Sandeep Rai
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sandeeprai.bsky.social
Sandeep Rai
@sandeeprai.bsky.social
40 followers 37 following 0 posts
Postdoc|Flynn lab| @BCHStemCell @HSCRB @SamratLabMohali @IiserMohali @iitdelhi Everything about RNA|Single-molecule biophysics|Super-resolution imaging 🔬.
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Reposted by Sandeep Rai
subhachem.bsky.social
www.nature.com/articles/s41...
Happy to share our latest article published in Nature Communications. #ReactionDiffusion system with Local inhibition Distal Activation..Potential to develop synthetic systems mimicking natural biological pathways with precise spatial and temporal control of signals.🧵
A chemoenzymatic reaction-diffusion system with local inhibition and distal activation - Nature Communications
Achieving spatiotemporal gating of signals is desirable for mimicking of biological processes, but is challenging to achieve in synthetic systems. Here, the authors report a multicomponent chemoenzyma...
www.nature.com
November 16, 2025 at 4:57 AM
Reposted by Sandeep Rai
raflynn5.bsky.social
Lab organized a pretty good costume
October 31, 2025 at 6:07 PM
Reposted by Sandeep Rai
cp-molcell.bsky.social
Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation
Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation
A new function of glycosylated RNAs has been discovered by Graziano et al. in which the glycosylation of RNA molecules shields acp³U RNA modification from triggering innate immune responses.
dlvr.it
October 20, 2025 at 10:57 PM
Reposted by Sandeep Rai
jerelleaj.bsky.social
Is there a way to directly connect microstructural dynamics of condensates to their mechanical response?

In his new pre-print, Pablo presents a “condensate Deborah number” that does just that!

www.biorxiv.org/content/10.1...
Biomolecular condensate viscoelasticity is dictated by the interplay between single-molecule shape memory and mesh reconfigurability
Biomolecular condensates are membraneless organelles that compartmentalize biological functions in living cells. Formed by the phase separation of biomolecules, condensates possess a wide range of mec...
www.biorxiv.org
October 7, 2025 at 11:32 PM
Reposted by Sandeep Rai
raflynn5.bsky.social
We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...
DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells
The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information ...
www.biorxiv.org
October 7, 2025 at 1:22 PM
Reposted by Sandeep Rai
raflynn5.bsky.social
Lead by postdoc in the lab Ruiqi Ge and in collaboration with Bob Coffey’s lab, we are happy to share rPAL-seq for rapid and sensitive sequencing based profiling of glycoRNAs @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
October 6, 2025 at 1:36 PM
Reposted by Sandeep Rai
nazlicanyurekli.bsky.social
🍬🔬Proteins are so sweet under the microscope .. 🍬🔬

As Möckl RG, for the first time, we image the single-protein glycosylation in native cell state with super-resolution microscopy, map cell-surface glycoproteins, and uncover their spatial organization.

#MöckIRG
#glycotime
#glycoprotein
#dnapaint
lmoeckl.bsky.social Leonhard Möckl @lmoeckl.bsky.social · Oct 2
NEW PREPRINT: Spatial mapping of cell-surface protein glycosylation at molecular resolution 🍭🍬🔬
For the first time, we can analyze the spatial architecture of the cell-surface glycoproteome at single-protein and single-sugar resolution. #glycotime

www.biorxiv.org/content/10.1...
Spatial mapping of cell-surface protein glycosylation at molecular resolution
Cell-surface protein glycosylation is a fundamental post-translational modification that plays a crucial role in membrane protein function and cellular behavior. However, elucidating the molecular spa...
www.biorxiv.org
October 2, 2025 at 12:16 PM
Reposted by Sandeep Rai
sfglycobiology.bsky.social
4/5 The Glycobiology Significant Achievement Award:
Dr. Ryan Flynn @raflynn5.bsky.social, Harvard University, 👏👏🥂
August 13, 2025 at 3:57 AM
Reposted by Sandeep Rai
cp-trendsbiochem.bsky.social
Available online - the Technology of the Month "Tools for illuminating the cell surface glycoRNA landscape" from Yuan Ma et al.

#glycoRNA #RNABindingProteins #RBP #ARPLA #HieCo2 #MDEM #drFRET

Read it here: authors.elsevier.com/a/1lOie3S6Gf...
July 11, 2025 at 3:57 PM
Reposted by Sandeep Rai
cdcode.bsky.social
☀️summer is here -
and so is CD-CODE v1.10 release!🤩

💡CD-CODE has now 719 manually curated #condensates (and ~40% are #human associated!)

💡Check out new #condensates and updated #protein - condensate connections at cd-code.org

#Bioinformatics #DatabaseUpdate #IDR #RNP #RBP #cdcode
June 11, 2025 at 1:33 PM
Reposted by Sandeep Rai
cdcode.bsky.social
The latest release was supported by the #condesathon joined by @mpi-cbg.de condensate community🤩

Big #thankyou to all the participants from
@hymanlab.bsky.social, @tothpetroczylab.bsky.social and von Appen labs for your support and enthusiasm!💜
June 11, 2025 at 1:33 PM
Reposted by Sandeep Rai
samratmukhopadhyay.bsky.social
Happy to share our latest paper published in Science Advances @aaas.org. Congratulations to my incredible students, Sandeep @sandeeprai.bsky.social, Roopali @roopsiek.bsky.social (co-first author), Anusha @anushasarbahi.bsky.social & Ashish @ashishjoshi.bsky.social.

www.science.org/doi/10.1126/...
Chaperone-mediated heterotypic phase separation regulates liquid-to-solid phase transitions of tau into amyloid fibrils
A chaperone tasked with protein quality control tunes the phase behavior of tau and prevents its pathological phase transitions.
www.science.org
June 7, 2025 at 12:28 AM
Reposted by Sandeep Rai
antonipetrov.bsky.social
🤯 Implications for OLE RNA as a natural integral membrane RNA from Ron Breaker's lab rnajournal.cshlp.org/content/earl...
May 23, 2025 at 8:21 PM
Reposted by Sandeep Rai
cp-trendsbiochem.bsky.social
Other articles include:
- a Feature Review on cell surface glycoRNAs and RBPs (@raflynn5.bsky.social)
- a Review on the ETC of methanogens
- an Opinion on transcription factor dynamics
- a Review on the repertoire of RNA-catalyzed reactions
- a Review on Mps1 kinase in chromosome segregation
May 1, 2025 at 8:55 PM
Reposted by Sandeep Rai
carolynbertozzi.bskyverified.social
Check it out - amazing new work by @raflynn5.bsky.social and Kostas Tzelepis labs, discovery of a cell surface RNA/glycoRNA binding protein that is also a cancer antigen, new target for antibody therapy!

www.nature.com/articles/s41...
Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein - Nature Biotechnology
An RNA-binding protein on leukemia cells provides an effective target in mouse models.
www.nature.com
April 25, 2025 at 5:19 AM
Reposted by Sandeep Rai
raflynn5.bsky.social
“Cell surface RNA biology: new roles for RNA binding proteins” Jennifer Porat and I discuss this new cellular topology on which to study RNA–RBP interactions and consider how changes in the csRBPs may drive autoimmune responses. @cp-trendsbiochem.bsky.social www.sciencedirect.com/science/arti...
Cell surface RNA biology: new roles for RNA binding proteins
Much of our understanding of RNA–protein interactions, and how these interactions shape gene expression and cell state, have come from studies looking…
www.sciencedirect.com
April 25, 2025 at 12:52 PM
Reposted by Sandeep Rai
rituraman.bsky.social
Happy to share the latest in 2.5D and 3D biohybrid robots from our lab with a packed room at RoboSoft! Thanks to all the organizers for putting together an exciting workshop on "Soft Robotic Actuation and Sensing Based on Functional Materials"!

robosoft2025.org
IEEE Robosoft 2025 - IEEE RoboSoft 2025
Celebrating Interdisciplinarity in Soft Robotics The theme for the 8th IEEE-RAS International Conference on Soft Robotics (RoboSoft 2025) centers on “Interdisciplinarity and Widening Horizons”, emphas...
robosoft2025.org
April 23, 2025 at 3:12 PM
Reposted by Sandeep Rai
raflynn5.bsky.social
Excited to share Benson’s and Maria’s work in collab w/Kostas Tzelepis: we found the nucleolar protein NPM1 is a marker of AML and can be targeted therapeutically

connecting ‘cell surface RNA biology’ to cancer biology

@natbiotech.nature.com
www.nature.com/articles/s41...
April 23, 2025 at 11:44 AM
Reposted by Sandeep Rai
lmoeckl.bsky.social
A wonderful study, published today in Nature Biotech.: NPM1 is a marker of AML and can be targeted for efficient therapy! @karimalmahayni.bsky.social created the first SR reconstructions of NPM1 on the cell surface. Great collaborative work, spearheaded by @raflynn5.bsky.social and Kostas Tzelepis!
raflynn5.bsky.social Ryan Flynn @raflynn5.bsky.social · Apr 23
Excited to share Benson’s and Maria’s work in collab w/Kostas Tzelepis: we found the nucleolar protein NPM1 is a marker of AML and can be targeted therapeutically

connecting ‘cell surface RNA biology’ to cancer biology

@natbiotech.nature.com
www.nature.com/articles/s41...
April 23, 2025 at 2:14 PM
Reposted by Sandeep Rai
rituraman.bsky.social
Excited to help organize a session on "Dynamic Extracellular Matrices to Control Cell Signaling" at #TERMISAM2025! The deadline for abstract submissions is April 28 - please consider joining our session and sharing your work in this space:
am2025.termis.org/abstract-ins...

@termisam.bsky.social
April 18, 2025 at 1:45 PM
Reposted by Sandeep Rai
raflynn5.bsky.social
www.sciencedirect.com/science/arti...

for fast readers
February 27, 2025 at 4:08 PM
Reposted by Sandeep Rai
raflynn5.bsky.social
Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA.

Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry
Mammalian cells present RNA-binding proteins on the cell surface that form clustered domains containing glycoRNAs.
www.cell.com
February 27, 2025 at 3:48 PM
Reposted by Sandeep Rai
slavov-n.bsky.social
Biological systems find ingenuous solutions. Almost anything that can happen, happens.

Still, I would not have guessed a role of RNA-binding proteins on the cell surface.

@raflynn5.bsky.social and his team are boldly investigating glycoRNAs and following their leads.
February 27, 2025 at 4:33 PM
Reposted by Sandeep Rai
wallaceucsf.bsky.social
Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology

www.biorxiv.org/content/10.1...
December 23, 2024 at 5:49 PM