Ed Phelps
@eaphelps.bsky.social
Associate Professor of Biomedical Engineering at the University of Florida. I study Beta Cell Biology, Biomaterials Engineering, and the Immunology of Type 1 Diabetes. https://www.bme.ufl.edu/labs/phelps/
Reposted by Ed Phelps
Insights on downstream immunity from blood methylome signatures in children exposed to maternal type 1 diabetes #T1D #Genetics #Epigenetics www.nature.com/articles/s42...
Blood methylome signatures in children exposed to maternal type 1 diabetes are linked to protection against islet autoimmunity - Nature Metabolism
Through an epigenome-wide blood analysis in children of mothers with or without type 1 diabetes, the authors identify epigenetic modifications of type 1 diabetes susceptibility loci through which mate...
www.nature.com
November 6, 2025 at 12:06 PM
Insights on downstream immunity from blood methylome signatures in children exposed to maternal type 1 diabetes #T1D #Genetics #Epigenetics www.nature.com/articles/s42...
Pleased to share our latest paper characterizing a beta cell specific GABA knockout by first-author and fantastic postdoc Sandra Ferreira
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Beta cell secreted GABA sets appropriate insulin secretion by modulating islet calcium oscillations
Gamma-aminobutyric acid (GABA) is produced in pancreatic beta cells and is implicated in modulating islet function, yet its precise physiological role…
www.sciencedirect.com
October 29, 2025 at 6:37 PM
Pleased to share our latest paper characterizing a beta cell specific GABA knockout by first-author and fantastic postdoc Sandra Ferreira
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Ed Phelps
New tool to study beta-cell biology on tissue slices www.biorxiv.org/content/10.1... #PancSky
Efficient transduction of pancreas tissue slices with genetically encoded calcium integrators
This study combines live pancreas tissue slices with adenoviral transduction of the Calcium Modulated Photoactivatable Ratiometric Integrator 2 (CaMPARI2) biosensor for high-throughput analysis of isl...
www.biorxiv.org
September 13, 2025 at 10:47 AM
New tool to study beta-cell biology on tissue slices www.biorxiv.org/content/10.1... #PancSky
Pleased to share our latest article by first author @molliehuber.bsky.social focusing on beta cell function in living pancreas tissue slices from organ donors with T1D, a co-equal collaboration with Clayton Mathews. Includes live videos of insulitis in human T1D. #nPOD
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis
Huber et al. used live pancreas slices from donors with recently diagnosed type 1
diabetes to reveal beta cell dysfunction independent of local immune cells. Real-time
imaging and molecular analyses u...
www.cell.com
August 29, 2025 at 5:57 PM
Pleased to share our latest article by first author @molliehuber.bsky.social focusing on beta cell function in living pancreas tissue slices from organ donors with T1D, a co-equal collaboration with Clayton Mathews. Includes live videos of insulitis in human T1D. #nPOD
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Ed Phelps
I am excited to announce our paper “Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis” is out in Cell Reports! @eaphelps.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis
Huber et al. used live pancreas slices from donors with recently diagnosed type 1
diabetes to reveal beta cell dysfunction independent of local immune cells. Real-time
imaging and molecular analyses u...
www.cell.com
August 28, 2025 at 2:24 PM
I am excited to announce our paper “Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis” is out in Cell Reports! @eaphelps.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Ed Phelps
Important first-in-human report today for donor pancreatic islet beta-cell transplant to an individual w/Type 1 diabetes. With genome editing, there was no immune response induced or need for immunosuppression. Major implications for transplantation in general @nejm.org
www.nejm.org/doi/pdf/10.1...
www.nejm.org/doi/pdf/10.1...
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM
The need to suppress a patient’s immune system after the transplantation of allogeneic
cells is associated with wide-ranging side effects. We report the outcomes of transplantation
of genetically m...
www.nejm.org
August 4, 2025 at 11:38 PM
Important first-in-human report today for donor pancreatic islet beta-cell transplant to an individual w/Type 1 diabetes. With genome editing, there was no immune response induced or need for immunosuppression. Major implications for transplantation in general @nejm.org
www.nejm.org/doi/pdf/10.1...
www.nejm.org/doi/pdf/10.1...
Reposted by Ed Phelps
Reposted by Ed Phelps
Human islet proteome changes in stage 1 type 1 diabetes reveals increased inflammation and decreased endoplasmic reticulum stress.
link.springer.com/article/10.1... 🔓
link.springer.com/article/10.1... 🔓
Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donor...
Aims/hypothesis Progression to type 1 diabetes is associated with genetic factors, the presence of autoantibodies and a decline in beta cell insulin secretion in response to glucose. Very little is kn...
link.springer.com
June 10, 2025 at 2:35 PM
Human islet proteome changes in stage 1 type 1 diabetes reveals increased inflammation and decreased endoplasmic reticulum stress.
link.springer.com/article/10.1... 🔓
link.springer.com/article/10.1... 🔓
I had a nightmare last night that I arrived at in-person NIH study section without having read a single assigned grant. And I was rev. 1 on the first grant up for discussion.
May 23, 2025 at 1:15 PM
I had a nightmare last night that I arrived at in-person NIH study section without having read a single assigned grant. And I was rev. 1 on the first grant up for discussion.
Reposted by Ed Phelps
When a Decision on Manuscript email arrives a minute before you go out to celebrate your birthday
May 20, 2025 at 4:37 PM
When a Decision on Manuscript email arrives a minute before you go out to celebrate your birthday
Reposted by Ed Phelps
How academics imagine their lives would look like if they decide to work in tech
April 11, 2025 at 7:15 PM
How academics imagine their lives would look like if they decide to work in tech
Reposted by Ed Phelps
I'm the 1st scientist in my family. My parents were amazed I could attend @caltech.edu, an elite private school, for my PhD studies FOR FREE. In fact, I was paid to become a PhD chemist. STEM is a pathway to a good career. I study TB- a disease that impacts millions. Fund NIH.
May 13, 2025 at 6:24 PM
I'm the 1st scientist in my family. My parents were amazed I could attend @caltech.edu, an elite private school, for my PhD studies FOR FREE. In fact, I was paid to become a PhD chemist. STEM is a pathway to a good career. I study TB- a disease that impacts millions. Fund NIH.
Reposted by Ed Phelps
Check out this pre-print from Vira Kravets, Andraz Stozer and myself, for the influence of alpha cells on heterogenous islet Ca2+ responses, including first-responders and first phase timing/amplitude. Was great to be part of this!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Role of GLP1-receptor-mediated α-β-cell communication in functional β-cell heterogeneity.
While the islet β-cells were traditionally viewed as a singular functional entity, findings of 1970s and up until recent years, reveal that individual β-cells differ in their calcium dynamics and insu...
www.biorxiv.org
April 29, 2025 at 8:59 PM
Check out this pre-print from Vira Kravets, Andraz Stozer and myself, for the influence of alpha cells on heterogenous islet Ca2+ responses, including first-responders and first phase timing/amplitude. Was great to be part of this!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Tracking Ca2+ responses in pancreas just got better! Our latest preprint by Charles Lazimi and Austin Stis showcases CaMPARI 🍸 as a fixable functional marker in living pancreas slices. @cherie-stabler.bsky.social @linnemannlab.bsky.social
www.biorxiv.org/content/10.1...
#CalciumImaging #Diabetes
www.biorxiv.org/content/10.1...
#CalciumImaging #Diabetes
March 26, 2025 at 11:54 PM
Tracking Ca2+ responses in pancreas just got better! Our latest preprint by Charles Lazimi and Austin Stis showcases CaMPARI 🍸 as a fixable functional marker in living pancreas slices. @cherie-stabler.bsky.social @linnemannlab.bsky.social
www.biorxiv.org/content/10.1...
#CalciumImaging #Diabetes
www.biorxiv.org/content/10.1...
#CalciumImaging #Diabetes
Reposted by Ed Phelps
Sitting in a journal club-style class right now and after the main presenters present, there are "roles" from others in the group, like the "archeologist" who looks into the citation trail, the "private investigator" who tries to dig into the history, and the "industry practitioner", etc. Cool idea!
March 18, 2025 at 3:15 PM
Sitting in a journal club-style class right now and after the main presenters present, there are "roles" from others in the group, like the "archeologist" who looks into the citation trail, the "private investigator" who tries to dig into the history, and the "industry practitioner", etc. Cool idea!
Reposted by Ed Phelps
We're looking for postdoctoral scholars to join our team in Vancouver 🇨🇦. We work on cell-based approaches aimed at curing type 1 diabetes. Bring your own ideas for projects or work on one that's already funded! More details here: www.nature.com/naturecareer...
Postdoctoral Research Fellow - Vancouver, British Columbia (CA) job with University of British Columbia Department of Surgery | 12837375
The successful candidate will work on a project developing cell-based therapies for those living with type 1 diabetes (T1D).
www.nature.com
March 10, 2025 at 11:48 PM
We're looking for postdoctoral scholars to join our team in Vancouver 🇨🇦. We work on cell-based approaches aimed at curing type 1 diabetes. Bring your own ideas for projects or work on one that's already funded! More details here: www.nature.com/naturecareer...
New aquarium denizens
March 9, 2025 at 2:48 AM
New aquarium denizens
Saturday March 8 is UF Biomedical Engineering STEM Outreach Day! Come and learn about the amazing world of Biomedical Engineering. See how our incredible research impacts human health. Event is free and open to the public with free parking! Free cookies and lemonade too!
bme.ufl.edu/events/uf-bi...
bme.ufl.edu/events/uf-bi...
February 26, 2025 at 7:58 PM
Saturday March 8 is UF Biomedical Engineering STEM Outreach Day! Come and learn about the amazing world of Biomedical Engineering. See how our incredible research impacts human health. Event is free and open to the public with free parking! Free cookies and lemonade too!
bme.ufl.edu/events/uf-bi...
bme.ufl.edu/events/uf-bi...
Reposted by Ed Phelps
Exiting the microscopy room
February 19, 2025 at 11:57 AM
Exiting the microscopy room
Reposted by Ed Phelps
Proud to share a new preprint from my lab that is the product of hard work from several talented lab members and collaboration with valued colleagues: www.biorxiv.org/content/10.1...
IFN-α Induces Heterogenous ROS Production in Human β-Cells
Type 1 diabetes (T1D) is a multifactorial disease involving genetic and environmental factors, including viral infection. We investigated the impact of interferon alpha (IFN-α), a cytokine produced du...
www.biorxiv.org
February 21, 2025 at 2:03 PM
Proud to share a new preprint from my lab that is the product of hard work from several talented lab members and collaboration with valued colleagues: www.biorxiv.org/content/10.1...
Reposted by Ed Phelps
We link molecular and functional phenotypes of islet cells from donors with type 1 diabetes to understand impaired insulin and glucagon secretion. Immune signalling, nuclear exclusion, mTOR and lysosomes in alpha cell dysfunction.
https://www.biorxiv.org/content/10.1101/2025.02.20.639325v1
https://www.biorxiv.org/content/10.1101/2025.02.20.639325v1
February 21, 2025 at 12:40 PM
We link molecular and functional phenotypes of islet cells from donors with type 1 diabetes to understand impaired insulin and glucagon secretion. Immune signalling, nuclear exclusion, mTOR and lysosomes in alpha cell dysfunction.
https://www.biorxiv.org/content/10.1101/2025.02.20.639325v1
https://www.biorxiv.org/content/10.1101/2025.02.20.639325v1
Reposted by Ed Phelps
Leading the pack: Glucokinase reinforces Ca2+-waves
#PancSky #BetaCellSky
elifesciences.org/articles/103...
#PancSky #BetaCellSky
elifesciences.org/articles/103...
Glucokinase activity controls peripherally located subpopulations of β-cells that lead islet Ca2+ oscillations
3D light-sheet imaging identifies the location and metabolic sensitivity of β-cell subpopulations that lead and coordinate islet Ca2+ oscillations.
elifesciences.org
February 13, 2025 at 8:29 PM
Leading the pack: Glucokinase reinforces Ca2+-waves
#PancSky #BetaCellSky
elifesciences.org/articles/103...
#PancSky #BetaCellSky
elifesciences.org/articles/103...
Reposted by Ed Phelps
I love @journeytomicro.bsky.social
but they don't seem active on here, so I'm going to post my favorite videos of theirs here to spread their chill science vibes
but they don't seem active on here, so I'm going to post my favorite videos of theirs here to spread their chill science vibes
Why Do Planarians Have Those Triangles on their Heads?
YouTube video by Journey to the Microcosmos
youtu.be
February 12, 2025 at 10:22 PM
I love @journeytomicro.bsky.social
but they don't seem active on here, so I'm going to post my favorite videos of theirs here to spread their chill science vibes
but they don't seem active on here, so I'm going to post my favorite videos of theirs here to spread their chill science vibes