DNA in foods is a source of nucleotides that are salvaged by tissues as building blocks for chromosomal and mitochondrial DNA. A recent study provided preliminary evidence that high-temperature cookin...

STING activates the innate immune system by inducing type-1 interferon (IFN) production and has been pursued as a therapeutic option in immuno-oncology. The targeted delivery of STING agonists to CCR2+ immune cells could enhance the therapeutic window of the agonists by selectively activating the STING pathway within targeted immune cells. The chemistry strategy was established to enable the targeted delivery of the cyclic dinucleotide STING agonist dazostinag to CCR2+ cells through an antibody-drug conjugate (ADC) approach. A self-immolative spacer between the adenine of dazostinag and the Cathepsin-B cleavable Val-Ala dipeptide linker rendered a linker payload that exhibits strong plasma stability while allowing the rapid payload release upon internalization into lysosomes. The stochastic cysteine conjugation of the dazostinag containing these linkers provided ADC TAK-500 and its mouse surrogate mTAK-500 with DAR = 4. In syngeneic tumor-bearing mouse models, mTAK-500 showed target specific antitumor activity as well as the induction of immune-stimulating cytokines.

STA is partnering with the Transit App to give local riders a chance to make public transportation less stressful with premium features like live GPS bus tracking.

Eastern Washington University has emerged as one of the nation’s cybersecurity education leaders, with hundreds of graduates working around the country to protect networks, devices and data.

The Nobel Prize rewards science, humanism and peace efforts. This is one of the central concepts in the will of Alfred Nobel, and it also permeates the outreach activities that have been developed for...

A "now renting" sign outside touts granite countertops. Inside, residents are trying to make sense of the raid that made their already neglected building even worse.

Request PDF | Structure, dynamics, and processing of 8oxoG:A in the nucleosome | Eukaryotic genomic DNA is packaged into chromatin through a repeating unit known as the nucleosome. In this chromatin e...