Interests: Getting trainees excited about ID/Research, ECMO infections, STIs, and Transfusion-Transmitted Infections
https://scholar.usuhs.edu/en/persons/joseph-marcus
💉 PK/PD concepts & considerations
🧫 antibacterials
🍄 antifungals
🦠 antivirals
🩺 management recommendations: dose optimization, challenges/recommendations, ABT stewardship
🔓 bit.ly/45vjrbt
💉 PK/PD concepts & considerations
🧫 antibacterials
🍄 antifungals
🦠 antivirals
🩺 management recommendations: dose optimization, challenges/recommendations, ABT stewardship
🔓 bit.ly/45vjrbt
Blood banks use PCR which can be positive for months to years after infection.
Guidance is to 🚫not treat unless positive smear
doi.org/10.1093/cid/...
Blood banks use PCR which can be positive for months to years after infection.
Guidance is to 🚫not treat unless positive smear
doi.org/10.1093/cid/...
Each year brings a flood of amazing ID literature.
Here are candidates for some of the most important ID papers of 2025, spanning guidelines, trials, antimicrobials, and vaccines.
👇
Each year brings a flood of amazing ID literature.
Here are candidates for some of the most important ID papers of 2025, spanning guidelines, trials, antimicrobials, and vaccines.
👇
-Similar rate of viral suppression (VL<50)
-Similar effect on CD4 count
Likely one step closer to a weekly oral HIV med.
#IDSky
www.acpjournals.org/doi/10.7326/...
-Similar rate of viral suppression (VL<50)
-Similar effect on CD4 count
Likely one step closer to a weekly oral HIV med.
#IDSky
www.acpjournals.org/doi/10.7326/...
African Trypanosomiasis: 🇬🇳 🇰🇪
Malaria: 🇬🇪 🇸🇷 🇹🇱
MTCT HBV: 🇲🇻
Onchocerciasis: 🇳🇪
Trachoma: 🇧🇮🇪🇬🇲🇷 🇵🇬
#IDSky
🇨🇻 🇪🇬-Malaria
🇧🇷 🇹🇱 - Lymphatic filariasis
🇯🇴-Leprosy
🇹🇩-African Trypanosomiasis
🇵🇰 🇮🇳 🇻🇳- Trachoma
www.npr.org/sections/goa...
#IDSky
African Trypanosomiasis: 🇬🇳 🇰🇪
Malaria: 🇬🇪 🇸🇷 🇹🇱
MTCT HBV: 🇲🇻
Onchocerciasis: 🇳🇪
Trachoma: 🇧🇮🇪🇬🇲🇷 🇵🇬
#IDSky
#IDSky
www.who.int/news/item/18...
#IDSky
www.who.int/news/item/18...
Comparison: abx targeting unblinded 🦴 cx or ulcer cx
Outcome: Remission at 12 months
Outcome: No difference RR 1.13; (95% CI 0.80-1.60).
Why? Both cxs concordant 85% of time
#IDSky
doi.org/10.1093/cid/...
Comparison: abx targeting unblinded 🦴 cx or ulcer cx
Outcome: Remission at 12 months
Outcome: No difference RR 1.13; (95% CI 0.80-1.60).
Why? Both cxs concordant 85% of time
#IDSky
doi.org/10.1093/cid/...
Available on all podcast apps. Transcript: www.idsociety.org/multimedia/p...
Available on all podcast apps. Transcript: www.idsociety.org/multimedia/p...
A 65M in NY developed severe P. falciparum malaria (16% parasitemia) after hospitalization for SDH.
Extensive tracing determined transmission at hospital with likely 🩸 borne transmission from returning traveler
#IDSky
doi.org/10.1093/ofid...
A 65M in NY developed severe P. falciparum malaria (16% parasitemia) after hospitalization for SDH.
Extensive tracing determined transmission at hospital with likely 🩸 borne transmission from returning traveler
#IDSky
doi.org/10.1093/ofid...
@kcawcutt.bsky.social @ichejournal.bsky.social #IDSky
www.cambridge.org/core/journal...
@kcawcutt.bsky.social @ichejournal.bsky.social #IDSky
www.cambridge.org/core/journal...
-70yo 🇺🇸 traveler to 🇨🇭 died from Tick-Borne Encephalitis after 🥾 in Alps
-12th case in 🇺🇸 traveler since 2000
-TBE vaccine 💉 recommended for travelers to Europe/Asia with⬆️ tick exposures
#IDSky
wwwnc.cdc.gov/eid/article/...
-70yo 🇺🇸 traveler to 🇨🇭 died from Tick-Borne Encephalitis after 🥾 in Alps
-12th case in 🇺🇸 traveler since 2000
-TBE vaccine 💉 recommended for travelers to Europe/Asia with⬆️ tick exposures
#IDSky
wwwnc.cdc.gov/eid/article/...
Unpreventable (53%)
-1/3 received no abx
-1/5 receive CPG abx only
Preventable (47%)
-1/4 conditions not on CPG
-1/4 non-CPG treatment given
Goal: ⬇️ preventable CDI
doi.org/10.1017/ash....
#IDSky
Unpreventable (53%)
-1/3 received no abx
-1/5 receive CPG abx only
Preventable (47%)
-1/4 conditions not on CPG
-1/4 non-CPG treatment given
Goal: ⬇️ preventable CDI
doi.org/10.1017/ash....
#IDSky
“It is a regrettable fact that discussion of syphilis of the nervous system and its treatment is still necessary”
H. Houston Merritt
@nejm.org
1939
#IDSky
www.nejm.org/doi/full/10....
“It is a regrettable fact that discussion of syphilis of the nervous system and its treatment is still necessary”
H. Houston Merritt
@nejm.org
1939
#IDSky
www.nejm.org/doi/full/10....
[In viral pneumonia] “briefly withholding antibiotics for patients with nonsevere illness to clarify the diagnosis is safe”
#IDSky
academic.oup.com/cid/advance-...
[In viral pneumonia] “briefly withholding antibiotics for patients with nonsevere illness to clarify the diagnosis is safe”
#IDSky
academic.oup.com/cid/advance-...
-🦇 Strain
-Symptoms 5 week transplant in kidney recipient
-Donor with neurological symptoms, but died at home from presumed cardiac arrest
#IDSky
www.cdc.gov/mmwr/volumes...
-🦇 Strain
-Symptoms 5 week transplant in kidney recipient
-Donor with neurological symptoms, but died at home from presumed cardiac arrest
#IDSky
www.cdc.gov/mmwr/volumes...
Are there hospitals were ID is very involved in antibiotic selection and duration?
Are there hospitals were ID is very involved in antibiotic selection and duration?
1) 🇺🇸 Pre-🫁 transplant ECMO associated with ⬆️ BSI post-transplant
link.springer.com/article/10.1...
2) 🇨🇭Post ❤️ transplant ECMO associated with ⬆️ 1 yr infections including bacterial and fungal
journals.lww.com/transplantat...
1) 🇺🇸 Pre-🫁 transplant ECMO associated with ⬆️ BSI post-transplant
link.springer.com/article/10.1...
2) 🇨🇭Post ❤️ transplant ECMO associated with ⬆️ 1 yr infections including bacterial and fungal
journals.lww.com/transplantat...
Pt1/4: +HBcAB, -HBVsAg, -HBVsAB
Pt2/3: +HBcAB, -HBVsAg,+HBVsAB
#IDSky
academic.oup.com/cid/advance-...
Pt1/4: +HBcAB, -HBVsAg, -HBVsAB
Pt2/3: +HBcAB, -HBVsAg,+HBVsAB
#IDSky
academic.oup.com/cid/advance-...
🔑 Critical illness contributes to more PK variability than ECMO
🔑 Lipopophilic, protein-bound
drugs sequestered by circuit
🔑 Use extended infusions for beta-lactams
www.sciencedirect.com/science/arti...
🔑 Critical illness contributes to more PK variability than ECMO
🔑 Lipopophilic, protein-bound
drugs sequestered by circuit
🔑 Use extended infusions for beta-lactams
www.sciencedirect.com/science/arti...
I’m excited to spend more time with the fellows!
#IDSky
I’m excited to spend more time with the fellows!
#IDSky
“English people called it the
“Spanish disease”… the Spanish called it mal inglés.
The Dutch called it “Spanish smallpox”
The Russians blamed the Poles, and the Turks referred to it as the “Christian disease””
#IDSky
academic.oup.com/jid/advance-...
“English people called it the
“Spanish disease”… the Spanish called it mal inglés.
The Dutch called it “Spanish smallpox”
The Russians blamed the Poles, and the Turks referred to it as the “Christian disease””
#IDSky
academic.oup.com/jid/advance-...