Background Sex differences in out-of-hospital cardiac arrest (OHCA) have been studied in adults but remain poorly explored in younger populations. We aimed to assess sex differences in OHCA across age...

Nature Reviews Cardiology, Published online: 07 November 2025; doi:10.1038/s41569-025-01232-0Shafqat Ahmad and Gull Rukh discuss a landmark, twin-based, epidemiological study that highlighted how genetic predisposition and environmental factors interact to influence the risk of coronary heart disease.

The blood-retina barrier (BRB) protects retinal neuronal function and enables vision. A compromised, leaky BRB is a hallmark of vision-threatening retinal diseases such as diabetic retinopathy (DR) an...

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Nature - In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.

The biological clock model LifeClock predicts biological age across all life stages from routine clinical data, revealing distinct pediatric and adult disease risk patterns.

Key PointsNK-cell phenotyping reveals impaired cytotoxicity, chronic activation, and exhaustion in VEXAS syndrome.Decreased circulating NK cells were indep

AbstractBackground. Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in huma

People with certain forms of the MC4R gene have lower cholesterol levels than do other individuals with a high body-mass index.

Modelling cardiomyocyte geometry reveals that mitochondrial–sarcoplasmic architecture enhances respiration by facilitating ion and lipid transfer for efficient cardiac metabolism.

Communications Biology - Modelling cardiomyocyte geometry reveals that mitochondrial–sarcoplasmic architecture enhances respiration by facilitating ion and lipid transfer for efficient...

Hopes of securing a United Nations treaty on plastic pollution are fading after the final round of negotiations ended without an agreement.

Nature Reviews Cardiology, Published online: 06 October 2025; doi:10.1038/s41569-025-01220-4In this Review, Nicholas Chew and colleagues use epidemiological data on the cardiovascular–liver–metabolic disease syndemic to illustrate current and future projections on the burden of these diseases and their risk factors, and propose a unified framework for integrating and implementing effective multisystem interventions to tackle key components of this syndemic.

An optimistic take on the state of the longevity field provides hope for treating a range of ageing-related diseases — but feels at odds with the current shape of US research.

Integrin alpha V (CD51) is a surface receptor that binds to extracellular matrix ligands and contributes to fibrotic responses, including post-infarct…

Background: Porcine genome editing has revolutionized xenotransplantation, recently enabling the first pig-to-human heart xenotransplants. However, the xeno-immune response in heart xenografts remains...

BACKGROUND: Endotheliopathy and coagulopathy are known complications of COVID-19, with a significant association with mortality. Although dexamethasone is the standard of care for patients with severe...