@piotrnowak75.bsky.social
Reposted
Antimicrobial in critically Ill adult patients receiving #ECMO: challenges, evidence, and future directions
💉 PK/PD concepts & considerations
🧫 antibacterials
🍄 antifungals
🦠 antivirals
🩺 management recommendations: dose optimization, challenges/recommendations, ABT stewardship
🔓 bit.ly/45vjrbt
💉 PK/PD concepts & considerations
🧫 antibacterials
🍄 antifungals
🦠 antivirals
🩺 management recommendations: dose optimization, challenges/recommendations, ABT stewardship
🔓 bit.ly/45vjrbt
December 28, 2025 at 6:32 PM
Antimicrobial in critically Ill adult patients receiving #ECMO: challenges, evidence, and future directions
💉 PK/PD concepts & considerations
🧫 antibacterials
🍄 antifungals
🦠 antivirals
🩺 management recommendations: dose optimization, challenges/recommendations, ABT stewardship
🔓 bit.ly/45vjrbt
💉 PK/PD concepts & considerations
🧫 antibacterials
🍄 antifungals
🦠 antivirals
🩺 management recommendations: dose optimization, challenges/recommendations, ABT stewardship
🔓 bit.ly/45vjrbt
Reposted
A phase 2 open label RCT of weekly Islatravir + Lenacapravir in patients living with HIV combared B/F/TAF:
-Similar rate of viral suppression (VL<50)
-Similar effect on CD4 count
Likely one step closer to a weekly oral HIV med.
#IDSky
www.acpjournals.org/doi/10.7326/...
-Similar rate of viral suppression (VL<50)
-Similar effect on CD4 count
Likely one step closer to a weekly oral HIV med.
#IDSky
www.acpjournals.org/doi/10.7326/...
Once-Weekly Oral Islatravir Plus Lenacapavir Versus Daily Oral Bictegravir, Emtricitabine, and Tenofovir Alafenamide in Persons With HIV-1: A Phase 2 Randomized Study: Annals of Internal Medicine: Vol...
Background: Once-weekly oral islatravir plus lenacapavir (ISL+LEN) has the potential to address adherence challenges with daily HIV-1 treatment. Objective: To evaluate efficacy and safety of once-week...
www.acpjournals.org
December 22, 2025 at 11:50 PM
A phase 2 open label RCT of weekly Islatravir + Lenacapravir in patients living with HIV combared B/F/TAF:
-Similar rate of viral suppression (VL<50)
-Similar effect on CD4 count
Likely one step closer to a weekly oral HIV med.
#IDSky
www.acpjournals.org/doi/10.7326/...
-Similar rate of viral suppression (VL<50)
-Similar effect on CD4 count
Likely one step closer to a weekly oral HIV med.
#IDSky
www.acpjournals.org/doi/10.7326/...
Reposted
Anti-interferon-γ autoantibodies and indeterminate QuantiFERONⓇ-TB Gold Plus Assays
✅ Just Accepted
🔗 https://bit.ly/4a4CFYR
✅ Just Accepted
🔗 https://bit.ly/4a4CFYR
December 6, 2025 at 4:48 PM
Anti-interferon-γ autoantibodies and indeterminate QuantiFERONⓇ-TB Gold Plus Assays
✅ Just Accepted
🔗 https://bit.ly/4a4CFYR
✅ Just Accepted
🔗 https://bit.ly/4a4CFYR
Reposted
Human-to-Human Rabies Transmission via Solid Organ Transplantation from a Donor with Undiagnosed Rabies — United States, October 2024–February 2025
MMWR
A man died of donor-derived rabies after receiving a kidney transplant from a donor scratched by a skunk.
www.cdc.gov/mmwr/volumes... #TxID
MMWR
A man died of donor-derived rabies after receiving a kidney transplant from a donor scratched by a skunk.
www.cdc.gov/mmwr/volumes... #TxID
Human-to-Human Rabies Transmission via Solid Organ...
This report describes the public health response to a patient who died after transplantation with an organ from a donor with undiagnosed rabies.
www.cdc.gov
December 6, 2025 at 4:56 PM
Human-to-Human Rabies Transmission via Solid Organ Transplantation from a Donor with Undiagnosed Rabies — United States, October 2024–February 2025
MMWR
A man died of donor-derived rabies after receiving a kidney transplant from a donor scratched by a skunk.
www.cdc.gov/mmwr/volumes... #TxID
MMWR
A man died of donor-derived rabies after receiving a kidney transplant from a donor scratched by a skunk.
www.cdc.gov/mmwr/volumes... #TxID
Reposted
This is gold. Thank you!!
November 5, 2025 at 4:35 PM
This is gold. Thank you!!
Reposted
Long-Acting Cabotegravir/Rilpivirine for Treatment of HIV During Pregnancy: A Case Series
✅ Just Accepted
#IDSky
🔗 https://bit.ly/4hxXPjI
✅ Just Accepted
#IDSky
🔗 https://bit.ly/4hxXPjI
November 2, 2025 at 4:21 PM
Long-Acting Cabotegravir/Rilpivirine for Treatment of HIV During Pregnancy: A Case Series
✅ Just Accepted
#IDSky
🔗 https://bit.ly/4hxXPjI
✅ Just Accepted
#IDSky
🔗 https://bit.ly/4hxXPjI
Reposted
Sustained HIV suppression with co-formulated tenofovir disoproxil fumarate/lamivudine/dolutegravir in a person with transmitted dolutegravir resistance and pre-treatment resistance to lamivudine: a case report from HPTN 083
✅ Just Accepted
#IDSky
🔗 https://bit.ly/4oxIGRA
✅ Just Accepted
#IDSky
🔗 https://bit.ly/4oxIGRA
October 27, 2025 at 9:35 PM
Sustained HIV suppression with co-formulated tenofovir disoproxil fumarate/lamivudine/dolutegravir in a person with transmitted dolutegravir resistance and pre-treatment resistance to lamivudine: a case report from HPTN 083
✅ Just Accepted
#IDSky
🔗 https://bit.ly/4oxIGRA
✅ Just Accepted
#IDSky
🔗 https://bit.ly/4oxIGRA
Reposted
Female sex is protective against MASLD with clinically significant fibrosis in a large cross-sectional cohort of persons with HIV
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Female sex is protective against MASLD with clinically significant fibrosis in a large cross-sectional cohort of persons with HIV
Men are at higher risk for metabolic dysfunction-associated steatotic liver disease (MASLD) with clinically significant fibrosis (CSF) than pre-menopausal women, but data are lacking in persons with HIV (PWH).
bit.ly
October 26, 2025 at 12:21 AM
Female sex is protective against MASLD with clinically significant fibrosis in a large cross-sectional cohort of persons with HIV
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Reposted
Join Dr. John Williamson as he shares prelim results of a Phase 2 trial of an allosteric integrase inhibitor, pirmitegravir (STP0404). Patients with HIV infection received 1 of 2 doses, either 200mg or 400mg daily, which was well tolerated & demonstrated a meaningful virologic effect. #IDWeek2025
October 20, 2025 at 3:29 PM
Join Dr. John Williamson as he shares prelim results of a Phase 2 trial of an allosteric integrase inhibitor, pirmitegravir (STP0404). Patients with HIV infection received 1 of 2 doses, either 200mg or 400mg daily, which was well tolerated & demonstrated a meaningful virologic effect. #IDWeek2025
Reposted
October 19, 2025 at 6:16 PM
Reposted
#idweek2025 #idsky Dr Caskey what’s hot in hiv basic science
October 19, 2025 at 5:38 PM
#idweek2025 #idsky Dr Caskey what’s hot in hiv basic science
Reposted
New #IDSAGuidelines! IDSA has released updated evidence-based recommendations on the use of nirmatrelvir/ritonavir, remdesivir, and molnupiravir in adults with mild to moderate COVID-19: https://bit.ly/3W5IdtT
October 16, 2025 at 5:39 PM
New #IDSAGuidelines! IDSA has released updated evidence-based recommendations on the use of nirmatrelvir/ritonavir, remdesivir, and molnupiravir in adults with mild to moderate COVID-19: https://bit.ly/3W5IdtT
Reposted
Two or three? Clinical and proteomic perspectives on dolutegravir/lamivudine versus bictegravir/emtricitabine/tenofovir alafenamide as initial HIV treatment.
✅ Just Accepted
#IDSky
🔗 https://bit.ly/3KJ6vY7
✅ Just Accepted
#IDSky
🔗 https://bit.ly/3KJ6vY7
October 16, 2025 at 8:46 PM
Two or three? Clinical and proteomic perspectives on dolutegravir/lamivudine versus bictegravir/emtricitabine/tenofovir alafenamide as initial HIV treatment.
✅ Just Accepted
#IDSky
🔗 https://bit.ly/3KJ6vY7
✅ Just Accepted
#IDSky
🔗 https://bit.ly/3KJ6vY7
Reposted
Sometimes, the sodium content of antibiotics matters. Just last week, there was a CHF patient with pneumonia who wasn’t improving - It turns out that the culprit wasn’t infection severity; it was likely the sodium load from Zosyn (piperacillin–tazobactam). Check out our "fry scale."
October 13, 2025 at 2:08 PM
Sometimes, the sodium content of antibiotics matters. Just last week, there was a CHF patient with pneumonia who wasn’t improving - It turns out that the culprit wasn’t infection severity; it was likely the sodium load from Zosyn (piperacillin–tazobactam). Check out our "fry scale."
Reposted
Antiretroviral therapy intensification with dolutegravir and/or maraviroc did not affect HIV-1 cell-associated DNA, RNA, and 2-LTR circles over twelve weeks
✅ Just Accepted
#IDSky
🔗 https://bit.ly/46JYkDp
✅ Just Accepted
#IDSky
🔗 https://bit.ly/46JYkDp
October 14, 2025 at 5:26 PM
Antiretroviral therapy intensification with dolutegravir and/or maraviroc did not affect HIV-1 cell-associated DNA, RNA, and 2-LTR circles over twelve weeks
✅ Just Accepted
#IDSky
🔗 https://bit.ly/46JYkDp
✅ Just Accepted
#IDSky
🔗 https://bit.ly/46JYkDp
Reposted
Incidence and clinical outcomes of multiple viral infections after allogeneic haematopoietic cell transplantation
✅ Just Accepted
#IDSky
🔗 https://bit.ly/3VM3V60
✅ Just Accepted
#IDSky
🔗 https://bit.ly/3VM3V60
October 9, 2025 at 9:14 PM
Incidence and clinical outcomes of multiple viral infections after allogeneic haematopoietic cell transplantation
✅ Just Accepted
#IDSky
🔗 https://bit.ly/3VM3V60
✅ Just Accepted
#IDSky
🔗 https://bit.ly/3VM3V60
Reposted
How exercise promotes the immune system vs cancer, working through a gut bacteria metabolite
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
October 2, 2025 at 6:56 PM
How exercise promotes the immune system vs cancer, working through a gut bacteria metabolite
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Reposted
Intact and Defective HIV Provirus Changes During Antiretroviral Therapy in People Treated during Acute or Chronic HIV Infection or as HIV Controllers
✅ Just Accepted
🔗 https://bit.ly/42F6EBV
✅ Just Accepted
🔗 https://bit.ly/42F6EBV
September 28, 2025 at 1:38 AM
Intact and Defective HIV Provirus Changes During Antiretroviral Therapy in People Treated during Acute or Chronic HIV Infection or as HIV Controllers
✅ Just Accepted
🔗 https://bit.ly/42F6EBV
✅ Just Accepted
🔗 https://bit.ly/42F6EBV
Reposted
Key findings from the U.S. Public Health Service's 2025 Guidelines for the Management of Occupational Exposure to HIV and Recommendations for PEP
The full guideline is available here: doi.org/10.1017/ice....
The full guideline is available here: doi.org/10.1017/ice....
September 15, 2025 at 8:59 PM
Key findings from the U.S. Public Health Service's 2025 Guidelines for the Management of Occupational Exposure to HIV and Recommendations for PEP
The full guideline is available here: doi.org/10.1017/ice....
The full guideline is available here: doi.org/10.1017/ice....
Reposted
Reposted
My smart and funny pal @drlaurajwaters.bsky.social posted this on LinkedIn -- thought I'd share it here since it is filled with wisdom! #IDSky #HIVSky
August 17, 2025 at 3:26 PM
My smart and funny pal @drlaurajwaters.bsky.social posted this on LinkedIn -- thought I'd share it here since it is filled with wisdom! #IDSky #HIVSky
Reposted
August 15, 2025 at 5:46 PM
Reposted
Happy DOTS Day, to those who celebrate. jamanetwork.com/journals/jam...
Dalbavancin for Treatment of Staphylococcus aureus Bacteremia
This clinical trial compares the efficacy and safety of dalbavancin vs standard therapy for completion of treatment of complicated Staphylococcus aureus bacteremia in hospitalized patients.
jamanetwork.com
August 13, 2025 at 8:00 PM
Happy DOTS Day, to those who celebrate. jamanetwork.com/journals/jam...
Reposted
“We’re asking the wrong question. Let’s use fundamental PK. Let’s get the drug to where the bug is, at a high enough concentration to kill the bug, and not worry about whether we label the drug static or cidal”.
As said by @bradspellberg.bsky.social 🤩😇
Fabulous conversation!
#IDSky #MedSky #AMSSky
As said by @bradspellberg.bsky.social 🤩😇
Fabulous conversation!
#IDSky #MedSky #AMSSky
Bactericidal vs Bacteriostatic Antibiotics. This controversial topic has important conceptual ramifications to treat severe infections. youtu.be/3z4BItBrzbk
Bactericidal vs Bacteriostatic Antibiotics - Editors in Conversation Podcast, Live from ASM Microbe
YouTube video by American Society for Microbiology
youtu.be
July 10, 2025 at 4:26 PM
“We’re asking the wrong question. Let’s use fundamental PK. Let’s get the drug to where the bug is, at a high enough concentration to kill the bug, and not worry about whether we label the drug static or cidal”.
As said by @bradspellberg.bsky.social 🤩😇
Fabulous conversation!
#IDSky #MedSky #AMSSky
As said by @bradspellberg.bsky.social 🤩😇
Fabulous conversation!
#IDSky #MedSky #AMSSky