Shifaan Thowfeequ
@shifaant.bsky.social
Research Scientist @UniofOxford, formerly @Columbia. Developmental biologist w/ interests in morphogenesis, evodevo, history/philosophy of science & education
The 'sparks' of life! Our latest work on the role of #calcium dynamics in the early #embryo. 🎇🔬🐁
@idrm.ox.ac.uk @oxforddpag.bsky.social @srinivas-lab.bsky.social #lightsheetmicroscopy #GCAMP
@idrm.ox.ac.uk @oxforddpag.bsky.social @srinivas-lab.bsky.social #lightsheetmicroscopy #GCAMP
During #development, distal visceral #endoderm (DVE) cells migrate to shape A-P axis specification. @m-stower.bsky.social @srinivas-lab.bsky.social &co reveal the role of Ca2+ dynamics in this, showing that inhibition of #calcium transients causes DVE arrest @plosbiology.org 🧪 plos.io/4nHWxF4
October 8, 2025 at 2:56 PM
The 'sparks' of life! Our latest work on the role of #calcium dynamics in the early #embryo. 🎇🔬🐁
@idrm.ox.ac.uk @oxforddpag.bsky.social @srinivas-lab.bsky.social #lightsheetmicroscopy #GCAMP
@idrm.ox.ac.uk @oxforddpag.bsky.social @srinivas-lab.bsky.social #lightsheetmicroscopy #GCAMP
Reposted by Shifaan Thowfeequ
During #development, distal visceral #endoderm (DVE) cells migrate to shape A-P axis specification. @m-stower.bsky.social @srinivas-lab.bsky.social &co reveal the role of Ca2+ dynamics in this, showing that inhibition of #calcium transients causes DVE arrest @plosbiology.org 🧪 plos.io/4nHWxF4
October 7, 2025 at 8:18 AM
During #development, distal visceral #endoderm (DVE) cells migrate to shape A-P axis specification. @m-stower.bsky.social @srinivas-lab.bsky.social &co reveal the role of Ca2+ dynamics in this, showing that inhibition of #calcium transients causes DVE arrest @plosbiology.org 🧪 plos.io/4nHWxF4
Reposted by Shifaan Thowfeequ
#OnThisDay in 1858, a seminal journal article comprised of papers by Alfred Russel Wallace FRS and Charles Darwin FRS on the theory of evolution by natural selection was published by the Linnean Society, the first public announcement of the theory of evolution. bit.ly/3k8fq4u
August 20, 2025 at 1:36 PM
#OnThisDay in 1858, a seminal journal article comprised of papers by Alfred Russel Wallace FRS and Charles Darwin FRS on the theory of evolution by natural selection was published by the Linnean Society, the first public announcement of the theory of evolution. bit.ly/3k8fq4u
Reposted by Shifaan Thowfeequ
*TODAY Wed 4 June 15:00 BST (UTC+1)*
Development presents... webinar, celebrating the winners of the @bsdb.bsky.social postdoc poster prize from the Biologists @ 100 conference. We'll hear from @giuliapaci.bsky.social and @shifaant.bsky.social
Register here: us02web.zoom.us/webinar/regi...
Development presents... webinar, celebrating the winners of the @bsdb.bsky.social postdoc poster prize from the Biologists @ 100 conference. We'll hear from @giuliapaci.bsky.social and @shifaant.bsky.social
Register here: us02web.zoom.us/webinar/regi...
June 4, 2025 at 7:37 AM
*TODAY Wed 4 June 15:00 BST (UTC+1)*
Development presents... webinar, celebrating the winners of the @bsdb.bsky.social postdoc poster prize from the Biologists @ 100 conference. We'll hear from @giuliapaci.bsky.social and @shifaant.bsky.social
Register here: us02web.zoom.us/webinar/regi...
Development presents... webinar, celebrating the winners of the @bsdb.bsky.social postdoc poster prize from the Biologists @ 100 conference. We'll hear from @giuliapaci.bsky.social and @shifaant.bsky.social
Register here: us02web.zoom.us/webinar/regi...
Reposted by Shifaan Thowfeequ
Very happy to share I've written a review on placental vascular formation in mice and humans, now published in @dev-journal.bsky.social.
journals.biologists.com/dev/article/...
@idrm.ox.ac.uk Funded by the @thebhf.bsky.social
journals.biologists.com/dev/article/...
@idrm.ox.ac.uk Funded by the @thebhf.bsky.social
Feto-placental blood vessel development
Summary: This Review contains an overview of placental vascular development and pathologies in mice and humans and highlights key remaining questions in the field.
journals.biologists.com
June 2, 2025 at 10:24 AM
Very happy to share I've written a review on placental vascular formation in mice and humans, now published in @dev-journal.bsky.social.
journals.biologists.com/dev/article/...
@idrm.ox.ac.uk Funded by the @thebhf.bsky.social
journals.biologists.com/dev/article/...
@idrm.ox.ac.uk Funded by the @thebhf.bsky.social
Reposted by Shifaan Thowfeequ
*This Wed 4 June 15:00 BST* Register to attend our next Development presents... webinar, celebrating the winners of the @bsdb.bsky.social postdoc poster prize from the Biologists @ 100 conference. We'll hear from @giuliapaci.bsky.social and @shifaant.bsky.social
us02web.zoom.us/webinar/regi...
us02web.zoom.us/webinar/regi...
June 2, 2025 at 8:58 AM
*This Wed 4 June 15:00 BST* Register to attend our next Development presents... webinar, celebrating the winners of the @bsdb.bsky.social postdoc poster prize from the Biologists @ 100 conference. We'll hear from @giuliapaci.bsky.social and @shifaant.bsky.social
us02web.zoom.us/webinar/regi...
us02web.zoom.us/webinar/regi...
Reposted by Shifaan Thowfeequ
Register now to attend our #DevPres webinar next week, featuring the winners of the @bsdb.bsky.social poster prize, @shifaant.bsky.social and @giuliapaci.bsky.social, and chaired by Abigail Tucker.
4 June at 15:00 BST
us02web.zoom.us/webinar/regi...
4 June at 15:00 BST
us02web.zoom.us/webinar/regi...
May 28, 2025 at 1:32 PM
Register now to attend our #DevPres webinar next week, featuring the winners of the @bsdb.bsky.social poster prize, @shifaant.bsky.social and @giuliapaci.bsky.social, and chaired by Abigail Tucker.
4 June at 15:00 BST
us02web.zoom.us/webinar/regi...
4 June at 15:00 BST
us02web.zoom.us/webinar/regi...
Reposted by Shifaan Thowfeequ
Visa costs will limit Britain's ability to court those who may seek to leave the U.S. after Trump's administration cut funding for universities and research bodies, says Professor Alison Noble FRS, Foreign Secretary of the Royal Society: www.reuters.com/world/uk/hig...
High UK visa costs deter international scientists and engineers
It took Ed Roberts over a year to find a senior scientist to work at his cancer research laboratory in Scotland, a delay he blames on high UK visa costs that made it harder to attract international workers.
www.reuters.com
April 15, 2025 at 4:20 PM
Visa costs will limit Britain's ability to court those who may seek to leave the U.S. after Trump's administration cut funding for universities and research bodies, says Professor Alison Noble FRS, Foreign Secretary of the Royal Society: www.reuters.com/world/uk/hig...
Reposted by Shifaan Thowfeequ
This is the head of a chicken embryo after 16 days of development, imaged with light sheet microscopy 🐣🔬🧪
April 10, 2025 at 8:33 AM
This is the head of a chicken embryo after 16 days of development, imaged with light sheet microscopy 🐣🔬🧪
The sun is shining over the beautiful city of Liverpool for @biologists.bsky.social ‘s Centenary Meeting ( #biologists100)
March 24, 2025 at 2:55 PM
The sun is shining over the beautiful city of Liverpool for @biologists.bsky.social ‘s Centenary Meeting ( #biologists100)
Reposted by Shifaan Thowfeequ
Very happy to share our work on lymphatic endothelial cell specification, which was published in Nature Cardiovascular Research this week.
January 22, 2025 at 4:14 PM
Very happy to share our work on lymphatic endothelial cell specification, which was published in Nature Cardiovascular Research this week.
Reposted by Shifaan Thowfeequ
✨Excited to share our work revisiting the developmental origins of mammalian lymphatic endothelial cells.✨
A summary of our key findings using scRNA-seq, snMultiome-seq and imaging to show the direct specification of mesenchymal progenitors to LECs🧵 #blutorial #blabstract
tinyurl.com/LECspec
A summary of our key findings using scRNA-seq, snMultiome-seq and imaging to show the direct specification of mesenchymal progenitors to LECs🧵 #blutorial #blabstract
tinyurl.com/LECspec
Direct specification of lymphatic endothelium from mesenchymal progenitors - Nature Cardiovascular Research
Lupu, Grainger, Kirschnick et al. show that, contrary to prevailing belief, the initial specification of mammalian lymphatic endothelial cells primarily occurs from previously unidentified mesenchymal...
tinyurl.com
January 13, 2025 at 2:31 PM
✨Excited to share our work revisiting the developmental origins of mammalian lymphatic endothelial cells.✨
A summary of our key findings using scRNA-seq, snMultiome-seq and imaging to show the direct specification of mesenchymal progenitors to LECs🧵 #blutorial #blabstract
tinyurl.com/LECspec
A summary of our key findings using scRNA-seq, snMultiome-seq and imaging to show the direct specification of mesenchymal progenitors to LECs🧵 #blutorial #blabstract
tinyurl.com/LECspec
Excited to have provided the cover images for the new Kaufman's Atlas of Mouse Development Supplement (edited by Gillian Morriss-Kay & Shankar Srinivas) – the go-to reference resource for all mammalian developmental biologists.
January 17, 2025 at 9:56 AM
Excited to have provided the cover images for the new Kaufman's Atlas of Mouse Development Supplement (edited by Gillian Morriss-Kay & Shankar Srinivas) – the go-to reference resource for all mammalian developmental biologists.
Have always been fascinated about these elusive giants–the beaked whales. Until now nothing was known about this extant species; known from only seven records and have never been seen alive at sea. Turns out it has a nine-chambered stomach and vestigial teeth! www.doc.govt.nz/news/media-r...
Spade-toothed whale reveals new discoveries
Vestigial teeth were just one of many new discoveries made by scientists during the dissection of the rarest whale in the world, Te Rūnanga o Ōtākou says.
www.doc.govt.nz
January 17, 2025 at 9:45 AM
Have always been fascinated about these elusive giants–the beaked whales. Until now nothing was known about this extant species; known from only seven records and have never been seen alive at sea. Turns out it has a nine-chambered stomach and vestigial teeth! www.doc.govt.nz/news/media-r...
Reposted by Shifaan Thowfeequ
Happy to share our latest review by @shifaant.bsky.social with @cwhanna.bsky.social. A detailed look at extraembryonic tissues – the 'other half' of the conceptus.
www.nature.com/articles/s41... @natrevmcb.bsky.social
www.nature.com/articles/s41... @natrevmcb.bsky.social
Origin, fate and function of extraembryonic tissues during mammalian development - Nature Reviews Molecular Cell Biology
During mammalian embryogenesis, extraembryonic tissues are required for the patterning and morphogenesis of the embryo. This Review discusses how signalling networks and epigenetic modifications regul...
www.nature.com
December 6, 2024 at 12:41 PM
Happy to share our latest review by @shifaant.bsky.social with @cwhanna.bsky.social. A detailed look at extraembryonic tissues – the 'other half' of the conceptus.
www.nature.com/articles/s41... @natrevmcb.bsky.social
www.nature.com/articles/s41... @natrevmcb.bsky.social
Beautifully written essay by @jbwallingford.bsky.social that every developmental biologist should read. aeon.co/essays/after...
After 3,000 years of science, the embryo is very different | Aeon Essays
For 3,000 years, humans have struggled to understand the embryo. Now there is a revolution underway
aeon.co
December 6, 2024 at 7:37 AM
Beautifully written essay by @jbwallingford.bsky.social that every developmental biologist should read. aeon.co/essays/after...
Nice to see our latest review published in
@natrevmcb.bsky.social today – a collaborative exploration of mammalian extraembryonic development with @cwhanna.bsky.social for an invaluable epigenetic focus. @srinivas-lab.bsky.social
www.nature.com/articles/s41...
@natrevmcb.bsky.social today – a collaborative exploration of mammalian extraembryonic development with @cwhanna.bsky.social for an invaluable epigenetic focus. @srinivas-lab.bsky.social
www.nature.com/articles/s41...
Origin, fate and function of extraembryonic tissues during mammalian development - Nature Reviews Molecular Cell Biology
During mammalian embryogenesis, extraembryonic tissues are required for the patterning and morphogenesis of the embryo. This Review discusses how signalling networks and epigenetic modifications regul...
www.nature.com
December 4, 2024 at 4:03 PM
Nice to see our latest review published in
@natrevmcb.bsky.social today – a collaborative exploration of mammalian extraembryonic development with @cwhanna.bsky.social for an invaluable epigenetic focus. @srinivas-lab.bsky.social
www.nature.com/articles/s41...
@natrevmcb.bsky.social today – a collaborative exploration of mammalian extraembryonic development with @cwhanna.bsky.social for an invaluable epigenetic focus. @srinivas-lab.bsky.social
www.nature.com/articles/s41...
A scenic walk to work this morning. Oxford, Oxfordshire.
November 19, 2024 at 7:42 PM
A scenic walk to work this morning. Oxford, Oxfordshire.
Reposted by Shifaan Thowfeequ
Happy to have the Srinivas lab on Bluesky!
Even our embryos are starting to feel a little festive in the Srinivas lab! We are excited to share our new bioRχiv pre-print – investigating the role of calcium in the early embryo
www.biorxiv.org/content/10.1...
Even our embryos are starting to feel a little festive in the Srinivas lab! We are excited to share our new bioRχiv pre-print – investigating the role of calcium in the early embryo
www.biorxiv.org/content/10.1...
November 18, 2024 at 4:44 PM
Happy to have the Srinivas lab on Bluesky!
Even our embryos are starting to feel a little festive in the Srinivas lab! We are excited to share our new bioRχiv pre-print – investigating the role of calcium in the early embryo
www.biorxiv.org/content/10.1...
Even our embryos are starting to feel a little festive in the Srinivas lab! We are excited to share our new bioRχiv pre-print – investigating the role of calcium in the early embryo
www.biorxiv.org/content/10.1...
Reposted by Shifaan Thowfeequ
Feeling Festive! Very happy to share our new bioRχiv pre-print – investigating the role of calcium signalling in the early mouse embryo:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 18, 2024 at 5:07 PM
Feeling Festive! Very happy to share our new bioRχiv pre-print – investigating the role of calcium signalling in the early mouse embryo:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Shifaan Thowfeequ
Calcium signalling is required for anterior patterning in the mouse embryo https://www.biorxiv.org/content/10.1101/2024.11.14.623160v1
Calcium signalling is required for anterior patterning in the mouse embryo https://www.biorxiv.org/content/10.1101/2024.11.14.623160v1
Anterior-Posterior axis formation in the mouse embryo requires the active migration of the DVE cell
www.biorxiv.org
November 15, 2024 at 5:30 AM
Calcium signalling is required for anterior patterning in the mouse embryo https://www.biorxiv.org/content/10.1101/2024.11.14.623160v1