Lightnews — Scholar-powered news

David Sancho

@sancholab.bsky.social

Gracias @caixaresearch.bsky.social por el sólido apoyo a nuestra investigación.
Este reporte es sobre las cDC1s en la generación de respuesta adaptativa en #atherosclerosis & #immunotherapy en el hilo www.ahajournals.org/doi/10.1161/...

También apoyo fundamental en: www.nature.com/articles/s41...

July 25, 2025 at 9:32 AM

Reposted by David Sancho

Samir Giri

@isamirgiri.bsky.social

This work identifies 'imidazole propionate' as a causal microbial metabolite that promotes atherosclerosis and shows that modulating its levels can potentially prevent cardiovascular disease risk, a promising therapeutic strategy.👇

David Sancho @sancholab.bsky.social · Jul 16

💥 A gut microbe metabolite that drives #atherosclerosis?
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky

Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature

Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

nature.com

July 23, 2025 at 4:51 PM

David Sancho

@sancholab.bsky.social

A gut microbiota metabolite linked to atherosclerosis could revolutionise diagnosis and treatment|ERC erc.europa.eu/news-events/...

A gut microbiota metabolite linked to atherosclerosis could revolutionise diagnosis and treatment

A new study led by the Spanish National Centre for Cardiovascular Research (CNIC) and funded by the European Reasearch Council (ERC) has identified imidazole propionate (ImP), a metabolite produced by...

erc.europa.eu

July 19, 2025 at 9:09 AM

David Sancho

@sancholab.bsky.social

Fantástico resumen por @manuelansede.bsky.social
🙏 @caixaresearch.bsky.social por financiar proyecto con 1 millón €
🙏 @ageinves.bsky.social por Severo Ochoa que inició el proyecto + 100K€ a nuestro lab
🙏 @erc.europa.eu ERC-CoG ERC-POC
#CNIC_CARDIO

Open acess: www.nature.com/articles/s41...

July 17, 2025 at 3:11 PM

Reposted by David Sancho

Manuel Ansede

@manuelansede.bsky.social

Revolución en la medicina: una molécula producida por bacterias del intestino causa la aterosclerosis, culpable de millones de muertes. El descubrimiento, del @sancholab.bsky.social, se acaba de publicar en la revista @nature.com 👇
elpais.com/salud-y-bien...

Revolución en la medicina: una molécula producida por bacterias del intestino causa la aterosclerosis, culpable de millones de muertes

El descubrimiento, gracias a un experimento con cientos de trabajadores del Banco Santander en Madrid, abre la puerta a nuevos tratamientos más allá de reducir el colesterol

elpais.com

July 16, 2025 at 8:33 PM

Reposted by David Sancho

caixaresearch.bsky.social

@caixaresearch.bsky.social

Esta investigación del CNIC revela que un metabolito de la microbiota intestinal favorece la aterosclerosis.

Descubre más de la mano de uno de los investigadores del equipo 👇🧬

David Sancho @sancholab.bsky.social · Jul 16

💥 A gut microbe metabolite that drives #atherosclerosis?
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky

Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature

Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

nature.com

July 17, 2025 at 10:37 AM

David Sancho

@sancholab.bsky.social

💥 A gut microbe metabolite that drives #atherosclerosis?
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky

Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature

Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

nature.com

July 16, 2025 at 5:37 PM

Reposted by David Sancho

Annalaura Mastrangelo

@annalaura-m.bsky.social

Thank you to my co-author @iroblesv.bsky.social and
@sancholab.bsky.social for believing in this project and to all the researchers who contributed to this work!!

July 16, 2025 at 4:52 PM

David Sancho

@sancholab.bsky.social

Congrats @iannaconelab.bsky.social & team on a wonderful work @natimmunol.nature.com on the immune regulation in the liver: CD4+ T cells license Kupffer cells to rescue CD8+ T cells through IL12 & mainly IL27. Highly relevant for liver immunotherapy!!!
👏🏻👏🏻👏🏻👏🏻👏🏻
#immunosky
👇🏻👇🏻👇🏻

Iannacone Lab @iannaconelab.bsky.social · Jun 30

1/ 🚨 Hot off the press in Nature Immunology: CD4⁺ T cells can license Kupffer cells to rescue dysfunctional CD8⁺ T cells in the liver. Hepatitis B virus (HBV) infection is just the proving ground—this is a paradigm shift in tissue immunity. www.nature.com/articles/s41... 🧵(1/11)

July 1, 2025 at 6:06 AM

David Sancho

@sancholab.bsky.social

🧬 New immunotherapy for atherosclerosis @ahajournals.bsky.social #CircRes
Type 1 dendritic cells (cDC1s) promote atherogenic immunity & can be targeted with tolerogenic nanoparticles.
🔗 doi.org/10.1161/CIRC...
#Immunotherapy #Atherosclerosis #Nanomedicine
#CNIC_CARDIO #immunosky #cardiosky

June 22, 2025 at 5:42 PM

David Sancho

@sancholab.bsky.social

Congrats Irene Adán-Barrientos: great thesis presentation & defense at CNIC & @uam.es

Thx thesis commitee: Julián Aragonés, Arantxa Cruz-Adalia & Bart Everts on wonderful discussion and visit!

Thx Gillian Dunphy @gilliandunphy.bsky.social on fantastic co-supervision!!!

June 17, 2025 at 1:30 PM

Reposted by David Sancho

IRB Barcelona

@irbbarcelona.org

A type of immune system cell boosts #immunotherapy and prevents #cancer relapse in animal models.

✍️ @ignaciohm.bsky.social @swculek.bsky.social @sancholab.bsky.social et al.

📰 @naturecomms.bsky.social

➡️ https://shorturl.at/DaPr3

📌DOI: 10.1038/s41467-025-58289-1. PMID: 40204706

🧪

April 29, 2025 at 9:02 AM

Reposted by David Sancho

gilliandunphy.bsky.social

@gilliandunphy.bsky.social

This week the world gained another Doctor of Immunology, and we are all the richer for it! Congratulations Dr. Irene on a great thesis and defense. Thank you to the examiners for the interesting discusion and to @sancholab.bsky.social for cosupervising with me these years - it has been a pleasure!

June 6, 2025 at 12:56 PM

Reposted by David Sancho

ACIR

@acir-org.bsky.social

Heras-Murillo et al. treated mice with tumor cell lysate-loaded syngeneic splenic selected cDC populations. bit.ly/4cKkXJp @sancholab.bsky.social

April 28, 2025 at 11:30 AM

Reposted by David Sancho

Annalaura Mastrangelo

@annalaura-m.bsky.social

Great talk by @sancholab.bsky.social shedding light on the role of #dendriticcells in #atherosclerosis: players in shaping immune responses within plaques. #ImmunoAthero

April 23, 2025 at 8:39 AM

David Sancho

@sancholab.bsky.social

Put a dendritic cell (DC) in your tumor #immunotherapy!
cDC1-based vaccines induce strong effector & memory anti-tumor T cell response. Improved immune memory prevents tumor relapse! #CNIC @ageinves.bsky.social @contracancerinv.bsky.social
www.nature.com/articles/s41...
#immunosky #cancersky (1/7)

Immunotherapy with conventional type-1 dendritic cells induces immune memory and limits tumor relapse - Nature Communications

Dendritic cells (DCs) induce infection-protective immune memory, which has yet to be exploited for cancer therapy. Here we show that type 1 DC vaccines quantitatively and qualitatively favors anti-tum...

www.nature.com

April 15, 2025 at 6:05 PM

Reposted by David Sancho

Waggoner Lab

@labwaggoner.bsky.social

Immunotherapy with cDC1 induces immune memory and limits tumor relapse @naturecomms.bsky.social @sancholab.bsky.social @swculek.bsky.social
www.nature.com/articles/s41...

April 10, 2025 at 5:38 PM

Reposted by David Sancho

The French DC Society - Club Francophone des DC (CFCD)

@frenchdcsociety.bsky.social

Kudos to @sancholab.bsky.social and @swculek.bsky.social for this work in @naturecomms.bsky.social showing that "that cDC1-based vaccination excels at immune memory induction and prevention of cancer recurrence"
www.nature.com/articles/s41...

Immunotherapy with conventional type-1 dendritic cells induces immune memory and limits tumor relapse - Nature Communications

Dendritic cells (DCs) induce infection-protective immune memory, which has yet to be exploited for cancer therapy. Here we show that type 1 DC vaccines quantitatively and qualitatively favors anti-tum...

www.nature.com

April 10, 2025 at 2:48 PM

Reposted by David Sancho

gilliandunphy.bsky.social

@gilliandunphy.bsky.social

And it gives me the chance the highlight the best CD4+ T cell/ice cream crossover review:
doi.org/10.1038/s415...

A fresh look at the T helper subset dogma - Nature Immunology

Single-cell-sequencing techniques enable the decades-old T helper subset dogma to be re-examined in an unsupervised manner, bringing nuance to the definition of known subsets while simultaneously iden...

doi.org

March 24, 2025 at 5:33 PM

Reposted by David Sancho

Silvestre Roig Lab

@silvestreroiglab.bsky.social

Stanley Huang told us about metabolic regulation of macrophages and Roser Vento gave us a great talk on spatial analysis of macrophages in reproductive tissues! What an amazing end of session. #EPW2025 #immunosky

March 29, 2025 at 10:02 PM

Reposted by David Sancho

Jose M. Adrover

@adrover.bsky.social

I had a wonderful time! Great conference and speakers! Thanks @casanova-acebes.bsky.social @sancholab.bsky.social and Carlos Silvestre for the great work organizing such an amazing meeting!