Our new paper is out! Trying to understand the molecular function of the PARP7, a PARP family enzyme with links to innate immunity and environmental toxins response. Congrats to Andrii and the rest of the team and collaborators.
www.pnas.org/doi/10.1073/...

New paper! We uncover mechanistic insights into the crosstalk between AHR (aryl hydrocarbon receptor, a transcription factor) and PARP7 (a nuclear enzyme that performs protein ADP-ribosylation). Both are promising cancer drug targets.

Big thanks to all co-authors!

www.pnas.org/doi/10.1073/...

We are highlighting Liz Robertson, @dev-journal.bsky.social Editor and the longest-standing Editor of @biologists.bsky.social journals, as an extraordinary biologist this week.
#100biologists

We have another postdoc position available to work on interplay between ADP-ribosylation and ubiquitination in regulation of genome stability. For this post expertise in cell biology is required.
my.corehr.com/pls/uoxrecru...

Online now - the Spotlight "Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells" from @kfeijszaja.bsky.social and colleagues.

#ADPribosylation #ubiquitination #MARUbylation #crosstalk

authors.elsevier.com/sd/article/S...

We would love feedback on a new NCBI-BLAST service we are launching today: sky-blast.com

Under the hood it's the same BLAST executable and databases provided by NCBI, with a replica of the NIH's interface - providing an alternative to the US gov service that's less congested, faster & more reliable

#MARUbylation:
@michaelnadbio.bsky.social @jnpruneda.bsky.social and colleagues find that IFN-β induces the novel post-translational modification, mono-ADP-ribosyl ubiquitylation, on several interferon-stimulated #PARPs such as PARP10, PARP7 and PARP14
www.embopress.org/doi/full/10....

We are delighted to share our latest work, characterising the role of BRCA2 and its binding partner PALB2 at centromeres, just out in the latest issue of Cell Reports. ⬇️

www.cell.com/cell-reports...

Potential PhD students who are interested in working in Ivan Ahel group are welcome to apply through the ILESLA programme.
#ADPribosylation
@dunnschool.bsky.social
@ox.ac.uk

iles.web.ox.ac.uk/how-apply

We just can't stop recruiting!

Associate professor in cell and molecular biology @dunnschool, with a preference for immunology, inflammation and/or infection - all defined broadly

Come and be our colleague

Deadline 28 Feb, please spread the word

www.path.ox.ac.uk/vacancy/asso...

📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: www.fmi.ch/education-ca...

We are advertising for a project looking at epigenetic inheritance in Drosophila at the Department of Biology, University of Oxford @oxfordbiology.bsky.social Please get in touch if you are interested! Only 1 month left to be considered for funding.

www.findaphd.com/phds/project...

Intriguing new paper by @mflangelier.bsky.social in the Pascal lab showing that PARP1 can generate free poly-ADP-ribose (PAR) (not attached to proteins) in vitro and in cells. In some cases PAR is attached to NAD+! #PARP #ADP-ribosylation #NAD+

www.cell.com/molecular-ce...

More #drosophila work, recently in @plos.bsky.social PLOS Biology (on the cover :))

“Wnt signaling modulates the response to DNA damage in the Drosophila wing imaginal disc by regulating the EGFR pathway” Ewen-Campen & Norbert Perrimon

journals.plos.org/plosbiology/...

interested in all things Parp and ADP-ribosylation? arguably the weirdest posttranslational modification EVER? here is a starter pack, compiled by @leunglab.bsky.social
go.bsky.app/CiRKAXJ

Important so please help spread the word...

Interested in postgrad research? Maybe do a PhD?

Oxford runs a summer internship scheme for UK students from under-represented and disadvantaged backgrounds

Stipend, free accommodation, mentoring...

Deadline 21 Feb

www.ox.ac.uk/admissions/g...