Serin Edwin Erayil
@serinerayil.bsky.social
Assistant Professor and Associate Program Director, UMN ID Fellowship Program. Storyteller. Writer. Research: Candidemia, Ocular candidiasis, Antifungal resistance in Candida. Opinions own.
Reposted by Serin Edwin Erayil
🧬 Pushing the Boundaries of Medical Research 🧫
Drs. Erayil, Kline, and Selmecki, along with the team from the Selmecki Lab, have uncovered critical insights into a persistent Candida glabrata bloodstream infection that developed resistance while under treatment with micafungin. #IDSky
Drs. Erayil, Kline, and Selmecki, along with the team from the Selmecki Lab, have uncovered critical insights into a persistent Candida glabrata bloodstream infection that developed resistance while under treatment with micafungin. #IDSky
Hotspot gene conversion between FKS1 and FKS2 in echinocandin resistant Candida glabrata serial isolates - npj Antimicrobials and Resistance
npj Antimicrobials and Resistance - Hotspot gene conversion between FKS1 and FKS2 in echinocandin resistant Candida glabrata serial isolates
www.nature.com
April 30, 2025 at 10:20 PM
🧬 Pushing the Boundaries of Medical Research 🧫
Drs. Erayil, Kline, and Selmecki, along with the team from the Selmecki Lab, have uncovered critical insights into a persistent Candida glabrata bloodstream infection that developed resistance while under treatment with micafungin. #IDSky
Drs. Erayil, Kline, and Selmecki, along with the team from the Selmecki Lab, have uncovered critical insights into a persistent Candida glabrata bloodstream infection that developed resistance while under treatment with micafungin. #IDSky
Excited to publish with @annaselmecki.bsky.social and team on echinocandin resistance in Candida glabrata, in @springernature.com's npj Antimicrobials & Resistance. Read it here: rdcu.be/eicmm
April 27, 2025 at 6:25 PM
Excited to publish with @annaselmecki.bsky.social and team on echinocandin resistance in Candida glabrata, in @springernature.com's npj Antimicrobials & Resistance. Read it here: rdcu.be/eicmm
Reposted by Serin Edwin Erayil
Post-hoc analysis of 📷 📷 study in MSSA/MRSA bacteremia:
Persistent fever = indicator for complicated infection
Fever on Day 4️⃣: aOR (3.7 (95% CI: 1.58-8.67)) mortality
Fever on Day 7️⃣: aOR: (8.78 (95% CI: 2.78-27.7)
🚫 assn between ⬆️CRP/WBC and mortality
#IDSky
academic.oup.com/ofid/advance...
Persistent fever = indicator for complicated infection
Fever on Day 4️⃣: aOR (3.7 (95% CI: 1.58-8.67)) mortality
Fever on Day 7️⃣: aOR: (8.78 (95% CI: 2.78-27.7)
🚫 assn between ⬆️CRP/WBC and mortality
#IDSky
academic.oup.com/ofid/advance...
Association of daily body temperature, white blood cell count, and C-reactive protein with mortality and persistent bacteremia in patients with Staphylococcus aureus bacteremia: a post-hoc analysis of...
AbstractIntroduction. Classification of patients with Staphylococcus aureus bacteremia (SAB) as complicated versus uncomplicated is based on a combination
academic.oup.com
January 31, 2025 at 2:33 AM
Post-hoc analysis of 📷 📷 study in MSSA/MRSA bacteremia:
Persistent fever = indicator for complicated infection
Fever on Day 4️⃣: aOR (3.7 (95% CI: 1.58-8.67)) mortality
Fever on Day 7️⃣: aOR: (8.78 (95% CI: 2.78-27.7)
🚫 assn between ⬆️CRP/WBC and mortality
#IDSky
academic.oup.com/ofid/advance...
Persistent fever = indicator for complicated infection
Fever on Day 4️⃣: aOR (3.7 (95% CI: 1.58-8.67)) mortality
Fever on Day 7️⃣: aOR: (8.78 (95% CI: 2.78-27.7)
🚫 assn between ⬆️CRP/WBC and mortality
#IDSky
academic.oup.com/ofid/advance...
Reposted by Serin Edwin Erayil
New retrospective eval of 1000 Karius tests
Clinical impact: positive 16%, negative 2%, none 82%(!)
Cx neg IE and fastidious/zoonotic/vector-borne increased likelihood of positive impact, but not immunocompromised status
#IDSky @ichejournal.bsky.social
pubmed.ncbi.nlm.nih.gov/39881594/
Clinical impact: positive 16%, negative 2%, none 82%(!)
Cx neg IE and fastidious/zoonotic/vector-borne increased likelihood of positive impact, but not immunocompromised status
#IDSky @ichejournal.bsky.social
pubmed.ncbi.nlm.nih.gov/39881594/
January 31, 2025 at 6:20 PM
New retrospective eval of 1000 Karius tests
Clinical impact: positive 16%, negative 2%, none 82%(!)
Cx neg IE and fastidious/zoonotic/vector-borne increased likelihood of positive impact, but not immunocompromised status
#IDSky @ichejournal.bsky.social
pubmed.ncbi.nlm.nih.gov/39881594/
Clinical impact: positive 16%, negative 2%, none 82%(!)
Cx neg IE and fastidious/zoonotic/vector-borne increased likelihood of positive impact, but not immunocompromised status
#IDSky @ichejournal.bsky.social
pubmed.ncbi.nlm.nih.gov/39881594/
Reposted by Serin Edwin Erayil
Faculty @serinerayil.bsky.social
explored a critical clinical dilemma.
Their study of 308 patients found that while 6% were diagnosed with presumed candida chorioretinitis, nearly half were asymptomatic. No cases of endophthalmitis were identified. #IDSky
academic.oup.com/ofid/advance...
explored a critical clinical dilemma.
Their study of 308 patients found that while 6% were diagnosed with presumed candida chorioretinitis, nearly half were asymptomatic. No cases of endophthalmitis were identified. #IDSky
academic.oup.com/ofid/advance...
Do patients with candidemia need an ophthalmologic examination?
Among 308 patients with candidemia, we found a 6% incidence of presumed candida chorioretinitis. The number needed to screen among asymptomatic patients wa
academic.oup.com
December 7, 2024 at 2:47 PM
Faculty @serinerayil.bsky.social
explored a critical clinical dilemma.
Their study of 308 patients found that while 6% were diagnosed with presumed candida chorioretinitis, nearly half were asymptomatic. No cases of endophthalmitis were identified. #IDSky
academic.oup.com/ofid/advance...
explored a critical clinical dilemma.
Their study of 308 patients found that while 6% were diagnosed with presumed candida chorioretinitis, nearly half were asymptomatic. No cases of endophthalmitis were identified. #IDSky
academic.oup.com/ofid/advance...
Reposted by Serin Edwin Erayil
Ocular Candidiasis:
- No significant association with symptoms or comorbidities.
- more likely to be found >7 days from first +ve candida blood culture.
- Number needed to screen in asymptomatic pts was 20
#IDSky, what has been your practice? @dralicehan.bsky.social @germhuntermd.bsky.social
- No significant association with symptoms or comorbidities.
- more likely to be found >7 days from first +ve candida blood culture.
- Number needed to screen in asymptomatic pts was 20
#IDSky, what has been your practice? @dralicehan.bsky.social @germhuntermd.bsky.social
#IDSky
👉 Should we prioritize routine eye screenings for asymptomatic patients to mitigate rare but severe risks, or can selective, symptom-driven approaches suffice?
academic.oup.com/ofid/advance...
👉 Should we prioritize routine eye screenings for asymptomatic patients to mitigate rare but severe risks, or can selective, symptom-driven approaches suffice?
academic.oup.com/ofid/advance...
Do patients with candidemia need an ophthalmologic examination?
Among 308 patients with candidemia, we found a 6% incidence of presumed candida chorioretinitis. The number needed to screen among asymptomatic patients wa
academic.oup.com
December 7, 2024 at 3:09 PM
Ocular Candidiasis:
- No significant association with symptoms or comorbidities.
- more likely to be found >7 days from first +ve candida blood culture.
- Number needed to screen in asymptomatic pts was 20
#IDSky, what has been your practice? @dralicehan.bsky.social @germhuntermd.bsky.social
- No significant association with symptoms or comorbidities.
- more likely to be found >7 days from first +ve candida blood culture.
- Number needed to screen in asymptomatic pts was 20
#IDSky, what has been your practice? @dralicehan.bsky.social @germhuntermd.bsky.social
Reposted by Serin Edwin Erayil
Great day at Emerging Infections in Clinical Practice and Public Health 2024 conference!
All of our @umn-idim.bsky.social fellows had a great time learning from ID & Public Health experts here in MN!
#IDSky
#MicroSky
All of our @umn-idim.bsky.social fellows had a great time learning from ID & Public Health experts here in MN!
#IDSky
#MicroSky
November 22, 2024 at 11:53 PM
Great day at Emerging Infections in Clinical Practice and Public Health 2024 conference!
All of our @umn-idim.bsky.social fellows had a great time learning from ID & Public Health experts here in MN!
#IDSky
#MicroSky
All of our @umn-idim.bsky.social fellows had a great time learning from ID & Public Health experts here in MN!
#IDSky
#MicroSky
Reposted by Serin Edwin Erayil
🎉 We’re thrilled to welcome to our newest fellows who are joining us on this journey of advancing infectious diseases care, research, and education. 🌟 #MatchDay
December 4, 2024 at 9:27 PM
🎉 We’re thrilled to welcome to our newest fellows who are joining us on this journey of advancing infectious diseases care, research, and education. 🌟 #MatchDay
What a great night of wisdom from Dr Trautner. Glad you caught that slide @tomschmidt30.bsky.social. That slide was everything.
Wonderful evening w/ our @umn-idim.bsky.social folks hosting the one & only, Dr. Barbara Trautner!
Discussed her career, academic medicine, & the sage wisdom she can pass on to us trainees…
We pulled out all the stops to welcome her, even turned on the snow for her 😉😂☃️
#IDSky
#MinneSnowta
Discussed her career, academic medicine, & the sage wisdom she can pass on to us trainees…
We pulled out all the stops to welcome her, even turned on the snow for her 😉😂☃️
#IDSky
#MinneSnowta
November 21, 2024 at 4:02 AM
What a great night of wisdom from Dr Trautner. Glad you caught that slide @tomschmidt30.bsky.social. That slide was everything.
Reposted by Serin Edwin Erayil
Wonderful evening w/ our @umn-idim.bsky.social folks hosting the one & only, Dr. Barbara Trautner!
Discussed her career, academic medicine, & the sage wisdom she can pass on to us trainees…
We pulled out all the stops to welcome her, even turned on the snow for her 😉😂☃️
#IDSky
#MinneSnowta
Discussed her career, academic medicine, & the sage wisdom she can pass on to us trainees…
We pulled out all the stops to welcome her, even turned on the snow for her 😉😂☃️
#IDSky
#MinneSnowta
November 21, 2024 at 3:15 AM
Wonderful evening w/ our @umn-idim.bsky.social folks hosting the one & only, Dr. Barbara Trautner!
Discussed her career, academic medicine, & the sage wisdom she can pass on to us trainees…
We pulled out all the stops to welcome her, even turned on the snow for her 😉😂☃️
#IDSky
#MinneSnowta
Discussed her career, academic medicine, & the sage wisdom she can pass on to us trainees…
We pulled out all the stops to welcome her, even turned on the snow for her 😉😂☃️
#IDSky
#MinneSnowta
Reposted by Serin Edwin Erayil
Vanc+pip/tazo and AKI: a sheep in wolf’s clothing?
For many, the notion that vanc+pip/tazo is nephrotoxic has become accepted dogma
True or pseudo-nephrotoxicity?
A myth as per @pulmcrit.bsky.social
Check his blog:
emcrit.org/pulmcrit/myt...
Below: Visual abstract Miano et Al in ICM #idsky
For many, the notion that vanc+pip/tazo is nephrotoxic has become accepted dogma
True or pseudo-nephrotoxicity?
A myth as per @pulmcrit.bsky.social
Check his blog:
emcrit.org/pulmcrit/myt...
Below: Visual abstract Miano et Al in ICM #idsky
November 18, 2024 at 3:37 AM
Vanc+pip/tazo and AKI: a sheep in wolf’s clothing?
For many, the notion that vanc+pip/tazo is nephrotoxic has become accepted dogma
True or pseudo-nephrotoxicity?
A myth as per @pulmcrit.bsky.social
Check his blog:
emcrit.org/pulmcrit/myt...
Below: Visual abstract Miano et Al in ICM #idsky
For many, the notion that vanc+pip/tazo is nephrotoxic has become accepted dogma
True or pseudo-nephrotoxicity?
A myth as per @pulmcrit.bsky.social
Check his blog:
emcrit.org/pulmcrit/myt...
Below: Visual abstract Miano et Al in ICM #idsky
Reposted by Serin Edwin Erayil
Any new folks from MN that need to be added to MN ID Pack?
Recent adds are:
@genomd.bsky.social
@devries-aaron.bsky.social
@serinerayil.bsky.social
@umn-idim.bsky.social
Any others to add?!?
#IDSky
#MedSky
go.bsky.app/7PAEndf
Recent adds are:
@genomd.bsky.social
@devries-aaron.bsky.social
@serinerayil.bsky.social
@umn-idim.bsky.social
Any others to add?!?
#IDSky
#MedSky
go.bsky.app/7PAEndf
November 17, 2024 at 5:25 PM
Any new folks from MN that need to be added to MN ID Pack?
Recent adds are:
@genomd.bsky.social
@devries-aaron.bsky.social
@serinerayil.bsky.social
@umn-idim.bsky.social
Any others to add?!?
#IDSky
#MedSky
go.bsky.app/7PAEndf
Recent adds are:
@genomd.bsky.social
@devries-aaron.bsky.social
@serinerayil.bsky.social
@umn-idim.bsky.social
Any others to add?!?
#IDSky
#MedSky
go.bsky.app/7PAEndf
Reposted by Serin Edwin Erayil
IDsky community, what reading materials would you recommend our future ID doctors? @sebpoule.bsky.social @gpollara.bsky.social @dralicehan.bsky.social @drtimothyli.bsky.social @germhuntermd.bsky.social @blancagonzalez.bsky.social @handle.invalid
November 14, 2024 at 10:04 PM
IDsky community, what reading materials would you recommend our future ID doctors? @sebpoule.bsky.social @gpollara.bsky.social @dralicehan.bsky.social @drtimothyli.bsky.social @germhuntermd.bsky.social @blancagonzalez.bsky.social @handle.invalid
Reposted by Serin Edwin Erayil
Large retrospective study out in JAMA IM today on midline vs. PICC lines for OPAT demonstrating safety in using midlines, especially if <14 days of abx.
Does any center regularly use midlines for OPAT?
#IDSky
jamanetwork.com/journals/jam...
Does any center regularly use midlines for OPAT?
#IDSky
jamanetwork.com/journals/jam...
Midline vs Peripherally Inserted Central Catheter for Outpatient Parenteral Antimicrobial Therapy
This cohort study compares outcomes from midline catheters vs peripherally inserted central catheters for outpatient parenteral antimicrobial therapy.
jamanetwork.com
November 11, 2024 at 11:25 PM
Large retrospective study out in JAMA IM today on midline vs. PICC lines for OPAT demonstrating safety in using midlines, especially if <14 days of abx.
Does any center regularly use midlines for OPAT?
#IDSky
jamanetwork.com/journals/jam...
Does any center regularly use midlines for OPAT?
#IDSky
jamanetwork.com/journals/jam...
Reposted by Serin Edwin Erayil
Diagnostic Performance of Serum & BAL Galactomannan Testing in Lung Transplant Recipients
"Serum GM is not a valuable test in the diagnosis of IA in our LTx recipients, is costly, & does not remove the need for bronchoscopy & BAL GM."
onlinelibrary.wiley.com/doi/10.1111/... #TxID #IDSky
"Serum GM is not a valuable test in the diagnosis of IA in our LTx recipients, is costly, & does not remove the need for bronchoscopy & BAL GM."
onlinelibrary.wiley.com/doi/10.1111/... #TxID #IDSky
November 11, 2024 at 8:02 PM
Diagnostic Performance of Serum & BAL Galactomannan Testing in Lung Transplant Recipients
"Serum GM is not a valuable test in the diagnosis of IA in our LTx recipients, is costly, & does not remove the need for bronchoscopy & BAL GM."
onlinelibrary.wiley.com/doi/10.1111/... #TxID #IDSky
"Serum GM is not a valuable test in the diagnosis of IA in our LTx recipients, is costly, & does not remove the need for bronchoscopy & BAL GM."
onlinelibrary.wiley.com/doi/10.1111/... #TxID #IDSky
Reposted by Serin Edwin Erayil
watching #IDsky #Medsky #Pharmsky grow has been the best thing this week ☀️
really missed an online community for selfless knowledge sharing & collaboration 📖
👋🏻 im Erin, ID pharmacist in Pittsburgh. I love immunocompromised ID, antimicrobial stewardship, & building systems that help all patients
really missed an online community for selfless knowledge sharing & collaboration 📖
👋🏻 im Erin, ID pharmacist in Pittsburgh. I love immunocompromised ID, antimicrobial stewardship, & building systems that help all patients
November 11, 2024 at 11:34 AM
Reposted by Serin Edwin Erayil
#IDsky
Do you treat all candidemia the same in terms of ophthalmologic exam? Do you recommend 👀 exam for every candidemia? Or only high grade?
@germhuntermd.bsky.social @fungaldoc.bsky.social @drneilstone.bsky.social @drtimothyli.bsky.social @drtoddlee.bsky.social
doi.org/10.1093/ofid...
Do you treat all candidemia the same in terms of ophthalmologic exam? Do you recommend 👀 exam for every candidemia? Or only high grade?
@germhuntermd.bsky.social @fungaldoc.bsky.social @drneilstone.bsky.social @drtimothyli.bsky.social @drtoddlee.bsky.social
doi.org/10.1093/ofid...
Do patients with candidemia need an ophthalmologic examination?
Among 308 patients with candidemia, we found a 6% incidence of presumed candida chorioretinitis. The number needed to screen among asymptomatic patients wa
doi.org
November 12, 2024 at 2:01 AM
#IDsky
Do you treat all candidemia the same in terms of ophthalmologic exam? Do you recommend 👀 exam for every candidemia? Or only high grade?
@germhuntermd.bsky.social @fungaldoc.bsky.social @drneilstone.bsky.social @drtimothyli.bsky.social @drtoddlee.bsky.social
doi.org/10.1093/ofid...
Do you treat all candidemia the same in terms of ophthalmologic exam? Do you recommend 👀 exam for every candidemia? Or only high grade?
@germhuntermd.bsky.social @fungaldoc.bsky.social @drneilstone.bsky.social @drtimothyli.bsky.social @drtoddlee.bsky.social
doi.org/10.1093/ofid...
Reposted by Serin Edwin Erayil
Glad to see our APD from UMN ID here!
IDSky
MedSky
IDSky
MedSky
Starting here by sharing our just-published work on the ocular candidiasis question. Hello #IDSky!
Do patients with candidemia need an ophthalmologic examination? academic.oup.com/ofid/article...
Do patients with candidemia need an ophthalmologic examination? academic.oup.com/ofid/article...
Do patients with candidemia need an ophthalmologic examination?
Among 308 patients with candidemia, we found a 6% incidence of presumed candida chorioretinitis. The number needed to screen among asymptomatic patients wa
academic.oup.com
November 12, 2024 at 4:00 PM
Glad to see our APD from UMN ID here!
IDSky
MedSky
IDSky
MedSky
Starting here by sharing our just-published work on the ocular candidiasis question. Hello #IDSky!
Do patients with candidemia need an ophthalmologic examination? academic.oup.com/ofid/article...
Do patients with candidemia need an ophthalmologic examination? academic.oup.com/ofid/article...
Do patients with candidemia need an ophthalmologic examination?
Among 308 patients with candidemia, we found a 6% incidence of presumed candida chorioretinitis. The number needed to screen among asymptomatic patients wa
academic.oup.com
November 12, 2024 at 3:28 PM
Starting here by sharing our just-published work on the ocular candidiasis question. Hello #IDSky!
Do patients with candidemia need an ophthalmologic examination? academic.oup.com/ofid/article...
Do patients with candidemia need an ophthalmologic examination? academic.oup.com/ofid/article...