scim.ag/3K4hcnC #ScienceMagArchives
Reposted by Soumen Basak
A new study reveals a signaling loop that drives metastasis in triple-negative breast cancer, discoveries about amylin receptor subunits could inform future drug design, and more this week in #ScienceSignaling. https://scim.ag/3HH1ePw
August 19, 2025 at 9:00 PM
A new study reveals a signaling loop that drives metastasis in triple-negative breast cancer, discoveries about amylin receptor subunits could inform future drug design, and more this week in #ScienceSignaling. https://scim.ag/3HH1ePw
Reposted by Soumen Basak
Time to transmute and grow even more.
July 2, 2025 at 9:16 PM
Time to transmute and grow even more.
Reposted by Soumen Basak
“GlycoCaging” uses gut bacteria to activate drugs for inflammatory bowel disease.
Learn more in a new #SciencePerspective: scim.ag/4ltfMk8
Learn more in a new #SciencePerspective: scim.ag/4ltfMk8
July 1, 2025 at 4:09 PM
“GlycoCaging” uses gut bacteria to activate drugs for inflammatory bowel disease.
Learn more in a new #SciencePerspective: scim.ag/4ltfMk8
Learn more in a new #SciencePerspective: scim.ag/4ltfMk8
www.science.org/doi/10.1126/...
Completing the circuit? Enteric neurons produce immunomodulatory neuropeptides. It seems that they also express cytokine receptors and that cytokine signals promote neuropeptide production by them. The study shows the importance of this crosstalk in helminth control.
Completing the circuit? Enteric neurons produce immunomodulatory neuropeptides. It seems that they also express cytokine receptors and that cytokine signals promote neuropeptide production by them. The study shows the importance of this crosstalk in helminth control.
Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense
Enteric nervous system (ENS)–derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is conside...
www.science.org
May 26, 2025 at 2:35 PM
www.science.org/doi/10.1126/...
Completing the circuit? Enteric neurons produce immunomodulatory neuropeptides. It seems that they also express cytokine receptors and that cytokine signals promote neuropeptide production by them. The study shows the importance of this crosstalk in helminth control.
Completing the circuit? Enteric neurons produce immunomodulatory neuropeptides. It seems that they also express cytokine receptors and that cytokine signals promote neuropeptide production by them. The study shows the importance of this crosstalk in helminth control.
Reposted by Soumen Basak
Students:
Reading is not a project. Definitely not a summer project.
That's what students do.
Just like breathing is what living organisms do.
@treelab.bsky.social there are no reading projects, but you can borrow books, or we can direct you to the aisle in the #iiserbhopal library.
Reading is not a project. Definitely not a summer project.
That's what students do.
Just like breathing is what living organisms do.
@treelab.bsky.social there are no reading projects, but you can borrow books, or we can direct you to the aisle in the #iiserbhopal library.
May 22, 2025 at 5:16 AM
Students:
Reading is not a project. Definitely not a summer project.
That's what students do.
Just like breathing is what living organisms do.
@treelab.bsky.social there are no reading projects, but you can borrow books, or we can direct you to the aisle in the #iiserbhopal library.
Reading is not a project. Definitely not a summer project.
That's what students do.
Just like breathing is what living organisms do.
@treelab.bsky.social there are no reading projects, but you can borrow books, or we can direct you to the aisle in the #iiserbhopal library.
Reposted by Soumen Basak
After 60 years, scientists finally know why ginger, calico, and tortoiseshell cats look the way they do. scim.ag/3BpxRxY
Gene behind orange fur in cats found at last
After 60 years, scientists know why gingers, calicos, and tortoiseshells look the way they do
scim.ag
May 21, 2025 at 3:54 PM
After 60 years, scientists finally know why ginger, calico, and tortoiseshell cats look the way they do. scim.ag/3BpxRxY
Reposted by Soumen Basak
#NewPublicationAlert
Himanchu Chattani & team from Prof Uma Ramakrishnan's lab present a method to identify predators using non-invasive genetic samples from kill sites.
Read here: bit.ly/3RO6T84
🎉Congratulations to the team!
Himanchu Chattani & team from Prof Uma Ramakrishnan's lab present a method to identify predators using non-invasive genetic samples from kill sites.
Read here: bit.ly/3RO6T84
🎉Congratulations to the team!
Trace DNA from kill sites identifies individual predators
Predation ecology and evidence-based conflict management strategies require reliable and accurate identification of individual predators. Identifying …
bit.ly
May 5, 2025 at 10:51 AM
#NewPublicationAlert
Himanchu Chattani & team from Prof Uma Ramakrishnan's lab present a method to identify predators using non-invasive genetic samples from kill sites.
Read here: bit.ly/3RO6T84
🎉Congratulations to the team!
Himanchu Chattani & team from Prof Uma Ramakrishnan's lab present a method to identify predators using non-invasive genetic samples from kill sites.
Read here: bit.ly/3RO6T84
🎉Congratulations to the team!
Reposted by Soumen Basak
It took an extension to the extension of the extension, but after more than 3 years of negotiations, governments around the globe—but notably, not the United States—have finally agreed on a treaty to improve how the world prevents, prepares for, and responds to future pandemics. scim.ag/4lDYcLe
Global pandemic treaty finalized, without U.S., in ‘a victory for multilateralism’
Three years in the making, the accord aims to increase equity and avoid errors of the COVID-19 pandemic
scim.ag
April 16, 2025 at 7:57 PM
It took an extension to the extension of the extension, but after more than 3 years of negotiations, governments around the globe—but notably, not the United States—have finally agreed on a treaty to improve how the world prevents, prepares for, and responds to future pandemics. scim.ag/4lDYcLe
Reposted by Soumen Basak
Two positions in the @TrEE_Lab
Looking for students who are interested in genomic work & have basic training in handling genomic data. If you have a penchant for coding, writing scripts, & an interest in solving population genetic patterns in plants, apply! April 15th deadline.
Looking for students who are interested in genomic work & have basic training in handling genomic data. If you have a penchant for coding, writing scripts, & an interest in solving population genetic patterns in plants, apply! April 15th deadline.
April 13, 2025 at 10:40 AM
Two positions in the @TrEE_Lab
Looking for students who are interested in genomic work & have basic training in handling genomic data. If you have a penchant for coding, writing scripts, & an interest in solving population genetic patterns in plants, apply! April 15th deadline.
Looking for students who are interested in genomic work & have basic training in handling genomic data. If you have a penchant for coding, writing scripts, & an interest in solving population genetic patterns in plants, apply! April 15th deadline.
Reposted by Soumen Basak
#Immunology out now @science.org
After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen.
buff.ly/49bKcTG
By Jobin, Seetharama, Rüttger et al.
After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen.
buff.ly/49bKcTG
By Jobin, Seetharama, Rüttger et al.
April 11, 2025 at 4:17 PM
#Immunology out now @science.org
After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen.
buff.ly/49bKcTG
By Jobin, Seetharama, Rüttger et al.
After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen.
buff.ly/49bKcTG
By Jobin, Seetharama, Rüttger et al.
wow....
In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.
Learn more: scim.ag/41PWgYc
Learn more: scim.ag/41PWgYc
In-cell architecture of the mitochondrial respiratory chain
Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, workin...
scim.ag
March 29, 2025 at 3:07 PM
wow....
dogma indeed!!
Quick Bluesky introduction- I’m Molly a 3rd year CRUK PhD student in @labedwards.bsky.social working on inflammation in colorectal cancer! 👩🔬 Interested in 3D tissue models, biomarker discovery & public engagement ✨
March 28, 2025 at 3:09 AM
dogma indeed!!
wonderful read for today!
—How to prevent chronic inflammation that increases with aging ("inflammaging")?
—Exercise
www.nytimes.com/2025/03/19/w...
gift link
—Exercise
www.nytimes.com/2025/03/19/w...
gift link
Here’s One More Reason to Try to Exercise (Gift Article)
Consistent workouts can be a powerful way to fight chronic inflammation.
www.nytimes.com
March 28, 2025 at 3:05 AM
wonderful read for today!
Reposted by Soumen Basak
I wouldn't have anticipated a Lupus self-directed antibody (4H2) might someday turn out to be an anti-cancer treatment
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells
Delivery of autoimmune disease–associated antibodies activates the immune system to fight glioblastomas.
www.science.org
March 25, 2025 at 6:37 PM
I wouldn't have anticipated a Lupus self-directed antibody (4H2) might someday turn out to be an anti-cancer treatment
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
So important article...
"When I feel myself drifting toward despair, I think about what I learned during the pandemic, the first crisis of my Ph.D.: Build community and keep sharing the value of science."
This week's #ScienceWorkingLife. scim.ag/4iJp6ir
This week's #ScienceWorkingLife. scim.ag/4iJp6ir
March 25, 2025 at 3:06 AM
So important article...
constant in variables!!!
New Perspective article from Scott McConnell & @acasadevall1.bsky.social @johnshopkinssph.bsky.social highlights the importance of constant regions in influencing the specificity and functionality of #antibodies
#immunology #immunosky
#immunology #immunosky
New insights into antibody structure with implications for specificity, variable region restriction and isotype choice - Nature Reviews Immunology
Immunoglobulins sample vast swathes of primary sequence and conformational space to generate and select B cell clones with exquisite selectivity and affinity for specific antigens. This Perspective article examines the interplay between antibody diversification mechanisms and highlights the importance of constant regions in influencing the specificity and functionality of individual antibodies.
www.nature.com
March 20, 2025 at 6:01 PM
constant in variables!!!
Reposted by Soumen Basak
Online now: Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism
Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism
Wang et al. reveal that DLAT, a pyruvate metabolism enzyme, modulates leucine metabolism by directly acetylating the leucine catabolism enzyme AUH at K109, leading to leucine accumulation and sustained mTOR activation in HCC. Restoring leucine catabolism…
dlvr.it
March 19, 2025 at 3:42 PM
Online now: Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism
Reposted by Soumen Basak
This has only been possible through NIH funding.
Funding biomedical science through the NIH has been one of the greatest accomplishments of the United States of America for America, and for the world.
We are ALL better for the work that passionate scientists funded by the NIH have been able to do.
Funding biomedical science through the NIH has been one of the greatest accomplishments of the United States of America for America, and for the world.
We are ALL better for the work that passionate scientists funded by the NIH have been able to do.
90% of people diagnosed with pancreatic cancer die from the disease. That's why the medical community is excited about the results of a small trial in which nearly half of the pancreatic cancer patients who received an mRNA vaccine for the disease remained relapse-free three years later.
A Vaccine For Pancreatic Cancer Continues To Show Promise
In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine for the disease had no relapse three years later.
www.sciencefriday.com
March 16, 2025 at 4:29 PM
This has only been possible through NIH funding.
Funding biomedical science through the NIH has been one of the greatest accomplishments of the United States of America for America, and for the world.
We are ALL better for the work that passionate scientists funded by the NIH have been able to do.
Funding biomedical science through the NIH has been one of the greatest accomplishments of the United States of America for America, and for the world.
We are ALL better for the work that passionate scientists funded by the NIH have been able to do.