Fabrice Leclerc
@rnomics.bsky.social
Reposted by Fabrice Leclerc
Check out our new study on water networks in high resolution cryo-EM RNA data!
@ Chiu Lab @ Das Lab
@ Chiu Lab @ Das Lab
January 25, 2025 at 8:01 PM
Check out our new study on water networks in high resolution cryo-EM RNA data!
@ Chiu Lab @ Das Lab
@ Chiu Lab @ Das Lab
Reposted by Fabrice Leclerc
Happy to share the first preprint from my lab by
@indrabekere.bsky.social and Veronika Merold! We solved the cryo-EM structure of the RNA immune sensor OAS2 and revealed how dimerization and subcellular localization regulate its activity!
Check out Indra’s thread for a summary:
@indrabekere.bsky.social and Veronika Merold! We solved the cryo-EM structure of the RNA immune sensor OAS2 and revealed how dimerization and subcellular localization regulate its activity!
Check out Indra’s thread for a summary:
I’m very excited to share our first preprint “Structural Basis for OAS2 Regulation and its Antiviral Function” from my postdoc together with Veronika Merold (Vroni) from NTase lab with @oliveiramann.bsky.social www.biorxiv.org/content/10.1...
January 29, 2025 at 1:57 PM
Happy to share the first preprint from my lab by
@indrabekere.bsky.social and Veronika Merold! We solved the cryo-EM structure of the RNA immune sensor OAS2 and revealed how dimerization and subcellular localization regulate its activity!
Check out Indra’s thread for a summary:
@indrabekere.bsky.social and Veronika Merold! We solved the cryo-EM structure of the RNA immune sensor OAS2 and revealed how dimerization and subcellular localization regulate its activity!
Check out Indra’s thread for a summary:
Reposted by Fabrice Leclerc
Nucleoporins shape germ granule architecture and balance small RNA silencing pathways
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Nucleoporins shape germ granule architecture and balance small RNA silencing pathways
Animals have evolved distinct small RNA pathways, including piRNA and siRNA, to silence invasive and selfish nucleic acids. piRNA pathway factors are concentrated in perinuclear germ granules that fre...
www.biorxiv.org
January 28, 2025 at 2:54 PM
Nucleoporins shape germ granule architecture and balance small RNA silencing pathways
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Fabrice Leclerc
Also, in this image, it shows that researchers discovered Scientists found all five nucleobases – the genetic components of DNA and RNA – within the Bennu samples.
This lends more evidence that the budling blocks for life may have been brought to Earth by asteroid impacts. 2/#
This lends more evidence that the budling blocks for life may have been brought to Earth by asteroid impacts. 2/#
January 29, 2025 at 4:45 PM
Also, in this image, it shows that researchers discovered Scientists found all five nucleobases – the genetic components of DNA and RNA – within the Bennu samples.
This lends more evidence that the budling blocks for life may have been brought to Earth by asteroid impacts. 2/#
This lends more evidence that the budling blocks for life may have been brought to Earth by asteroid impacts. 2/#
Reposted by Fabrice Leclerc
Found amino acids – 14 of the 20 that life on Earth uses to make proteins – & all 5 nucleobases that life on Earth uses to store and transmit genetic instructions complex terrestrial biomolecules, such as DNA & RNA, including how to arrange amino acids into proteins
www.nasa.gov/news-release...
www.nasa.gov/news-release...
NASA’s Asteroid Bennu Sample Reveals Mix of Life’s Ingredients - NASA
Studies of rock and dust from asteroid Bennu delivered to Earth by NASA’s OSIRIS-REx (Origins, Spectral Interpretation, Resource Identification and
www.nasa.gov
February 1, 2025 at 4:56 AM
Found amino acids – 14 of the 20 that life on Earth uses to make proteins – & all 5 nucleobases that life on Earth uses to store and transmit genetic instructions complex terrestrial biomolecules, such as DNA & RNA, including how to arrange amino acids into proteins
www.nasa.gov/news-release...
www.nasa.gov/news-release...
Reposted by Fabrice Leclerc
The asteroid Bennu contains 16 of the 20 amino acids normally found in proteins and all the nucleobases found in DNA and RNA, suggesting “Our odds of finding life elsewhere are increasing” 🧪
nam02.safelinks.protection.outlook.com?url=https%3A...
nam02.safelinks.protection.outlook.com?url=https%3A...
Life’s Building Blocks Lurked Inside NASA’s Bennu Asteroid Samples (Gift Article)
Scientists studying samples that NASA collected from the asteroid Bennu found a wide assortment of organic molecules that shed light on how life arose.
nam02.safelinks.protection.outlook.com
January 30, 2025 at 8:55 PM
The asteroid Bennu contains 16 of the 20 amino acids normally found in proteins and all the nucleobases found in DNA and RNA, suggesting “Our odds of finding life elsewhere are increasing” 🧪
nam02.safelinks.protection.outlook.com?url=https%3A...
nam02.safelinks.protection.outlook.com?url=https%3A...
Reposted by Fabrice Leclerc
Samples from asteroid Bennu hold the building blocks of life, including ammonia, amino acids, and the bases for DNA and RNA.
Life’s Building Blocks Found in Bennu Samples - Eos
The discovery of amino acids, abundant ammonia, and the bases of DNA and RNA on asteroid Bennu suggest that materials essential to life might be widespread throughout the solar system.
eos.org
February 1, 2025 at 9:22 PM
Samples from asteroid Bennu hold the building blocks of life, including ammonia, amino acids, and the bases for DNA and RNA.
Reposted by Fabrice Leclerc
Learning the language of life with A.I.
@science.org
In today's essay, I review the phenomenal progress in foundation models of DNA, RNA, proteins, ligands, cells, their interactions, the Virtual Lab, and the aspiration for the Virtual Cell
www.science.org/doi/10.1126/...
@science.org
In today's essay, I review the phenomenal progress in foundation models of DNA, RNA, proteins, ligands, cells, their interactions, the Virtual Lab, and the aspiration for the Virtual Cell
www.science.org/doi/10.1126/...
Learning the language of life with AI
In 2021, a year before ChatGPT took the world by storm amid the excitement about generative artificial intelligence (AI), AlphaFold 2 cracked the 50-year-old protein-folding problem, predicting three-...
www.science.org
January 30, 2025 at 7:40 PM
Learning the language of life with A.I.
@science.org
In today's essay, I review the phenomenal progress in foundation models of DNA, RNA, proteins, ligands, cells, their interactions, the Virtual Lab, and the aspiration for the Virtual Cell
www.science.org/doi/10.1126/...
@science.org
In today's essay, I review the phenomenal progress in foundation models of DNA, RNA, proteins, ligands, cells, their interactions, the Virtual Lab, and the aspiration for the Virtual Cell
www.science.org/doi/10.1126/...
Reposted by Fabrice Leclerc
Not only does Bennu contain all 5 of the nucleobases that form DNA and RNA on Earth and 14 of the 20 amino acids found in known proteins, the asteroid’s amino acids hold a surprise
https://go.nature.com/4hDJnFM
https://go.nature.com/4hDJnFM
Asteroid fragments upend theory of how life on Earth bloomed
Nature - Samples from Bennu contain the chemical building blocks of life — but with a twist.
go.nature.com
February 1, 2025 at 11:22 AM
Not only does Bennu contain all 5 of the nucleobases that form DNA and RNA on Earth and 14 of the 20 amino acids found in known proteins, the asteroid’s amino acids hold a surprise
https://go.nature.com/4hDJnFM
https://go.nature.com/4hDJnFM
Reposted by Fabrice Leclerc
We discovered 3 RNA families that form homo-oligomeric RNA-only complexes! Studying nature continues to expand my wildest imagination. Read about it: doi.org/10.1101/2024...
Vivian Wu, Svetlana Shabalina, Hyunbin Lee, Grace Nye, Eugene Koonin, Alex Gao, Rhiju Das, Wah Chiu
Vivian Wu, Svetlana Shabalina, Hyunbin Lee, Grace Nye, Eugene Koonin, Alex Gao, Rhiju Das, Wah Chiu
December 13, 2024 at 12:42 AM
We discovered 3 RNA families that form homo-oligomeric RNA-only complexes! Studying nature continues to expand my wildest imagination. Read about it: doi.org/10.1101/2024...
Vivian Wu, Svetlana Shabalina, Hyunbin Lee, Grace Nye, Eugene Koonin, Alex Gao, Rhiju Das, Wah Chiu
Vivian Wu, Svetlana Shabalina, Hyunbin Lee, Grace Nye, Eugene Koonin, Alex Gao, Rhiju Das, Wah Chiu