Stefan Schandelmaier
@sschandelmaier.bsky.social
Health research methodologist, methods guidance & implementation, meta-science.
www.LIGHTS.science
@lightsdatabase.bsky.social
www.ICEMAN.help
@clinepi-basel.bsky.social
www.LIGHTS.science
@lightsdatabase.bsky.social
www.ICEMAN.help
@clinepi-basel.bsky.social
Pinned
ICEMAN
Welcome to the web pages for ICEMAN! ICEMAN is an instrument to help researchers identify credible effect modification (also called subgroup effect, statistical interaction, moderation, or heterogenei...
www.iceman.help
I’m thrilled that leading research groups now recommend our #ICEMANtool to evaluate possible subgroup effects:
#Cochrane in their handbook Chapter 10.6
#GRADE in their guidance No. 36
Germany's #IQWIG in their general methods
www.iceman.help
www.cmaj.ca/content/192/...
#Cochrane in their handbook Chapter 10.6
#GRADE in their guidance No. 36
Germany's #IQWIG in their general methods
www.iceman.help
www.cmaj.ca/content/192/...
Reposted by Stefan Schandelmaier
With over 96% of global trial data on this topic included, this #IPDMA, published in @lancetrespirmed.bsky.social and initiated by #EU-RESPONSE, provides the most comprehensive analysis for JAK inhibitors for adults hospitalized due to #COVID19.
Full article: www.thelancet.com/journals/lan...
Full article: www.thelancet.com/journals/lan...
Effects of Janus kinase inhibitors in adults admitted to hospital due to COVID-19: a systematic review and individual participant data meta-analysis of randomised clinical trials
This IPDMA of RCTs in adults admitted to hospital due to COVID-19 found that JAK inhibitors
reduced mortality across all levels of respiratory support, independent of dexamethasone
or tocilizumab, and...
www.thelancet.com
May 15, 2025 at 6:15 AM
With over 96% of global trial data on this topic included, this #IPDMA, published in @lancetrespirmed.bsky.social and initiated by #EU-RESPONSE, provides the most comprehensive analysis for JAK inhibitors for adults hospitalized due to #COVID19.
Full article: www.thelancet.com/journals/lan...
Full article: www.thelancet.com/journals/lan...
Reposted by Stefan Schandelmaier
I’m thrilled that leading research groups now recommend our #ICEMANtool to evaluate possible subgroup effects:
#Cochrane in their handbook Chapter 10.6
#GRADE in their guidance No. 36
Germany's #IQWIG in their general methods
www.iceman.help
www.cmaj.ca/content/192/...
#Cochrane in their handbook Chapter 10.6
#GRADE in their guidance No. 36
Germany's #IQWIG in their general methods
www.iceman.help
www.cmaj.ca/content/192/...
ICEMAN
Welcome to the web pages for ICEMAN! ICEMAN is an instrument to help researchers identify credible effect modification (also called subgroup effect, statistical interaction, moderation, or heterogenei...
www.iceman.help
February 27, 2025 at 11:09 AM
I’m thrilled that leading research groups now recommend our #ICEMANtool to evaluate possible subgroup effects:
#Cochrane in their handbook Chapter 10.6
#GRADE in their guidance No. 36
Germany's #IQWIG in their general methods
www.iceman.help
www.cmaj.ca/content/192/...
#Cochrane in their handbook Chapter 10.6
#GRADE in their guidance No. 36
Germany's #IQWIG in their general methods
www.iceman.help
www.cmaj.ca/content/192/...
Reposted by Stefan Schandelmaier
Ian Fleming's original James Bond novels haven't aged well. For example, Moonraker - published almost exactly 70 years ago in April 1955 - features a villain who's a super-rich industrialist and rocket-maker seeking to cause chaos because he's a secret Nazi. Such a silly idea!
a man with a beard is sitting in a room with a harp in the background
ALT: a man with a beard is sitting in a room with a harp in the background
media.tenor.com
February 22, 2025 at 6:57 PM
Ian Fleming's original James Bond novels haven't aged well. For example, Moonraker - published almost exactly 70 years ago in April 1955 - features a villain who's a super-rich industrialist and rocket-maker seeking to cause chaos because he's a secret Nazi. Such a silly idea!
Reposted by Stefan Schandelmaier
Time to evict AirBnB from your life, if you have't already.
Airbnb’s co-founder is joining Elon Musk’s DOGE
Gebbia, a close friend of Musk, has praised DOGE’s work and defended it against criticisms on social media
www.independent.co.uk
February 16, 2025 at 1:27 AM
Time to evict AirBnB from your life, if you have't already.
Reposted by Stefan Schandelmaier
Have you checked our risk-stratified #RapidRecs on #PCSK9 inhibitors and #ezetimibe for the reduction of cardiovascular events ?
@magicevidence.bsky.social @bmj.com
-->https://www.bmj.com/content/377/bmj-2021-069066
@magicevidence.bsky.social @bmj.com
-->https://www.bmj.com/content/377/bmj-2021-069066
February 4, 2025 at 9:19 AM
Have you checked our risk-stratified #RapidRecs on #PCSK9 inhibitors and #ezetimibe for the reduction of cardiovascular events ?
@magicevidence.bsky.social @bmj.com
-->https://www.bmj.com/content/377/bmj-2021-069066
@magicevidence.bsky.social @bmj.com
-->https://www.bmj.com/content/377/bmj-2021-069066
Reposted by Stefan Schandelmaier
The risks of backing scattered islands of sensible points in a sea of nonsense: kucharski.substack.com/p/islands-of...
February 2, 2025 at 7:01 AM
The risks of backing scattered islands of sensible points in a sea of nonsense: kucharski.substack.com/p/islands-of...
Reposted by Stefan Schandelmaier
J Clin EPi @jclinepi.bsky.social has a unique focus on meta-research. I've co-led a November editorial reflecting on the variety its content, and how an even richer balance might be achieved. Methodologists assemble! www.jclinepi.com/article/S089... @davidit.bsky.social @andreatricco.bsky.social
What advice can we offer to authors? Reflections from the statisticians’ bench
What are the statistical issues on which the Journal of Clinical Epidemiology editorial
team should be offering advice to authors? Lists of statistical bugbears and elephant
traps in health research r...
www.jclinepi.com
November 29, 2024 at 10:02 AM
J Clin EPi @jclinepi.bsky.social has a unique focus on meta-research. I've co-led a November editorial reflecting on the variety its content, and how an even richer balance might be achieved. Methodologists assemble! www.jclinepi.com/article/S089... @davidit.bsky.social @andreatricco.bsky.social
So true!
I just saw this elsewhere and it made me think of our discussion here:
January 11, 2025 at 12:51 PM
So true!
Reposted by Stefan Schandelmaier
Happy New Year! I wrote a list of numerical coincidences involving 2025, see if you spot something fun!
#MathsSky #MathSky #MathsToday #MathChat
#MathsSky #MathSky #MathsToday #MathChat
Numerical coincidences for 2025
There seem to be a lot of numerical coincidences bouncing around concerning the new year 2025. For example, it’s a square number: \( 2025 = 45^2 \). The last square year was \(44^2 = 1936\), …
aperiodical.com
January 1, 2025 at 9:58 AM
Happy New Year! I wrote a list of numerical coincidences involving 2025, see if you spot something fun!
#MathsSky #MathSky #MathsToday #MathChat
#MathsSky #MathSky #MathsToday #MathChat
Reposted by Stefan Schandelmaier
Ever wonder about the basis for fear-mongering & conspiracy theories about mRNA vax? Wish you had a place to go when someone cites "proof"?
I've got you covered! In my latest @plos.org I buckle up for the waves of anti-vax muck likely to come in 2025. 1/2
absolutelymaybe.plos.org/2024/12/28/g...
I've got you covered! In my latest @plos.org I buckle up for the waves of anti-vax muck likely to come in 2025. 1/2
absolutelymaybe.plos.org/2024/12/28/g...
Getting Ready for More mRNA Vaccine Fear-Mongering: A Compendium - Absolutely Maybe
Recently, I wrote about a depressingly successful campaign against the introduction of a next generation Covid vaccine in Japan. It is a…
absolutelymaybe.plos.org
December 28, 2024 at 7:06 AM
Ever wonder about the basis for fear-mongering & conspiracy theories about mRNA vax? Wish you had a place to go when someone cites "proof"?
I've got you covered! In my latest @plos.org I buckle up for the waves of anti-vax muck likely to come in 2025. 1/2
absolutelymaybe.plos.org/2024/12/28/g...
I've got you covered! In my latest @plos.org I buckle up for the waves of anti-vax muck likely to come in 2025. 1/2
absolutelymaybe.plos.org/2024/12/28/g...
Reposted by Stefan Schandelmaier
1/ Excited to share thoughts on two excellent blog posts about clinical trials! First up: "The Case for Clinical Trial Abundance" by @ruxandrabio.bsky.social and Willy Chertman . They argue we need more clinical trials & that bureaucracy hampers faster progress. A sentiment I fully share!
The case for clinical trial abundance
A supply-side reform agenda for one of our most urgent problems
www.slowboring.com
December 23, 2024 at 12:32 PM
1/ Excited to share thoughts on two excellent blog posts about clinical trials! First up: "The Case for Clinical Trial Abundance" by @ruxandrabio.bsky.social and Willy Chertman . They argue we need more clinical trials & that bureaucracy hampers faster progress. A sentiment I fully share!
Reposted by Stefan Schandelmaier
Vaccines stopped polio.
December 23, 2024 at 9:15 PM
Vaccines stopped polio.
Methods guidance is evolving. Here the authors chose to provide explicit recommendations both in favor but also agains certain methods. I think that that’s the way forward!
Very nice summary recommendations on how to evaluate a prediction model from a group of top researchers in the field.
December 22, 2024 at 7:49 PM
Methods guidance is evolving. Here the authors chose to provide explicit recommendations both in favor but also agains certain methods. I think that that’s the way forward!
Reposted by Stefan Schandelmaier
Does #randomization ensures balance of risk factors between groups? Consider this:
In Denmark 860 individuals were randomly allocated to either intervention or control. Individuals were unaware of their allocation. No intervention took place. Mortality was higher in the intervention group (p=0.003)
In Denmark 860 individuals were randomly allocated to either intervention or control. Individuals were unaware of their allocation. No intervention took place. Mortality was higher in the intervention group (p=0.003)
November 26, 2024 at 1:38 PM
Does #randomization ensures balance of risk factors between groups? Consider this:
In Denmark 860 individuals were randomly allocated to either intervention or control. Individuals were unaware of their allocation. No intervention took place. Mortality was higher in the intervention group (p=0.003)
In Denmark 860 individuals were randomly allocated to either intervention or control. Individuals were unaware of their allocation. No intervention took place. Mortality was higher in the intervention group (p=0.003)
Reposted by Stefan Schandelmaier
This is leadership
November 26, 2024 at 10:31 AM
This is leadership
Reposted by Stefan Schandelmaier
Launching this week, MetaROR will be a free, open platform where anyone working with metaresearch can share their work and receive transparent, open peer reviews.
Join us at one of our launch events to find out more: researchonresearch.org/metaror-laun...
Join us at one of our launch events to find out more: researchonresearch.org/metaror-laun...
November 18, 2024 at 1:26 PM
Launching this week, MetaROR will be a free, open platform where anyone working with metaresearch can share their work and receive transparent, open peer reviews.
Join us at one of our launch events to find out more: researchonresearch.org/metaror-laun...
Join us at one of our launch events to find out more: researchonresearch.org/metaror-laun...
Reposted by Stefan Schandelmaier
A podcasting highlight!
Thanks so much to Editor-in-Chief of Science @holdenthorp.bsky.social for such a generous interview - calling for increased HPS teaching across high school and uni science curricula
Check the ep out on the pod today!
#hps #sts #histstm #philsci #academicsky #metasci
Thanks so much to Editor-in-Chief of Science @holdenthorp.bsky.social for such a generous interview - calling for increased HPS teaching across high school and uni science curricula
Check the ep out on the pod today!
#hps #sts #histstm #philsci #academicsky #metasci
"We need to get [scientists] to realise that history and philosophy of science has much to contribute to science itself"
A highly quotable episode with Editor-in-Chief of Science @holdenthorp.bsky.social
Out on @hpspodcast.bsky.social now!
#hps #philsci #histsci #sts🧪
A highly quotable episode with Editor-in-Chief of Science @holdenthorp.bsky.social
Out on @hpspodcast.bsky.social now!
#hps #philsci #histsci #sts🧪
S4 Ep 9 - Holden Thorp on 'Teach History and Philosophy of Science' - The HPS Podcast - Conversations from History, Philosophy and Social Studies of Science
“This is Holden Thorp. I'm the Editor in Chief of Science and thanks to Sam and Carmelina for all they're doing to get the word out about the history and philosophy of science”Today's guest is Holden ...
thehpspodcast.buzzsprout.com
November 14, 2024 at 6:43 AM
A podcasting highlight!
Thanks so much to Editor-in-Chief of Science @holdenthorp.bsky.social for such a generous interview - calling for increased HPS teaching across high school and uni science curricula
Check the ep out on the pod today!
#hps #sts #histstm #philsci #academicsky #metasci
Thanks so much to Editor-in-Chief of Science @holdenthorp.bsky.social for such a generous interview - calling for increased HPS teaching across high school and uni science curricula
Check the ep out on the pod today!
#hps #sts #histstm #philsci #academicsky #metasci
Reposted by Stefan Schandelmaier
What a talent. RIP Quincy Jones.
Quincy Jones, producer and entertainment powerhouse, dies aged 91
Quincy Jones, producer and entertainment powerhouse, dies aged 91
Widely and wildly talented musician and industry mogul worked with Michael Jackson, Frank Sinatra, Will Smith and others
www.theguardian.com
November 4, 2024 at 8:15 AM
What a talent. RIP Quincy Jones.
Hi qualitative researchers!
For my teaching, I was searching for something like PICO for qualitative. I found SPIDER and like it! pubmed.ncbi.nlm.nih.gov/22829486/
Is anybody aware of any other scheme for systematic question / problem / objective formulation in a qualitative study?
For my teaching, I was searching for something like PICO for qualitative. I found SPIDER and like it! pubmed.ncbi.nlm.nih.gov/22829486/
Is anybody aware of any other scheme for systematic question / problem / objective formulation in a qualitative study?
October 31, 2024 at 11:12 AM
Hi qualitative researchers!
For my teaching, I was searching for something like PICO for qualitative. I found SPIDER and like it! pubmed.ncbi.nlm.nih.gov/22829486/
Is anybody aware of any other scheme for systematic question / problem / objective formulation in a qualitative study?
For my teaching, I was searching for something like PICO for qualitative. I found SPIDER and like it! pubmed.ncbi.nlm.nih.gov/22829486/
Is anybody aware of any other scheme for systematic question / problem / objective formulation in a qualitative study?
Reposted by Stefan Schandelmaier
For patient-focused research, there are very few useful research aims, and none of them are "identifying risk factors.”
Seriously! 😜
(ICYMI)
statsepi.substack.com/p/sorry-what...
Seriously! 😜
(ICYMI)
statsepi.substack.com/p/sorry-what...
Sorry, what was the question again?
And again. And again. And again...
statsepi.substack.com
October 27, 2024 at 1:04 PM
For patient-focused research, there are very few useful research aims, and none of them are "identifying risk factors.”
Seriously! 😜
(ICYMI)
statsepi.substack.com/p/sorry-what...
Seriously! 😜
(ICYMI)
statsepi.substack.com/p/sorry-what...