Sarah Lempriere
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sarahlempriere.bsky.social
Sarah Lempriere
@sarahlempriere.bsky.social
1.2K followers 2K following 88 posts
Senior Editor at Science. I handle Perspective articles in neuroscience, genetics, biochemistry and plant science. Views are my own.
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Reposted by Sarah Lempriere
labwaggoner.bsky.social
The structure of the bacterial genotoxin colibactin bound to DNA shows how it might contribute to cancer risk @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
December 5, 2025 at 1:43 AM
Reposted by Sarah Lempriere
lpargyle.bsky.social
Looking for a tl;dr for these two excellent papers? I've got you covered: www.science.org/doi/10.1126/...
December 4, 2025 at 10:20 PM
Reposted by Sarah Lempriere
mbernst.bsky.social
@jennyallen.bsky.social and @jatucker.bsky.social
add a fantastic Perspective piece on the importance of platform-independent experiments on social media's impact on us: science.org/doi/10.1126/...

Strongly agree!
Platform-independent experiments on social media
Changing algorithms with artificial intelligence tools can influence partisan animosity
science.org
December 1, 2025 at 7:33 PM
sarahlempriere.bsky.social
www.science.org/doi/10.1126/...
The cat diaspora out of Africa
Ancient DNA illuminates the origin and spread of the domestic cat
www.science.org
November 27, 2025 at 7:51 PM
sarahlempriere.bsky.social
www.science.org/doi/10.1126/...
Platform-independent experiments on social media
Changing algorithms with artificial intelligence tools can influence partisan animosity
www.science.org
November 27, 2025 at 7:50 PM
Reposted by Sarah Lempriere
science.org
In a new #SciencePolicyForum, researchers argue that international drug policy must distinguish between the coca leaf—a sacred plant long cultivated in South America—and its purified chemical derivative, cocaine. https://scim.ag/3WNrR9j
"Whereas cocaine’s 165-year history is marked by health risks and social disruption, the use of coca leaf has played a positive role in Andean and Amazonian societies …" White et al.
October 20, 2025 at 3:02 PM
Reposted by Sarah Lempriere
leadcoalition.bsky.social
APOE gene raises delirium risk even without dementia, global analysis reveals www.nature.com/articles/s43...

#delirium #dementia #genetics #geriatrics #GeriSky #neurology #NeuroSkyence
Dissecting the genetic and proteomic risk factors for delirium - Nature Aging
Delirium is a sudden change in mental function that is common in hospitalized older adults. To better understand this serious condition, Raptis et al. analyze large-scale genetic and proteomic dataset...
www.nature.com
November 24, 2025 at 11:03 PM
sarahlempriere.bsky.social
Lab-grown models of human brains are advancing rapidly. Can ethics keep pace? | Science | AAAS www.science.org/content/arti...
Lab-grown models of human brains are advancing rapidly. Can ethics keep pace?
Whether neural organoids feel pain or should be placed in animals are among the questions swirling around biology’s hot new technology
www.science.org
November 21, 2025 at 3:35 PM
Reposted by Sarah Lempriere
erictopol.bsky.social
New discovery in ulcerative colitis: a bacterial toxin that kills macrophages and increases inflammation, which could be the foundation for a new treatment
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
A bacterial toxin disarms gut defenses against inflammation
Macrophage-toxic bacteria from patients with ulcerative colitis worsen gut inflammation in mice
science.org
November 20, 2025 at 7:25 PM
Reposted by Sarah Lempriere
flyeyelab.bsky.social
Check out my Perspective article “The Retina’s Rhythm” which accompanies an exciting paper by Claude Desplan in Science. I highlight his discovery that waves of calcium are required to finalize the honeycomb-like structure of the Drosophila retina.

www.science.org/doi/epdf/10....
The retina’s rhythm
Calcium waves facilitate the emergence of sight
www.science.org
November 21, 2025 at 2:00 PM
Reposted by Sarah Lempriere
maddyseale.bsky.social
And now we have Arabidopsis plants with 8 chromosomes instead of 10 and no obvious phenotypic differences, this week in @science.org
#PlantScience
Paper here: www.science.org/doi/10.1126/...

Perspective here:
www.science.org/doi/10.1126/...
CRISPR-Cas–mediated heritable chromosome fusions in Arabidopsis
The genome of Arabidopsis thaliana consists of 10 chromosomes. By inducing CRISPR-Cas–mediated breaks at subcentromeric and subtelomeric sequences, we fused entire chromosome arms, obtaining two eight...
www.science.org
November 21, 2025 at 10:20 AM
Reposted by Sarah Lempriere
science.org
Using an integrative phylogenomic approach, new research in Science reveals unprecedented phylogenomic support for sponges as the sister lineage to all other animals.

Learn more in a new #SciencePerspective: https://scim.ag/4r7SLqm
Sponging away phylogenomic incongruence
Genes with strong and consistent signals favor sponges as humans’ most distant animal relatives
scim.ag
November 19, 2025 at 8:54 PM
Reposted by Sarah Lempriere
harriswang.bsky.social
also, an excellent perspective by @dbikard.bsky.social summarizing the work! 🙏
www.science.org/doi/10.1126/...
Programmable DNA insertion in native gut bacteria
A gene-editing approach enables modification of bacteria within the mouse gut
www.science.org
November 13, 2025 at 9:39 PM
Reposted by Sarah Lempriere
jlsteenwyk.bsky.social
I just finished my 2nd reading of this perspective. It is so great. The article captures a great deal about the sponge/ctenophore and is measured in its assessment of what the true tree is.

I absolutely share this position
bsky.app/profile/jlst...
November 14, 2025 at 4:36 AM
sarahlempriere.bsky.social
www.thetransmitter.org/sex-hormones...
Perimenopause: An understudied transition for the brain
We know little about the mechanisms underlying well-known perimenopause symptoms in the brain. More research—in animals and humans—is essential.
www.thetransmitter.org
November 12, 2025 at 12:17 PM
Reposted by Sarah Lempriere
natrevneuro.nature.com
The neural circuits and signalling pathways of opioid use disorder — a Review by Victor P. Mathis, Aliza T. Ehrlich & Emmanuel Darcq

#neuroscience #neuroskyence

www.nature.com/articles/s41...
The neural circuits and signalling pathways of opioid use disorder - Nature Reviews Neuroscience
In many parts of the world, opioid use disorder presents a growing challenge to public health, reinforcing the need to decipher its underlying mechanisms. Mathis et al. provide an overview of our curr...
www.nature.com
November 6, 2025 at 4:26 PM
Reposted by Sarah Lempriere
boron110.bsky.social
This week on the @science.org podcast: A 3-decade partnership between archaeologists and the Kuikuro people offers a model of collaboration—and documents the complexity of early Amazonian societies.

LISTEN HERE 🎧 www.science.org/content/podc...
November 6, 2025 at 9:05 PM
Reposted by Sarah Lempriere
science.org
Fat storage in the body relies on specialized structures called lipid droplets. In a new Science study, researchers identified the microprotein adipogenin as a regulator of adipocyte lipid droplet size, revealing a key mechanism in lipid homeostasis.

Learn more this week: https://scim.ag/4nFEGO7
Lipid droplet growth is orchestrated by the seipin complex, which provides a structural platform for droplet nucleation and expansion. The microprotein adipogenin fine-tunes seipin’s conformation, remodeling its architecture to regulate lipid storage capacity. This modulation results in the formation of fewer but larger lipid droplets, revealing a key mechanism in lipid homeostasis.
November 6, 2025 at 7:05 PM
Reposted by Sarah Lempriere
erictopol.bsky.social
How do mRNA vaccines help fight cancer?
A @nature.com paper today tells the story, one with big implications, as reviewed here
erictopol.substack.com/p/how-mrna-v...
How mRNA Vaccines Can Help Fight Cancer
Turning "cold" tumors "hot"
erictopol.substack.com
October 22, 2025 at 3:19 PM
sarahlempriere.bsky.social
Some beautiful images in this Perspective piece, and the science is fascinating too! www.science.org/doi/10.1126/...
How common cuckoos adapt to multiple hosts
Genomic data reveal the complexity of egg mimicry evolution in cuckoos
www.science.org
October 30, 2025 at 8:40 PM
Reposted by Sarah Lempriere
danpeppe.bsky.social
Also check out the great summary perspectives in @science.org by Lindsay Zanno featuring @nataliajagielska.bsky.social’s incredible illustration of the end-Cretaceous asteroid impact: www.science.org/doi/10.1126/...
End-Cretaceous asteroid impact
October 24, 2025 at 12:39 AM
Reposted by Sarah Lempriere
dmcoda.bsky.social
🚨The paper from my postdoc in @graeffjohannes.bsky.social’s lab at @epfl-brainmind.bsky.social is out! We show that memories can be switched on and off by simply changing the « packaging » of DNA in neurons through epigenetic editing. www.nature.com/articles/s41...
Cell-type- and locus-specific epigenetic editing of memory expression - Nature Genetics
CRISPR-based epigenetic editing is used in a cell-type-specific, locus-restricted and temporally controllable manner in the adult mouse brain to modulate memory expression.
www.nature.com
October 29, 2025 at 11:11 AM
sarahlempriere.bsky.social
There is a form of mosquito that lives in subways and tube tunnels across the world - did it evolve recently to take advantage of this urban environment or has it been around for much longer? www.science.org/doi/10.1126/...
Urban pests traveled with ancient humans
Population genomics reveals the pre-urban origins of a common mosquito
www.science.org
October 23, 2025 at 6:37 PM
sarahlempriere.bsky.social
Parasitic plants attach to host plants to siphon off water and nutrients, but how do they avoid parasitizing their own kind? www.science.org/doi/10.1126/...
The paradox of kin avoidance in parasitic plants
Parasitic plants use glucosylation to avoid kin parasitism
www.science.org
October 23, 2025 at 6:29 PM
Reposted by Sarah Lempriere
thetransmitter.bsky.social
Naturalistic approaches such as Ulanovsky’s open up “potential opportunities to really reveal why the brain is structured in the way it’s structured,” says Iain Couzin.

By @claudia-lopez.bsky.social

#neuroskyence

www.thetransmitter.org/neuroetholog...
Diving in with Nachum Ulanovsky
With an eye toward realism, the neuroscientist, who has a new study about bats out today, creates microcosms of the natural world to understand animal behavior.
www.thetransmitter.org
October 20, 2025 at 7:03 PM