DrPrincessTheSpaceCat
@prcatstronaut.bsky.social
spinster (in multiple ways) | she/her | comp bio phd/data vis | crochet | audhd | ace | queer | fat | pgh | fairy-type | dnd/lancer | stardew/fields of mistria | tng/ds9/voy | I do science for money, but I nerd for free
Pinned
Or if anyone wants a queerplatonic partner to help run a household with, I’d be down for that. Let’s Golden-Girls-it up
Reposted by DrPrincessTheSpaceCat
To probe gene-scale chromatin physics, we built 96-mer (20 kb) arrays with defined histone marks. Combining single-molecule tracking, AFM imaging, and developing in vitro Hi-C, we saw how specific modifications dictate chromatin structure and dynamics. www.science.org/doi/10.1126/...
Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture
Reconstituting 20-kb chromatin shows that tuning acetylation alone reshapes its folding, dynamics, and contact domain formation.
www.science.org
November 20, 2025 at 7:46 AM
To probe gene-scale chromatin physics, we built 96-mer (20 kb) arrays with defined histone marks. Combining single-molecule tracking, AFM imaging, and developing in vitro Hi-C, we saw how specific modifications dictate chromatin structure and dynamics. www.science.org/doi/10.1126/...
Reposted by DrPrincessTheSpaceCat
I mean I know I should probably be more freaked out about this but the guy is flailing, he’s losing on every front and he’s watching television and screaming into the void again
everyone is going to pretend this didn’t happen like they do every time he does something like this
everyone is going to pretend this didn’t happen like they do every time he does something like this
November 20, 2025 at 3:38 PM
I mean I know I should probably be more freaked out about this but the guy is flailing, he’s losing on every front and he’s watching television and screaming into the void again
everyone is going to pretend this didn’t happen like they do every time he does something like this
everyone is going to pretend this didn’t happen like they do every time he does something like this
Reposted by DrPrincessTheSpaceCat
In a new MBE Perspective, @jomcinerney.bsky.social introduces the concepts of epaktovars and xenotypes, providing a framework for describing phenotypic convergence and shared genetic material resulting from gene transfer across diverse lineages.
🔗 doi.org/10.1093/molbev/msaf279
#evobio #molbio
🔗 doi.org/10.1093/molbev/msaf279
#evobio #molbio
Classifying Convergences in the Light of Horizontal Gene Transfer: Epaktovars and Xenotypes
Abstract. The classification of living systems presents significant challenges due to the prevalence of gene transfer between genomes. Traditional taxonomi
doi.org
November 20, 2025 at 3:48 PM
In a new MBE Perspective, @jomcinerney.bsky.social introduces the concepts of epaktovars and xenotypes, providing a framework for describing phenotypic convergence and shared genetic material resulting from gene transfer across diverse lineages.
🔗 doi.org/10.1093/molbev/msaf279
#evobio #molbio
🔗 doi.org/10.1093/molbev/msaf279
#evobio #molbio
Reposted by DrPrincessTheSpaceCat
Data on race and ethnicity has put us on the cusp of breakthroughs in treating kidney failure, which disproportionately affects Black Americans. But the Trump administration has halted that data collection as part of its war on supposed "DEI." Important new story from @laylaayanna.bsky.social
The Trump Admin’s War on Data Is Compromising Major Health Advancements for Black Americans
Thanks to a 2009 medical breakthrough, researchers could be on the precipice...
talkingpointsmemo.com
November 20, 2025 at 12:55 PM
Data on race and ethnicity has put us on the cusp of breakthroughs in treating kidney failure, which disproportionately affects Black Americans. But the Trump administration has halted that data collection as part of its war on supposed "DEI." Important new story from @laylaayanna.bsky.social
Reposted by DrPrincessTheSpaceCat
Reposted by DrPrincessTheSpaceCat
I want things to be easier in the sense that we can better take care of ourselves and each other. Not robots and AI crap doing everything so our brains and hearts turn to mush.
November 20, 2025 at 3:52 PM
I want things to be easier in the sense that we can better take care of ourselves and each other. Not robots and AI crap doing everything so our brains and hearts turn to mush.
Reposted by DrPrincessTheSpaceCat
…2) if we're now out here telling individual states what they can and can't regulate, "AI" or otherwise, then I ask again:
*Lil Jon Voice* States' Rights to What
November 20, 2025 at 3:20 PM
…2) if we're now out here telling individual states what they can and can't regulate, "AI" or otherwise, then I ask again:
Reposted by DrPrincessTheSpaceCat
The CDC website is peddling false information about autism.
👉 Do not trust CDC for vaccine info or guidance
👉 Look to professional orgs or Public Health Canada (NACI) for unbiased, evidence-based guidance
Gift link:
wapo.st/4idz3Wn
👉 Do not trust CDC for vaccine info or guidance
👉 Look to professional orgs or Public Health Canada (NACI) for unbiased, evidence-based guidance
Gift link:
wapo.st/4idz3Wn
CDC in turmoil after agency backpedals on debunking vaccines-autism link
The CDC’s website now says health authorities ignored evidence of a potential connection between vaccines and autism, despite dozens of studies showing no link.
wapo.st
November 20, 2025 at 2:13 PM
The CDC website is peddling false information about autism.
👉 Do not trust CDC for vaccine info or guidance
👉 Look to professional orgs or Public Health Canada (NACI) for unbiased, evidence-based guidance
Gift link:
wapo.st/4idz3Wn
👉 Do not trust CDC for vaccine info or guidance
👉 Look to professional orgs or Public Health Canada (NACI) for unbiased, evidence-based guidance
Gift link:
wapo.st/4idz3Wn
Reposted by DrPrincessTheSpaceCat
Good Morning ! No one plays the victim more than the one who caused the damage.
November 20, 2025 at 4:02 PM
Good Morning ! No one plays the victim more than the one who caused the damage.
Reposted by DrPrincessTheSpaceCat
Our latest paper is out with @adiop.bsky.social and @gmdouglas.bsky.social. We analyzed the extent of homologous recombination between bacterial species (introgression) and how it affects species borders (it can vary a lot depending on the approach used to classify species!). rdcu.be/eQAMf
Introgression impacts the evolution of bacteria, but species borders are rarely fuzzy
Nature Communications - It is commonly thought that bacterial species borders tend to be fuzzy, due to frequent exchange of DNA. Here, Diop et al. quantify the patterns of gene flow between core...
rdcu.be
November 18, 2025 at 9:01 PM
Our latest paper is out with @adiop.bsky.social and @gmdouglas.bsky.social. We analyzed the extent of homologous recombination between bacterial species (introgression) and how it affects species borders (it can vary a lot depending on the approach used to classify species!). rdcu.be/eQAMf
Reposted by DrPrincessTheSpaceCat
Very happy to see this piece out in @plosbiology.org, on the bacterial immune systems and microbial communities. It was a great team effort with Rafael Custodio, @brockhurstlab.bsky.social , @brownlab.bsky.social, and Edze Westra! 🦠🧫 #phagesky #mevosky
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Bacterial immune systems as causes and consequences of microbiome structure
Bacterial immune systems have evolved in response to diverse molecular "parasites", yet their ecological roles remain poorly understood. This Essay explores how interactions between mobile genetic ele...
journals.plos.org
November 19, 2025 at 6:35 PM
Very happy to see this piece out in @plosbiology.org, on the bacterial immune systems and microbial communities. It was a great team effort with Rafael Custodio, @brockhurstlab.bsky.social , @brownlab.bsky.social, and Edze Westra! 🦠🧫 #phagesky #mevosky
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Reposted by DrPrincessTheSpaceCat
It’s good to explain that the CDC is lying and vaccines still unequivocally do not cause autism, even if it just reaches one person on here who has doubts. But the fight is out there, not in here; and the time to let go of the information deficit model of science communication was decades ago
November 20, 2025 at 5:40 AM
It’s good to explain that the CDC is lying and vaccines still unequivocally do not cause autism, even if it just reaches one person on here who has doubts. But the fight is out there, not in here; and the time to let go of the information deficit model of science communication was decades ago
Reposted by DrPrincessTheSpaceCat
Workers deserve protection from coercive employment practices that trap them in jobs & force them into debt so corporations can line their pockets.
@markey.senate.gov and I wrote to multiple federal agencies to demand answers on what they're doing to protect workers & combat stay-or-pay agreements.
@markey.senate.gov and I wrote to multiple federal agencies to demand answers on what they're doing to protect workers & combat stay-or-pay agreements.
November 20, 2025 at 4:12 PM
Workers deserve protection from coercive employment practices that trap them in jobs & force them into debt so corporations can line their pockets.
@markey.senate.gov and I wrote to multiple federal agencies to demand answers on what they're doing to protect workers & combat stay-or-pay agreements.
@markey.senate.gov and I wrote to multiple federal agencies to demand answers on what they're doing to protect workers & combat stay-or-pay agreements.
Reposted by DrPrincessTheSpaceCat
"Somehow, it all feels connected: the denigration of professionals doing their job, the fetishization of young women, the older men’s blindness to their own abuse of power. I’ve felt ... like we’re revisiting the same characters over and over, with no consequences and no forward momentum."
"He has proved himself time and again to be entirely self-seeking, totally amoral, cruel by nature, and impossibly fragile. And the rewards he’s gained in the process have emboldened others to be just as unabashedly themselves as he is." www.theatlantic.com/culture/2025...
The Pig Is in the White House
This is what consequence-free misogyny looks like.
www.theatlantic.com
November 20, 2025 at 4:16 PM
"Somehow, it all feels connected: the denigration of professionals doing their job, the fetishization of young women, the older men’s blindness to their own abuse of power. I’ve felt ... like we’re revisiting the same characters over and over, with no consequences and no forward momentum."
Reposted by DrPrincessTheSpaceCat
I really can't stress how important it is for progressive and leftists to contend for school, library, water, etc etc boards. Hyper local involvement in our communities where we can actually influence lives.
Following the recent election, leadership will be changing in many districts where conservative values previously dominated school board meetings and community actions.
epgn.com/2025/11/18/v...
epgn.com/2025/11/18/v...
Voters shift school boards toward LGBTQ+ inclusion across PA and N.J. - Philadelphia Gay News
School boards in PA and NJ are shifting fast—LGBTQ+ leaders are winning, conservatives are losing, and policy battles are heating up.
epgn.com
November 20, 2025 at 2:41 AM
I really can't stress how important it is for progressive and leftists to contend for school, library, water, etc etc boards. Hyper local involvement in our communities where we can actually influence lives.
Reposted by DrPrincessTheSpaceCat
Yes, which is exactly the goal - to make US a terrible place to do science.
The administration is building a legal pathway for ad hoc grant terminations:
"if the agency determines that the award no longer effectuates the program goals or agency priorities"
Converting multiyear grants to 'at whim' coin flips will undermine the stability & leadership of American science.
"if the agency determines that the award no longer effectuates the program goals or agency priorities"
Converting multiyear grants to 'at whim' coin flips will undermine the stability & leadership of American science.
Update on a significant development NIH grant terms.
On 10/1, a change to grant making regs went into effect that gives NIH more power to terminate grants for policy reasons.
But to use this power, new grant terms must include specific language. See @aniloza.bsky.social w/ the story from July.
1/
On 10/1, a change to grant making regs went into effect that gives NIH more power to terminate grants for policy reasons.
But to use this power, new grant terms must include specific language. See @aniloza.bsky.social w/ the story from July.
1/
November 20, 2025 at 4:12 PM
Yes, which is exactly the goal - to make US a terrible place to do science.
Reposted by DrPrincessTheSpaceCat
the gulf between the swift brutality with which places like harvard treated students protesting genocide and the endless, endless latitude those same institutions have given people like larry summers tells you everything you need to know
November 20, 2025 at 1:36 AM
the gulf between the swift brutality with which places like harvard treated students protesting genocide and the endless, endless latitude those same institutions have given people like larry summers tells you everything you need to know
Reposted by DrPrincessTheSpaceCat
it's almost as if being politically engaged as a scientist was always a necessity
The administration is building a legal pathway for ad hoc grant terminations:
"if the agency determines that the award no longer effectuates the program goals or agency priorities"
Converting multiyear grants to 'at whim' coin flips will undermine the stability & leadership of American science.
"if the agency determines that the award no longer effectuates the program goals or agency priorities"
Converting multiyear grants to 'at whim' coin flips will undermine the stability & leadership of American science.
Update on a significant development NIH grant terms.
On 10/1, a change to grant making regs went into effect that gives NIH more power to terminate grants for policy reasons.
But to use this power, new grant terms must include specific language. See @aniloza.bsky.social w/ the story from July.
1/
On 10/1, a change to grant making regs went into effect that gives NIH more power to terminate grants for policy reasons.
But to use this power, new grant terms must include specific language. See @aniloza.bsky.social w/ the story from July.
1/
November 20, 2025 at 4:21 PM
it's almost as if being politically engaged as a scientist was always a necessity
Reposted by DrPrincessTheSpaceCat
Hey folks, I often do posts calling for indie developers to link me their games so I can signal boost them. Today I want to do something similar for all trans creatives.
If you are a trans game dev, artist, writer, streamer or YouTuber, reply here with a link to your work. Only one rule: no GenAI.💜
If you are a trans game dev, artist, writer, streamer or YouTuber, reply here with a link to your work. Only one rule: no GenAI.💜
November 20, 2025 at 12:28 PM
Hey folks, I often do posts calling for indie developers to link me their games so I can signal boost them. Today I want to do something similar for all trans creatives.
If you are a trans game dev, artist, writer, streamer or YouTuber, reply here with a link to your work. Only one rule: no GenAI.💜
If you are a trans game dev, artist, writer, streamer or YouTuber, reply here with a link to your work. Only one rule: no GenAI.💜
Reposted by DrPrincessTheSpaceCat
Molecular Evolution under Macro-Perturbation Barrier and the Fixation Process of Polyploidization https://www.biorxiv.org/content/10.1101/2025.11.19.689354v1
November 20, 2025 at 4:32 PM
Molecular Evolution under Macro-Perturbation Barrier and the Fixation Process of Polyploidization https://www.biorxiv.org/content/10.1101/2025.11.19.689354v1
Reposted by DrPrincessTheSpaceCat
happy transgender day of remembrance
thank you for sticking around in the hardest of times. if you haven't, you are missed dearly
please live 💜
thank you for sticking around in the hardest of times. if you haven't, you are missed dearly
please live 💜
November 20, 2025 at 10:57 AM
happy transgender day of remembrance
thank you for sticking around in the hardest of times. if you haven't, you are missed dearly
please live 💜
thank you for sticking around in the hardest of times. if you haven't, you are missed dearly
please live 💜
Reposted by DrPrincessTheSpaceCat
This is bad. How can any university hire people, build facilities, make any plans, if the funding can be arbitrarily removed on a whim from an agency? This goes far beyond currently disfavored topics.
Update on a significant development NIH grant terms.
On 10/1, a change to grant making regs went into effect that gives NIH more power to terminate grants for policy reasons.
But to use this power, new grant terms must include specific language. See @aniloza.bsky.social w/ the story from July.
1/
On 10/1, a change to grant making regs went into effect that gives NIH more power to terminate grants for policy reasons.
But to use this power, new grant terms must include specific language. See @aniloza.bsky.social w/ the story from July.
1/
HHS devises legal playbook for future grant terminations, internal memo shows
Exclusive: HHS devises a legal playbook for future research grant terminations, an internal memo shows.
www.statnews.com
November 20, 2025 at 4:40 PM
This is bad. How can any university hire people, build facilities, make any plans, if the funding can be arbitrarily removed on a whim from an agency? This goes far beyond currently disfavored topics.
Reposted by DrPrincessTheSpaceCat
Dual RNA Polymerase I Inhibition with CX-5461 and BMH-21 Synergizes in Breast Cancer by Activating p53-Dependent Stress https://www.biorxiv.org/content/10.1101/2025.11.19.689351v1
November 20, 2025 at 4:48 PM
Dual RNA Polymerase I Inhibition with CX-5461 and BMH-21 Synergizes in Breast Cancer by Activating p53-Dependent Stress https://www.biorxiv.org/content/10.1101/2025.11.19.689351v1
Reposted by DrPrincessTheSpaceCat
Tonight! Join Us!
November 20, 2025 at 4:53 PM
Tonight! Join Us!
Reposted by DrPrincessTheSpaceCat
In some moments, I am tied to the idea that transition is about making me love myself more. But as I've progressed, I've realized the true point of it is to allow you to relax enough to love others more effectively.
November 20, 2025 at 1:54 PM
In some moments, I am tied to the idea that transition is about making me love myself more. But as I've progressed, I've realized the true point of it is to allow you to relax enough to love others more effectively.