Marcus Robinson
@robinsonmj.bsky.social
Lab Head at Monash Immunology | B cells | Allergy | Vaccine Biology
Seems important, and I really like the concept. if I follow correctly interepitope competition is permissive whereas intra kills low affinity cells.
Antibody feedback establishes an affinity brake in the germinal center https://www.biorxiv.org/content/10.1101/2025.11.13.688298v1
November 14, 2025 at 10:18 PM
Seems important, and I really like the concept. if I follow correctly interepitope competition is permissive whereas intra kills low affinity cells.
Excited that IL-3 is playing a role in the type 2 response here!
S. aureus exposure during cutaneous antigen sensitization causes basophil- and interleukin-4-dependent exaggerated food anaphylaxis: Immunity www.cell.com/immunity/ful...
S. aureus exposure during cutaneous antigen sensitization causes basophil- and interleukin-4-dependent exaggerated food anaphylaxis: Immunity www.cell.com/immunity/ful...
S. aureus exposure during cutaneous antigen sensitization causes basophil- and interleukin-4-dependent exaggerated food anaphylaxis
S. aureus skin colonization is associated with food allergy in atopic dermatitis,
but the mechanism of this association is unknown. Das et al. reveal that cutaneous
exposure to S. aureus causes a baso...
www.cell.com
November 12, 2025 at 8:53 AM
Excited that IL-3 is playing a role in the type 2 response here!
S. aureus exposure during cutaneous antigen sensitization causes basophil- and interleukin-4-dependent exaggerated food anaphylaxis: Immunity www.cell.com/immunity/ful...
S. aureus exposure during cutaneous antigen sensitization causes basophil- and interleukin-4-dependent exaggerated food anaphylaxis: Immunity www.cell.com/immunity/ful...
Reposted by Marcus Robinson
Antibodies, Memory B Cells, and Antigen Valency Reshape B Cell Responses to Drifted Influenza Virus Vaccination https://www.biorxiv.org/content/10.1101/2025.11.07.687210v1
November 8, 2025 at 6:16 PM
Antibodies, Memory B Cells, and Antigen Valency Reshape B Cell Responses to Drifted Influenza Virus Vaccination https://www.biorxiv.org/content/10.1101/2025.11.07.687210v1
Reposted by Marcus Robinson
T cell fate is dictated by different antigen presenting cells in response to dietary versus gut epithelial self-antigen https://www.biorxiv.org/content/10.1101/2025.11.06.687030v1
November 8, 2025 at 4:16 AM
T cell fate is dictated by different antigen presenting cells in response to dietary versus gut epithelial self-antigen https://www.biorxiv.org/content/10.1101/2025.11.06.687030v1
Reposted by Marcus Robinson
Antibody-mediated feedback modulates interclonal competition in the germinal center https://www.biorxiv.org/content/10.1101/2025.11.06.686519v1
November 8, 2025 at 3:16 AM
Antibody-mediated feedback modulates interclonal competition in the germinal center https://www.biorxiv.org/content/10.1101/2025.11.06.686519v1
Reposted by Marcus Robinson
Our B cell Keystone is getting closer! Short talk abstracts and scholarship applications are due on November 13 - get to it! www.keystonesymposia.org/conferences/...
November 4, 2025 at 10:58 PM
Our B cell Keystone is getting closer! Short talk abstracts and scholarship applications are due on November 13 - get to it! www.keystonesymposia.org/conferences/...
Following from Maria Lafaille's discoveries of a couple of days ago, we found that BCL2, BCLXL or BCLW dominates over MCL1 in the survival of IgE PC, which localise atypically for long-lived cells.
Full text link below.
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Full text link below.
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
kwnsfk27.r.eu-west-1.awstrack.me
November 4, 2025 at 8:48 PM
Following from Maria Lafaille's discoveries of a couple of days ago, we found that BCL2, BCLXL or BCLW dominates over MCL1 in the survival of IgE PC, which localise atypically for long-lived cells.
Full text link below.
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Full text link below.
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Reposted by Marcus Robinson
Online now: Long-lived IgE plasma cells that reside in the spleen contribute to the persistence of the IgE response
Long-lived IgE plasma cells that reside in the spleen contribute to the persistence of the IgE response
Allergies can persist even in the absence of allergen exposure. Miranda-Waldetario et al. find that IgE-producing plasma cells mature, acquire survival adaptations, and persist for extended periods of time in the spleen and bone marrow, secreting antibodies that can trigger anaphylaxis.
dlvr.it
November 1, 2025 at 2:48 PM
Online now: Long-lived IgE plasma cells that reside in the spleen contribute to the persistence of the IgE response
Reposted by Marcus Robinson
B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes https://www.biorxiv.org/content/10.1101/2025.10.30.685663v1
November 1, 2025 at 10:16 PM
B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes https://www.biorxiv.org/content/10.1101/2025.10.30.685663v1
Reposted by Marcus Robinson
Thank you Diana! Credit to @smguillaume.bsky.social for leading this work. Lung B cells in ectopic germinal centers undergo affinity maturation | PNAS share.google/6zXPfzAaAcva...
August 28, 2025 at 4:01 PM
Thank you Diana! Credit to @smguillaume.bsky.social for leading this work. Lung B cells in ectopic germinal centers undergo affinity maturation | PNAS share.google/6zXPfzAaAcva...
I know this is late, but one of the most important PC survival advances in recent years. Key conception. Check it out!
doi.org/10.1038/s415...
www.nature.com/articles/s41...
doi.org/10.1038/s415...
www.nature.com/articles/s41...
Bone marrow plasma cells require P2RX4 to sense extracellular ATP - Nature
We demonstrate the role of the ligand-gated purinergic ion channel P2RX4 in maintaining mouse plasma cells in their bone marrow niche.
www.nature.com
August 3, 2025 at 5:50 AM
I know this is late, but one of the most important PC survival advances in recent years. Key conception. Check it out!
doi.org/10.1038/s415...
www.nature.com/articles/s41...
doi.org/10.1038/s415...
www.nature.com/articles/s41...
Just dropped! Complicated impacts of il21 on gc exit to memory. Kudos to @alidvorscek.bsky.social and Jesse Mulder!
IL-21 contributes to type 2 memory B cell formation url: academic.oup.com/jimmunol/art...
IL-21 contributes to type 2 memory B cell formation url: academic.oup.com/jimmunol/art...
IL-21 contributes to type 2 memory B cell formation
Abstract. Type 2 memory B cells (mBC2), identified in mice as IgG1+CD23+IL-4Rα+CD38+ B cells, which require IL-4 for genesis, are precursors for IgE plasma
academic.oup.com
July 9, 2025 at 10:21 PM
Just dropped! Complicated impacts of il21 on gc exit to memory. Kudos to @alidvorscek.bsky.social and Jesse Mulder!
IL-21 contributes to type 2 memory B cell formation url: academic.oup.com/jimmunol/art...
IL-21 contributes to type 2 memory B cell formation url: academic.oup.com/jimmunol/art...
Reposted by Marcus Robinson
HIF-1α+ CD4 T cells coordinate a tissue resident immune cell network in the lung https://www.biorxiv.org/content/10.1101/2025.06.13.659476v1
June 18, 2025 at 4:16 AM
HIF-1α+ CD4 T cells coordinate a tissue resident immune cell network in the lung https://www.biorxiv.org/content/10.1101/2025.06.13.659476v1
This is a two-part post.
I am privileged to do tax-payer funded research into allergy cures and ways to improve vaccines. My goals are to improve people's lives, stability of the food supply and minimise risks of future pandemics. However,
I am privileged to do tax-payer funded research into allergy cures and ways to improve vaccines. My goals are to improve people's lives, stability of the food supply and minimise risks of future pandemics. However,
June 9, 2025 at 5:08 AM
This is a two-part post.
I am privileged to do tax-payer funded research into allergy cures and ways to improve vaccines. My goals are to improve people's lives, stability of the food supply and minimise risks of future pandemics. However,
I am privileged to do tax-payer funded research into allergy cures and ways to improve vaccines. My goals are to improve people's lives, stability of the food supply and minimise risks of future pandemics. However,
Reposted by Marcus Robinson
🎓 PhD positions available @MonashUni
Join our lab to explore how neurons and immune cells shape gut immunity!
🧬 Single-cell RNAseq
🔬 3D imaging
🧠 Neuro-immune interactions
👥 Great mentoring & collaborations
Apply now 👉 tinyurl.com/Seilletlab
Join our lab to explore how neurons and immune cells shape gut immunity!
🧬 Single-cell RNAseq
🔬 3D imaging
🧠 Neuro-immune interactions
👥 Great mentoring & collaborations
Apply now 👉 tinyurl.com/Seilletlab
Understanding the neuroimmune regulation of innate immunity | Supervisor Connect
tinyurl.com
June 2, 2025 at 6:59 AM
🎓 PhD positions available @MonashUni
Join our lab to explore how neurons and immune cells shape gut immunity!
🧬 Single-cell RNAseq
🔬 3D imaging
🧠 Neuro-immune interactions
👥 Great mentoring & collaborations
Apply now 👉 tinyurl.com/Seilletlab
Join our lab to explore how neurons and immune cells shape gut immunity!
🧬 Single-cell RNAseq
🔬 3D imaging
🧠 Neuro-immune interactions
👥 Great mentoring & collaborations
Apply now 👉 tinyurl.com/Seilletlab
Vaccination in left arm, right arm, or both?? @labphan.bsky.social congrats and looking to you for the answer 😄
Macrophages direct location-dependent recall of B cell memory to vaccination: Cell www.cell.com/cell/fulltex...
Macrophages direct location-dependent recall of B cell memory to vaccination: Cell www.cell.com/cell/fulltex...
Macrophages direct location-dependent recall of B cell memory to vaccination
Subcapsular sinus macrophages in the draining lymph node help retain resident memory
B cells in the subcapsular niche and promote their re-entry into secondary germinal
centers. Boosting vaccines in t...
www.cell.com
April 29, 2025 at 7:32 AM
Vaccination in left arm, right arm, or both?? @labphan.bsky.social congrats and looking to you for the answer 😄
Macrophages direct location-dependent recall of B cell memory to vaccination: Cell www.cell.com/cell/fulltex...
Macrophages direct location-dependent recall of B cell memory to vaccination: Cell www.cell.com/cell/fulltex...
Reposted by Marcus Robinson
New Highlight of @cp-immunity.bsky.social paper by Nelson et al. @loyolachicago.bsky.social reporting that lung-resident IgG1+ memory B cells class-switch to IgE to mediate airway hypersensitivity in asthma
#immunosky #immunology #asthma
#immunosky #immunology #asthma
Lung-resident memory B cells class-switch to IgE - Nature Reviews Immunology
Nelson et al. report that lung-resident IgG1+ memory B cells class-switch to IgE to mediate airway hypersensitivity in asthma.
www.nature.com
April 7, 2025 at 2:23 PM
New Highlight of @cp-immunity.bsky.social paper by Nelson et al. @loyolachicago.bsky.social reporting that lung-resident IgG1+ memory B cells class-switch to IgE to mediate airway hypersensitivity in asthma
#immunosky #immunology #asthma
#immunosky #immunology #asthma
Reposted by Marcus Robinson
Great to have our paper out in @pnas.org showing that lung B cells in ectopic germinal centers undergo affinity maturation.
@smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...
@smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...
Lung B cells in ectopic germinal centers undergo affinity maturation | PNAS
The lungs are constantly exposed to the external environment and a myriad of antigenic
challenges within the air. Chronic exposure to allergens and...
doi.org
April 3, 2025 at 3:03 AM
Great to have our paper out in @pnas.org showing that lung B cells in ectopic germinal centers undergo affinity maturation.
@smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...
@smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...
Reposted by Marcus Robinson
New preprint alert 🚨
My team and I are pleased to share our most recent story about how bacterial pathogen (Streptococcus pyogenes, Strep A) exposure induces antibody responses against glycan and protein antigens.
For paper: SSRN ssrn.com/abstract=519...
biorxiv : doi: doi.org/10.1101/2025...
My team and I are pleased to share our most recent story about how bacterial pathogen (Streptococcus pyogenes, Strep A) exposure induces antibody responses against glycan and protein antigens.
For paper: SSRN ssrn.com/abstract=519...
biorxiv : doi: doi.org/10.1101/2025...
April 4, 2025 at 12:01 AM
New preprint alert 🚨
My team and I are pleased to share our most recent story about how bacterial pathogen (Streptococcus pyogenes, Strep A) exposure induces antibody responses against glycan and protein antigens.
For paper: SSRN ssrn.com/abstract=519...
biorxiv : doi: doi.org/10.1101/2025...
My team and I are pleased to share our most recent story about how bacterial pathogen (Streptococcus pyogenes, Strep A) exposure induces antibody responses against glycan and protein antigens.
For paper: SSRN ssrn.com/abstract=519...
biorxiv : doi: doi.org/10.1101/2025...
Reposted by Marcus Robinson
As a first Bluesky post, I’m happy to share our latest publication @emboreports.org:
www.embopress.org/doi/full/10....
Led by Craig McKenzie, we used CRISPR-Cas9 gene editing to investigate how Syndecan-1 (CD138) and -4 (SDC4) influence B-cell development and activation.
#ImmunoSky #MonashUni
www.embopress.org/doi/full/10....
Led by Craig McKenzie, we used CRISPR-Cas9 gene editing to investigate how Syndecan-1 (CD138) and -4 (SDC4) influence B-cell development and activation.
#ImmunoSky #MonashUni
March 31, 2025 at 11:45 AM
As a first Bluesky post, I’m happy to share our latest publication @emboreports.org:
www.embopress.org/doi/full/10....
Led by Craig McKenzie, we used CRISPR-Cas9 gene editing to investigate how Syndecan-1 (CD138) and -4 (SDC4) influence B-cell development and activation.
#ImmunoSky #MonashUni
www.embopress.org/doi/full/10....
Led by Craig McKenzie, we used CRISPR-Cas9 gene editing to investigate how Syndecan-1 (CD138) and -4 (SDC4) influence B-cell development and activation.
#ImmunoSky #MonashUni
Reposted by Marcus Robinson
Reposted by Marcus Robinson
KLF2 expression in IgG plasma cells at their induction site regulates the migration program, say Wataru Ise, Takuya Koike, Tomohiro Kurosaki @osaka_univ_e and colleagues: buff.ly/41bbKEF
February 27, 2025 at 9:04 PM
KLF2 expression in IgG plasma cells at their induction site regulates the migration program, say Wataru Ise, Takuya Koike, Tomohiro Kurosaki @osaka_univ_e and colleagues: buff.ly/41bbKEF
Team, this piece is great if you're interested in Abs! TLDR: GC-derived ASC maintain a proliferative burst post-differentiation proportional to affinity/help to explain overrepresentation of high affinity in PC despite differentiation from all affinities.
#immunosky
www.science.org/doi/10.1126/...
#immunosky
www.science.org/doi/10.1126/...
Affinity maturation of antibody responses is mediated by differential plasma cell proliferation
Increased antibody affinity over time after vaccination, known as affinity maturation, is a prototypical feature of immune responses. Recent studies have shown that a diverse collection of B cells, pr...
www.science.org
February 7, 2025 at 9:29 PM
Team, this piece is great if you're interested in Abs! TLDR: GC-derived ASC maintain a proliferative burst post-differentiation proportional to affinity/help to explain overrepresentation of high affinity in PC despite differentiation from all affinities.
#immunosky
www.science.org/doi/10.1126/...
#immunosky
www.science.org/doi/10.1126/...
Reposted by Marcus Robinson
Prof Kjesten Wiig has been appointed Director of the Malaghan Institute as Professor Graham Le Gros continues in a leadership capacity as Deputy Chair of the Trust Board and advisor to the new Director @grahamlegros.bsky.social
Kjesten Wiig appointed Director of Malaghan Institute as Graham Le Gros steps into new role
www.malaghan.org.nz
December 11, 2024 at 1:10 AM
Prof Kjesten Wiig has been appointed Director of the Malaghan Institute as Professor Graham Le Gros continues in a leadership capacity as Deputy Chair of the Trust Board and advisor to the new Director @grahamlegros.bsky.social
Reposted by Marcus Robinson
November 17, 2024 at 7:19 AM