Patrick Steinmetz
@prhsteinmetz.bsky.social
Group leader at Michael Sars Centre, University of Bergen. How food regulates growth in a sea anemone. Also: Wildlife & landscape photography. Hiking. Fishing. Consciousness. Meditation.
#EvoDevo #Development #EvoPhysio
https://orcid.org/0000-0002-3705-277
#EvoDevo #Development #EvoPhysio
https://orcid.org/0000-0002-3705-277
Pinned
Excited to have been part of this Special Issue in Development!
Read about the cellular basis of sea anemone growth & shrinkage: t.co/jgrEBb98Kl
@msarscentre.bsky.social
Read about the cellular basis of sea anemone growth & shrinkage: t.co/jgrEBb98Kl
@msarscentre.bsky.social
Reposted by Patrick Steinmetz
Our paper on the role of neurons in Nematostella head regeneration is now out at @currentbiology.bsky.social Big thank you to all collaborators, it was a pleasure!
Ectopic head regeneration after nervous system ablation in a sea anemone: Current Biology www.cell.com/current-biol...
Ectopic head regeneration after nervous system ablation in a sea anemone: Current Biology www.cell.com/current-biol...
Ectopic head regeneration after nervous system ablation in a sea anemone
Via genetic ablation of neurons, Mazloumi Gavgani et al. show that the nervous system
is essential for defining axial polarity during whole-body regeneration in the sea
anemone Nematostella vectensis.
www.cell.com
November 18, 2025 at 10:00 AM
Our paper on the role of neurons in Nematostella head regeneration is now out at @currentbiology.bsky.social Big thank you to all collaborators, it was a pleasure!
Ectopic head regeneration after nervous system ablation in a sea anemone: Current Biology www.cell.com/current-biol...
Ectopic head regeneration after nervous system ablation in a sea anemone: Current Biology www.cell.com/current-biol...
Reposted by Patrick Steinmetz
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes - Nature Genetics
Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.
www.nature.com
November 18, 2025 at 12:00 PM
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Reposted by Patrick Steinmetz
A molecular, spatial and regulatory atlas of the Hydra vulgaris nervous system
Read this #LifelongDevSI #OA Techniques and Resources Article by Hannah Morris Little, Abby S. Primack, Jennifer Tsverov, Celina E. Juliano (@julianolab.bsky.social) and colleagues:
doi.org/10.1242/dev....
Read this #LifelongDevSI #OA Techniques and Resources Article by Hannah Morris Little, Abby S. Primack, Jennifer Tsverov, Celina E. Juliano (@julianolab.bsky.social) and colleagues:
doi.org/10.1242/dev....
November 3, 2025 at 3:53 PM
A molecular, spatial and regulatory atlas of the Hydra vulgaris nervous system
Read this #LifelongDevSI #OA Techniques and Resources Article by Hannah Morris Little, Abby S. Primack, Jennifer Tsverov, Celina E. Juliano (@julianolab.bsky.social) and colleagues:
doi.org/10.1242/dev....
Read this #LifelongDevSI #OA Techniques and Resources Article by Hannah Morris Little, Abby S. Primack, Jennifer Tsverov, Celina E. Juliano (@julianolab.bsky.social) and colleagues:
doi.org/10.1242/dev....
Reposted by Patrick Steinmetz
Very happy to see our paper published online natcomms.nature.com. Thank you to @wellcometrust.bsky.social for funding this work during my time with @robklose.bsky.social and David Booth! Thanks also to collaborators @garcialabms.bsky.social @alexdemendoza.bsky.social and the other authors!
Chromatin profiling identifies putative dual roles for H3K27me3 in regulating cell type-specific genes and transposable elements in choanoflagellates
Nature Communications - Here, the authors investigate chromatin-based gene regulation in the closest relative of animal, choanoflagellates. They uncover a putative dual role for the histone...
rdcu.be
October 29, 2025 at 1:40 PM
Very happy to see our paper published online natcomms.nature.com. Thank you to @wellcometrust.bsky.social for funding this work during my time with @robklose.bsky.social and David Booth! Thanks also to collaborators @garcialabms.bsky.social @alexdemendoza.bsky.social and the other authors!
If you need to move things fast…
October 23, 2025 at 8:35 PM
If you need to move things fast…
Reposted by Patrick Steinmetz
I am very excited to announce the opening of the submission site for the upcoming Conférences Jacques Monod on Developmental Biology, May 18-22, 2026 cjm.sb-roscoff.fr/en/conferenc...
@lionlchristiaen.bsky.social and I have an exciting program of speakers and slots for selected short talks, etc.
@lionlchristiaen.bsky.social and I have an exciting program of speakers and slots for selected short talks, etc.
October 23, 2025 at 12:49 PM
I am very excited to announce the opening of the submission site for the upcoming Conférences Jacques Monod on Developmental Biology, May 18-22, 2026 cjm.sb-roscoff.fr/en/conferenc...
@lionlchristiaen.bsky.social and I have an exciting program of speakers and slots for selected short talks, etc.
@lionlchristiaen.bsky.social and I have an exciting program of speakers and slots for selected short talks, etc.
Reposted by Patrick Steinmetz
Very sad news, John Gurdon has died.
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
Professor Sir John Gurdon FRS (1933-2025) | Magdalene College
Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.
www.magd.cam.ac.uk
October 7, 2025 at 4:02 PM
Very sad news, John Gurdon has died.
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
Reposted by Patrick Steinmetz
Latest from ours: www.cell.com/cell-reports...
This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
October 5, 2025 at 10:35 AM
Latest from ours: www.cell.com/cell-reports...
This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
@malinkjosavik.bsky.social was fantastic giving her first talk at a conference!
Fantastic presentation by @malinkjosavik.bsky.social at the Tutzing basal metazoan workshop 👏 She shared her work on starvation and metabolism in Nematostella, conducted in collaboration between the @prhsteinmetz.bsky.social lab and the Dept of Biomedicine @unibergen.bsky.social ✨
September 25, 2025 at 4:45 PM
@malinkjosavik.bsky.social was fantastic giving her first talk at a conference!
Reposted by Patrick Steinmetz
Fantastic presentation by @malinkjosavik.bsky.social at the Tutzing basal metazoan workshop 👏 She shared her work on starvation and metabolism in Nematostella, conducted in collaboration between the @prhsteinmetz.bsky.social lab and the Dept of Biomedicine @unibergen.bsky.social ✨
September 25, 2025 at 12:57 PM
Fantastic presentation by @malinkjosavik.bsky.social at the Tutzing basal metazoan workshop 👏 She shared her work on starvation and metabolism in Nematostella, conducted in collaboration between the @prhsteinmetz.bsky.social lab and the Dept of Biomedicine @unibergen.bsky.social ✨
Reposted by Patrick Steinmetz
How Did Hands Evolve? The Answer Is Behind You. (My story of some surprising evo-devo!) nyti.ms/42Cg8xH
September 17, 2025 at 9:21 PM
How Did Hands Evolve? The Answer Is Behind You. (My story of some surprising evo-devo!) nyti.ms/42Cg8xH
Reposted by Patrick Steinmetz
Are digits modified fins, or evolutionary innovations? Read how we tackled this old question from a new angle🧪
A story with @chasebolt.bsky.social, @homeobox.bsky.social and myself, coordinated by @denisduboule.bsky.social from @college-de-france.fr and published in @nature.com today!
#InHoxWeTrust
A story with @chasebolt.bsky.social, @homeobox.bsky.social and myself, coordinated by @denisduboule.bsky.social from @college-de-france.fr and published in @nature.com today!
#InHoxWeTrust
September 17, 2025 at 5:26 PM
Are digits modified fins, or evolutionary innovations? Read how we tackled this old question from a new angle🧪
A story with @chasebolt.bsky.social, @homeobox.bsky.social and myself, coordinated by @denisduboule.bsky.social from @college-de-france.fr and published in @nature.com today!
#InHoxWeTrust
A story with @chasebolt.bsky.social, @homeobox.bsky.social and myself, coordinated by @denisduboule.bsky.social from @college-de-france.fr and published in @nature.com today!
#InHoxWeTrust
Reposted by Patrick Steinmetz
New short paper from our lab @currentbiology.bsky.social, in which we discover of a new mode of cell motility for choanoflagellates: flagellar gliding. www.cell.com/current-biol... - A 🧵
Flagellar gliding in choanoflagellates
Freire-Delgado and Brunet discover a new mode of cell motility in choanoflagellates,
the closest relatives of animals. Under mild confinement, choanoflagellate move over
surfaces without cell deformat...
www.cell.com
September 9, 2025 at 6:12 PM
New short paper from our lab @currentbiology.bsky.social, in which we discover of a new mode of cell motility for choanoflagellates: flagellar gliding. www.cell.com/current-biol... - A 🧵
Reposted by Patrick Steinmetz
Look at this crazy thing!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
One mother for two species via obligate cross-species cloning in ants - Nature
In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same moth...
www.nature.com
September 3, 2025 at 7:05 PM
Look at this crazy thing!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Patrick Steinmetz
Our work on the function of miR-51/miR-100 is out! miR-100 is widely conserved across eumetazoans but its function has been mysterious. Emilio Santillán found in worms it regulates signaling and extracellular matrix genes, some of which seem to be conserved targets! www.science.org/doi/10.1126/...
An ancient and essential miRNA family controls cellular interaction pathways in C. elegans
A microRNA that arose at the origin of eumetazoans regulates cell adhesion and signaling in C. elegans through conserved targets.
www.science.org
September 3, 2025 at 6:16 PM
Our work on the function of miR-51/miR-100 is out! miR-100 is widely conserved across eumetazoans but its function has been mysterious. Emilio Santillán found in worms it regulates signaling and extracellular matrix genes, some of which seem to be conserved targets! www.science.org/doi/10.1126/...
Reposted by Patrick Steinmetz
Finally, the excellent postdoc work of Emmanuel Haillot is out, where he dissected the integration of Wnt, MAPK and Notch signaling in defining mesoderm and endoderm identities in the diploblast Nematostella. Strikingly similar to sea urchins. www.nature.com/articles/s41...
August 29, 2025 at 9:04 PM
Finally, the excellent postdoc work of Emmanuel Haillot is out, where he dissected the integration of Wnt, MAPK and Notch signaling in defining mesoderm and endoderm identities in the diploblast Nematostella. Strikingly similar to sea urchins. www.nature.com/articles/s41...
Reposted by Patrick Steinmetz
At long last, the version of record of our paper on the #platynereis #connectome
"Whole-body connectome of a segmented annelid larva" is out.
Explore the rich online presentation with all the videos, figures and source data here:
https://doi.org/10.7554/eLife.97964
@eLife
@biology […]
"Whole-body connectome of a segmented annelid larva" is out.
Explore the rich online presentation with all the videos, figures and source data here:
https://doi.org/10.7554/eLife.97964
@eLife
@biology […]
Original post on biologists.social
biologists.social
August 28, 2025 at 12:26 PM
At long last, the version of record of our paper on the #platynereis #connectome
"Whole-body connectome of a segmented annelid larva" is out.
Explore the rich online presentation with all the videos, figures and source data here:
https://doi.org/10.7554/eLife.97964
@eLife
@biology […]
"Whole-body connectome of a segmented annelid larva" is out.
Explore the rich online presentation with all the videos, figures and source data here:
https://doi.org/10.7554/eLife.97964
@eLife
@biology […]
Reposted by Patrick Steinmetz
Congratulations Dr. Fournon Berodia @inesfournon.bsky.social 🎉🤩 We are very proud of Inés for successfully defending her PhD thesis conducted in the @prhsteinmetz.bsky.social lab. Thank you to opponents @ragkousik.bsky.social & @levayerr.bsky.social for insightful discussions 👏
August 26, 2025 at 2:09 PM
Congratulations Dr. Fournon Berodia @inesfournon.bsky.social 🎉🤩 We are very proud of Inés for successfully defending her PhD thesis conducted in the @prhsteinmetz.bsky.social lab. Thank you to opponents @ragkousik.bsky.social & @levayerr.bsky.social for insightful discussions 👏
Reposted by Patrick Steinmetz
New preprint from the @pawelburkhardt.bsky.social lab 🤩 @annaferraioli.bsky.social & colleagues created a 3D model of the ctenophore apical organ, revealing cell-type diversity and exciting new insights into the evolution of central nervous systems 🧠🧪 Congratulations to the team! 👏
Ctenophores possess a unique aboral organ that acts as a multisensory center, controlling complex behaviors. We’ve now created a ctenophore model integrated with our 3D volume EM data. Puts it into perspective.
Check out our recent work here: www.biorxiv.org/content/10.1...
#ctenophores #volumeEM
Check out our recent work here: www.biorxiv.org/content/10.1...
#ctenophores #volumeEM
August 7, 2025 at 9:49 AM
New preprint from the @pawelburkhardt.bsky.social lab 🤩 @annaferraioli.bsky.social & colleagues created a 3D model of the ctenophore apical organ, revealing cell-type diversity and exciting new insights into the evolution of central nervous systems 🧠🧪 Congratulations to the team! 👏
Reposted by Patrick Steinmetz
Reposted by Patrick Steinmetz
Researchers from @imev-mer.fr recently visited us for a workshop supported by the French-Norwegian mobility program Åsgard 🌊 Between seminars, lab demos and discussions, new ideas and plans for long-term collaborations emerged 🤩 Read more about this exciting partnership below ⤵️
Åsgard workshop sparks new collaborations at the Michael Sars Centre
Researchers from the Institut de la Mer de Villefranche and the Michael Sars Centre received support from the French-Norwegian mobility program Åsgard. Through seminars and discussions, participants l...
tinyurl.com
July 17, 2025 at 12:21 PM
Researchers from @imev-mer.fr recently visited us for a workshop supported by the French-Norwegian mobility program Åsgard 🌊 Between seminars, lab demos and discussions, new ideas and plans for long-term collaborations emerged 🤩 Read more about this exciting partnership below ⤵️
Reposted by Patrick Steinmetz
Pls. share widely
Calling all transposon fans & lovers of genetic innovation
MOBILE GENOME welcomes you in Heidelberg, Nov. 4–7 2025
→ Vibrant & friendly community
→ Cutting-edge talks from mechanisms to physiology
→ Plenty of surprises (TEs never stop innovating)
submit abstract by July 29
Calling all transposon fans & lovers of genetic innovation
MOBILE GENOME welcomes you in Heidelberg, Nov. 4–7 2025
→ Vibrant & friendly community
→ Cutting-edge talks from mechanisms to physiology
→ Plenty of surprises (TEs never stop innovating)
submit abstract by July 29
⏰ Abstract deadline for 'The mobile genome' is 29 July!
👉 https://s.embl.org/mge25-01-bl
Join us 4–7 Nov 2025 at EMBL Heidelberg (or online) to explore the impact of TEs across biology. 🧬🔍
⭐🧑🏼🔬 24 talks + 15 flash talks from posters – don't miss out!
#EMBOMobileGenome
👉 https://s.embl.org/mge25-01-bl
Join us 4–7 Nov 2025 at EMBL Heidelberg (or online) to explore the impact of TEs across biology. 🧬🔍
⭐🧑🏼🔬 24 talks + 15 flash talks from posters – don't miss out!
#EMBOMobileGenome
July 16, 2025 at 8:43 AM
Pls. share widely
Calling all transposon fans & lovers of genetic innovation
MOBILE GENOME welcomes you in Heidelberg, Nov. 4–7 2025
→ Vibrant & friendly community
→ Cutting-edge talks from mechanisms to physiology
→ Plenty of surprises (TEs never stop innovating)
submit abstract by July 29
Calling all transposon fans & lovers of genetic innovation
MOBILE GENOME welcomes you in Heidelberg, Nov. 4–7 2025
→ Vibrant & friendly community
→ Cutting-edge talks from mechanisms to physiology
→ Plenty of surprises (TEs never stop innovating)
submit abstract by July 29
Reposted by Patrick Steinmetz
'Vacations.'
The word is 'vacations.'
The word is 'vacations.'
July 7, 2025 at 5:53 PM
'Vacations.'
The word is 'vacations.'
The word is 'vacations.'
Reposted by Patrick Steinmetz
#MetabolismMondays
Meet @kstapornwongkul.bsky.social, #newPI at @imbavienna.bsky.social @vbcscitraining.bsky.social, alumni from @viktri08.bsky.social @embl.org - discussing metabolism of embryonic development using #gastruloids.
#theNodeCorrespondents #ecr @the-node.bsky.social #DevBio #stemcell
Meet @kstapornwongkul.bsky.social, #newPI at @imbavienna.bsky.social @vbcscitraining.bsky.social, alumni from @viktri08.bsky.social @embl.org - discussing metabolism of embryonic development using #gastruloids.
#theNodeCorrespondents #ecr @the-node.bsky.social #DevBio #stemcell
Metabolic Origins: Steering of early developmental fate #MetabolismMondays - the Node
All the world's a metabolic dance, early career scientists are leading the way! Emerging perspectives in metabolism Dr Kristina StapornwongkulX:
thenode.biologists.com
July 7, 2025 at 11:33 AM
#MetabolismMondays
Meet @kstapornwongkul.bsky.social, #newPI at @imbavienna.bsky.social @vbcscitraining.bsky.social, alumni from @viktri08.bsky.social @embl.org - discussing metabolism of embryonic development using #gastruloids.
#theNodeCorrespondents #ecr @the-node.bsky.social #DevBio #stemcell
Meet @kstapornwongkul.bsky.social, #newPI at @imbavienna.bsky.social @vbcscitraining.bsky.social, alumni from @viktri08.bsky.social @embl.org - discussing metabolism of embryonic development using #gastruloids.
#theNodeCorrespondents #ecr @the-node.bsky.social #DevBio #stemcell
Reposted by Patrick Steinmetz
Latest #MetabolismMondays interview has just dropped 👀
Find out more about #newPI @kstapornwongkul.bsky.social and her research 👇
Find out more about #newPI @kstapornwongkul.bsky.social and her research 👇
#MetabolismMondays
Meet @kstapornwongkul.bsky.social, #newPI at @imbavienna.bsky.social @vbcscitraining.bsky.social, alumni from @viktri08.bsky.social @embl.org - discussing metabolism of embryonic development using #gastruloids.
#theNodeCorrespondents #ecr @the-node.bsky.social #DevBio #stemcell
Meet @kstapornwongkul.bsky.social, #newPI at @imbavienna.bsky.social @vbcscitraining.bsky.social, alumni from @viktri08.bsky.social @embl.org - discussing metabolism of embryonic development using #gastruloids.
#theNodeCorrespondents #ecr @the-node.bsky.social #DevBio #stemcell
Metabolic Origins: Steering of early developmental fate #MetabolismMondays - the Node
All the world's a metabolic dance, early career scientists are leading the way! Emerging perspectives in metabolism Dr Kristina StapornwongkulX:
thenode.biologists.com
July 7, 2025 at 1:02 PM
Latest #MetabolismMondays interview has just dropped 👀
Find out more about #newPI @kstapornwongkul.bsky.social and her research 👇
Find out more about #newPI @kstapornwongkul.bsky.social and her research 👇