The Henrique ⌬
@scihenrique.bsky.social
Brazilian hobbit 🇧🇷
--> https://orcid.org/0000-0002-8973-4902
Padawan / MSc / PhD Student / MedChem 🥼🧪
Coffee enthusiast and medicinal chemist🧬☕️
--> https://orcid.org/0000-0002-8973-4902
Padawan / MSc / PhD Student / MedChem 🥼🧪
Coffee enthusiast and medicinal chemist🧬☕️
Reposted by The Henrique ⌬
No therapies are licensed to treat hereditary hemorrhagic telangiectasia, despite the considerable disease burden. Research findings with the AKT1 and AKT2 inhibitor engasertib are summarized in a new Quick Take video. nej.md/43PdHc1
#MedSky #Hematology
#MedSky #Hematology
December 2, 2025 at 2:02 PM
No therapies are licensed to treat hereditary hemorrhagic telangiectasia, despite the considerable disease burden. Research findings with the AKT1 and AKT2 inhibitor engasertib are summarized in a new Quick Take video. nej.md/43PdHc1
#MedSky #Hematology
#MedSky #Hematology
Reposted by The Henrique ⌬
Colocaram implantes cerebrais em uma mulher que perdeu os movimentos e agora ela consegue tocar piano só com os impulsos nervosos enquanto ela imagina tocar. Muito legal.
O twist: os eletrodos lêem os impulsos antes de serem registrados pela consciência. Então ela sente que o piano toca sozinho.
O twist: os eletrodos lêem os impulsos antes de serem registrados pela consciência. Então ela sente que o piano toca sozinho.
Mind-reading devices can now predict preconscious thoughts: is it time to worry?
Ethicists say AI-powered advances will threaten the privacy and autonomy of people who use neurotechnology.
www.nature.com
December 2, 2025 at 5:17 PM
Colocaram implantes cerebrais em uma mulher que perdeu os movimentos e agora ela consegue tocar piano só com os impulsos nervosos enquanto ela imagina tocar. Muito legal.
O twist: os eletrodos lêem os impulsos antes de serem registrados pela consciência. Então ela sente que o piano toca sozinho.
O twist: os eletrodos lêem os impulsos antes de serem registrados pela consciência. Então ela sente que o piano toca sozinho.
Por uns anos talvez eu tenha esquecido quem eu era e o meu maior sonho, mas também eu percebi que não precisava ficar concentrado em apenas 1 sonho ou apenas 1 plano, poderia ter mais focos na minha vida...
Porém, agora tá tudo meio confuso.. Sei lá..
Porém, agora tá tudo meio confuso.. Sei lá..
November 7, 2025 at 12:23 PM
Por uns anos talvez eu tenha esquecido quem eu era e o meu maior sonho, mas também eu percebi que não precisava ficar concentrado em apenas 1 sonho ou apenas 1 plano, poderia ter mais focos na minha vida...
Porém, agora tá tudo meio confuso.. Sei lá..
Porém, agora tá tudo meio confuso.. Sei lá..
The big problem is that: You only live once
October 18, 2025 at 2:20 PM
The big problem is that: You only live once
A-ha sempre sendo a melhor companhia das manhãs 😊
October 14, 2025 at 10:11 AM
A-ha sempre sendo a melhor companhia das manhãs 😊
Preciso melhorar minha conversão em inglês pra ontem, no entanto, todavia... estou sem dinheiro 😭
October 11, 2025 at 2:46 PM
Preciso melhorar minha conversão em inglês pra ontem, no entanto, todavia... estou sem dinheiro 😭
Reposted by The Henrique ⌬
Blocking erythrocyte invasion during the blood stage of Plasmodium infection can prevent malaria. A Review in Nature Reviews Microbiology discusses structural insights on this invasion by the merozoite form of Plasmodium to aid rational design of a malaria vaccine.
go.nature.com/4o6prP4 🔒
go.nature.com/4o6prP4 🔒
Erythrocyte invasion in malaria: from molecular mechanisms to rational vaccines - Nature Reviews Microbiology
If erythrocyte invasion is blocked during the blood stage of infection by Plasmodium parasites, malaria can be prevented. In this Review, structural insights on erythrocyte invasion by the merozoite form of Plasmodium are discussed in the context of rational design of a blood-stage malaria vaccine.
go.nature.com
October 10, 2025 at 1:09 PM
Blocking erythrocyte invasion during the blood stage of Plasmodium infection can prevent malaria. A Review in Nature Reviews Microbiology discusses structural insights on this invasion by the merozoite form of Plasmodium to aid rational design of a malaria vaccine.
go.nature.com/4o6prP4 🔒
go.nature.com/4o6prP4 🔒
Uma tarde toda hoje apenas para análise de RMN
Meu lob occipital que aguente
Meu lob occipital que aguente
October 10, 2025 at 2:03 PM
Uma tarde toda hoje apenas para análise de RMN
Meu lob occipital que aguente
Meu lob occipital que aguente
Já tô enviando compostos para serem testados em SP 😭
Favela vencendo
Favela vencendo
October 9, 2025 at 5:06 PM
Já tô enviando compostos para serem testados em SP 😭
Favela vencendo
Favela vencendo
Depois de 3 semanas sem RMN, o dito cujo voltou.. agora tô com milhares de amostras e a ansiedade no céu para saber se todas as reações funcionaram
😭😭😭
😭😭😭
October 9, 2025 at 2:05 PM
Depois de 3 semanas sem RMN, o dito cujo voltou.. agora tô com milhares de amostras e a ansiedade no céu para saber se todas as reações funcionaram
😭😭😭
😭😭😭
Berkeley domina o Nobel… Lá que tem o verdadeiro suco, será??
October 9, 2025 at 1:09 AM
Berkeley domina o Nobel… Lá que tem o verdadeiro suco, será??
Maybe hurt… maybe broken…
October 7, 2025 at 1:45 AM
Maybe hurt… maybe broken…
What an amazing podcast with Dr. Zimmer! So much discussion about Brazilian brains and neuroscience. I'm so excited to know that science is being done at this level in Brazil.
youtu.be/WJw-XW9ZJC0?...
youtu.be/WJw-XW9ZJC0?...
O cérebro do brasileiro precisa ser estudado (sério) - Podcast Não Ficção
YouTube video by Atila Iamarino
youtu.be
October 5, 2025 at 12:26 PM
What an amazing podcast with Dr. Zimmer! So much discussion about Brazilian brains and neuroscience. I'm so excited to know that science is being done at this level in Brazil.
youtu.be/WJw-XW9ZJC0?...
youtu.be/WJw-XW9ZJC0?...
My spider sense is so confusing now... It's not common.
October 4, 2025 at 2:44 PM
My spider sense is so confusing now... It's not common.
Nobel prize segunda feira
a man wearing a red shirt with the word flash on it
ALT: a man wearing a red shirt with the word flash on it
media.tenor.com
October 3, 2025 at 4:44 PM
Nobel prize segunda feira
Reposted by The Henrique ⌬
NSAIDs are known to alleviate pain by reducing inflammation. A study in Nature Communications shows that selective inhibition of the prostaglandin E2 receptor in Schwann cells eliminates pain without disrupting the protective and healing functions of inflammation. #medsky 🧪
Targeting prostaglandin E2 receptor 2 in Schwann cells inhibits inflammatory pain but not inflammation - Nature Communications
Non-steroidal anti-inflammatory drugs (NSAIDs) are known to alleviate pain by reducing inflammation. To the contrary, here, the authors show that selective inhibition of the prostaglandin E2 receptor (EP2) in Schwann cells eliminates pain without disrupting the protective and healing functions of inflammation.
go.nature.com
October 2, 2025 at 7:12 PM
NSAIDs are known to alleviate pain by reducing inflammation. A study in Nature Communications shows that selective inhibition of the prostaglandin E2 receptor in Schwann cells eliminates pain without disrupting the protective and healing functions of inflammation. #medsky 🧪
Triste que no twitter não se consegue mais desabafar...
Maaas, aproveitando o espaço daqui:
Não sei que cargas d'agua o meu humor vem oscilando de alegria a tristeza profunda em um período muito curto.. Isso tá me fazendo muito mal!!
Maaas, aproveitando o espaço daqui:
Não sei que cargas d'agua o meu humor vem oscilando de alegria a tristeza profunda em um período muito curto.. Isso tá me fazendo muito mal!!
October 3, 2025 at 12:58 AM
Triste que no twitter não se consegue mais desabafar...
Maaas, aproveitando o espaço daqui:
Não sei que cargas d'agua o meu humor vem oscilando de alegria a tristeza profunda em um período muito curto.. Isso tá me fazendo muito mal!!
Maaas, aproveitando o espaço daqui:
Não sei que cargas d'agua o meu humor vem oscilando de alegria a tristeza profunda em um período muito curto.. Isso tá me fazendo muito mal!!
Structure–Activity Relationships of Inactive‐Conformation Binding EGFR Inhibitors: Linking the ATP and Allosteric Pockets - Chitnis - 2025 - Archiv der Pharmazie - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
Structure–Activity Relationships of Inactive‐Conformation Binding EGFR Inhibitors: Linking the ATP and Allosteric Pockets
EGFR inhibitors can be made especially effective through binding small-molecule inhibitors that target the allosteric pocket. Structural and functional analysis affords new insights into the composit....
onlinelibrary.wiley.com
September 27, 2025 at 11:50 PM
Structure–Activity Relationships of Inactive‐Conformation Binding EGFR Inhibitors: Linking the ATP and Allosteric Pockets - Chitnis - 2025 - Archiv der Pharmazie - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
Foi tooooop
🇧🇷🇧🇷🇧🇷🇧🇷
Holy shit he fuckin did it!!! Sandro Dias fuckin did it!!!
September 26, 2025 at 12:15 AM
Foi tooooop
A systematic review highlighting the most common methods for studying the action of potential compounds against Alzheimer's disease in rodents.
The findings show the most common substance or method used to damage the AChE pathway in rodents.
www.eurekaselect.com/article/150112
#MedChem #ChemBio 🧪
The findings show the most common substance or method used to damage the AChE pathway in rodents.
www.eurekaselect.com/article/150112
#MedChem #ChemBio 🧪
Evidence of the Efficacy of Acetylcholinesterase Inhibitors in In Vivo Studies: A Systematic Review
Introduction: This systematic review aimed to provide an updated overview of studies
using anticholinesterases with in vivo activity for the treatment of Alzheimer's disease.
Methods: A systematic re...
www.eurekaselect.com
September 21, 2025 at 2:58 PM
A systematic review highlighting the most common methods for studying the action of potential compounds against Alzheimer's disease in rodents.
The findings show the most common substance or method used to damage the AChE pathway in rodents.
www.eurekaselect.com/article/150112
#MedChem #ChemBio 🧪
The findings show the most common substance or method used to damage the AChE pathway in rodents.
www.eurekaselect.com/article/150112
#MedChem #ChemBio 🧪
Reposted by The Henrique ⌬
Are you an enthusiast of #ChemBio? Do not miss the chance to register for free for the 5th Virtual @chembiotalks.bsky.social on September 30th!
web.cvent.com/event/60e9f3...
#ChemSky #DrugDiscovery #Webinar
web.cvent.com/event/60e9f3...
#ChemSky #DrugDiscovery #Webinar
We are very much looking forward to the 5th Virtual @chembiotalks.bsky.social on September 30th with seven exciting talks including our keynotes Sarah O'Connor (@oconnorlab.bsky.social) and @craigmcrews.bsky.social.
Make sure to register for free: web.cvent.com/event/60e9f3...
#ChemSky #ChemBio
Make sure to register for free: web.cvent.com/event/60e9f3...
#ChemSky #ChemBio
September 21, 2025 at 1:10 PM
Are you an enthusiast of #ChemBio? Do not miss the chance to register for free for the 5th Virtual @chembiotalks.bsky.social on September 30th!
web.cvent.com/event/60e9f3...
#ChemSky #DrugDiscovery #Webinar
web.cvent.com/event/60e9f3...
#ChemSky #DrugDiscovery #Webinar
isso é muita loucura..
The world’s greatest mathematician avoided politics. Then Trump cut science funding.
Terence Tao, often called the “Mozart of Math,” is focused on fundraising after federal research funding to UCLA was suspended.
www.washingtonpost.com/science/2025...
Terence Tao, often called the “Mozart of Math,” is focused on fundraising after federal research funding to UCLA was suspended.
www.washingtonpost.com/science/2025...
The world’s greatest mathematician avoided politics. Then Trump cut science funding.
Terence Tao, a renowned mathematician at UCLA, faced funding challenges after the Trump administration froze federal research funds.
www.washingtonpost.com
September 16, 2025 at 12:55 AM
isso é muita loucura..
I see this researcher and imagine "how is it possible to publish more than five hundred articles???"
September 14, 2025 at 11:17 AM
I see this researcher and imagine "how is it possible to publish more than five hundred articles???"
Reposted by The Henrique ⌬
New paper out today in J. Med. Chem. pubs.acs.org/doi/10.1021/...
Profiling and Optimizing Targeted Covalent Inhibitors through EGFR-Guided Studies
Targeted covalent inhibitors (TCIs) are actively pursued in drug discovery due to their prolonged target engagement and clinical efficacy. Although kinetic parameters provide a path to their optimizat...
pubs.acs.org
August 13, 2025 at 6:19 PM
New paper out today in J. Med. Chem. pubs.acs.org/doi/10.1021/...
Depois de um longo tempo, bateu saudade do Bsky...
September 13, 2025 at 11:34 PM
Depois de um longo tempo, bateu saudade do Bsky...