Philipp Denninger
@philipp-denninger.bsky.social
Group leader @TU München. Interested in cell biology, cell polarity, fertilization and plants in general. Big fan of microscopy!
Reposted by Philipp Denninger
Autoinhibitory calcium ATPases regulate the calcium gradient required for rapid polarized growth, say Samantha Ryken, Magdalena Bezanilla and colleagues (Dartmouth College): rupress.org/jcb/article/...
#PlantBiology #Trafficking #Cytoskeleton
#PlantBiology #Trafficking #Cytoskeleton
November 11, 2025 at 4:15 PM
Autoinhibitory calcium ATPases regulate the calcium gradient required for rapid polarized growth, say Samantha Ryken, Magdalena Bezanilla and colleagues (Dartmouth College): rupress.org/jcb/article/...
#PlantBiology #Trafficking #Cytoskeleton
#PlantBiology #Trafficking #Cytoskeleton
Reposted by Philipp Denninger
Antagonism between blue and red light-signalling controls thallus flatness in Marchantia polymorpha https://www.biorxiv.org/content/10.1101/2025.11.10.687525v1
November 11, 2025 at 2:24 PM
Antagonism between blue and red light-signalling controls thallus flatness in Marchantia polymorpha https://www.biorxiv.org/content/10.1101/2025.11.10.687525v1
Reposted by Philipp Denninger
Rab5 GTPases mediate the targeting of ROP signalling to establish polarity for pollen germination
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Rab5 GTPases mediate the targeting of ROP signalling to establish polarity for pollen germination - Nature Plants
Rab5 GTPases deliver RopGEF8 from endosomes to the pollen plasma membrane, establishing polarity for germination. This crosstalk between trafficking and signalling GTPases is crucial for the reproduct...
www.nature.com
November 6, 2025 at 10:06 PM
Rab5 GTPases mediate the targeting of ROP signalling to establish polarity for pollen germination
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Philipp Denninger
Now, Maria Dolores Lopez Bueno from @philipp-denninger.bsky.social lab in Munich is telling us more about the evolution of novel RHO OF PLANTS signalling activators during the adaptation from water to land #MAdLand2025
October 1, 2025 at 12:44 PM
Now, Maria Dolores Lopez Bueno from @philipp-denninger.bsky.social lab in Munich is telling us more about the evolution of novel RHO OF PLANTS signalling activators during the adaptation from water to land #MAdLand2025
Reposted by Philipp Denninger
Reposted by Philipp Denninger
Next PLANT PEPTIDE AND RECEPTOR MEETING will be in Muenchen in 2026 organized by @julien-gronnier.bsky.social and friends. #watchthisspace
September 10, 2025 at 5:16 PM
Next PLANT PEPTIDE AND RECEPTOR MEETING will be in Muenchen in 2026 organized by @julien-gronnier.bsky.social and friends. #watchthisspace
Reposted by Philipp Denninger
A Phosphorelay Circuit Drives Extracellular Alkalinization in Plant Receptor Kinase Signaling https://www.biorxiv.org/content/10.1101/2025.08.16.670655v1
August 20, 2025 at 5:03 PM
A Phosphorelay Circuit Drives Extracellular Alkalinization in Plant Receptor Kinase Signaling https://www.biorxiv.org/content/10.1101/2025.08.16.670655v1
Reposted by Philipp Denninger
Our latest on brassinosteroid signaling: Ligand binding spectrum, specificity & selectivity of all BR receptors in Arabidopsis. By @albertocaregnato.bsky.social , @hmchen93.bsky.social and our great chemistry collaborators Mirek Kvasnica, Jana Oklestkova and Mirek Strnad.
August 9, 2025 at 9:01 PM
Our latest on brassinosteroid signaling: Ligand binding spectrum, specificity & selectivity of all BR receptors in Arabidopsis. By @albertocaregnato.bsky.social , @hmchen93.bsky.social and our great chemistry collaborators Mirek Kvasnica, Jana Oklestkova and Mirek Strnad.
Reposted by Philipp Denninger
Semi-automated high content analysis of pollen performance using tubetracker
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Semi-automated high content analysis of pollen performance using tubetracker - Plant Reproduction
Key message TubeTracker provides a method to partially automate analysis of pollen tube growth using live imaging. Abstract Pollen function is critical for successful plant reproduction and crop produ...
link.springer.com
June 16, 2025 at 9:38 PM
Semi-automated high content analysis of pollen performance using tubetracker
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Philipp Denninger
📜 MIK2-clade receptor function in perception of a Fusarium-derived elicitor is conserved among different plant families
🧑🔬 Julian Maroschek, Ralph Hückelhoven, et al.
📔 @biorxiv-plants.bsky.social
🔗 www.biorxiv.org/content/10.1...
#️⃣ #PlantScience #PlantImmunity #FusariumOxysporum #Fusarium
🧑🔬 Julian Maroschek, Ralph Hückelhoven, et al.
📔 @biorxiv-plants.bsky.social
🔗 www.biorxiv.org/content/10.1...
#️⃣ #PlantScience #PlantImmunity #FusariumOxysporum #Fusarium
MIK2 clade receptor function in perception of a Fusarium-derived elicitor is conserved among different plant families
Plants constantly monitor their environment to adapt to potential threats to their health and fitness. This involves cell-surface receptors that can detect conserved microbe-associated molecular patte...
www.biorxiv.org
May 25, 2025 at 2:03 PM
📜 MIK2-clade receptor function in perception of a Fusarium-derived elicitor is conserved among different plant families
🧑🔬 Julian Maroschek, Ralph Hückelhoven, et al.
📔 @biorxiv-plants.bsky.social
🔗 www.biorxiv.org/content/10.1...
#️⃣ #PlantScience #PlantImmunity #FusariumOxysporum #Fusarium
🧑🔬 Julian Maroschek, Ralph Hückelhoven, et al.
📔 @biorxiv-plants.bsky.social
🔗 www.biorxiv.org/content/10.1...
#️⃣ #PlantScience #PlantImmunity #FusariumOxysporum #Fusarium
Reposted by Philipp Denninger
Over the last couple of years I have been writing individual chapters of what I call
𝗔 𝗦𝗵𝗼𝗿𝘁 𝗛𝗶𝘀𝘁𝗼𝗿𝘆 𝗼𝗳 𝗣𝗹𝗮𝗻𝘁 𝗦𝗰𝗶𝗲𝗻𝗰𝗲
Each chapter covers a specific, basic, but for some reason special and interesting aspect of #PlantScience research.
Have a look here 👇🧵
𝗔 𝗦𝗵𝗼𝗿𝘁 𝗛𝗶𝘀𝘁𝗼𝗿𝘆 𝗼𝗳 𝗣𝗹𝗮𝗻𝘁 𝗦𝗰𝗶𝗲𝗻𝗰𝗲
Each chapter covers a specific, basic, but for some reason special and interesting aspect of #PlantScience research.
Have a look here 👇🧵
May 17, 2025 at 2:18 PM
Over the last couple of years I have been writing individual chapters of what I call
𝗔 𝗦𝗵𝗼𝗿𝘁 𝗛𝗶𝘀𝘁𝗼𝗿𝘆 𝗼𝗳 𝗣𝗹𝗮𝗻𝘁 𝗦𝗰𝗶𝗲𝗻𝗰𝗲
Each chapter covers a specific, basic, but for some reason special and interesting aspect of #PlantScience research.
Have a look here 👇🧵
𝗔 𝗦𝗵𝗼𝗿𝘁 𝗛𝗶𝘀𝘁𝗼𝗿𝘆 𝗼𝗳 𝗣𝗹𝗮𝗻𝘁 𝗦𝗰𝗶𝗲𝗻𝗰𝗲
Each chapter covers a specific, basic, but for some reason special and interesting aspect of #PlantScience research.
Have a look here 👇🧵
Reposted by Philipp Denninger
So nice ! 😍😍😍
Sabine Muller's group paper is out! 🍀🧪🧬🔬
Livanos et al., showed that POK2 arrives at the PPB utilizing a secondary Mt-binding site.
POK2 tethering to the plasma membrane is achieved through non-specific electrostatic interactions with phospholipids 🤩
👇
www.nature.com/articles/s41...
Sabine Muller's group paper is out! 🍀🧪🧬🔬
Livanos et al., showed that POK2 arrives at the PPB utilizing a secondary Mt-binding site.
POK2 tethering to the plasma membrane is achieved through non-specific electrostatic interactions with phospholipids 🤩
👇
www.nature.com/articles/s41...
Kinesin-12 POK2 polarization is a prerequisite for a fully functional division site and aids cell plate positioning - Nature Communications
Livanos et al. provide mechanistic insight into the recruitment and maintenance of kinesin-12 POK2, a central component of the division site in plants that is required for cell plate positioning durin...
www.nature.com
May 16, 2025 at 12:24 PM
So nice ! 😍😍😍
Sabine Muller's group paper is out! 🍀🧪🧬🔬
Livanos et al., showed that POK2 arrives at the PPB utilizing a secondary Mt-binding site.
POK2 tethering to the plasma membrane is achieved through non-specific electrostatic interactions with phospholipids 🤩
👇
www.nature.com/articles/s41...
Sabine Muller's group paper is out! 🍀🧪🧬🔬
Livanos et al., showed that POK2 arrives at the PPB utilizing a secondary Mt-binding site.
POK2 tethering to the plasma membrane is achieved through non-specific electrostatic interactions with phospholipids 🤩
👇
www.nature.com/articles/s41...
Reposted by Philipp Denninger
Catch & Release - rapid cost-effective protein purification from plants using a DIY GFP-Trap-protease approach https://www.biorxiv.org/content/10.1101/2025.05.15.654187v1
May 15, 2025 at 3:03 PM
Catch & Release - rapid cost-effective protein purification from plants using a DIY GFP-Trap-protease approach https://www.biorxiv.org/content/10.1101/2025.05.15.654187v1
Reposted by Philipp Denninger
🌱🌻Finally out! All ICIPS PIs had their say in a seminal 31 page review on the evolution of land plant sexual reproduction. With lots of fine figures to share! Thanks to @icips.bsky.social and @dfg.de for funding our work.
#PlantScienceResarch, #PlantEvoDevo
rdcu.be/elOeI
#PlantScienceResarch, #PlantEvoDevo
rdcu.be/elOeI
Sexual reproduction in land plants: an evolutionary perspective
rdcu.be
May 13, 2025 at 8:17 AM
🌱🌻Finally out! All ICIPS PIs had their say in a seminal 31 page review on the evolution of land plant sexual reproduction. With lots of fine figures to share! Thanks to @icips.bsky.social and @dfg.de for funding our work.
#PlantScienceResarch, #PlantEvoDevo
rdcu.be/elOeI
#PlantScienceResarch, #PlantEvoDevo
rdcu.be/elOeI
Reposted by Philipp Denninger
🚨Our paper is out!
If you ever wonder how four-way junctions are avoided during plant cell division, some answers here 🧬🍀🔬🧪🤓
👇
www.sciencedirect.com/science/arti...
If you ever wonder how four-way junctions are avoided during plant cell division, some answers here 🧬🍀🔬🧪🤓
👇
www.sciencedirect.com/science/arti...
Conserved mechanical hallmark guides four-way junction avoidance during plant cytokinesis
When building an organ, adjacent cells coordinate to form topologically stable junctions by integrating mechanosensitive signaling pathways. Positioni…
www.sciencedirect.com
May 8, 2025 at 5:09 PM
🚨Our paper is out!
If you ever wonder how four-way junctions are avoided during plant cell division, some answers here 🧬🍀🔬🧪🤓
👇
www.sciencedirect.com/science/arti...
If you ever wonder how four-way junctions are avoided during plant cell division, some answers here 🧬🍀🔬🧪🤓
👇
www.sciencedirect.com/science/arti...
Reposted by Philipp Denninger
Our paper is just out www.nature.com/articles/s41... from the Jacobsen, Doudna, and Banfield labs on viral delivery of a tiny CRISPR system for transgene free germline editing in plants, tinyurl.com/3k223r3x. Looking for postdocs to join the team for the next phase of this work!
Viral delivery of an RNA-guided genome editor for transgene-free germline editing in Arabidopsis - Nature Plants
Weiss et al. engineered the tobacco rattle virus to express the RNA-guided TnpB enzyme ISYmu1 and guide RNA for transgene-free germline editing in Arabidopsis thaliana.
www.nature.com
May 1, 2025 at 2:24 PM
Our paper is just out www.nature.com/articles/s41... from the Jacobsen, Doudna, and Banfield labs on viral delivery of a tiny CRISPR system for transgene free germline editing in plants, tinyurl.com/3k223r3x. Looking for postdocs to join the team for the next phase of this work!
Reposted by Philipp Denninger
PLease share to spread the word. Logo by designed by @hsuanpai.bsky.social
April 30, 2025 at 2:08 PM
PLease share to spread the word. Logo by designed by @hsuanpai.bsky.social
Specific ROPGEFs drive pollen germination in Arabidopsis
The first paper from my group @TUM is finally out in @plosbiology.org tinyurl.com/5n69jyuy
#PlantScience #Polarity #Pollen #ROPGEF #microscopy #Fertilization
Improved & with new results compared to the bioRxiv version
tinyurl.com/4hejrrp9
The first paper from my group @TUM is finally out in @plosbiology.org tinyurl.com/5n69jyuy
#PlantScience #Polarity #Pollen #ROPGEF #microscopy #Fertilization
Improved & with new results compared to the bioRxiv version
tinyurl.com/4hejrrp9
Polarized subcellular activation of Rho proteins by specific ROPGEFs drives pollen germination in Arabidopsis thaliana
RHO OF PLANTS (ROPs) signaling and their activating factors ROPGEFs are essential for initiating polar growth, but which ones activate pollen germination is unknown. These authors show polarization of...
dx.plos.org
April 22, 2025 at 11:34 AM
Specific ROPGEFs drive pollen germination in Arabidopsis
The first paper from my group @TUM is finally out in @plosbiology.org tinyurl.com/5n69jyuy
#PlantScience #Polarity #Pollen #ROPGEF #microscopy #Fertilization
Improved & with new results compared to the bioRxiv version
tinyurl.com/4hejrrp9
The first paper from my group @TUM is finally out in @plosbiology.org tinyurl.com/5n69jyuy
#PlantScience #Polarity #Pollen #ROPGEF #microscopy #Fertilization
Improved & with new results compared to the bioRxiv version
tinyurl.com/4hejrrp9
Reposted by Philipp Denninger
Finally out…
„Transport of phenoxyacetic acid herbicides by PIN-FORMED auxin transporters“ www.nature.com/articles/s41.... A collaboration between my group and @bjornppedersen.bsky.social led by the magic duo @lukas-schulz.bsky.social and @unglam.bsky.social
„Transport of phenoxyacetic acid herbicides by PIN-FORMED auxin transporters“ www.nature.com/articles/s41.... A collaboration between my group and @bjornppedersen.bsky.social led by the magic duo @lukas-schulz.bsky.social and @unglam.bsky.social
Transport of phenoxyacetic acid herbicides by PIN-FORMED auxin transporters - Nature Plants
PIN transporters are key players in distributing phenoxyacetic acid herbicides. Mutagenesis and cryo-EM structures elucidate substrate specificity and transport mechanisms, paving the way for improved...
www.nature.com
April 22, 2025 at 9:19 AM
Finally out…
„Transport of phenoxyacetic acid herbicides by PIN-FORMED auxin transporters“ www.nature.com/articles/s41.... A collaboration between my group and @bjornppedersen.bsky.social led by the magic duo @lukas-schulz.bsky.social and @unglam.bsky.social
„Transport of phenoxyacetic acid herbicides by PIN-FORMED auxin transporters“ www.nature.com/articles/s41.... A collaboration between my group and @bjornppedersen.bsky.social led by the magic duo @lukas-schulz.bsky.social and @unglam.bsky.social
Reposted by Philipp Denninger
Rho of Plant are signalling HUB and GEF behave as signal specific switches. We found that GEF14 specicaly activates ROP6 during osmotic signal. by 2 excellent young researcher L.Gorgues and M.Smokvarska One more great collaboration with
@yvonjaillais.bsky.social
www.embopress.org/doi/full/10....
@yvonjaillais.bsky.social
www.embopress.org/doi/full/10....
GEF14 acts as a specific activator of the plant osmotic signaling pathway by controlling ROP6 nanodomain formation | EMBO reports
imageimageRho Of Plant 6 (ROP6) acts as hub for several independent signaling processes and
relies on stimuli-dependent membrane nanodomain formation. This study reveals that
the GEF isoform GEF14 is ...
www.embopress.org
March 18, 2025 at 6:21 AM
Rho of Plant are signalling HUB and GEF behave as signal specific switches. We found that GEF14 specicaly activates ROP6 during osmotic signal. by 2 excellent young researcher L.Gorgues and M.Smokvarska One more great collaboration with
@yvonjaillais.bsky.social
www.embopress.org/doi/full/10....
@yvonjaillais.bsky.social
www.embopress.org/doi/full/10....
Reposted by Philipp Denninger
The minimal cell-cycle control system in Marchantia as a framework for understanding plant cell proliferation https://www.biorxiv.org/content/10.1101/2025.03.12.642684v1
March 13, 2025 at 7:02 PM
The minimal cell-cycle control system in Marchantia as a framework for understanding plant cell proliferation https://www.biorxiv.org/content/10.1101/2025.03.12.642684v1
Reposted by Philipp Denninger
Exited to announce our study on ER-Golgi Intermediate Compartment (ERGIC) in plants!! www.nature.com/articles/s41... Amazing and innovative work from @louisefougere.bsky.social and Magali Grison from @lbm-bordeaux.bsky.social, #SuperResolution, @naturecellbiology.bsky.social
ER-to-Golgi trafficking through a dynamic intermediate cis-Golgi tubular network in Arabidopsis - Nature Cell Biology
Fougère, Grison et al. show that the ER–Golgi intermediate compartment (ERGIC) in plants is a tubulo-vesicular network marked by MEMBRIN proteins that is largely Golgi-independent. The plant ERGIC mat...
www.nature.com
February 25, 2025 at 10:11 AM
Exited to announce our study on ER-Golgi Intermediate Compartment (ERGIC) in plants!! www.nature.com/articles/s41... Amazing and innovative work from @louisefougere.bsky.social and Magali Grison from @lbm-bordeaux.bsky.social, #SuperResolution, @naturecellbiology.bsky.social
Reposted by Philipp Denninger
📜 Endogenous RALF peptide function is required for powdery mildew host colonization
🧑🔬 Henriette Leicher, Martin Stegmann, et al.
📔 @biorxiv-plants.bsky.social
🔗 www.biorxiv.org/content/10.1...
#️⃣ #PlantScience #PlantImmunity
🧑🔬 Henriette Leicher, Martin Stegmann, et al.
📔 @biorxiv-plants.bsky.social
🔗 www.biorxiv.org/content/10.1...
#️⃣ #PlantScience #PlantImmunity
Endogenous RALF peptide function is required for powdery mildew host colonization
The receptor kinase FERONIA (FER) is a susceptibility factor for biotrophic powdery mildew fungal pathogens in Arabidopsis thaliana, but the underlying molecular mechanisms remain largely unknown. FER...
www.biorxiv.org
February 4, 2025 at 7:38 AM
📜 Endogenous RALF peptide function is required for powdery mildew host colonization
🧑🔬 Henriette Leicher, Martin Stegmann, et al.
📔 @biorxiv-plants.bsky.social
🔗 www.biorxiv.org/content/10.1...
#️⃣ #PlantScience #PlantImmunity
🧑🔬 Henriette Leicher, Martin Stegmann, et al.
📔 @biorxiv-plants.bsky.social
🔗 www.biorxiv.org/content/10.1...
#️⃣ #PlantScience #PlantImmunity
Reposted by Philipp Denninger
Preprint: Distinct localization patterns of actin microfilaments during early cell plate formation in plants through deep learning-based image restoration
www.biorxiv.org/content/10.1...
BY-2 cells visualized during mitosis using YFP-TUB6 (microtubules) and Lifeact-RFP (actin)
www.biorxiv.org/content/10.1...
BY-2 cells visualized during mitosis using YFP-TUB6 (microtubules) and Lifeact-RFP (actin)
February 4, 2025 at 3:17 PM
Preprint: Distinct localization patterns of actin microfilaments during early cell plate formation in plants through deep learning-based image restoration
www.biorxiv.org/content/10.1...
BY-2 cells visualized during mitosis using YFP-TUB6 (microtubules) and Lifeact-RFP (actin)
www.biorxiv.org/content/10.1...
BY-2 cells visualized during mitosis using YFP-TUB6 (microtubules) and Lifeact-RFP (actin)
Reposted by Philipp Denninger
📜 The actin cytoskeleton regulates danger-associated molecular pattern signaling and PEP1 RECEPTOR1 internalization
🧑🔬 Hongping Qian, Xinxiu Zuo, Yi Man, Yaning Cui, et al.
📔 @plantphys.bsky.social
🔗 academic.oup.com/plphys/advan...
#️⃣ #PlantScience #PlantImmunity #PlantCytoskeleton
🧑🔬 Hongping Qian, Xinxiu Zuo, Yi Man, Yaning Cui, et al.
📔 @plantphys.bsky.social
🔗 academic.oup.com/plphys/advan...
#️⃣ #PlantScience #PlantImmunity #PlantCytoskeleton
The actin cytoskeleton regulates danger-associated molecular pattern signaling and PEP1 RECEPTOR1 internalization
The actin cytoskeleton influences the dynamics and endocytosis of a receptor-like kinase that plays a general role in pathogen perception and immune respon
academic.oup.com
January 22, 2025 at 8:03 AM
📜 The actin cytoskeleton regulates danger-associated molecular pattern signaling and PEP1 RECEPTOR1 internalization
🧑🔬 Hongping Qian, Xinxiu Zuo, Yi Man, Yaning Cui, et al.
📔 @plantphys.bsky.social
🔗 academic.oup.com/plphys/advan...
#️⃣ #PlantScience #PlantImmunity #PlantCytoskeleton
🧑🔬 Hongping Qian, Xinxiu Zuo, Yi Man, Yaning Cui, et al.
📔 @plantphys.bsky.social
🔗 academic.oup.com/plphys/advan...
#️⃣ #PlantScience #PlantImmunity #PlantCytoskeleton