This study reconstructs the gene regulatory networks that define cell types in the sea anemone Nematostella vectensis, providing a valuable resource for comparative regulatory genomics and the evoluti...

A group of scientists who are experts at spotting fraudulent research outline five essential steps to combat industrialized scientific misconduct.

Five years after the start of Covid, we appear to be trying to teach ourselves the lessons of the pandemic the hard way.

Research in mice points towards a mechanism that avoids ‘catastrophic forgetting’.

The method could be used to develop a blood test to identify inflammatory-bowel-disease patients most at risk.

Join this online session to learn the basics of science communication, and enhance your skills in making complex ideas clear and engaging.

Sellers, van Beek and colleagues show that intermittent cold exposure for 10 days, which induced 1 h of shivering per day, improves glucose homeostasis, lipid metabolism and blood pressure in adults…

Stay safe and reduce the risk of fire over summer. Find out what you need to do before you light a fire outdoors and whether you need a fire permit.

Significance: Cellular senescence is a critical process underlying aging and is associated with age-related diseases such as Alzheimer’s disease. Lipids are implicated in cellular senescence. Fatty acids, particularly eicosanoids, have been associated with various forms of senescence and inflammation, and the associated reactive oxygen species production has been proposed as a therapeutic target for mitigating senescence. When overactivated, calcium-dependent phospholipase A2 (cPLA2) catalyzes the conversion of arachidonic acid into eicosanoids such as leukotrienes and prostaglandins. Recent Advances: With a growing understanding of the importance of lipids as mediators and modulators of senescence, cPLA2 has emerged as a compelling drug target. cPLA2 overactivation plays a significant role in several pathways associated with senescence, including neuroinflammation and oxidative stress. Critical Issues: Previous cPLA2 inhibitors have shown potential in ameliorating inflammation and oxidative stress, but the dominant hurdles in the central nervous system-targeting drug discovery are specificity and blood–brain barrier penetrance. Future Directions: With the need for more effective drugs against neurological diseases, we emphasize the significance of discovering new brain-penetrant, potent, and specific cPLA2 inhibitors. We discuss how the recently developed Virtual Synthon Hierarchical Enumeration Screening, an iterative synthon-based approach for fast structure-based virtual screening of billions of compounds, provides an efficient exploration of large chemical spaces for the discovery of brain-penetrant cPLA2 small-molecule inhibitors. Antioxid. Redox Signal. 00, 000–000.

Renault Trucks has officially announced a new version of the E-Tech T with a range of up to 600 kilometres for 2026. Sister company Volvo Trucks wants to present an electric long-haul truck with a sim...

Tracing tagged turtles reveals more than 30 new seagrass sites in the Red Sea

Majestic.