rachellcosby.bsky.social
@rachellcosby.bsky.social
Reposted by rachellcosby.bsky.social
So excited to share this preprint from the Rosin lab in collaboration with the Hawley lab and @eelcotromer.bsky.social on moth spermatogenesis! We investigate the meiotic errors that occur during the formation of apyrene sperm (that have no DNA) in silkworms!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Programmed meiotic errors facilitate dichotomous sperm production in the silkworm, Bombyx mori
The goal of meiosis is typically to produce haploid gametes (eggs or sperm). Failure to do so is catastrophic for fertility and offspring health. However, Lepidopteran (moths and butterflies) males pr...
www.biorxiv.org
August 4, 2025 at 10:38 AM
So excited to share this preprint from the Rosin lab in collaboration with the Hawley lab and @eelcotromer.bsky.social on moth spermatogenesis! We investigate the meiotic errors that occur during the formation of apyrene sperm (that have no DNA) in silkworms!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by rachellcosby.bsky.social
How the complex issue of delineating #Transposons families plays out in the interpretation of epigenetic experiments. Congrats Xun Chen and @guilbourque.bsky.social for leading this work, and thank you for having me on this! www.science.org/doi/10.1126/... #TEsky
A phylogenetic approach uncovers cryptic endogenous retrovirus subfamilies in the primate lineage
A phylogenetic approach reveals cryptic LTR subfamilies and functional insights at nucleotide resolution in primates.
www.science.org
July 23, 2025 at 5:22 PM
How the complex issue of delineating #Transposons families plays out in the interpretation of epigenetic experiments. Congrats Xun Chen and @guilbourque.bsky.social for leading this work, and thank you for having me on this! www.science.org/doi/10.1126/... #TEsky
Reposted by rachellcosby.bsky.social
Is the annotation of viruses in the human genome accurate? We think not. Take a look at our new paper and let us know if you agree! www.science.org/doi/10.1126/...
A phylogenetic approach uncovers cryptic endogenous retrovirus subfamilies in the primate lineage
A phylogenetic approach reveals cryptic LTR subfamilies and functional insights at nucleotide resolution in primates.
www.science.org
July 21, 2025 at 1:51 PM
Is the annotation of viruses in the human genome accurate? We think not. Take a look at our new paper and let us know if you agree! www.science.org/doi/10.1126/...
Reposted by rachellcosby.bsky.social
Are you bravely deciding to do a postdoc in the US? And also interested in some combination of genomics, immunology, and transposons? If so, consider applying to my lab at the BioFrontiers Institute in Boulder, Colorado!
jobs.colorado.edu/jobs/JobDeta...
🧪🧬 #TESky #interferosky
jobs.colorado.edu/jobs/JobDeta...
🧪🧬 #TESky #interferosky
July 17, 2025 at 7:36 PM
Are you bravely deciding to do a postdoc in the US? And also interested in some combination of genomics, immunology, and transposons? If so, consider applying to my lab at the BioFrontiers Institute in Boulder, Colorado!
jobs.colorado.edu/jobs/JobDeta...
🧪🧬 #TESky #interferosky
jobs.colorado.edu/jobs/JobDeta...
🧪🧬 #TESky #interferosky
Reposted by rachellcosby.bsky.social
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics
Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...
www.nature.com
July 9, 2025 at 10:05 AM
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Reposted by rachellcosby.bsky.social
Our (@jeffsekelsky.bsky.social Corbin Jones, & me) #Meiosis, Recombination & Evolution of Sex class @uncchapelhill.bsky.social loved talking w/ @scienceleah.bsky.social about her lab's @plos.org Genetics paper on a unique chromosome segregation mechanism in holocentric moths. doi.org/10.1371/jour...
April 11, 2025 at 7:31 PM
Our (@jeffsekelsky.bsky.social Corbin Jones, & me) #Meiosis, Recombination & Evolution of Sex class @uncchapelhill.bsky.social loved talking w/ @scienceleah.bsky.social about her lab's @plos.org Genetics paper on a unique chromosome segregation mechanism in holocentric moths. doi.org/10.1371/jour...
Reposted by rachellcosby.bsky.social
New preprint from my group! Here we studied the contribution of a subset of human- and hominoid-specific transposons (SVA, LTR5HS) to the evolution of human craniofacial development. We specifically focussed on cranial neural crest (CNCC) formation and migration 1/n
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Human-specific transposable elements shaped the evolution of craniofacial development through regulation of neural crest migration
Craniofacial development and neural crest specification are evolutionarily conserved processes, yet subtle modifications to their gene regulatory networks drive species-specific craniofacial diversity...
www.biorxiv.org
April 7, 2025 at 1:26 PM
New preprint from my group! Here we studied the contribution of a subset of human- and hominoid-specific transposons (SVA, LTR5HS) to the evolution of human craniofacial development. We specifically focussed on cranial neural crest (CNCC) formation and migration 1/n
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by rachellcosby.bsky.social
I’m excited to share a new preprint from some of my work in the lab of @toddmacfarlan.bsky.social ! 😄
We dived into young KZFP gene clusters in different mouse strains and species to uncover mechanisms that facilitated their evolution and diversification in mice
We dived into young KZFP gene clusters in different mouse strains and species to uncover mechanisms that facilitated their evolution and diversification in mice
Young KRAB-zinc finger gene clusters are highly dynamic incubators of ERV-driven genetic heterogeneity in mice https://www.biorxiv.org/content/10.1101/2025.02.26.640358v1
March 3, 2025 at 6:41 PM
I’m excited to share a new preprint from some of my work in the lab of @toddmacfarlan.bsky.social ! 😄
We dived into young KZFP gene clusters in different mouse strains and species to uncover mechanisms that facilitated their evolution and diversification in mice
We dived into young KZFP gene clusters in different mouse strains and species to uncover mechanisms that facilitated their evolution and diversification in mice
Reposted by rachellcosby.bsky.social
Here is the peer-reviewed version of our study showing how some TAD borders are essential for gene regulation and development.
Loss of a single CTCF motif is sufficient to cause embryonic lethality.
www.sciencedirect.com/science/arti...
Loss of a single CTCF motif is sufficient to cause embryonic lethality.
www.sciencedirect.com/science/arti...
Deletion of a single CTCF motif at the boundary of a chromatin domain with three FGF genes disrupts gene expression and embryonic development
Chromatin domains delimited by CTCF can restrict the range of enhancer action. However, disruption of some domain boundaries results in mild gene dysr…
www.sciencedirect.com
February 26, 2025 at 9:22 PM
Here is the peer-reviewed version of our study showing how some TAD borders are essential for gene regulation and development.
Loss of a single CTCF motif is sufficient to cause embryonic lethality.
www.sciencedirect.com/science/arti...
Loss of a single CTCF motif is sufficient to cause embryonic lethality.
www.sciencedirect.com/science/arti...
Reposted by rachellcosby.bsky.social
Feels awkward but necessary to celebrate scientific progress in this imperiled time for US biomedical research.
Proud of our latest paper out today exploring the role of transposable elements in antiviral resistance to HIV 🦠
genomebiology.biomedcentral.com/articles/10....
🧵1/n
Proud of our latest paper out today exploring the role of transposable elements in antiviral resistance to HIV 🦠
genomebiology.biomedcentral.com/articles/10....
🧵1/n
Transposable elements may enhance antiviral resistance in HIV-1 elite controllers - Genome Biology
Background Less than 0.5% of people living with HIV-1 are elite controllers (ECs)—individuals who maintain undetectable plasma viremia without antiretroviral therapy, despite having replication-compet...
genomebiology.biomedcentral.com
February 24, 2025 at 12:27 PM
Feels awkward but necessary to celebrate scientific progress in this imperiled time for US biomedical research.
Proud of our latest paper out today exploring the role of transposable elements in antiviral resistance to HIV 🦠
genomebiology.biomedcentral.com/articles/10....
🧵1/n
Proud of our latest paper out today exploring the role of transposable elements in antiviral resistance to HIV 🦠
genomebiology.biomedcentral.com/articles/10....
🧵1/n
Reposted by rachellcosby.bsky.social
