James Connolly
@ruamicro.bsky.social
MRC Career Development Fellow at Newcastle University. Studying how pathogens control their genes
Pinned
James Connolly
@ruamicro.bsky.social
· Jul 30
Convergent evolution of distinct D-ribulose utilisation pathways in attaching and effacing pathogens - Nature Communications
Cottam et al. identify distinct pathways for D-ribulose utilisation in pathogenic Escherichia coli and Citrobacter rodentium, providing mechanistic details and suggesting convergent evolution towards ...
www.nature.com
Absolutely delighted to share the labs latest work. We identify and characterise two pathways for D-ribulose utilisation in pathogenic EHEC and Citrobacter.
Reposted by James Connolly
Finally out! Right on time for the holidays 🎄🎁
Big thanks to Nick Scott, @giseladivenanzio.bsky.social, Clay and Mario @feldmanlab.bsky.social who made it happen!
www.pnas.org/doi/10.1073/...
Big thanks to Nick Scott, @giseladivenanzio.bsky.social, Clay and Mario @feldmanlab.bsky.social who made it happen!
www.pnas.org/doi/10.1073/...
December 9, 2025 at 7:40 PM
Finally out! Right on time for the holidays 🎄🎁
Big thanks to Nick Scott, @giseladivenanzio.bsky.social, Clay and Mario @feldmanlab.bsky.social who made it happen!
www.pnas.org/doi/10.1073/...
Big thanks to Nick Scott, @giseladivenanzio.bsky.social, Clay and Mario @feldmanlab.bsky.social who made it happen!
www.pnas.org/doi/10.1073/...
Join our live webinar today at 16:00 (GMT) to hear more about the VTEC conference, and why you should come. STEC/VTEC continues to be priority pathogen. The aim is to share cutting-edge scientific knowledge, addressing the questions about why the outbreaks occur and how best to manage this pathogen.
About - (VTEC 2026) International Symposium On Shiga Toxin Producing Escherichia Coli Infections - P&J Live
www.vtec2026.org
December 3, 2025 at 12:00 PM
Join our live webinar today at 16:00 (GMT) to hear more about the VTEC conference, and why you should come. STEC/VTEC continues to be priority pathogen. The aim is to share cutting-edge scientific knowledge, addressing the questions about why the outbreaks occur and how best to manage this pathogen.
Reposted by James Connolly
Fantastic to have Prof Matthias Wilmanns from EMBL Hamburg hosted by @kshbeckham.bsky.social to give a @mhd-newcastle.bsky.social seminar on mycobacterial infection #dreamtheme
December 2, 2025 at 12:13 PM
Fantastic to have Prof Matthias Wilmanns from EMBL Hamburg hosted by @kshbeckham.bsky.social to give a @mhd-newcastle.bsky.social seminar on mycobacterial infection #dreamtheme
Reposted by James Connolly
💎MRC AIM PhD advert💎 Uncharted territory - the Akkermansia muciniphila import system.
Liang Wu, David Tourigny, and I are looking for someone to work on how A. muciniphila imports mucin.
www.findaphd.com/phds/project...
Liang Wu, David Tourigny, and I are looking for someone to work on how A. muciniphila imports mucin.
www.findaphd.com/phds/project...
Uncharted territory - the Akkermansia muciniphila import system at University of Birmingham on FindAPhD.com
PhD Project - Uncharted territory - the Akkermansia muciniphila import system at University of Birmingham, listed on FindAPhD.com
www.findaphd.com
December 2, 2025 at 7:08 PM
💎MRC AIM PhD advert💎 Uncharted territory - the Akkermansia muciniphila import system.
Liang Wu, David Tourigny, and I are looking for someone to work on how A. muciniphila imports mucin.
www.findaphd.com/phds/project...
Liang Wu, David Tourigny, and I are looking for someone to work on how A. muciniphila imports mucin.
www.findaphd.com/phds/project...
Reposted by James Connolly
🔊 Interested in doing a PhD on RNA-binding proteins in an abundant microbiota species and becoming a member of the German Priority Programme “Illuminating Gene Functions in the Human Gut Microbiome”? Apply here: www.uni-wuerzburg.de/karriere/sin...
Job offer for a PhD student position at the Chair of Microbiology
www.uni-wuerzburg.de
December 1, 2025 at 9:20 AM
🔊 Interested in doing a PhD on RNA-binding proteins in an abundant microbiota species and becoming a member of the German Priority Programme “Illuminating Gene Functions in the Human Gut Microbiome”? Apply here: www.uni-wuerzburg.de/karriere/sin...
Reposted by James Connolly
Today, we are lucky to have Imane El Meouche from IAME, France to give a MCM seminar @medicalsciencesncl.bsky.social (chaired by @henrikstrahl.bsky.social) on antibiotics tolerance in E. Coli
December 1, 2025 at 1:07 PM
Today, we are lucky to have Imane El Meouche from IAME, France to give a MCM seminar @medicalsciencesncl.bsky.social (chaired by @henrikstrahl.bsky.social) on antibiotics tolerance in E. Coli
Reposted by James Connolly
Why does daptomycin resistance appear so fast in Enterococcus? We finally have a clue.
DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.
DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.
A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin https://www.biorxiv.org/content/10.1101/2025.11.16.688641v1
November 17, 2025 at 8:27 PM
Why does daptomycin resistance appear so fast in Enterococcus? We finally have a clue.
DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.
DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.
Fabulous opportunity to study phage biology with Andreas Haag in St Andrews. Don’t miss out.
EASTBIO: When Phages Collide: Understanding How Multiple Prophages Shape Bacterial Behaviour at University of St Andrews on FindAPhD.com
PhD Project - EASTBIO: When Phages Collide: Understanding How Multiple Prophages Shape Bacterial Behaviour at University of St Andrews, listed on FindAPhD.com
www.findaphd.com
November 17, 2025 at 3:24 PM
Fabulous opportunity to study phage biology with Andreas Haag in St Andrews. Don’t miss out.
Theres still time to apply for our PhD project on UPEC/immune cell interactions. Deadline December 4th
If you are interested in researching how drug resistant bacteria evade killing by our immune system, them this PhD project is for you. Come join the our team at Newcastle, in collaboration with University of Liverpool, and lead research at the interface of microbiology, immunology and metabolomics.
MRC DiMeN Doctoral Training Partnership: Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils at Newcastle University on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils at Newcastle University, listed on Fin...
www.findaphd.com
November 16, 2025 at 8:22 PM
Theres still time to apply for our PhD project on UPEC/immune cell interactions. Deadline December 4th
Reposted by James Connolly
🚨 Publication alert! We are stoked to report the structural basis for activity of a novel class of antimicrobials targeting Gram positive priority pathogens in @natcomms.nature.com. There is something for everyone on this paper, and I will highlight a few things below 👇 1/9 doi.org/10.1038/s414...
A unique inhibitor conformation selectively targets the DNA polymerase PolC of Gram-positive priority pathogens - Nature Communications
In this work, Urem et al. characterize the mode of action as well as mechanism of reduced susceptibility related to a class of antimicrobials that is in development for the treatment of infections wit...
doi.org
November 6, 2025 at 10:29 AM
🚨 Publication alert! We are stoked to report the structural basis for activity of a novel class of antimicrobials targeting Gram positive priority pathogens in @natcomms.nature.com. There is something for everyone on this paper, and I will highlight a few things below 👇 1/9 doi.org/10.1038/s414...
Reposted by James Connolly
Looks like a great meeting :)
Registration is now LIVE for the 2026 international symposium on Shiga toxin producing E. coli (VTEC), being held in Aberdeen on the the 10-13th of May 2026.
The early bird deadline is February 27th so don’t miss out and register now.
www.vtec2026.org
The early bird deadline is February 27th so don’t miss out and register now.
www.vtec2026.org
About - (VTEC 2026) International Symposium On Shiga Toxin Producing Escherchia Coli Infections - P&J Live
www.vtec2026.org
November 3, 2025 at 12:36 PM
Looks like a great meeting :)
Registration is now LIVE for the 2026 international symposium on Shiga toxin producing E. coli (VTEC), being held in Aberdeen on the the 10-13th of May 2026.
The early bird deadline is February 27th so don’t miss out and register now.
www.vtec2026.org
The early bird deadline is February 27th so don’t miss out and register now.
www.vtec2026.org
About - (VTEC 2026) International Symposium On Shiga Toxin Producing Escherchia Coli Infections - P&J Live
www.vtec2026.org
November 3, 2025 at 12:01 PM
Registration is now LIVE for the 2026 international symposium on Shiga toxin producing E. coli (VTEC), being held in Aberdeen on the the 10-13th of May 2026.
The early bird deadline is February 27th so don’t miss out and register now.
www.vtec2026.org
The early bird deadline is February 27th so don’t miss out and register now.
www.vtec2026.org
Reposted by James Connolly
Fantastic PhD opportunity 👇
If you are interested in researching how drug resistant bacteria evade killing by our immune system, them this PhD project is for you. Come join the our team at Newcastle, in collaboration with University of Liverpool, and lead research at the interface of microbiology, immunology and metabolomics.
MRC DiMeN Doctoral Training Partnership: Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils at Newcastle University on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils at Newcastle University, listed on Fin...
www.findaphd.com
November 3, 2025 at 8:35 AM
Fantastic PhD opportunity 👇
Reposted by James Connolly
Reposted by James Connolly
Want to find ways to combat TB? Check out this PhD position 👇
November 2, 2025 at 8:44 PM
Want to find ways to combat TB? Check out this PhD position 👇
Reposted by James Connolly
Want to work within a multidisciplinary group to combat antifungal resistance in Candida spp? Fully-funded MRC PhD studentship in collaboration with @nclfungalgroup.bsky.social and Francesco Del Carratore on the mode of action of a new class of antifungal drugs. www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: Targeting thioredoxin reductase to combat antifungal resistance in Candida spp. at Newcastle University on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Targeting thioredoxin reductase to combat antifungal resistance in Candida spp. at Newcastle University, listed on FindAPhD.com
www.findaphd.com
October 31, 2025 at 10:35 AM
Want to work within a multidisciplinary group to combat antifungal resistance in Candida spp? Fully-funded MRC PhD studentship in collaboration with @nclfungalgroup.bsky.social and Francesco Del Carratore on the mode of action of a new class of antifungal drugs. www.findaphd.com/phds/project...
Reposted by James Connolly
Interested in a PhD at the intersection of biophysics and microbiology?
Apply for this MRC-funded opportunity at Newcastle University to do cutting-edge microscopy in Mycobacterium tuberculosis! 🔬🦠
Closing 4 Dec!
www.findaphd.com/phds/project...
Apply for this MRC-funded opportunity at Newcastle University to do cutting-edge microscopy in Mycobacterium tuberculosis! 🔬🦠
Closing 4 Dec!
www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: Molecular mechanism of slow growth and antibiotic tolerance in Mycobacterium tuberculosis using single-molecule microscopy at Newcastle University on FindAPhD....
PhD Project - MRC DiMeN Doctoral Training Partnership: Molecular mechanism of slow growth and antibiotic tolerance in Mycobacterium tuberculosis using single-molecule microscopy at Newcastle Universit...
www.findaphd.com
October 31, 2025 at 1:09 PM
Interested in a PhD at the intersection of biophysics and microbiology?
Apply for this MRC-funded opportunity at Newcastle University to do cutting-edge microscopy in Mycobacterium tuberculosis! 🔬🦠
Closing 4 Dec!
www.findaphd.com/phds/project...
Apply for this MRC-funded opportunity at Newcastle University to do cutting-edge microscopy in Mycobacterium tuberculosis! 🔬🦠
Closing 4 Dec!
www.findaphd.com/phds/project...
If you are interested in researching how drug resistant bacteria evade killing by our immune system, them this PhD project is for you. Come join the our team at Newcastle, in collaboration with University of Liverpool, and lead research at the interface of microbiology, immunology and metabolomics.
MRC DiMeN Doctoral Training Partnership: Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils at Newcastle University on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils at Newcastle University, listed on Fin...
www.findaphd.com
November 2, 2025 at 8:22 PM
If you are interested in researching how drug resistant bacteria evade killing by our immune system, them this PhD project is for you. Come join the our team at Newcastle, in collaboration with University of Liverpool, and lead research at the interface of microbiology, immunology and metabolomics.
Reposted by James Connolly
Exciting PhD opportunity with a great supervisor @ruamicro.bsky.social. www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils at Newcastle University on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils at Newcastle University, listed on Fin...
www.findaphd.com
October 31, 2025 at 12:32 PM
Exciting PhD opportunity with a great supervisor @ruamicro.bsky.social. www.findaphd.com/phds/project...
Reposted by James Connolly
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 12:22 PM
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
Reposted by James Connolly
Enhanced virulence and stress tolerance are signatures of epidemiologically successful Shigella sonnei
@sydneylmiles.bsky.social @katholt.bsky.social
🙏to transformative collaborative effort
www.nature.com/articles/s41...
@sydneylmiles.bsky.social @katholt.bsky.social
🙏to transformative collaborative effort
www.nature.com/articles/s41...
October 13, 2025 at 9:48 PM
Enhanced virulence and stress tolerance are signatures of epidemiologically successful Shigella sonnei
@sydneylmiles.bsky.social @katholt.bsky.social
🙏to transformative collaborative effort
www.nature.com/articles/s41...
@sydneylmiles.bsky.social @katholt.bsky.social
🙏to transformative collaborative effort
www.nature.com/articles/s41...
Reposted by James Connolly
Delighted to share our latest paper - A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics. Excellently led by Dr. Kuan-Yi Lu. We think it's a great proof-of-concept that altering immune cell behavior can make antibiotics work better www.nature.com/articles/s41...
A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics - Nature Microbiology
The authors developed a screen to find compounds that modulate intracellular Staphylococcus aureus metabolism and discovered KL1, which sensitizes persisters to antibiotics by reversing host-induced tolerance.
www.nature.com
October 10, 2025 at 1:24 PM
Delighted to share our latest paper - A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics. Excellently led by Dr. Kuan-Yi Lu. We think it's a great proof-of-concept that altering immune cell behavior can make antibiotics work better www.nature.com/articles/s41...
Reposted by James Connolly
Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.
October 8, 2025 at 9:45 PM
Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.
Reposted by James Connolly
Check it out! A proper team effort from past and present group members and a great collaboration with @sergemostowylab.bsky.social
The Staphylococcus aureus LXG-domain toxins EsxX and SAR0287 do not promote virulence in a zebrafish larval infection model https://www.biorxiv.org/content/10.1101/2025.10.04.680436v1
October 5, 2025 at 8:11 AM
Check it out! A proper team effort from past and present group members and a great collaboration with @sergemostowylab.bsky.social
Reposted by James Connolly
PhD opportunity to come and work in Glasgow, developing advanced tissue culture models to study Staphylococcus aureus colonisation and infection #microsky #PhD #DTPprogram
Enquiries from potential applicants are welcome.
www.gla.ac.uk/postgraduate...
www.findaphd.com/phds/program...
Enquiries from potential applicants are welcome.
www.gla.ac.uk/postgraduate...
www.findaphd.com/phds/program...
University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Understanding Pathogens, from Molecules to Phenotypes - Justine Rudkin
www.gla.ac.uk
September 30, 2025 at 12:52 PM
PhD opportunity to come and work in Glasgow, developing advanced tissue culture models to study Staphylococcus aureus colonisation and infection #microsky #PhD #DTPprogram
Enquiries from potential applicants are welcome.
www.gla.ac.uk/postgraduate...
www.findaphd.com/phds/program...
Enquiries from potential applicants are welcome.
www.gla.ac.uk/postgraduate...
www.findaphd.com/phds/program...