genomebiology.biomedcentral.com/articles/10....

We were delighted to get a reviewers choice award for the abstract describing our work applying duet evoC to early detection of early stage cancer, available as a preprint here www.biorxiv.org/content/10.1... #ASHG24

Just landed back in London, still buzzing from #ASHG24. It's been great to see the growing interest in multiomics in the ASHG community and the interest in our technology as part of that. We are shaping up for an exciting 2025 🚀

🔍 What Secrets Lie Within Cancer Genetics and Epigenetics?
The answers await at the 2025 Cancer Genetics and Epigenetics GRC to be held in May!
Thanks to our sponsors: Biomodal, Zymo, NEB, T-ONE, AtlasXomics, Olink, Geneseeq, and Active Motif.
Join us: www.grc.org/cancer-genet...

I don't know how much activity happens on here these days, but if anyone on here will be at #ASHG24 next week and would like to chat abouy 5mC / 5hmC and the six-base genome, please reach out. I'll be there Tuesday to Friday afternoon with several posters and an industrial session from biomodal

Very happy to share this work. We show that measuring both 5mC and 5hmC provides greater discrimination of stage I colorectal cancer in cfDNA! www.biorxiv.org/content/10.1... 🧬💻

#MLCB2024 will be Sept 5-6 as a hybrid event in Seattle (nice time to be in the PNW!) with a great lineup of keynotes from @avapamini, @ChikinaLab, @zhou_jian and Nilah Ioannidis. Registration is free and submission deadline is June 15th. More deets at mlcb.github.io.

AI Doomerism in the LRB www.lrb.co.uk/the-paper/v4...

Just over 10 years ago in my postdoc I wrote a review on CpG island hypermethylation in cancer. At the time, the molecular mechanisms were unclear. Its amazing how far we've come since then 😮 and this new pre-print is another important part of the puzzle:
www.biorxiv.org/content/10.1...
#Epigenetics

Exciting developments in Alzheimers Disease research. Five molecular subtypes with distinct outcomes identified through mass spec proteomics of CSF, potentially paving the way for precision medicine in AD!
www.nature.com/articles/s43... 🧬

Inferring gene expression from cfDNA
www.nature.com/articles/s41.... Excited by the potential to infer tumour gene expression without accessing tumour tissue 🧬

Genome of a bottle www.nature.com/articles/s42... 🧬

Ultima Genomics coming into th limelight with a big partner:

www.businesswire.com/news/home/20...

Ada, Countess of Lovelace, daughter of Lord Byron, mathematician & a pioneer of computing, born #OTD 1815.
@GovArtCol

The Agile Fluency Model, one of the clearest ways to think about Agile I've seen martinfowler.com/articles/agi...

The #gnomAD team is proud to announce the release of gnomAD v4! The v4 dataset includes 730,947 exomes & 76,215 genomes, which is ~5x larger than the v2 & v3 releases combined, & includes nearly 120K indivs of non-European genetic ancestry broad.io/gnomad #ASHG23 (1/11)

Check out Aman Patel's plenary talk at #ASHG23 #ASHG #ASHG2023 tomorrow. He will explore the regulatory impact of genetic variants from archaic hominids using deep learning models of chromatin accessibility profiles of > 1000 diverse ENCODE biosamples from modern humans! Details below

On my way to #ASHG23. Looking forward to learning about exciting new research in genetics and talking to people about biomodal and tools for simultaneous sequencing of genetics and epigenetics in 🧬