@orecoder.bsky.social
Reposted
By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12
Redirecting
doi.org
December 2, 2024 at 4:44 PM
By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12
Reposted
Research Highlight by @drleitang.bsky.social: the Elling lab introduces CRISPR-StAR to bring CRISPR screening into in vivo biology.
Paper: nature.com/articles/s41...
Highlight: www.nature.com/articles/s41...
Paper: nature.com/articles/s41...
Highlight: www.nature.com/articles/s41...
Tackling in vivo screening complexity - Nature Methods
Nature Methods - Tackling in vivo screening complexity
www.nature.com
February 14, 2025 at 2:49 PM
Research Highlight by @drleitang.bsky.social: the Elling lab introduces CRISPR-StAR to bring CRISPR screening into in vivo biology.
Paper: nature.com/articles/s41...
Highlight: www.nature.com/articles/s41...
Paper: nature.com/articles/s41...
Highlight: www.nature.com/articles/s41...
Reposted
Our featured article: Structural variants in the 3D genome as drivers of disease - Review by Varun K. A. Sreenivasan, Verónica Yumiceba & Malte Spielmann go.nature.com/4oiPdPQ
Free to read here: rdcu.be/eu0KR
Free to read here: rdcu.be/eu0KR
Structural variants in the 3D genome as drivers of disease
Nature Reviews Genetics - Disruption of the 3D genome caused by structural variation contributes to developmental disorders and cancer. The authors review the causes and molecular and clinical...
rdcu.be
October 15, 2025 at 11:54 AM
Our featured article: Structural variants in the 3D genome as drivers of disease - Review by Varun K. A. Sreenivasan, Verónica Yumiceba & Malte Spielmann go.nature.com/4oiPdPQ
Free to read here: rdcu.be/eu0KR
Free to read here: rdcu.be/eu0KR
Reposted
How do mammalian cells adapt to cold? 🐻 ❄️ 🐿️ Read more in this new Communications Biology review about the various adaptation strategies used by cells - from ion channels to epigenetics and learn from hibernators about therapeutic approaches in metabolism and neuroprotection.
doi.org/10.1038/s420...
doi.org/10.1038/s420...
Molecular mediators of cold adaptation in mammalian cells - Communications Biology
This review outlines how mammalian cells adapt to cold via ion channels, uncoupling proteins, epigenetic changes, and RNA-binding proteins, with insights from hibernators highlighting therapeutic pote...
doi.org
October 16, 2025 at 11:13 AM
How do mammalian cells adapt to cold? 🐻 ❄️ 🐿️ Read more in this new Communications Biology review about the various adaptation strategies used by cells - from ion channels to epigenetics and learn from hibernators about therapeutic approaches in metabolism and neuroprotection.
doi.org/10.1038/s420...
doi.org/10.1038/s420...