Sophia Goladze
@sophiagol.bsky.social
PhD student at the University of Jyväskylä 🇫🇮
Interested in Phage-Bacterium-Host Interactions 🧬👩🔬
Believer of Open Science
Supporter of Phage Therapy
Interested in Phage-Bacterium-Host Interactions 🧬👩🔬
Believer of Open Science
Supporter of Phage Therapy
Reposted by Sophia Goladze
uit.no/nyheter/arti...
From the Marine Bioprospecting group of the @cansuit.bsky.social @uitnorgesarktiske.bsky.social
From the Marine Bioprospecting group of the @cansuit.bsky.social @uitnorgesarktiske.bsky.social
Gammelt virus gir nytt håp mot resistente bakterier | UiT
En bakteriofag fra 1920-tallet viser seg å kunne angripe en bakterie som første gang ble funnet av UiT-forskere hundre år senere. Funnet kan bety nye behandlingsmuligheter i møte med økende antibiotik...
uit.no
October 28, 2025 at 9:50 AM
uit.no/nyheter/arti...
From the Marine Bioprospecting group of the @cansuit.bsky.social @uitnorgesarktiske.bsky.social
From the Marine Bioprospecting group of the @cansuit.bsky.social @uitnorgesarktiske.bsky.social
Reposted by Sophia Goladze
New preprint!
Ever wondered why only a fraction of genomes encode CRISPR immunity? 🧬 🦠
Turns out CRISPR is rarely beneficial against virulent phages, being most beneficial against those for which resistance mutations are rare!
An epic effort by Rosanna Wright
www.biorxiv.org/content/10.1...
Ever wondered why only a fraction of genomes encode CRISPR immunity? 🧬 🦠
Turns out CRISPR is rarely beneficial against virulent phages, being most beneficial against those for which resistance mutations are rare!
An epic effort by Rosanna Wright
www.biorxiv.org/content/10.1...
Resistance mutation supply modulates the benefit of CRISPR immunity against virulent phages
Only a fraction of bacterial genomes encode CRISPR-Cas systems but the selective causes of this variation are unexplained. How naturally virulent bacteriophages (phages) select for CRISPR immunity has...
www.biorxiv.org
October 6, 2025 at 6:27 AM
New preprint!
Ever wondered why only a fraction of genomes encode CRISPR immunity? 🧬 🦠
Turns out CRISPR is rarely beneficial against virulent phages, being most beneficial against those for which resistance mutations are rare!
An epic effort by Rosanna Wright
www.biorxiv.org/content/10.1...
Ever wondered why only a fraction of genomes encode CRISPR immunity? 🧬 🦠
Turns out CRISPR is rarely beneficial against virulent phages, being most beneficial against those for which resistance mutations are rare!
An epic effort by Rosanna Wright
www.biorxiv.org/content/10.1...
Reposted by Sophia Goladze
Ensuring the integrity of your research is vital for credibility and impact. Discover ten essential tips to uphold ethical standards and trustworthiness in your work.
Learn more: www.elsevier.com/connect/ten-...
#ResearchEthics #ResearchIntegrity #AcademicResearch
Learn more: www.elsevier.com/connect/ten-...
#ResearchEthics #ResearchIntegrity #AcademicResearch
September 22, 2025 at 7:00 PM
Ensuring the integrity of your research is vital for credibility and impact. Discover ten essential tips to uphold ethical standards and trustworthiness in your work.
Learn more: www.elsevier.com/connect/ten-...
#ResearchEthics #ResearchIntegrity #AcademicResearch
Learn more: www.elsevier.com/connect/ten-...
#ResearchEthics #ResearchIntegrity #AcademicResearch
Reposted by Sophia Goladze
📝New preprint!
We investigated how spatial structure affects cooperation between phages, combining mathematical modelling and experiments.
A short thread 🧶
We investigated how spatial structure affects cooperation between phages, combining mathematical modelling and experiments.
A short thread 🧶
The ambivalent effect of spatial structure on the spread of cooperative anti-CRISPR phages https://www.biorxiv.org/content/10.1101/2025.08.06.668856v1
August 7, 2025 at 12:19 PM
📝New preprint!
We investigated how spatial structure affects cooperation between phages, combining mathematical modelling and experiments.
A short thread 🧶
We investigated how spatial structure affects cooperation between phages, combining mathematical modelling and experiments.
A short thread 🧶
Reposted by Sophia Goladze
Thrilled to see our Kiwa story out today! A membrane-associated supercomplex that senses infection and blocks replication and transcription.
www.cell.com/cell/fulltex...
Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.
www.cell.com/cell/fulltex...
Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.
Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites
Zhang, Todeschini, and Wu et al. show that the bacterial defense system Kiwa senses
phage attachment at the membrane and assembles a transmembrane complex that halts
infection by blocking phage DNA re...
www.cell.com
July 28, 2025 at 7:43 PM
Thrilled to see our Kiwa story out today! A membrane-associated supercomplex that senses infection and blocks replication and transcription.
www.cell.com/cell/fulltex...
Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.
www.cell.com/cell/fulltex...
Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.
Importance of mucin O-glycans in regularing bacterial metabolism and virulence 🦠🧫
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Commercial porcine gastric mucin contributes to variation in production of small molecule virulence factors by Pseudomonas aeruginosa when cultured in different formulations of artificial sputum mediu...
Site-specific in vitro culture media are being developed to investigate microbial pathogenicity and ecology in nutrient environments that are more reflective of disease. For microbial ecology research...
www.biorxiv.org
July 16, 2025 at 10:12 PM
Importance of mucin O-glycans in regularing bacterial metabolism and virulence 🦠🧫
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sophia Goladze
📚 I am happy to share that our latest paper is out in Glycobiology!
🦠 We developed a synthetic community of human gut microbes that completely degrades mucin glycans.
🔬 We studied its enzymes and ecological interactions in vitro.
#glycotime #mucin #microbiome
academic.oup.com/glycob/artic...
🦠 We developed a synthetic community of human gut microbes that completely degrades mucin glycans.
🔬 We studied its enzymes and ecological interactions in vitro.
#glycotime #mucin #microbiome
academic.oup.com/glycob/artic...
Mucin-driven ecological interactions in an in vitro synthetic community of human gut microbes
Abstract. Specific human gut microbes inhabit the outer mucus layer of the gastrointestinal tract. Certain residents of this niche can degrade the large an
academic.oup.com
December 11, 2024 at 1:34 PM
📚 I am happy to share that our latest paper is out in Glycobiology!
🦠 We developed a synthetic community of human gut microbes that completely degrades mucin glycans.
🔬 We studied its enzymes and ecological interactions in vitro.
#glycotime #mucin #microbiome
academic.oup.com/glycob/artic...
🦠 We developed a synthetic community of human gut microbes that completely degrades mucin glycans.
🔬 We studied its enzymes and ecological interactions in vitro.
#glycotime #mucin #microbiome
academic.oup.com/glycob/artic...
Reposted by Sophia Goladze
This was a fun collaboration between many scientists in the lab (go sponge team!), as well as our dear collaborators Renee Chang and Philip Kranzusch
Read the thread by talented scientist Nitzan Tal, who led the study, explaining our discoveries:
bsky.app/profile/nitz...
Read the thread by talented scientist Nitzan Tal, who led the study, explaining our discoveries:
bsky.app/profile/nitz...
📢Preprint out!
Excited to share my final work from the @soreklab.bsky.social!
We mined phage dark matter using structural features shared by anti-defense proteins (viral tools that help phages bypass bacterial immunity) to guide discovery.
Found 3 new families targeting immune signaling!
Excited to share my final work from the @soreklab.bsky.social!
We mined phage dark matter using structural features shared by anti-defense proteins (viral tools that help phages bypass bacterial immunity) to guide discovery.
Found 3 new families targeting immune signaling!
July 14, 2025 at 7:36 AM
This was a fun collaboration between many scientists in the lab (go sponge team!), as well as our dear collaborators Renee Chang and Philip Kranzusch
Read the thread by talented scientist Nitzan Tal, who led the study, explaining our discoveries:
bsky.app/profile/nitz...
Read the thread by talented scientist Nitzan Tal, who led the study, explaining our discoveries:
bsky.app/profile/nitz...
Reposted by Sophia Goladze
Phage therapy in a patient with prosthetic join infection in Spain! Another sucessful treatment from the #EnBiVir #VLCphagehunters @i2sysbio.es and #EvolvingTherapeutics in collaboration with Dr. de la Villa #GregorioMarañon
@uv.es
@csic.es
www.sciencedirect.com/science/arti...
@uv.es
@csic.es
www.sciencedirect.com/science/arti...
Successful phage therapy in a patient with prosthetic joint infection
www.sciencedirect.com
July 11, 2025 at 2:52 PM
Phage therapy in a patient with prosthetic join infection in Spain! Another sucessful treatment from the #EnBiVir #VLCphagehunters @i2sysbio.es and #EvolvingTherapeutics in collaboration with Dr. de la Villa #GregorioMarañon
@uv.es
@csic.es
www.sciencedirect.com/science/arti...
@uv.es
@csic.es
www.sciencedirect.com/science/arti...