This study demonstrates that inducible, adipocyte-specific overexpression of FGF21 in adult male mice improves metabolic health and extends lifespan during high-fat diet feeding. These benefits occur independently of growth suppression and are associated with reduced visceral adipose inflammation and ceramide levels, offering mechanistic insights into FGF21’s pro-longevity effects under metabolic stress.

Conditional cysteine restriction in mice causes substantial weight loss, exceeding that seen with essential amino acid restriction, by activating the integrated stress and oxidative stress respon...

Universität des Saarlandes bietet Stelle als W2 Professorship (with tenure track to W3) in the Dynamics of Biological Systems (m/f/x) in Saarbrücken - jetzt bewerben!

FGF21, a mainly liver-derived hormone, has multiple beneficial metabolic effects. Sobuj Mia et al. reveal a pathologic FGF21-based hepato-cardiac crosstalk mechanism that is induced with pressure over...

Aims/hypothesis The endoplasmic reticulum (ER) stress-induced unfolded protein response helps determine beta cell survival rate in diabetes. The alternative eukaryotic translation initiation factor 2A...

Senior investigator at Mount Sinai Hospital was one of five researchers jointly awarded US$3-million in world’s largest science prize

We are looking for exceptional early-career scientists conducting computational research with a proven record of accomplishment. The primary focus of this call is on candidates proposing research on b...

By stimulating hepatic glucose production, glucagon (released by islet α-cells) restores normal blood glucose levels when they fall below the normal range.

Aims/hypothesis Diabetes is associated with the dysfunction of glucagon-producing pancreatic islet alpha cells, although the underlying mechanisms regulating glucagon secretion and alpha cell dysfunct...

Nature - Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.

Trump's massive attack on science is driving US researchers away. German research institutions could benefit, but they’re also concerned about Trump’s impact on global science.

Rabah et al. discover an astrocyte-to-neuron hydrogen peroxide signalling cascade, which is crucial for long-term memory formation in Drosophila. This signalling is found to be inhibited by amyloid-β ...

Halofuginone curbs weight gain in mice and pigs.