Pilar Cacheiro
@pilarcacheiro.bsky.social
Computational biologist. Genetics of Rare Diseases, Essential Genes, Statistics, R.
Honesty matters.
Honesty matters.
Reposted by Pilar Cacheiro
Whether we like it or not, AI is here and not going anywhere. The excellent colleagues behind @callingbullshit.bsky.social (@jevinwest.bsky.social & @carlbergstrom.com) now have a great resource to help us understand AI and how to deal with it. Highly recommended!
thebullshitmachines.com/index.html
thebullshitmachines.com/index.html
September 6, 2025 at 7:54 PM
Whether we like it or not, AI is here and not going anywhere. The excellent colleagues behind @callingbullshit.bsky.social (@jevinwest.bsky.social & @carlbergstrom.com) now have a great resource to help us understand AI and how to deal with it. Highly recommended!
thebullshitmachines.com/index.html
thebullshitmachines.com/index.html
Reposted by Pilar Cacheiro
A common type of ant in Europe breaks a fundamental rule in biology: its queens can produce male offspring that are a whole different species
go.nature.com/4mOb5T9
go.nature.com/4mOb5T9
‘Almost unimaginable’: these ants are different species but share a mother
Ant queens of one species clone ants of another to create hybrid workers that do their bidding.
go.nature.com
September 3, 2025 at 3:34 PM
A common type of ant in Europe breaks a fundamental rule in biology: its queens can produce male offspring that are a whole different species
go.nature.com/4mOb5T9
go.nature.com/4mOb5T9
Reposted by Pilar Cacheiro
Look at this crazy thing!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
One mother for two species via obligate cross-species cloning in ants - Nature
In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same moth...
www.nature.com
September 3, 2025 at 7:05 PM
Look at this crazy thing!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
One of those days when you feel very lucky to have the job you do. Everyone is working hard, your colleagues go the extra mike to support you, and things work out, even if at the last minute.
August 19, 2025 at 6:16 PM
One of those days when you feel very lucky to have the job you do. Everyone is working hard, your colleagues go the extra mike to support you, and things work out, even if at the last minute.
I guess art is there for us to agree or disagree with.
August 15, 2025 at 10:27 PM
I guess art is there for us to agree or disagree with.
My one and only reply from now on to anyone making fun of Spaniards for their siesta habits.
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
N2 sleep promotes the occurrence of ‘aha’ moments in a perceptual insight task
Sleep supports memory consolidation, but can it also facilitate memory reorganization? This study reveals that N2 sleep, but not N1 sleep during a nap, increases the likelihood of having an 'aha' mome...
journals.plos.org
August 7, 2025 at 5:37 PM
My one and only reply from now on to anyone making fun of Spaniards for their siesta habits.
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Reposted by Pilar Cacheiro
This sounds true to me
!["When you vibe code, you are incurring tech debt as fast as the LLM can spit it out.
Which is why vibe coding is perfect for prototypes and throwaway projects: It'
s only
legacy code if you have to maintain it! !...]
The worst possible situation is to have a non-programmer vibe code a large project that they intend to maintain. This would be the equivalent of giving a credit card to a child without first explaining the concept of debt. [...]"](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:gxxr4j7mf2sc3ebakcghqm6p/bafkreiehhrnrupyuwkvewpvj22ozapeqpwtyvs43plc4yseyvda4vt4qem@jpeg)
August 5, 2025 at 10:34 AM
This sounds true to me
Reposted by Pilar Cacheiro
The mathematician John Venn was born on this day in 1834. To commemorate the occasion, here’s a poem in the form of a Venn diagram.
August 4, 2025 at 9:27 AM
The mathematician John Venn was born on this day in 1834. To commemorate the occasion, here’s a poem in the form of a Venn diagram.
If I ever get rich I won't tell anyone, but there will be signs.
August 2, 2025 at 1:32 PM
If I ever get rich I won't tell anyone, but there will be signs.
So long, and thanks for all the fish.
July 29, 2025 at 7:19 PM
So long, and thanks for all the fish.
Not entirely sure what the lunch menu is, but it sure made fishing look easy.
July 27, 2025 at 1:08 PM
Not entirely sure what the lunch menu is, but it sure made fishing look easy.
If you were a gannet, where would you want to live?
July 25, 2025 at 7:10 PM
If you were a gannet, where would you want to live?
We all need a rest sometimes.
July 24, 2025 at 11:15 AM
We all need a rest sometimes.
Reposted by Pilar Cacheiro
Telomere-to-telomere DNA sequencing is set to transform the field of human genetics in coming years. For a flavour of what's coming, see this exciting work on nearly complete genomes of 65 individuals from diverse populations, out today in @nature.com by @glennislogsdon.bsky.social & colleagues. 👇🧬🧪
Complex genetic variation in nearly complete human genomes - Nature
Using sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed.
www.nature.com
July 23, 2025 at 4:20 PM
Telomere-to-telomere DNA sequencing is set to transform the field of human genetics in coming years. For a flavour of what's coming, see this exciting work on nearly complete genomes of 65 individuals from diverse populations, out today in @nature.com by @glennislogsdon.bsky.social & colleagues. 👇🧬🧪
Reposted by Pilar Cacheiro
📢 We're hiring 5 postdocs across multiple projects!
Spanning germline demethylation, gene regulation and genome architecture in development and disease!
Apply now!
Spanning germline demethylation, gene regulation and genome architecture in development and disease!
Apply now!
MRC Postdoctoral Research Scientists x 5 - MRC Laboratory of Medical Sciences
Applications are now open for up to five postdoctoral positions in the area of developmental epigenetics.
lms.mrc.ac.uk
July 21, 2025 at 3:37 PM
📢 We're hiring 5 postdocs across multiple projects!
Spanning germline demethylation, gene regulation and genome architecture in development and disease!
Apply now!
Spanning germline demethylation, gene regulation and genome architecture in development and disease!
Apply now!
Reposted by Pilar Cacheiro
Interested in using functional data to understand clinical variants? Been hunting for a good review of the topic? We just wrote one! rdcu.be/exaEU
Multiplexed assays of variant effect for clinical variant interpretation
Nature Reviews Genetics - Multiplexed assays of variant effect (MAVEs) are highly scalable experimental approaches used to generate functional data for genetic variants. In this Review, McEwen et...
www.nature.com
July 21, 2025 at 7:34 PM
Interested in using functional data to understand clinical variants? Been hunting for a good review of the topic? We just wrote one! rdcu.be/exaEU
Reposted by Pilar Cacheiro
Remember folks, your AI is only as good as the training data and so it looks backwards rather than forwards….
Study finds A.I. LLMs advise women to ask for lower salaries than men. When prompted w/ a user profile of same education, experience & job role, differing only by gender, ChatGPT advised the female applicant to request $280K salary; Male applicant=$400K.
thenextweb.com/news/chatgpt...
thenextweb.com/news/chatgpt...
ChatGPT advises women to ask for lower salaries, study finds
A new study has found that large language models (LLMs) like ChatGPT consistently advise women to ask for lower salaries than men.
thenextweb.com
July 21, 2025 at 6:32 AM
Remember folks, your AI is only as good as the training data and so it looks backwards rather than forwards….
Walking back home so deep in my thoughts that the corner shop guy stops me to ask: is everything ok? So this is my face after an actually very good day. I don't want to imagine how I look after a bad one.
July 17, 2025 at 6:56 PM
Walking back home so deep in my thoughts that the corner shop guy stops me to ask: is everything ok? So this is my face after an actually very good day. I don't want to imagine how I look after a bad one.
Reposted by Pilar Cacheiro
Sometimes 8:30pm in London looks like this
July 16, 2025 at 8:23 PM
Sometimes 8:30pm in London looks like this
as a clear blue sky
all my favourite people
somehow just feel right
all my favourite people
somehow just feel right
July 16, 2025 at 8:56 PM
as a clear blue sky
all my favourite people
somehow just feel right
all my favourite people
somehow just feel right
Reposted by Pilar Cacheiro
"Tan absurdo y fugaz es nuestro paso por el mundo, que solo me deja tranquila el saber que he sido auténtica, que he logrado ser lo mas parecida a mí misma que he podido”.
En recuerdo de Magdalena Carmen Frida Kahlo Calderón, nacida tal día como hoy de 1907.
#FridaKahlo
En recuerdo de Magdalena Carmen Frida Kahlo Calderón, nacida tal día como hoy de 1907.
#FridaKahlo
July 6, 2025 at 6:52 PM
"Tan absurdo y fugaz es nuestro paso por el mundo, que solo me deja tranquila el saber que he sido auténtica, que he logrado ser lo mas parecida a mí misma que he podido”.
En recuerdo de Magdalena Carmen Frida Kahlo Calderón, nacida tal día como hoy de 1907.
#FridaKahlo
En recuerdo de Magdalena Carmen Frida Kahlo Calderón, nacida tal día como hoy de 1907.
#FridaKahlo
Reposted by Pilar Cacheiro
skipping my vacation because chatgpt can simply summarize everywhere I would have visited for me
July 6, 2025 at 11:34 PM
skipping my vacation because chatgpt can simply summarize everywhere I would have visited for me
Reposted by Pilar Cacheiro
Sleep when the baby sleeps, eat when the baby eats, edit your manuscript when the baby edits their manuscript
October 2, 2024 at 1:29 PM
Sleep when the baby sleeps, eat when the baby eats, edit your manuscript when the baby edits their manuscript
Reposted by Pilar Cacheiro
The UK Govt just released its 10 year plan for the NHS and it is legitimately ambitious and exciting. Genomic population health features heavily... on the cover even! assets.publishing.service.gov.uk/media/686638...
July 4, 2025 at 2:45 AM
The UK Govt just released its 10 year plan for the NHS and it is legitimately ambitious and exciting. Genomic population health features heavily... on the cover even! assets.publishing.service.gov.uk/media/686638...
Reposted by Pilar Cacheiro
AI summaries kill search traffic. This has been an obvious consequence of Google's AI summary strategy since its inception.
Apparently the training data is so valuable that Google is willing to risk the neck of the goose that lays golden eggs.
Screenshot: thebullshitmachines.com/lesson-9-blu...
Apparently the training data is so valuable that Google is willing to risk the neck of the goose that lays golden eggs.
Screenshot: thebullshitmachines.com/lesson-9-blu...
July 5, 2025 at 7:38 AM
AI summaries kill search traffic. This has been an obvious consequence of Google's AI summary strategy since its inception.
Apparently the training data is so valuable that Google is willing to risk the neck of the goose that lays golden eggs.
Screenshot: thebullshitmachines.com/lesson-9-blu...
Apparently the training data is so valuable that Google is willing to risk the neck of the goose that lays golden eggs.
Screenshot: thebullshitmachines.com/lesson-9-blu...