Seeger Lab
@seegerlab.bsky.social
Lab of Prof. Markus A. Seeger, @UZH_en, posts by group members; great admirers of membrane proteins, nanobodies, sybodies, structural biology and microbiology
Reposted by Seeger Lab
This was a fun collaboration between Ophélie & the @seegerlab.bsky.social using sybody libraries to target the SMC complex in living bacteria. With a suprising finding: the 14 isolated sybodies bind to the middle of the SMC coiled coil rather than the more conserved ATPase heads.
Single Domain Antibody Inhibitors Target the Coiled Coil Arms of the Bacillus subtilis SMC complex https://www.biorxiv.org/content/10.1101/2025.10.16.682983v1
October 20, 2025 at 8:15 AM
This was a fun collaboration between Ophélie & the @seegerlab.bsky.social using sybody libraries to target the SMC complex in living bacteria. With a suprising finding: the 14 isolated sybodies bind to the middle of the SMC coiled coil rather than the more conserved ATPase heads.
Reposted by Seeger Lab
A laser flash melting procedure, followed by rapid revitrification, provides a simple approach to help mitigate the preferred orientation problem that plagues cryo-EM analysis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Laser flash melting cryo-EM samples to overcome preferred orientation - Nature Methods
Individual proteins tend to adopt preferred orientations when subjected to vitrification for cryo-electron microscopy analysis. A laser flash melting procedure followed by rapid revitrification provid...
www.nature.com
August 29, 2025 at 6:44 PM
A laser flash melting procedure, followed by rapid revitrification, provides a simple approach to help mitigate the preferred orientation problem that plagues cryo-EM analysis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Seeger Lab
We are hiring a Postdoc in membrane protein cryo-EM at the University of Georgia. Looking for candidates with expertise in membrane protein purification and biochemistry. Fully funded for up to 5 years. Join us in Athens, GA. Apply: camilo.perez@uga.edu
August 21, 2025 at 2:26 PM
We are hiring a Postdoc in membrane protein cryo-EM at the University of Georgia. Looking for candidates with expertise in membrane protein purification and biochemistry. Fully funded for up to 5 years. Join us in Athens, GA. Apply: camilo.perez@uga.edu
Reposted by Seeger Lab
always a pleasure discussing all things #tuberculosis with this group @seegerlab.bsky.social @berndwollscheid.bsky.social & Michael Berney
August 20, 2025 at 4:17 PM
always a pleasure discussing all things #tuberculosis with this group @seegerlab.bsky.social @berndwollscheid.bsky.social & Michael Berney
Reposted by Seeger Lab
Dear all,
I am very excited about the upcoming 842 WE-Heraeus-Seminar #Cryo-EM on the Move. @djanuliene.bsky.social and I are looking forward to a great conference with many exciting speakers!
I am very excited about the upcoming 842 WE-Heraeus-Seminar #Cryo-EM on the Move. @djanuliene.bsky.social and I are looking forward to a great conference with many exciting speakers!
April 28, 2025 at 9:09 AM
Dear all,
I am very excited about the upcoming 842 WE-Heraeus-Seminar #Cryo-EM on the Move. @djanuliene.bsky.social and I are looking forward to a great conference with many exciting speakers!
I am very excited about the upcoming 842 WE-Heraeus-Seminar #Cryo-EM on the Move. @djanuliene.bsky.social and I are looking forward to a great conference with many exciting speakers!
Reposted by Seeger Lab
We had an amazing time with the ABC family and already miss you all! Can’t wait to hear your exciting talks, have great discussions, and hit the slopes of the Alps again. #ABC2025
See you next time!🗻⛷️🚠🧬🧫🧪💙
See you next time!🗻⛷️🚠🧬🧫🧪💙
March 7, 2025 at 9:13 AM
We had an amazing time with the ABC family and already miss you all! Can’t wait to hear your exciting talks, have great discussions, and hit the slopes of the Alps again. #ABC2025
See you next time!🗻⛷️🚠🧬🧫🧪💙
See you next time!🗻⛷️🚠🧬🧫🧪💙
Reposted by Seeger Lab
Structural biology:
#Mycobacteria use molecules called mycobactins to capture iron, then taken up by a membrane transporter
Gonda et al. show that mycobactin slides down a crevice at the transporter surface & goes across the membrane in a “credit card” mechanism
🦠🧪
www.nature.com/articles/s41...
#Mycobacteria use molecules called mycobactins to capture iron, then taken up by a membrane transporter
Gonda et al. show that mycobactin slides down a crevice at the transporter surface & goes across the membrane in a “credit card” mechanism
🦠🧪
www.nature.com/articles/s41...
February 17, 2025 at 10:14 AM
Structural biology:
#Mycobacteria use molecules called mycobactins to capture iron, then taken up by a membrane transporter
Gonda et al. show that mycobactin slides down a crevice at the transporter surface & goes across the membrane in a “credit card” mechanism
🦠🧪
www.nature.com/articles/s41...
#Mycobacteria use molecules called mycobactins to capture iron, then taken up by a membrane transporter
Gonda et al. show that mycobactin slides down a crevice at the transporter surface & goes across the membrane in a “credit card” mechanism
🦠🧪
www.nature.com/articles/s41...
Reposted by Seeger Lab
Markus from @seegerlab.bsky.social wakes us up with a fresh take on metal metabolism in Mycobacteria... So you think you have an exporter on your hands? Make sure it doesn't import instead - no iron(y) 😁
March 2, 2025 at 8:28 AM
Markus from @seegerlab.bsky.social wakes us up with a fresh take on metal metabolism in Mycobacteria... So you think you have an exporter on your hands? Make sure it doesn't import instead - no iron(y) 😁
Congrats to Dr. Sille Remm for winning the 1st special prize from the President of Estonian Academy of Science "for the most elegant work" in the Estonian National Student Science Competition!🥳👏 So proud of you!
March 13, 2025 at 8:27 PM
Congrats to Dr. Sille Remm for winning the 1st special prize from the President of Estonian Academy of Science "for the most elegant work" in the Estonian National Student Science Competition!🥳👏 So proud of you!
Proud to see our DMS paper out in @nchembio after going through a productive review process🥳EfrCD's drug efflux activity profile determined for >1400 single variants. Identified single mutations that convert the exporter into a drug-specific ABC importer!
nature.com/articles/s4158…
nature.com/articles/s4158…
March 13, 2025 at 8:27 PM
Proud to see our DMS paper out in @nchembio after going through a productive review process🥳EfrCD's drug efflux activity profile determined for >1400 single variants. Identified single mutations that convert the exporter into a drug-specific ABC importer!
nature.com/articles/s4158…
nature.com/articles/s4158…
Congrats to the @uzh iGEM team for winning the best therapeutics project🥇 and best new basic part awards🥇 and for getting into the top 10 among the 350 projects at this year's @iGEM Jamboree in Paris! We're happy for all your achievements! 🤩👏It was fun to host you in our lab!
March 13, 2025 at 8:27 PM
Congrats to the @uzh iGEM team for winning the best therapeutics project🥇 and best new basic part awards🥇 and for getting into the top 10 among the 350 projects at this year's @iGEM Jamboree in Paris! We're happy for all your achievements! 🤩👏It was fun to host you in our lab!
new group photo... PARKOUR!🤸🏻♀️💨
March 13, 2025 at 8:27 PM
new group photo... PARKOUR!🤸🏻♀️💨
March 13, 2025 at 8:27 PM
The climax of a 5 year collaborative project with the @enricabordignon lab: spin-labelled nanobodies to probe the conformational space of MsbA in intact cells published in @ScienceAdvances. Structures by @MoellerGroup and MD simulations by Lars Schäfer lab
science.org/doi/10.1126/sc…
science.org/doi/10.1126/sc…
March 13, 2025 at 8:27 PM
The climax of a 5 year collaborative project with the @enricabordignon lab: spin-labelled nanobodies to probe the conformational space of MsbA in intact cells published in @ScienceAdvances. Structures by @MoellerGroup and MD simulations by Lars Schäfer lab
science.org/doi/10.1126/sc…
science.org/doi/10.1126/sc…
Congrats to Sille Remm for successfully defending her PhD thesis!🥳👩🎓 You did very well biting through this tough project! We're so proud of you!☺️☺️
March 13, 2025 at 8:27 PM
Congrats to Sille Remm for successfully defending her PhD thesis!🥳👩🎓 You did very well biting through this tough project! We're so proud of you!☺️☺️
The temperature dropped by a few degrees yesterday, so we decided to have a raclette on our rooftop🧀😋
March 13, 2025 at 8:27 PM
The temperature dropped by a few degrees yesterday, so we decided to have a raclette on our rooftop🧀😋
March 13, 2025 at 8:27 PM
Four weeks of time flied so fast! We're happy that you enjoyed your stay and we had a great time with you too. Many thanks for all the scientific discussions and after work beers🍻😉. We're excited to see the sybody selection platform being implemented in the @Intein lab🥳
t.co/x5vKO8BMQu
t.co/x5vKO8BMQu
March 13, 2025 at 8:26 PM
Four weeks of time flied so fast! We're happy that you enjoyed your stay and we had a great time with you too. Many thanks for all the scientific discussions and after work beers🍻😉. We're excited to see the sybody selection platform being implemented in the @Intein lab🥳
t.co/x5vKO8BMQu
t.co/x5vKO8BMQu
We're happy to announce that our latest review about biomolecules capturing live bacteria from clinical samples is out on @TrendsBiochem !!🥳🥳
doi.org/10.1016/j.tibs…
doi.org/10.1016/j.tibs…
March 13, 2025 at 8:26 PM
We're happy to announce that our latest review about biomolecules capturing live bacteria from clinical samples is out on @TrendsBiochem !!🥳🥳
doi.org/10.1016/j.tibs…
doi.org/10.1016/j.tibs…
On a special mission to join a delegation of the Round Table Antibiotics to talk with members of the Swiss parliament about the urgent need to increase the federal budget to fight #AMR 💊🦠
March 13, 2025 at 8:26 PM
On a special mission to join a delegation of the Round Table Antibiotics to talk with members of the Swiss parliament about the urgent need to increase the federal budget to fight #AMR 💊🦠
📢Our rapid response to the COVID-19 pandemic finally in peer-reviewed form @emboreports in collaboration with Philippe Plattet, @CPaulino_ @MembraneEnzymo1 🥳
„Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance“
doi.org/10.15252/embr.…
„Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance“
doi.org/10.15252/embr.…
March 13, 2025 at 8:26 PM
📢Our rapid response to the COVID-19 pandemic finally in peer-reviewed form @emboreports in collaboration with Philippe Plattet, @CPaulino_ @MembraneEnzymo1 🥳
„Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance“
doi.org/10.15252/embr.…
„Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance“
doi.org/10.15252/embr.…
Preparing E.coli produced avocado smoothie🥑 for the afternoon apéro... or is it GFP-tagged protein?😜
March 13, 2025 at 8:26 PM
Preparing E.coli produced avocado smoothie🥑 for the afternoon apéro... or is it GFP-tagged protein?😜
March 13, 2025 at 8:26 PM