Sarah Ashley
@sarah-ashley.bsky.social
Computational biologist @MCRI | Naarm Melbourne
Center for Food Allergy Research | National Allergy Centre of Excellence | #WomenInSTEM 🧑🏻🔬
Postdoctoral fellow working on treatments for food allergies 🥜
#scRNAseq #systemsbiology
#VIIN Emerging Leaders ELC
Center for Food Allergy Research | National Allergy Centre of Excellence | #WomenInSTEM 🧑🏻🔬
Postdoctoral fellow working on treatments for food allergies 🥜
#scRNAseq #systemsbiology
#VIIN Emerging Leaders ELC
Pinned
Sarah Ashley
@sarah-ashley.bsky.social
· Jul 23
Our new paper is out in Allergy! 🚨
Understanding the Variability of Peanut-Oral Immunotherapy Responses by Multi-Omics Profiling of Immune Cells
I personally like the ILC3 link with OIT :^)
onlinelibrary.wiley.com/doi/10.1111/...
Understanding the Variability of Peanut-Oral Immunotherapy Responses by Multi-Omics Profiling of Immune Cells
I personally like the ILC3 link with OIT :^)
onlinelibrary.wiley.com/doi/10.1111/...
Understanding the Variability of Peanut‐Oral Immunotherapy Responses by Multi‐Omics Profiling of Immune Cells
This study analyzes molecular drivers of OIT responsiveness. Multi-omics profiling of peanut-stimulated PBMCs in a controlled peanut-OIT trial identifies immune, transcriptomic, and epigenetic change...
onlinelibrary.wiley.com
📝 So happy to share that the multi-omic mechanisms of peanut OIT 🥜 study I worked on during my postdoc in Berlin is now published and open access. I am excited to share these new findings❗️
Reposted by Sarah Ashley
📢Are you a postdoctoral researcher with an excellent track record in #immunology and/or related field? We are hiring, but hurry, call closes 27 November! Apply and join us in Finland! Read more 👉 https://bit.ly/4r83ktP
#ImmunoSky #MedSky #LifeScience
#ImmunoSky #MedSky #LifeScience
November 21, 2025 at 8:48 AM
📢Are you a postdoctoral researcher with an excellent track record in #immunology and/or related field? We are hiring, but hurry, call closes 27 November! Apply and join us in Finland! Read more 👉 https://bit.ly/4r83ktP
#ImmunoSky #MedSky #LifeScience
#ImmunoSky #MedSky #LifeScience
Had an absolute blast attending my first #VIINYIS! Such a great day of exciting science hearing from our young investigators in the VIIN community. Thanks for a fab conference #youngVIIN2025
Until next time!
Until next time!
That wraps up an incredible day of science! A huge shoutout to all presenters, our amazing keynote speakers, Marcel Doerflinger and Nancy Wang, and a round of applause for the award winners! Thanks for making this symposium a success. We look forward to seeing you next year!
#YoungVIIN2025 #VIINYIS
#YoungVIIN2025 #VIINYIS
November 14, 2025 at 11:02 AM
Had an absolute blast attending my first #VIINYIS! Such a great day of exciting science hearing from our young investigators in the VIIN community. Thanks for a fab conference #youngVIIN2025
Until next time!
Until next time!
Reposted by Sarah Ashley
Inspiring Keynote from Nancy Wang Ruth Bishop Fellow and new Team Leader at MCRI. She took us through her research harnessing CD4T cell-mediated immunity against Salmonella working to develop candidate protein vaccines and on immune-based assays for enteric fever surveillance
#YoungVIIN2025 #VIINYIS
#YoungVIIN2025 #VIINYIS
November 14, 2025 at 4:45 AM
Inspiring Keynote from Nancy Wang Ruth Bishop Fellow and new Team Leader at MCRI. She took us through her research harnessing CD4T cell-mediated immunity against Salmonella working to develop candidate protein vaccines and on immune-based assays for enteric fever surveillance
#YoungVIIN2025 #VIINYIS
#YoungVIIN2025 #VIINYIS
Reposted by Sarah Ashley
Fantastic talk "A high-dimensional flow cytometry profiling on peripheral blood mononuclear cells of transitioning transgender individuals" by Den Celesta from @mcri.bsky.social @unimelb.bsky.social
#YoungVIIN2025 #VIINYIS
#YoungVIIN2025 #VIINYIS
November 14, 2025 at 5:32 AM
Fantastic talk "A high-dimensional flow cytometry profiling on peripheral blood mononuclear cells of transitioning transgender individuals" by Den Celesta from @mcri.bsky.social @unimelb.bsky.social
#YoungVIIN2025 #VIINYIS
#YoungVIIN2025 #VIINYIS
Reposted by Sarah Ashley
Our first Keynote speaker group leader Marcel Doerflinger from @wehi-research.bsky.social giving an overview of his career trajectory to becoming a lab head, including 6 key tips on how to succeed #YoungVIIN2025 #VIINYIS
November 13, 2025 at 11:09 PM
Our first Keynote speaker group leader Marcel Doerflinger from @wehi-research.bsky.social giving an overview of his career trajectory to becoming a lab head, including 6 key tips on how to succeed #YoungVIIN2025 #VIINYIS
Reposted by Sarah Ashley
An excellent talk from @therealmonocyte.bsky.social from MCRI about the Determinants of innate immune cytokine responses in pre-school children!
#YoungVIIN2025 #VIINYIS
#YoungVIIN2025 #VIINYIS
November 13, 2025 at 10:38 PM
An excellent talk from @therealmonocyte.bsky.social from MCRI about the Determinants of innate immune cytokine responses in pre-school children!
#YoungVIIN2025 #VIINYIS
#YoungVIIN2025 #VIINYIS
Here bright and early for #YoungVIIN2025 #VIINYIS 🧪🧫🧬
Ready for an inspiring day of infection and immunology presentations!! Can't wait to hear from our young investigators #YoungVIIN2025 #VIINYIS
November 13, 2025 at 9:39 PM
Here bright and early for #YoungVIIN2025 #VIINYIS 🧪🧫🧬
Reposted by Sarah Ashley
By popular demand, oral abstract submissions for Lorne Infection and Immunity 2026 have been extended to Friday 17th October!
Join our exciting 2026 program alongside a fantastic line-up of International and National Invited Speakers.
⏰Only three days left, so don't miss out!
Join our exciting 2026 program alongside a fantastic line-up of International and National Invited Speakers.
⏰Only three days left, so don't miss out!
October 13, 2025 at 11:58 PM
By popular demand, oral abstract submissions for Lorne Infection and Immunity 2026 have been extended to Friday 17th October!
Join our exciting 2026 program alongside a fantastic line-up of International and National Invited Speakers.
⏰Only three days left, so don't miss out!
Join our exciting 2026 program alongside a fantastic line-up of International and National Invited Speakers.
⏰Only three days left, so don't miss out!
Reposted by Sarah Ashley
I am looking forward to attending Lorne I&I next year. To my friends and colleagues overseas, this is the excuse you were looking for to come visit Australia!!!! 🦘🐨🧫🧬🧪🦠
‼️Deadline approaching - Don't miss your chance to submit an oral abstract for 16th Annual Lorne Infection & Immunity Conference
📍Held 18-20 of February 2026 at the Mantra Lorne
📝 Career Development Awards also available
Apply at www.lorneinfectionimmunity.org
Deadline: Friday, 10th of October
📍Held 18-20 of February 2026 at the Mantra Lorne
📝 Career Development Awards also available
Apply at www.lorneinfectionimmunity.org
Deadline: Friday, 10th of October
October 8, 2025 at 10:28 AM
I am looking forward to attending Lorne I&I next year. To my friends and colleagues overseas, this is the excuse you were looking for to come visit Australia!!!! 🦘🐨🧫🧬🧪🦠
PSA, deadline for the 16th Annual Lorne Infection & Immunity Conference this Friday!🏃♂️💨
Don't miss your chance to submit an oral abstract and apply for a Career Development Award
Don't miss your chance to submit an oral abstract and apply for a Career Development Award
‼️Deadline approaching - Don't miss your chance to submit an oral abstract for 16th Annual Lorne Infection & Immunity Conference
📍Held 18-20 of February 2026 at the Mantra Lorne
📝 Career Development Awards also available
Apply at www.lorneinfectionimmunity.org
Deadline: Friday, 10th of October
📍Held 18-20 of February 2026 at the Mantra Lorne
📝 Career Development Awards also available
Apply at www.lorneinfectionimmunity.org
Deadline: Friday, 10th of October
October 8, 2025 at 9:25 AM
PSA, deadline for the 16th Annual Lorne Infection & Immunity Conference this Friday!🏃♂️💨
Don't miss your chance to submit an oral abstract and apply for a Career Development Award
Don't miss your chance to submit an oral abstract and apply for a Career Development Award
Reposted by Sarah Ashley
Join us for our annual VIIN Young Investigator Symposium!
🗓️ Fri 14th Nov 8:00am-7:30pm
📍Monash Institute of Pharmaceutical Sciences, Parkville
Abstract submissions close next Fri 29th Aug!
Register now! 👇
bit.ly/471WFK0
#VIINYIS
🗓️ Fri 14th Nov 8:00am-7:30pm
📍Monash Institute of Pharmaceutical Sciences, Parkville
Abstract submissions close next Fri 29th Aug!
Register now! 👇
bit.ly/471WFK0
#VIINYIS
August 22, 2025 at 8:24 AM
Join us for our annual VIIN Young Investigator Symposium!
🗓️ Fri 14th Nov 8:00am-7:30pm
📍Monash Institute of Pharmaceutical Sciences, Parkville
Abstract submissions close next Fri 29th Aug!
Register now! 👇
bit.ly/471WFK0
#VIINYIS
🗓️ Fri 14th Nov 8:00am-7:30pm
📍Monash Institute of Pharmaceutical Sciences, Parkville
Abstract submissions close next Fri 29th Aug!
Register now! 👇
bit.ly/471WFK0
#VIINYIS
Reposted by Sarah Ashley
📝 Working on a manuscript? Not sure on how to navigate the submission process?
Join our next workshop “Manuscript Mastery” for all the tips and tricks on how to prepare your work for publication!
🕰️ Wed 10th Sept 10am - 12pm
Register by 5pm Friday 5th September
bit.ly/45gWCst
Join our next workshop “Manuscript Mastery” for all the tips and tricks on how to prepare your work for publication!
🕰️ Wed 10th Sept 10am - 12pm
Register by 5pm Friday 5th September
bit.ly/45gWCst
August 14, 2025 at 5:56 AM
📝 Working on a manuscript? Not sure on how to navigate the submission process?
Join our next workshop “Manuscript Mastery” for all the tips and tricks on how to prepare your work for publication!
🕰️ Wed 10th Sept 10am - 12pm
Register by 5pm Friday 5th September
bit.ly/45gWCst
Join our next workshop “Manuscript Mastery” for all the tips and tricks on how to prepare your work for publication!
🕰️ Wed 10th Sept 10am - 12pm
Register by 5pm Friday 5th September
bit.ly/45gWCst
Reposted by Sarah Ashley
Thor: a platform for cell-level investigation of spatial transcriptomics and histology. #SpatialTranscriptomics @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Thor: a platform for cell-level investigation of spatial transcriptomics and histology - Nature Communications
Zhang, Chen, and colleagues present Thor, a platform that turns spot-level spatial transcriptomics into single-cell gene maps using the paired histology image, without using single-cell RNA-seq data.…
www.nature.com
August 13, 2025 at 11:15 AM
Thor: a platform for cell-level investigation of spatial transcriptomics and histology. #SpatialTranscriptomics @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sarah Ashley
taxburst v0.3.0 is now released - this is an update of the Krona visualization system for microbiome/metagenome taxonomy analyses. Enjoy!
Announcing taxburst, an update of the Krona software for taxonomy exploration
Announcing taxburst for metagenome taxonomy!
ivory.idyll.org
August 8, 2025 at 2:19 PM
taxburst v0.3.0 is now released - this is an update of the Krona visualization system for microbiome/metagenome taxonomy analyses. Enjoy!
Reposted by Sarah Ashley
What is the mechanism of food-induced anaphylaxis?
Today @science.org unravelled
www.science.org/doi/full/10....
Gut mast cell leukotriene release
@rmedzhitov.bsky.social
Today @science.org unravelled
www.science.org/doi/full/10....
Gut mast cell leukotriene release
@rmedzhitov.bsky.social
August 7, 2025 at 8:06 PM
What is the mechanism of food-induced anaphylaxis?
Today @science.org unravelled
www.science.org/doi/full/10....
Gut mast cell leukotriene release
@rmedzhitov.bsky.social
Today @science.org unravelled
www.science.org/doi/full/10....
Gut mast cell leukotriene release
@rmedzhitov.bsky.social
Reposted by Sarah Ashley
Thoroughly #enjoyed #reading this #paper. #Genetics here is amazing. Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice | Science www.science.org/doi/10.1126/...
Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice
Food-specific immunoglobulin E (IgE) triggers life-threatening anaphylaxis; however, for unclear reasons, some people with food-specific IgE are asymptomatic upon allergen consumption. We studied stra...
www.science.org
August 8, 2025 at 2:59 PM
Thoroughly #enjoyed #reading this #paper. #Genetics here is amazing. Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice | Science www.science.org/doi/10.1126/...
Reposted by Sarah Ashley
"Current patterns of plastic production, use, and disposal cause disease, disability, and death at every stage of the plastic lifecycle." @thelancet.com
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
August 4, 2025 at 2:07 PM
"Current patterns of plastic production, use, and disposal cause disease, disability, and death at every stage of the plastic lifecycle." @thelancet.com
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Reposted by Sarah Ashley
One in 4 people carry one copy of the APOE4 allele, the strongest known genetic risk factor for Alzheimer's disease. We've just learned how that risk is mediated—the immune system
erictopol.substack.com/p/our-braini...
erictopol.substack.com/p/our-braini...
August 4, 2025 at 9:09 PM
One in 4 people carry one copy of the APOE4 allele, the strongest known genetic risk factor for Alzheimer's disease. We've just learned how that risk is mediated—the immune system
erictopol.substack.com/p/our-braini...
erictopol.substack.com/p/our-braini...
The future of multi-omics?
🔍 A supervised deep neural network trained on longitudinal multi-omic data (BioMapAI) enabled identification of disease and symptom specific biomarkers in ME/CFS and construction of a connectivity map of the microbiome, immune system and plasma metabolome
🔍 A supervised deep neural network trained on longitudinal multi-omic data (BioMapAI) enabled identification of disease and symptom specific biomarkers in ME/CFS and construction of a connectivity map of the microbiome, immune system and plasma metabolome
Multi-omics with A.I. analytics demonstrates critical role of the gut microbiome and immune response and enables accurate diagnosis of ME/CFS, may also be applicable to Long Covid.
www.nature.com/articles/s41...
www.ft.com/content/9cdf...
www.nature.com/articles/s41...
www.ft.com/content/9cdf...
AI-driven multi-omics modeling of myalgic encephalomyelitis/chronic fatigue syndrome - Nature Medicine
Analysis of a deeply phenotyped, longitudinal cohort of 249 participants elucidates the network of concurrent molecular and macroscopic patterns related to insurgence and course of ME/CFS.
www.nature.com
July 30, 2025 at 11:29 PM
The future of multi-omics?
🔍 A supervised deep neural network trained on longitudinal multi-omic data (BioMapAI) enabled identification of disease and symptom specific biomarkers in ME/CFS and construction of a connectivity map of the microbiome, immune system and plasma metabolome
🔍 A supervised deep neural network trained on longitudinal multi-omic data (BioMapAI) enabled identification of disease and symptom specific biomarkers in ME/CFS and construction of a connectivity map of the microbiome, immune system and plasma metabolome
Reposted by Sarah Ashley
Predicting the translation efficiency of messenger RNA in mammalian cells. #TranslationEfficiency #TranslationalControl @natbiotech.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 29, 2025 at 9:15 AM
Predicting the translation efficiency of messenger RNA in mammalian cells. #TranslationEfficiency #TranslationalControl @natbiotech.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sarah Ashley
Combined single-cell profiling of chromatin–transcriptome and splicing across brain cell types, regions and disease state. #SingleCellProfiling #RNAsplicing #Chromatin #Transcriptome @natbiotech.nature.com 🧬
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 29, 2025 at 10:30 AM
Combined single-cell profiling of chromatin–transcriptome and splicing across brain cell types, regions and disease state. #SingleCellProfiling #RNAsplicing #Chromatin #Transcriptome @natbiotech.nature.com 🧬
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sarah Ashley
Great to hear about Dr Halina Pietrzak’s work as a clinical trials coordinator. Highlighting the direct impact she sees on patients through their work, and how important communication and problem solving are for her position!
#VIINcareers
#VIINcareers
July 30, 2025 at 9:18 PM
Great to hear about Dr Halina Pietrzak’s work as a clinical trials coordinator. Highlighting the direct impact she sees on patients through their work, and how important communication and problem solving are for her position!
#VIINcareers
#VIINcareers
Reposted by Sarah Ashley
Thanks to Dr Andrew Foers to showing us what it takes to go from PhD to patent scientist! Andrew shared valuable perspectives on how skills from PhD and post-doc can transfer over to patents but also key differences!
#VIINcareers
#VIINcareers
July 30, 2025 at 9:16 PM
Thanks to Dr Andrew Foers to showing us what it takes to go from PhD to patent scientist! Andrew shared valuable perspectives on how skills from PhD and post-doc can transfer over to patents but also key differences!
#VIINcareers
#VIINcareers
Reposted by Sarah Ashley
Thanks to Dr Rebecca Smith for starting off our Careers Evening! Giving us insight in her journey from research to development. As Rebecca put it "Be brave, take a few risks, be kind to yourself. Things will evolve as they need to."
#VIINcareers
#VIINcareers
July 30, 2025 at 9:15 PM
Thanks to Dr Rebecca Smith for starting off our Careers Evening! Giving us insight in her journey from research to development. As Rebecca put it "Be brave, take a few risks, be kind to yourself. Things will evolve as they need to."
#VIINcareers
#VIINcareers
Reposted by Sarah Ashley
A great talk from Dr Jodie Abramovitch accompanied by excellent art and insights into the role of a principal scientist at a contract research organisation. Thanks for reminding us all of to trust ourselves and our guts!
#VIINcareers
#VIINcareers
July 30, 2025 at 11:06 AM
A great talk from Dr Jodie Abramovitch accompanied by excellent art and insights into the role of a principal scientist at a contract research organisation. Thanks for reminding us all of to trust ourselves and our guts!
#VIINcareers
#VIINcareers