Josh
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reeding-biochemist.bsky.social
Josh
@reeding-biochemist.bsky.social
130 followers 640 following 1 posts
Lover of chemical biology and all things neuropsychology & immunology. Though not my thing, also interested in climate research.

Avid swimmer & hiker, occasional cyclist, amateur yogi.

🏳️‍🌈✊🍉
Posts Replies Media Videos
Reposted by Josh
apanagopoulos.bsky.social
Delighted to share that the results of my main postdoc project are now published in @nature.com

🔗 doi.org/10.1038/s415...
Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature
A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...
doi.org
May 21, 2025 at 3:27 PM
Reposted by Josh
karaswisher.bsky.social
Watch a major campaign being born.
aoc.bsky.social Alexandria Ocasio-Cortez @aoc.bsky.social · Apr 14
20,000 in ruby red Utah on their feet, in community, and ready to organize for a better world.

A better world is possible.
acyn.bsky.social Acyn @acyn.bsky.social · Apr 14
Strong moment from AOC’s speech in Utah
April 14, 2025 at 4:19 AM
Reposted by Josh
lozanzi.bsky.social
#WeekendRead! #LiveForever! Zhu &co show @ Science Advances that Citrulline decreases with aging & that its long-term administration leads to protective effects by inhibiting mTOR & glycolysis in macrophages, countering inflammaging
www.science.org/doi/10.1126/...
Citrulline regulates macrophage metabolism and inflammation to counter aging in mice
Citrulline acts as an endogenous metabolite antagonist to aging and inflammation by regulating mTOR-HIF1α-glycolysis pathway.
www.science.org
April 12, 2025 at 2:53 PM
Reposted by Josh
bencollins.bsky.social
Kinda hard to see a free and fair 2028 election where she doesn’t win by a lot.
acyn.bsky.social Acyn @acyn.bsky.social · Apr 12
AOC: How can anyone possibly make an objective vote on healthcare, energy, or war when their personal wealth is tied up in pharmaceutical, oil and gas, or defense company stock?
April 12, 2025 at 11:04 PM
Reposted by Josh
timothysnyder.bsky.social
"On Tyranny" is a #1 NYT bestseller again. I wish the moment were different. But I’m glad the book is useful. And grateful for all the kind words about putting the 20 lessons to work.
snyder.substack.com/p/twenty-les...
Twenty Lessons, read by John Lithgow
Key selections from On Tyranny, for viewing and sharing
snyder.substack.com
April 12, 2025 at 5:33 PM
Reposted by Josh
johnvibes.bsky.social
I hope everyone realizes that scrubbing historical references from web sites is no different than burning books
April 12, 2025 at 12:14 PM
Reposted by Josh
propublica.org
Federal workers: We understand you may be taking a risk in contacting us, and we take your confidentiality extremely seriously.

To collect tips, we use encrypted forms and apps, so messages cannot be read by anybody other than you and ProPublica.

➡️ Reach out here: propublica.org/tips
How to Contact ProPublica or Send a Tip Securely — ProPublica
Our job is to hold people and institutions accountable. To do that, we need evidence.
propublica.org
April 12, 2025 at 2:02 AM
Reposted by Josh
natbiotech.nature.com
Proteome-wide measurements of dose–response curves for 144 drugs reveal drug mechanisms of action go.nature.com/4a9lMs8
rdcu.be/egMl1
Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics - Nature Biotechnology
Proteome-wide measurements of dose–response curves for 144 drugs reveal drug mechanisms of action.
go.nature.com
April 9, 2025 at 4:30 AM
Reposted by Josh
roto-rub.bsky.social
You can still register for today's talk in our Lecture Series! Just click on this link to join the talk and discussion at 4pm (CET) on zoom: rotorub.wordpress.com/roto-lecture...
#HPBio #PhilSci #PhilMed
roto-rub.bsky.social ROTO Research Group @roto-rub.bsky.social · Apr 3
On Monday, we welcome @msimang.bsky.social as the first speaker in our Lecture Series for this semester. Phila will talk about racial and ethnic classifications in medicine. 💊 Just click on the link to register for the talk: rotorub.wordpress.com/roto-lecture...
#HPBio #PhilSci #PhilMed
Poster for the talk by Phila M. Msimang, entitled "Should we use racial and ethnic classifications in medicine?". It will take place on Monday, 7 April, at 4pm CET on Zoom.
April 7, 2025 at 9:20 AM
Reposted by Josh
karaswisher.bsky.social
In years to come, the people who did this will be the ones who will go to jail.
60minutes.bsky.social 60 Minutes @60minutes.bsky.social · Apr 7
60 Minutes found no criminal record for 75% of the Venezuelan migrants the U.S. sent to a mega-prison in El Salvador. https://cbsn.ws/4lC4Vp5
April 7, 2025 at 5:23 AM
Reposted by Josh
fischmidtlab.bsky.social
Late #WeekendRead: We describe a novel reporter to visualize endogenous #inflammasome assembly. Suitable for cell lines, primary cells, and tissues as well as quantification by #microscopy and #flowcytometry. Happy to share. www.biorxiv.org/content/10.1...
April 6, 2025 at 12:41 PM
Reposted by Josh
science.org
In a new Science study, researchers present ESM3, a protein language model that enables the programmed generation of protein structure and sequence in response to user prompts.

Learn more: scim.ag/40l2z3J
Simulating 500 million years of evolution with a language model
More than 3 billion years of evolution have produced an image of biology encoded into the space of natural proteins. Here, we show that language models trained at scale on evolutionary data can genera...
scim.ag
February 26, 2025 at 8:08 PM
Reposted by Josh
sethabramson.bsky.social
February 16, 2025 at 2:22 PM
Reposted by Josh
isaacrowlett.bsky.social
from “Parable of the Talents” by Octavia Butler
From EARTHSEED: THE BOOKS OF THE LIVING Choose your leaders with wisdom and forethought. To be led by a coward is to be controlled by all that the coward fears. To be led by a fool is to be led by the opportunists who control the fool. To be led by a thief is to offer up your most precious treasures to be stolen. To be led by a liar is to ask to be told lies. To be led by a tyrant is to sell yourself and those you love into slavery.
February 16, 2025 at 2:28 PM
Reposted by Josh
natureportfolio.nature.com
A study in Nature Medicine of a rare case of asymptomatic dominantly inherited Alzheimer’s reveals confined tau pathology and unique proteomic features, highlighting potential resilience mechanisms decades beyond expected onset. https://go.nature.com/41fiZfS 🔒
This is figure 2, which shows z-scored voxel-wise PET images of the exceptional resilience mutation carrier and of averaged symptomatic mutation carriers relative to non-carriers.
February 16, 2025 at 5:23 PM
Reposted by Josh
cbarbermd.bsky.social
BREAKING: VIRUS FROM NEVADA DAIRY WORKER WITH BIRD FLU HAS THE SAME GENETIC MUTATION seen in the Nevada cows – a change of PB2 D701N that has previously been assoc with more efficient virus replication in ppl & mammals.

CDC told Fortune that the D1.1 variant in this worker is the same strain of
February 11, 2025 at 12:12 AM
Reposted by Josh
hankgreen.bsky.social
Perhaps if he had not spent so much time playing video games so that he could be the #1 video game player he would know that the answer to this question is "All of them."
Mike Lee tweets "name a fascist dictator whose agenda entailed limit the size cost and power of government." Elon quote tweeted it with a laugh emoji and an arrow hitting a bullseye emoji.
February 5, 2025 at 8:55 PM
Reposted by Josh
erinwelsh.bsky.social
Hello #Bluesky! Let's talk diseases, medicine, history, biology, and whatever else is on your mind/bookshelf.
November 12, 2024 at 10:06 PM
Reposted by Josh
erinwelsh.bsky.social
A peer-reviewed guide to infectious disease podcasts?! And @tpwky.bsky.social made the list?! Yes please!!

academic.oup.com/ofid/article...
“Like and Subscribe”: A Compendium of Infectious Diseases Audio Podcasts
Abstract. In little more than 15 years, the podcast has gone from being virtually unknown to becoming a multibillion-dollar industry. There are an estimate
academic.oup.com
November 27, 2024 at 4:47 AM
Reposted by Josh
natrevgastrohep.nature.com
#Immunotherapy has changed the treatment landscape for patients with cancer. This REVIEW explores immune-mediated liver injury from checkpoint inhibitors, from mechanisms to management
www.nature.com/articles/s41...

#Sharedit link: rdcu.be/d5IOa

#Oncsky #Gastrosky #Liversky
This figure shows the potential mechanisms of immune-mediated liver injury from checkpoint inhibitors, showing key steps in monocyte recruitment and activation, CD8+ T cell recruitment and activation, and hepatocyte apoptosis
January 9, 2025 at 9:21 AM
Reposted by Josh
elizabeth-warren.bsky.social
Last time I checked, nobody voted for the richest man in the world to run the federal government.
December 20, 2024 at 9:16 PM
Reposted by Josh
dijiang319.bsky.social
In this week's @science.org from @lucksmith.bsky.social and colleagues @mskcancercenter.bsky.social | Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA–mediated silencing
#RNA #microRNA #miRNA #siRNA #argonaute🧬🧪
www.science.org/doi/10.1126/...
Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA–mediated silencing
microRNAs (miRNAs) and small interfering RNAs (siRNAs) are 21- to 22-nucleotide RNAs that guide Argonaute-class effectors to targets for repression. In this work, we uncover 5-aminolevulinic acid synt...
www.science.org
December 20, 2024 at 5:14 PM
Reposted by Josh
hankgreen.bsky.social
People paying attention to the drone stuff, am I missing something or is there no actual evidence of large drones?
December 20, 2024 at 12:59 AM
Reposted by Josh
elizabeth-warren.bsky.social
The American people deserve to know whether an “unofficial co-president” is advancing policies that are good for the country or just good for his own bottom line.
www.boston25news.com/news/local/u...
‘Unofficial co-president’: Sen. Warren presses President-elect Trump for answers on Elon Musk’s role
Warren is demanding answers from Trump on Musk’s role as a top advisor in his incoming administration, expressing concerns in a letter about the billionaire’s “massive conflicts of interest.”
www.boston25news.com
December 18, 2024 at 7:10 PM