@pateinakis.bsky.social
Reposted
Drs. Joel Topf and Brad Rovin spoke at #KidneyWk about the latest on belimumab and lupus nephritis therapies. #nephrology #lupusnephritis #nephsky @kidneyboy.bsky.social www.docwirenews.com/post/lupus-n...
Lupus Nephritis: Belimumab and Beyond | Docwire News
Joel Topf, MD, and Brad Rovin, MD, discussed belimumab and other therapeutic advances in lupus nephritis at the American Society of Nephrology (ASN) Kidney Week 2025.
www.docwirenews.com
December 1, 2025 at 3:20 PM
Drs. Joel Topf and Brad Rovin spoke at #KidneyWk about the latest on belimumab and lupus nephritis therapies. #nephrology #lupusnephritis #nephsky @kidneyboy.bsky.social www.docwirenews.com/post/lupus-n...
Reposted
One of the more subtle cases of amyloidosis I have seen. Few spicules on silver stain. Minimal congo red positivity. Despite early amyloid deposition, pt had nephrotic syndrome. Likely AL type (pt has LPL); MS pending. #renalpath #pathsky #nephsky
December 3, 2025 at 5:05 PM
One of the more subtle cases of amyloidosis I have seen. Few spicules on silver stain. Minimal congo red positivity. Despite early amyloid deposition, pt had nephrotic syndrome. Likely AL type (pt has LPL); MS pending. #renalpath #pathsky #nephsky
Reposted
IgG3κ Monoclonal Membranous Nephropathy Associated With Acquired Lecithin Cholesterol Acyltransferase Deficiency
bit.ly/3Le1OFK
bit.ly/3Le1OFK
December 2, 2025 at 11:01 PM
IgG3κ Monoclonal Membranous Nephropathy Associated With Acquired Lecithin Cholesterol Acyltransferase Deficiency
bit.ly/3Le1OFK
bit.ly/3Le1OFK
Reposted
Bx for progressive CKD in a pt with CML, in remission. Limited biopsy with prominent debris filled proximal tubule lysosomes + for lysozyme (no evidence for light chain restriction (F/P) or chromogranin). Suspicious for lysozyme nephropathy. #renalpath #pathksy #nephsky
December 4, 2025 at 6:22 PM
Bx for progressive CKD in a pt with CML, in remission. Limited biopsy with prominent debris filled proximal tubule lysosomes + for lysozyme (no evidence for light chain restriction (F/P) or chromogranin). Suspicious for lysozyme nephropathy. #renalpath #pathksy #nephsky
Reposted
Unfortunate but not rare IgAN presentation. Pt in their 30's, no PMHx, presented with HTN emergency, CKD, hematuria, proteinuria. Advanced IgAN with severe IFTA, focal active crescents (M1 E1 S1 T2 C1). Wish we could catch these cases earlier. #renalpath #pathsky #nephsky
November 23, 2025 at 3:50 PM
Unfortunate but not rare IgAN presentation. Pt in their 30's, no PMHx, presented with HTN emergency, CKD, hematuria, proteinuria. Advanced IgAN with severe IFTA, focal active crescents (M1 E1 S1 T2 C1). Wish we could catch these cases earlier. #renalpath #pathsky #nephsky
Reposted
Unusual granular casts with annular appearance. Light chain, hemoglobin, myoglobin, chromogranin casts excluded. Patient on IV vancomycin. Suspicious for vancomycin cast nephropathy. pubmed.ncbi.nlm.nih.gov/31871855/ #renalpath #pathsky #nephsky
November 21, 2025 at 3:11 PM
Unusual granular casts with annular appearance. Light chain, hemoglobin, myoglobin, chromogranin casts excluded. Patient on IV vancomycin. Suspicious for vancomycin cast nephropathy. pubmed.ncbi.nlm.nih.gov/31871855/ #renalpath #pathsky #nephsky
Reposted
Bx for nephrotic syndrome in an IV drug user with multiple infections. LM was all medulla, but good enough to make a diagnosis. AA amyloidosis; very common bx result in this clinical setting. #renalpath #pathsky #nephsky
October 7, 2025 at 5:32 PM
Bx for nephrotic syndrome in an IV drug user with multiple infections. LM was all medulla, but good enough to make a diagnosis. AA amyloidosis; very common bx result in this clinical setting. #renalpath #pathsky #nephsky
Reposted
A startling biopsy. Severe acute TMA in a pt with suspected scleroderma renal crisis. Massive vascular thrombosis, mucoid intimal edema, and early onion skin change associated with severe cortical necrosis. #renalpath #nephsky #pathsky
October 9, 2025 at 3:08 AM
A startling biopsy. Severe acute TMA in a pt with suspected scleroderma renal crisis. Massive vascular thrombosis, mucoid intimal edema, and early onion skin change associated with severe cortical necrosis. #renalpath #nephsky #pathsky
Reposted
Interesting case of AL-amyloidosis. Massive vascular deposits, even in hilar arterioles with glomerular sparring. Patient had minimal proteinuria given lack of glomerular amyloid. #renalpath #pathsky #nephsky
September 4, 2025 at 11:14 PM
Interesting case of AL-amyloidosis. Massive vascular deposits, even in hilar arterioles with glomerular sparring. Patient had minimal proteinuria given lack of glomerular amyloid. #renalpath #pathsky #nephsky
Reposted
Kidney txp biopsy with histologic features of acute pyelonephritis. Neutrophilic tubulitis, neutrophilic casts, and tubules which seem to explode out. Cellular rejection typically is not neutrophilic and inflammation hits the tubules from the outside in. #renalpath #nephsky #pathsky
August 11, 2025 at 5:28 PM
Kidney txp biopsy with histologic features of acute pyelonephritis. Neutrophilic tubulitis, neutrophilic casts, and tubules which seem to explode out. Cellular rejection typically is not neutrophilic and inflammation hits the tubules from the outside in. #renalpath #nephsky #pathsky
Reposted
🔸Mostly adults
🔸Proteinuria/hematuria
🔸ESRD 10-20 yrs
🔸No specific treatment
References:
pubmed.ncbi.nlm.nih.gov/29055354/
(2/2)
🔸Proteinuria/hematuria
🔸ESRD 10-20 yrs
🔸No specific treatment
References:
pubmed.ncbi.nlm.nih.gov/29055354/
(2/2)
AJKD Atlas of Renal Pathology: Fibronectin Glomerulopathy - PubMed
AJKD Atlas of Renal Pathology: Fibronectin Glomerulopathy
pubmed.ncbi.nlm.nih.gov
August 6, 2025 at 3:18 AM
🔸Mostly adults
🔸Proteinuria/hematuria
🔸ESRD 10-20 yrs
🔸No specific treatment
References:
pubmed.ncbi.nlm.nih.gov/29055354/
(2/2)
🔸Proteinuria/hematuria
🔸ESRD 10-20 yrs
🔸No specific treatment
References:
pubmed.ncbi.nlm.nih.gov/29055354/
(2/2)
Reposted
Fibronectin glomerulopathy
🔸Massive fibronectin deposits
🔸AD mutation FN1
🔸MPGN-like pattern
🔸Silver-neg, PAS+, trichrome-red
🔸EM: Homogeneous granular + variable fibrils
🔸IF/IHC strongly + fibronectin
🔸renal-limited
(1/2) more below
#renalpath #pathsky #nephsky
🔸Massive fibronectin deposits
🔸AD mutation FN1
🔸MPGN-like pattern
🔸Silver-neg, PAS+, trichrome-red
🔸EM: Homogeneous granular + variable fibrils
🔸IF/IHC strongly + fibronectin
🔸renal-limited
(1/2) more below
#renalpath #pathsky #nephsky
August 6, 2025 at 3:18 AM
Fibronectin glomerulopathy
🔸Massive fibronectin deposits
🔸AD mutation FN1
🔸MPGN-like pattern
🔸Silver-neg, PAS+, trichrome-red
🔸EM: Homogeneous granular + variable fibrils
🔸IF/IHC strongly + fibronectin
🔸renal-limited
(1/2) more below
#renalpath #pathsky #nephsky
🔸Massive fibronectin deposits
🔸AD mutation FN1
🔸MPGN-like pattern
🔸Silver-neg, PAS+, trichrome-red
🔸EM: Homogeneous granular + variable fibrils
🔸IF/IHC strongly + fibronectin
🔸renal-limited
(1/2) more below
#renalpath #pathsky #nephsky
Reposted
#RenalPath: Lecithin–cholesterol acyltransferase deficiency with mild mesangial expansion with slight foamy appearance. Capillary walls show segmental thickening (hematoxylin and eosin stain).
bit.ly/2tQDkJx (FREE)
bit.ly/2tQDkJx (FREE)
April 13, 2025 at 10:01 AM
#RenalPath: Lecithin–cholesterol acyltransferase deficiency with mild mesangial expansion with slight foamy appearance. Capillary walls show segmental thickening (hematoxylin and eosin stain).
bit.ly/2tQDkJx (FREE)
bit.ly/2tQDkJx (FREE)
Reposted
Excuse the “taking a picture of a computer screen” quality here - this looks like early MN pattern (IgG, IgG1 here) by IF, but EM has absolutely no deposits (EM on frozen material done on this glom). Still MN (“by IF only”?!)? @glombandit.bsky.social @arkanalabs.bsky.social @jzrenalpath.bsky.social
August 9, 2025 at 5:03 PM
Excuse the “taking a picture of a computer screen” quality here - this looks like early MN pattern (IgG, IgG1 here) by IF, but EM has absolutely no deposits (EM on frozen material done on this glom). Still MN (“by IF only”?!)? @glombandit.bsky.social @arkanalabs.bsky.social @jzrenalpath.bsky.social
AVF dysfunction due to partial thrombosis at the anastomosis. Previous gradual anastomotic thrombosis led to peripheral blood flow and arteriopoesis with aneurysmatous dilation of cannulation site, which is now collapsing at blood flow rates higher then 200ml/min.
July 16, 2025 at 8:10 PM
AVF dysfunction due to partial thrombosis at the anastomosis. Previous gradual anastomotic thrombosis led to peripheral blood flow and arteriopoesis with aneurysmatous dilation of cannulation site, which is now collapsing at blood flow rates higher then 200ml/min.
Reposted
Pt has DM, heavy proteinuria & CKD. Bx shows fx of nodular diabetic GS. BUT EM also shows large substructures. IF with strong fibrinogen in similar glomerular distribution as substructures. Other than linear weak IgG & albumin, Ig's & LC's (-). What could they be?
#renalpath #pathsky #nephsky
#renalpath #pathsky #nephsky
April 5, 2025 at 3:44 AM
Pt has DM, heavy proteinuria & CKD. Bx shows fx of nodular diabetic GS. BUT EM also shows large substructures. IF with strong fibrinogen in similar glomerular distribution as substructures. Other than linear weak IgG & albumin, Ig's & LC's (-). What could they be?
#renalpath #pathsky #nephsky
#renalpath #pathsky #nephsky
Reposted
#RenalPath: Postinfectious glomerulonephritis with irregular, coarse granular capillary loop and mesangial staining for immunoglobulin G (immunofluorescence microscopy).
bit.ly/2KwRGU4 (FREE)
bit.ly/2KwRGU4 (FREE)
April 6, 2025 at 10:00 AM
#RenalPath: Postinfectious glomerulonephritis with irregular, coarse granular capillary loop and mesangial staining for immunoglobulin G (immunofluorescence microscopy).
bit.ly/2KwRGU4 (FREE)
bit.ly/2KwRGU4 (FREE)
Reposted
Abundant amyloid. Nephrotic syndrome and AKI in a patient with history of IV drug abuse, multiple infections, and HCV. Type AA (Amyloid A IHC picture). #renalpath #pathsky #nephsky
March 13, 2025 at 12:53 PM
Abundant amyloid. Nephrotic syndrome and AKI in a patient with history of IV drug abuse, multiple infections, and HCV. Type AA (Amyloid A IHC picture). #renalpath #pathsky #nephsky
Reposted
Angry ANCA vasculitis. Pacui immune crescentic GN with exploding glomerulus. Multiple foci of necrotizing arteritis. Fibrinogen staining in necrosis in a crescent and arterial wall. #renalpath #pathsky #nephsky
March 12, 2025 at 10:21 PM
Angry ANCA vasculitis. Pacui immune crescentic GN with exploding glomerulus. Multiple foci of necrotizing arteritis. Fibrinogen staining in necrosis in a crescent and arterial wall. #renalpath #pathsky #nephsky
Reposted
My patients live at the margins of society. They don’t have much. Just getting to dialysis three times a week is a big ask. Taking from them to fund tax breaks for the rich is just cruel.
I want to be outraged but I just feel like crying.
I want to be outraged but I just feel like crying.
July 2, 2025 at 12:20 AM
My patients live at the margins of society. They don’t have much. Just getting to dialysis three times a week is a big ask. Taking from them to fund tax breaks for the rich is just cruel.
I want to be outraged but I just feel like crying.
I want to be outraged but I just feel like crying.
Reposted
Anti-tubular basement membrane (TBM) disease
🔸Rare type of tubulointerstitial nephritis
🔸Strong linear polyclonal IgG restricted to TBMs
🔸No deposits by EM
🔸Autoantibody to TIN-ag in proximal TBM
🔸AKI/CKD, polyuria, polydipsia
Reference: ajkd.org/article/s027...
#renalpath #pathsky #nephsky
🔸Rare type of tubulointerstitial nephritis
🔸Strong linear polyclonal IgG restricted to TBMs
🔸No deposits by EM
🔸Autoantibody to TIN-ag in proximal TBM
🔸AKI/CKD, polyuria, polydipsia
Reference: ajkd.org/article/s027...
#renalpath #pathsky #nephsky
July 3, 2025 at 4:00 AM
Anti-tubular basement membrane (TBM) disease
🔸Rare type of tubulointerstitial nephritis
🔸Strong linear polyclonal IgG restricted to TBMs
🔸No deposits by EM
🔸Autoantibody to TIN-ag in proximal TBM
🔸AKI/CKD, polyuria, polydipsia
Reference: ajkd.org/article/s027...
#renalpath #pathsky #nephsky
🔸Rare type of tubulointerstitial nephritis
🔸Strong linear polyclonal IgG restricted to TBMs
🔸No deposits by EM
🔸Autoantibody to TIN-ag in proximal TBM
🔸AKI/CKD, polyuria, polydipsia
Reference: ajkd.org/article/s027...
#renalpath #pathsky #nephsky
Reposted
In late March, the FDA approved iptacopan to reduce proteinuria in patients with C3 glomerulopathy. With additional approvals anticipated to treat this rare condition, education on identifying and treating C3G is critical. kidney.pub/KN1706-02
#ASNKidneyNews
#ASNKidneyNews
July 3, 2025 at 3:00 PM
In late March, the FDA approved iptacopan to reduce proteinuria in patients with C3 glomerulopathy. With additional approvals anticipated to treat this rare condition, education on identifying and treating C3G is critical. kidney.pub/KN1706-02
#ASNKidneyNews
#ASNKidneyNews
Reposted
Example of necrotizing lupus vasculopathy. Hilar arterioles with luminal immune complex deposit and mural necrosis. Ig deposition in lumen of vessel and fibrinogen staining by IF. #renalpath #pathsky #nephsky
January 24, 2025 at 1:26 AM
Example of necrotizing lupus vasculopathy. Hilar arterioles with luminal immune complex deposit and mural necrosis. Ig deposition in lumen of vessel and fibrinogen staining by IF. #renalpath #pathsky #nephsky
Reposted
So very happy with this publication! I hope it will assist trainees in #nephrology and #renalpath in the uses of IF.
karger.com/gdz/article/...
karger.com/gdz/article/...
Immunofluorescence Use and Techniques in Glomerular Diseases: A Review
Abstract. Background: Immunofluorescence (IF) studies play an essential role in the evaluation of medical renal biopsies. Particularly, in the study of renal glomerular diseases, where it provides fun...
karger.com
December 13, 2024 at 2:04 PM
So very happy with this publication! I hope it will assist trainees in #nephrology and #renalpath in the uses of IF.
karger.com/gdz/article/...
karger.com/gdz/article/...
Reposted
#RenalPath: CNI nephrotoxicity with TMA involving an arteriole (Jones silver stain).
bit.ly/2qeBWhV (FREE)
bit.ly/2qeBWhV (FREE)
June 22, 2025 at 10:01 AM
#RenalPath: CNI nephrotoxicity with TMA involving an arteriole (Jones silver stain).
bit.ly/2qeBWhV (FREE)
bit.ly/2qeBWhV (FREE)