Pascal Albanese
@pascalalbanese.bsky.social
Researcher @cea_grenoble 🇫🇷 — dealing with Light, Protein structures, and Mass Spectra - MSCA alumn - Previously 🇳🇱🇮🇹@UniUtrecht@PoliTOnews@UniPadova
Pinned
Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”.
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
Inceptor binds to and directs insulin towards lysosomal degradation in β cells - Nature Metabolism
The insulin inhibitory receptor (inceptor) is found to bind to insulin and to regulate insulin stores by directing proinsulin and insulin towards lysosomal degradation.
doi.org
Great post to kickstart on Bsky!
Inceptor was a tough one for #Massspec. Together with Sem Tamara we showed, among others, that #inceptor ectodomain binds #insulin and pro-insulin at low pH. Maybe #XL-MS will tell us where? 🙃
Thanks @heikolickert.bsky.social for involving us on this milestone :)
Inceptor was a tough one for #Massspec. Together with Sem Tamara we showed, among others, that #inceptor ectodomain binds #insulin and pro-insulin at low pH. Maybe #XL-MS will tell us where? 🙃
Thanks @heikolickert.bsky.social for involving us on this milestone :)
Reposted by Pascal Albanese
Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n
openrxiv.org/enabling-rev...
openrxiv.org/enabling-rev...
Enabling options for review: from training and transparency to author-centered AI tools - openRxiv
Peer review is widely viewed as a critical aspect of biomedical communication. Ideally, it provides authors with feedback so they can improve manuscripts and gives readers, particularly nonspecialists...
openrxiv.org
November 6, 2025 at 2:32 PM
Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n
openrxiv.org/enabling-rev...
openrxiv.org/enabling-rev...
Reposted by Pascal Albanese
🌶️Publication Alert📢: Introducing #XL_MS, a workflow for enrichment of PhoX crosslinked peptides using #MagReSyn_Zr_IMAC from #TeamReSynBio but adapted for plant research! @pascalalbanese.bsky.social and team help decipher thylakoids and photosynthesis! doi.org/10.1101/2025...
October 9, 2025 at 1:10 PM
🌶️Publication Alert📢: Introducing #XL_MS, a workflow for enrichment of PhoX crosslinked peptides using #MagReSyn_Zr_IMAC from #TeamReSynBio but adapted for plant research! @pascalalbanese.bsky.social and team help decipher thylakoids and photosynthesis! doi.org/10.1101/2025...
Reposted by Pascal Albanese
Your sleep pressure is powered by your mitochondria! Sleep, energy, and ageing are all connected through mitochondrial bioenergetics in neurons. Brilliant work from Gero Miesenböck’s lab, just out in Nature @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 16, 2025 at 10:57 PM
Your sleep pressure is powered by your mitochondria! Sleep, energy, and ageing are all connected through mitochondrial bioenergetics in neurons. Brilliant work from Gero Miesenböck’s lab, just out in Nature @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Pascal Albanese
Science builds bridges🇮🇷🤝🇮🇱
Join me in welcoming our new postdoc Vida who brings PhD in plant sciences and will contribute to new bioenergetic studies. Vida is from Tabriz where her family's lives were disrupted by war. Thankfully no casualties, but career delays to her siblings and psychological toll
Join me in welcoming our new postdoc Vida who brings PhD in plant sciences and will contribute to new bioenergetic studies. Vida is from Tabriz where her family's lives were disrupted by war. Thankfully no casualties, but career delays to her siblings and psychological toll
July 11, 2025 at 4:06 AM
Science builds bridges🇮🇷🤝🇮🇱
Join me in welcoming our new postdoc Vida who brings PhD in plant sciences and will contribute to new bioenergetic studies. Vida is from Tabriz where her family's lives were disrupted by war. Thankfully no casualties, but career delays to her siblings and psychological toll
Join me in welcoming our new postdoc Vida who brings PhD in plant sciences and will contribute to new bioenergetic studies. Vida is from Tabriz where her family's lives were disrupted by war. Thankfully no casualties, but career delays to her siblings and psychological toll
Reposted by Pascal Albanese
Folddisco detects (partial) motifs, allowing for substitutions and angle-length variations, by utilizing an index storing all residue pairs within 20Å encoded as geometric features. For space efficiency, it omits positions and compresses ids through run-length encoding (1.4TB for 53M structures) 2/9
July 7, 2025 at 8:21 AM
Folddisco detects (partial) motifs, allowing for substitutions and angle-length variations, by utilizing an index storing all residue pairs within 20Å encoded as geometric features. For space efficiency, it omits positions and compresses ids through run-length encoding (1.4TB for 53M structures) 2/9
Reposted by Pascal Albanese
Bluesky needs more music, and the world needs more nerds. This, ladies and gentlemen, is a blast from the past. And a reminder not to underestimate the chemists 😉. #chemsky youtu.be/f8FAJXPBdOg?...
The Molecular Shape of You (Ed Sheeran Parody) | A Capella Science
YouTube video by acapellascience
youtu.be
June 29, 2025 at 7:30 PM
Bluesky needs more music, and the world needs more nerds. This, ladies and gentlemen, is a blast from the past. And a reminder not to underestimate the chemists 😉. #chemsky youtu.be/f8FAJXPBdOg?...
Reposted by Pascal Albanese
Remarkable paper explaining how sea slugs maintain chloroplasts obtained by kleptoplasty active for many month & eventually digest them for resources www.cell.com/cell/fulltex...
A host organelle integrates stolen chloroplasts for animal photosynthesis
Sea slugs steal foreign chloroplasts and store them in specialized organelles that
facilitate photosynthesis and eventual digestion to mediate starvation resistance.
www.cell.com
June 26, 2025 at 6:41 AM
Remarkable paper explaining how sea slugs maintain chloroplasts obtained by kleptoplasty active for many month & eventually digest them for resources www.cell.com/cell/fulltex...
Reposted by Pascal Albanese
Free structural MS hands-on workshop @ BIOCEV (CZ)
📅 Sept 15–19, 2025
For PhDs, postdocs & undergrads (CZ/SK)
HDX-MS, native MS, cross-linking, high-res MS, data processing
Apply by July 31 → bit.ly/3HNyzIg
@spidocs.bsky.social @mbuavcr.bsky.social @ciisbinstructcz.bsky.social
📅 Sept 15–19, 2025
For PhDs, postdocs & undergrads (CZ/SK)
HDX-MS, native MS, cross-linking, high-res MS, data processing
Apply by July 31 → bit.ly/3HNyzIg
@spidocs.bsky.social @mbuavcr.bsky.social @ciisbinstructcz.bsky.social
June 25, 2025 at 9:14 AM
Free structural MS hands-on workshop @ BIOCEV (CZ)
📅 Sept 15–19, 2025
For PhDs, postdocs & undergrads (CZ/SK)
HDX-MS, native MS, cross-linking, high-res MS, data processing
Apply by July 31 → bit.ly/3HNyzIg
@spidocs.bsky.social @mbuavcr.bsky.social @ciisbinstructcz.bsky.social
📅 Sept 15–19, 2025
For PhDs, postdocs & undergrads (CZ/SK)
HDX-MS, native MS, cross-linking, high-res MS, data processing
Apply by July 31 → bit.ly/3HNyzIg
@spidocs.bsky.social @mbuavcr.bsky.social @ciisbinstructcz.bsky.social
Reposted by Pascal Albanese
Remember, everything Netanyahu does is to keep himself out of prison. For the sake of one crook's liberty, tens of thousands of people have been murdered, and now a possible full-scale war has been provoked. Israel must rise up and unseat him.
June 13, 2025 at 5:53 AM
Remember, everything Netanyahu does is to keep himself out of prison. For the sake of one crook's liberty, tens of thousands of people have been murdered, and now a possible full-scale war has been provoked. Israel must rise up and unseat him.
Reposted by Pascal Albanese
I'm happy to say that our new paper (and the first one out of my PhD thesis) is out!
We describe the CryoEM structure of the phycobilisomes expressed during far-red light photoacclimation, and try to make sense of why these cyano are fond of "minimalism" :)
doi.org/10.1038/s420...
We describe the CryoEM structure of the phycobilisomes expressed during far-red light photoacclimation, and try to make sense of why these cyano are fond of "minimalism" :)
doi.org/10.1038/s420...
Structure of a stripped-down and tuned-up far-red phycobilisome - Communications Biology
CryoEM structure of far-red light adapted allophycocyanin unveils evolutionary adaptations for far-red light photosynthesis and the molecular strategies for efficient light-harvesting under far-red li...
doi.org
June 12, 2025 at 2:18 PM
I'm happy to say that our new paper (and the first one out of my PhD thesis) is out!
We describe the CryoEM structure of the phycobilisomes expressed during far-red light photoacclimation, and try to make sense of why these cyano are fond of "minimalism" :)
doi.org/10.1038/s420...
We describe the CryoEM structure of the phycobilisomes expressed during far-red light photoacclimation, and try to make sense of why these cyano are fond of "minimalism" :)
doi.org/10.1038/s420...
Reposted by Pascal Albanese
90% of you probably don’t need to read this.
But maybe some of you are curious & 10% will feel seen. Or a little less alone. This isn’t about seeking sympathy.
It’s about sharing something hard to say out loud;
partly to heal, partly in case someone needs to hear it too. (1/3)
tinyurl.com/DudinO
But maybe some of you are curious & 10% will feel seen. Or a little less alone. This isn’t about seeking sympathy.
It’s about sharing something hard to say out loud;
partly to heal, partly in case someone needs to hear it too. (1/3)
tinyurl.com/DudinO
Omaya Dudin
Interview with Omaya Dudin, who uses Ichthyosporea as models to study how and why
unicellular organisms evolved multicellularity at the University of Geneva.
www.cell.com
June 10, 2025 at 9:41 AM
90% of you probably don’t need to read this.
But maybe some of you are curious & 10% will feel seen. Or a little less alone. This isn’t about seeking sympathy.
It’s about sharing something hard to say out loud;
partly to heal, partly in case someone needs to hear it too. (1/3)
tinyurl.com/DudinO
But maybe some of you are curious & 10% will feel seen. Or a little less alone. This isn’t about seeking sympathy.
It’s about sharing something hard to say out loud;
partly to heal, partly in case someone needs to hear it too. (1/3)
tinyurl.com/DudinO
Reposted by Pascal Albanese
Problem cryo-ET structure alert. A recent paper by Lange et al. in @natcellbio.nature.com (tinyurl.com/38s6a4dn) reported an unusual-looking model of the prohibitin complex in situ. We asked: how was this structure generated? Our reanalysis offers an explanation: tinyurl.com/mszdtwxx 🧵
May 20, 2025 at 8:58 PM
Problem cryo-ET structure alert. A recent paper by Lange et al. in @natcellbio.nature.com (tinyurl.com/38s6a4dn) reported an unusual-looking model of the prohibitin complex in situ. We asked: how was this structure generated? Our reanalysis offers an explanation: tinyurl.com/mszdtwxx 🧵
Reposted by Pascal Albanese
To all #ChlamyDataset enthusiasts, here is a script that lets you directly import the pre-processed results from EMPIAR-11830 into #RELION v5 for subtomogram averaging:
github.com/Chromatin-St...
#Chlamydomonas #TeamTomo #CryoET #OpenSoftwareAcceleratesScience
github.com/Chromatin-St...
#Chlamydomonas #TeamTomo #CryoET #OpenSoftwareAcceleratesScience
ChlamyAnnotations/chlamydataset2relion5 at master · Chromatin-Structure-Rhythms-Lab/ChlamyAnnotations
Particle annotations for the large-scale cryo-ET dataset of Chlamydomonas reinhardtii - Chromatin-Structure-Rhythms-Lab/ChlamyAnnotations
github.com
April 28, 2025 at 1:16 PM
To all #ChlamyDataset enthusiasts, here is a script that lets you directly import the pre-processed results from EMPIAR-11830 into #RELION v5 for subtomogram averaging:
github.com/Chromatin-St...
#Chlamydomonas #TeamTomo #CryoET #OpenSoftwareAcceleratesScience
github.com/Chromatin-St...
#Chlamydomonas #TeamTomo #CryoET #OpenSoftwareAcceleratesScience
Reposted by Pascal Albanese
"Our LPD-3 complex structural data reveal protein–lipid interactions that suggest a model for how the native LPD-3 complex mediates bulk lipid transport and provides a foundation for mechanistic studies of bridge-like lipid transport proteins (BLTPs)." 🤯🤯😍
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structural basis of lipid transfer by a bridge-like lipid-transfer protein - Nature
The LPD-3 complex structure reveals protein–lipid interactions that suggest a model for how the native LPD-3 complex mediates bulk lipid transport and provides a foundation for mechanistic studies of ...
www.nature.com
April 25, 2025 at 7:48 AM
"Our LPD-3 complex structural data reveal protein–lipid interactions that suggest a model for how the native LPD-3 complex mediates bulk lipid transport and provides a foundation for mechanistic studies of bridge-like lipid transport proteins (BLTPs)." 🤯🤯😍
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Pascal Albanese
TREC is now on Bluesky! The expedition has gathered samples all along Europe’s coasts – now scientists are exploring what the data tell us. We’ll be sharing insights into this amazing ongoing work! Spread the word! @embl.org @taraoceans-science.bsky.social @embrc-eu.bsky.social 📸Massimo Del Prete
April 9, 2025 at 9:24 AM
TREC is now on Bluesky! The expedition has gathered samples all along Europe’s coasts – now scientists are exploring what the data tell us. We’ll be sharing insights into this amazing ongoing work! Spread the word! @embl.org @taraoceans-science.bsky.social @embrc-eu.bsky.social 📸Massimo Del Prete
Reposted by Pascal Albanese
Biochemist Nick Lane on the body electric ⚡ and the cycle that drives all carbon based life-forms on earth 🍃🌍
youtu.be/vBiIDwBOqQA #KrebsCycle #Complexity #Science #Biochemistry #Life 🧬🦠🔬
youtu.be/vBiIDwBOqQA #KrebsCycle #Complexity #Science #Biochemistry #Life 🧬🦠🔬
How the Krebs cycle powers life and death – with Nick Lane
YouTube video by The Royal Institution
youtu.be
April 21, 2025 at 2:30 PM
Biochemist Nick Lane on the body electric ⚡ and the cycle that drives all carbon based life-forms on earth 🍃🌍
youtu.be/vBiIDwBOqQA #KrebsCycle #Complexity #Science #Biochemistry #Life 🧬🦠🔬
youtu.be/vBiIDwBOqQA #KrebsCycle #Complexity #Science #Biochemistry #Life 🧬🦠🔬
Reposted by Pascal Albanese
"Wound wood" is ecological engineering by the Earth Mother at its best! The tree seals the damage, fungi move in, beetles make tunnels, and here, Anolis carolinesis (green anole lizards) use it for a home. Decay signals transformation, not THE END. #WoundWood #Trees #Naturalist #botany #photography
April 19, 2025 at 6:12 PM
"Wound wood" is ecological engineering by the Earth Mother at its best! The tree seals the damage, fungi move in, beetles make tunnels, and here, Anolis carolinesis (green anole lizards) use it for a home. Decay signals transformation, not THE END. #WoundWood #Trees #Naturalist #botany #photography
Reposted by Pascal Albanese
Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics www.nature.com/articles/s42...
Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics - Nature Metabolism
Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pat...
www.nature.com
April 11, 2025 at 11:35 AM
Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics www.nature.com/articles/s42...
Reposted by Pascal Albanese
Pretty much everything is fucked, but here is some beautiful and exciting science from @archaeon-alex.bsky.social and colleagues.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Tissue-like multicellular development triggered by mechanical compression in archaea
The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...
www.science.org
April 4, 2025 at 3:40 AM
Pretty much everything is fucked, but here is some beautiful and exciting science from @archaeon-alex.bsky.social and colleagues.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Pascal Albanese
#HeardToday “You can’t solve mechanisms with genomics. For that you need to go to the trenches and do BIOCHEMISTRY!”
two men in military uniforms are standing next to each other and one has a badge on his arm that says ' a '
ALT: two men in military uniforms are standing next to each other and one has a badge on his arm that says ' a '
media.tenor.com
April 3, 2025 at 2:53 PM
#HeardToday “You can’t solve mechanisms with genomics. For that you need to go to the trenches and do BIOCHEMISTRY!”
Reposted by Pascal Albanese
🌿Join us for the 2025 congress of the French Society of Photosynthesis in Paris May 26–28!
🌱 Exciting sessions on a broad range of topics related to photosynthesis.
📌 Abstract deadline: March 31
✨ Free registration for students & postdocs 😁
👉 mfp2025.sciencesconf.org?lang=en
#Photosynthesis
🌱 Exciting sessions on a broad range of topics related to photosynthesis.
📌 Abstract deadline: March 31
✨ Free registration for students & postdocs 😁
👉 mfp2025.sciencesconf.org?lang=en
#Photosynthesis
March 18, 2025 at 1:39 PM
🌿Join us for the 2025 congress of the French Society of Photosynthesis in Paris May 26–28!
🌱 Exciting sessions on a broad range of topics related to photosynthesis.
📌 Abstract deadline: March 31
✨ Free registration for students & postdocs 😁
👉 mfp2025.sciencesconf.org?lang=en
#Photosynthesis
🌱 Exciting sessions on a broad range of topics related to photosynthesis.
📌 Abstract deadline: March 31
✨ Free registration for students & postdocs 😁
👉 mfp2025.sciencesconf.org?lang=en
#Photosynthesis
Reposted by Pascal Albanese
Who does that? We rented a train JUST for the conference, that will take the participants from Prague to the woods of Bohemia. There'll be talks ON THE TRAIN. In Prague we'll have 5 locations with different atmospheres.
#theconferencetoendallconferences Register now:
woodstock.img.cas.cz
#theconferencetoendallconferences Register now:
woodstock.img.cas.cz
April 1, 2025 at 4:58 PM
Who does that? We rented a train JUST for the conference, that will take the participants from Prague to the woods of Bohemia. There'll be talks ON THE TRAIN. In Prague we'll have 5 locations with different atmospheres.
#theconferencetoendallconferences Register now:
woodstock.img.cas.cz
#theconferencetoendallconferences Register now:
woodstock.img.cas.cz
Reposted by Pascal Albanese
MITOtalks this week
April 1, 2025 at 4:10 PM
MITOtalks this week
Reposted by Pascal Albanese
IMBA is recruiting a Junior Group Leader! Are you interested in starting your own lab, pursuing curiosity-driven basic research in the life sciences? Apply now to our group leader position. The deadline is May 28. Link is below.
March 28, 2025 at 11:15 AM
IMBA is recruiting a Junior Group Leader! Are you interested in starting your own lab, pursuing curiosity-driven basic research in the life sciences? Apply now to our group leader position. The deadline is May 28. Link is below.