PMC Protein Modules Community
LightNews LightNews
banner
pmc-modularity.bsky.social
PMC Protein Modules Community
@pmc-modularity.bsky.social
74 followers 34 following 22 posts
Global community driving the study of short linear motifs, modular protein domains, molecular pathways and signaling in cell regulation, health and disease.

www.proteinmodules.org
Posts Replies Media Videos
pmc-modularity.bsky.social
Catch our last seminar for the year on Dec 8 at 3pm CET! With Dr. Martin Rennie (@martinrennie.bsky.social), Jamal Fahoum (@hebrewuniversity.bsky.social), and Dr. Boglárka Zámbó (@zbobo2.bsky.social)

Register to attend: tinyurl.com/PMCseminar2

Previous seminars: www.youtube.com/@PMCModularity
November 14, 2025 at 8:31 AM
pmc-modularity.bsky.social
Don't forget to tune in to our next seminar on Monday Nov 10 at 3pm CET!
pmc-modularity.bsky.social PMC Protein Modules Community @pmc-modularity.bsky.social · Oct 21
Catch our next seminar on November 10 at 3pm CET! You'll see presentations from Prof. Gideon Schreiber (@weizmanninstitute.bsky.social) and Alessandro Lussana (‪‬@alussana.bsky.social).

Register to attend: tinyurl.com/PMCseminar2

Recordings of previous seminars: www.youtube.com/@PMCModularity
November 7, 2025 at 8:09 AM
pmc-modularity.bsky.social
Catch our next seminar on November 10 at 3pm CET! You'll see presentations from Prof. Gideon Schreiber (@weizmanninstitute.bsky.social) and Alessandro Lussana (‪‬@alussana.bsky.social).

Register to attend: tinyurl.com/PMCseminar2

Recordings of previous seminars: www.youtube.com/@PMCModularity
October 21, 2025 at 12:58 PM
pmc-modularity.bsky.social
Don't forget to catch out next seminar on October 13 at 3pm CEST!
October 10, 2025 at 1:57 PM
pmc-modularity.bsky.social
Tune in to our next seminar on October 13 at 3pm CEST! We’ll hear from Dr. Cris Viéitez (@crisvieitez.bsky.social) and Dr. Patrick Brunner (@humboldtuni.bsky.social).

Register to attend: tinyurl.com/PMCseminar2

Recordings of previous seminars: www.youtube.com/@PMCModularity
September 15, 2025 at 10:29 AM
pmc-modularity.bsky.social
Remember to tune in to our next Seminar on Monday September 8!
pmc-modularity.bsky.social PMC Protein Modules Community @pmc-modularity.bsky.social · Aug 15
We are back with an exciting seminar on September 8 at 3pm CEST! We’ll hear from Prof. Birthe Kragelund and Maximilian Vieler (@uu.se).

Register to attend:
tinyurl.com/PMCseminar2

Recordings of previous seminars: www.youtube.com/@PMCModularity
September 5, 2025 at 7:59 AM
pmc-modularity.bsky.social
We are back with an exciting seminar on September 8 at 3pm CEST! We’ll hear from Prof. Birthe Kragelund and Maximilian Vieler (@uu.se).

Register to attend:
tinyurl.com/PMCseminar2

Recordings of previous seminars: www.youtube.com/@PMCModularity
August 15, 2025 at 3:36 PM
pmc-modularity.bsky.social
Remember to tune in next Monday (June 16) at 3pm CET. We’ll hear from Dr. Lucía Chemes (@unsamoficial.bsky.social) and Julian van Gerwen (@julianvangerwen.bsky.social).

Register to attend:
tinyurl.com/PMCseminar2

Recordings of previous seminars: www.youtube.com/@PMCModularity
June 13, 2025 at 2:40 PM
pmc-modularity.bsky.social
TIME CHANGE - Because of a public holiday, we have moved the next seminar to Monday June 16 at 3pm CET. Tune in to hear from Dr. Lucía Chemes (@unsamoficial.bsky.social) and Julian van Gerwen (@julianvangerwen.bsky.social).

Register to attend:
tinyurl.com/PMCseminar2

(1/2)
June 6, 2025 at 3:19 PM
pmc-modularity.bsky.social
Remember to tune it at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute.bsky.social) and Dr. Jesús Alvarado-Valverde (@jesusav.bsky.social).

Register to attend:
tinyurl.com/PMCseminar2
May 9, 2025 at 2:19 PM
pmc-modularity.bsky.social
Join us at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute.bsky.social) and Dr. Jesús Alvardo Valverde (@jesusav.bsky.social).

Register to attend:
tinyurl.com/PMCseminar2
(1/2)
April 24, 2025 at 5:02 AM
pmc-modularity.bsky.social
Thanks to everyone who has attended the PMC seminars!

We have decided to review the timing of the seminar series. If you have any thoughts about the timing of the seminars (currently 6-7pm CET every 2nd Mon of the month), please fill out this form: forms.gle/VZkU2fWkswxY...

Thanks for your input!
PMC Seminar feedback
Thank you for your interest in our seminar series! Whether you've been able to attend or were interested but unable to join us, we value your feedback. Your input will help us improve future sessions ...
forms.gle
April 15, 2025 at 3:38 PM
pmc-modularity.bsky.social
Remember to join us at 6pm CET April 14 for the next seminar in our series with Prof. Anne-Claude Gingras (@uoft.bsky.social) and Dr. Veronica Venafra.

Register to attend: tinyurl.com/register-pmc-seminar

You can find recordings of previous seminars here: www.youtube.com/@PMCModularity
April 11, 2025 at 7:58 AM
Reposted by PMC Protein Modules Community
natchembio.nature.com
ARAF uniquely enhances RAS activity via its N-terminal disordered sequence, forming membrane ARAF-RAS condensates that shield RAS from negative regulation and drive cancer drug resistance

www.nature.com/articles/s41...
Plasma membrane-associated ARAF condensates fuel RAS-related cancer drug resistance - Nature Chemical Biology
ARAF uniquely enhances RAS activity via N-terminal disordered sequence, forming membrane ARAF–RAS condensates that shield RAS from negative regulation and drive cancer drug resistance.
www.nature.com
January 31, 2025 at 2:59 PM
pmc-modularity.bsky.social
Join us at 6pm CET April 14 for the next seminar in our series with Prof. Anne-Claude Gingras (@uoft.bsky.social) and Dr. Veronica Venafra.

Register to attend: tinyurl.com/register-pmc-seminar
(1/2)
March 25, 2025 at 2:53 PM
Reposted by PMC Protein Modules Community
lindorfflarsen.bsky.social
Our review on machine learning methods to study sequence–ensemble–function relationships in disordered proteins is now out in COSB

authors.elsevier.com/sd/article/S...
Led by @sobuelow.bsky.social and Giulio Tesei
Figure from the paper illustrating sequence–ensemble–function relationships for disordered proteins. ML prediction (black) and design (orange) approaches are highlighted on the connecting arrows. Prediction of properties/functions from sequence (or vice versa, design) can include biophysics approaches via structural ensembles, or bioinformatics approaches via other hetero- geneous sources. The lower panels show examples of properties and functions of IDRs for predictions or design targets. ML, machine learning; IDRs, intrinsically disordered proteins and regions.
March 12, 2025 at 9:35 PM
pmc-modularity.bsky.social
Remember to join us at 6pm CET Mar 10 for the next seminar in our series with Dr. Dezső Módos (@imperialcollegeldn.bsky.social ) and Dr. Joanna Koszela (@uofglasgow.bsky.social ).

Register to attend: tinyurl.com/register-pmc-seminar

(1/2)
March 7, 2025 at 3:04 PM
Reposted by PMC Protein Modules Community
juliarurogers.bsky.social
Enjoying #BPS2025! I'll present my development of a ML predictor of domain–peptide binding affinity to understand how affinity is optimized across the proteome for cell signaling. Finish out the meeting by coming to my talk tomorrow (Wed) @ 1pm!
February 18, 2025 at 4:04 PM
pmc-modularity.bsky.social
Remember to join us on Monday Feb 10 at 6pm CET for the first session of our online seminar series!

Register to attend: tinyurl.com/register-pmc-seminar
February 7, 2025 at 5:24 PM
Reposted by PMC Protein Modules Community
martinsteinegger.bsky.social
Foldseek-Multimer—now published in @naturemethods.bsky.social—our fast multimer search tool, enables complex comparisons against the full PDB in seconds. It comes with BFMD, a collection of 300K+ predictions gathered from community projects.
📄 nature.com/articles/s41...
🌐 search.foldseek.com
February 6, 2025 at 8:25 AM
Reposted by PMC Protein Modules Community
lindorfflarsen.bsky.social
If you are a PhD student and like protein disorder (or want to learn more), Birthe Kragelund @bbkrage.bsky.social and Kristian Strømgaard are organizing a PhD course on How IDPs work 🧶🧬🧪 Note the cost if you are not at a Danish university.

Details: phdcourses.ku.dk/DetailKursus...
Flyer for the course Keeping up with the interactome - How IDPs work including a list of speakers: Professor Tanja Mittag, St Jude Children’s Hospital, Memphis, US Professor Kresten Lindorff-Larsen, BIO, SCIENCE, UCPH Professor Ylva Ivarsson, Uppsala University, Sweden Dr. Michael Wehr, Systasy Bioscience, Munich, Germany Professor Zsuzsanna Dostztányi, Eötvös Loránd University, Hungary Professor Kristian Strømgaard, HEALTH, UCPH Professor Stefano Gianni, Sprienza University of Rome, Italy Professor Per Jemth, Uppsala University, Sweden Dr. Franziska Schöppe, Novo Nordisk A/S, Denmark Professor Benjamin Schuler, University of Zurich, Switzerland Professor Alfonse De Simone, University of Naples, Italy Dr. Malene Ringkjøbing Jensen, CNRS, Grenoble, France Alleyn Plowright, Chief Scientific Officer, Pangea Bio, London UK Professor Birthe B. Kragelund, BIO, SCIENCE, UCPH
November 25, 2024 at 4:13 PM
Reposted by PMC Protein Modules Community
ebi.embl.org
Kinases play a role in many diseases, making them prime targets for therapeutic intervention.

Enter PhosX, a new tool transforming the way researchers analyse and interpret kinase activity.

Read the full article: academic.oup.com/bioinformati...

@alussana.bsky.social @epetsalaki.bsky.social
PhosX: data-driven kinase activity inference from phosphoproteomics experiments
AbstractSummary. The inference of kinase activity from phosphoproteomics data can point to causal mechanisms driving signalling processes and potential dru
academic.oup.com
January 27, 2025 at 11:57 AM
Reposted by PMC Protein Modules Community
sfb-tpd-vienna.bsky.social
Join us in Vienna 8-9 May for the #Ubiquitin & Friends Symposium 2025! Excellent line-up of guest speakers👇And many slots for talks from abstracts, plus flash-talks & posters! Lots of opportunities to network with peers & experts in a friendly atmosphere! ➡️ www.protein-degradation.org/symposium/
January 27, 2025 at 12:07 PM
pmc-modularity.bsky.social
Join us for our new online seminar series, featuring two talks on protein modules every month! The first session kicks off at 6pm CET Feb 10 with Dr. Gergő Gógl and Dr. Ugo Dionne.

Register to attend: tinyurl.com/register-pmc-seminar
January 15, 2025 at 4:21 PM