Oliver Grant
@olivercgrant.bsky.social
Research Scientist doing glycomaterial and glycoprotein molecular modeling. I also develop the glyco webtools for https://www.glycam.org
Pinned
Generating 3D Models of Carbohydrates with GLYCAM-Web
The carbohydrate 3D structure-prediction tools (builders) at GLYCAM-Web (glycam.org) are widely used for generating experimentally-consistent 3D structures of oligosaccharides suitable for data interp...
www.biorxiv.org
After 20 years and a recent big overhaul we're finally publishing the carbohydrate 3D structure builders on GLYCAM-Web (glycam.org)! Pre-print: (www.biorxiv.org/content/10.1...) #glycotime tools
Reposted by Oliver Grant
A few GlycoDraw-related highlights of the upcoming glycowork v1.6 update (dropping in a few weeks):
- our very own rendering engine (GlycoDraw for the masses, thanks to glycorender!);
- SNFG-gradients;
- automated Alt text;
- reverse-highlighting;
- even more support for highly complex sequences
- our very own rendering engine (GlycoDraw for the masses, thanks to glycorender!);
- SNFG-gradients;
- automated Alt text;
- reverse-highlighting;
- even more support for highly complex sequences
May 12, 2025 at 8:23 AM
A few GlycoDraw-related highlights of the upcoming glycowork v1.6 update (dropping in a few weeks):
- our very own rendering engine (GlycoDraw for the masses, thanks to glycorender!);
- SNFG-gradients;
- automated Alt text;
- reverse-highlighting;
- even more support for highly complex sequences
- our very own rendering engine (GlycoDraw for the masses, thanks to glycorender!);
- SNFG-gradients;
- automated Alt text;
- reverse-highlighting;
- even more support for highly complex sequences
After 20 years and a recent big overhaul we're finally publishing the carbohydrate 3D structure builders on GLYCAM-Web (glycam.org)! Pre-print: (www.biorxiv.org/content/10.1...) #glycotime tools
Generating 3D Models of Carbohydrates with GLYCAM-Web
The carbohydrate 3D structure-prediction tools (builders) at GLYCAM-Web (glycam.org) are widely used for generating experimentally-consistent 3D structures of oligosaccharides suitable for data interp...
www.biorxiv.org
May 9, 2025 at 12:47 PM
After 20 years and a recent big overhaul we're finally publishing the carbohydrate 3D structure builders on GLYCAM-Web (glycam.org)! Pre-print: (www.biorxiv.org/content/10.1...) #glycotime tools
Reposted by Oliver Grant
Nice #glycotime review that pulls together the emerging story of glycosyltransferase specificity for cellular substrates
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
Glycoproteins, Glycolipids, or Both: Why do Glycosyltransferases Recognize Different Acceptors?
Glycosylation is an important post-translational modification catalyzed by glycosyltransferases (GTs), which comprise a large group of enzymes with diversified specificity. Most GTs show high specifi...
chemistry-europe.onlinelibrary.wiley.com
May 7, 2025 at 11:42 AM
Nice #glycotime review that pulls together the emerging story of glycosyltransferase specificity for cellular substrates
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Oliver Grant
Reposted by Oliver Grant
I have a PhD position open in my lab! viruses and glycans... who does not love that combo😉. Please share!. #glycotime #lovevirology www.uu.nl/en/organisat...
PhD Position in Virus-Glycan Interactions
If you're ready to solve virus-glycan interaction puzzles and shape the future of novel in vitro models, join us!
www.uu.nl
March 17, 2025 at 11:36 AM
I have a PhD position open in my lab! viruses and glycans... who does not love that combo😉. Please share!. #glycotime #lovevirology www.uu.nl/en/organisat...
Reposted by Oliver Grant
Polysialic acids are upregulated on activated T cells #glycotime
Polysialylation is a general feature of immune activation
Sialic acids are critical regulators of immune responses and the sialic acid-Siglec axis has receive much attention recently for it role as a new immune checkpoint. While α2,3- and α2,6-linked sialosi...
www.biorxiv.org
January 16, 2025 at 8:42 PM
Polysialic acids are upregulated on activated T cells #glycotime
Reposted by Oliver Grant
MagLOV!
MagLOV is a fluorescent protein you can "turn off" with a handheld magnet, engineered by @mariaingaramo.bsky.social.
We think/hope we can use it to turn arbitrary proteins (including drugs!) on and off in opaque creatures (including humans!).
bsky.app/profile/addg...
MagLOV is a fluorescent protein you can "turn off" with a handheld magnet, engineered by @mariaingaramo.bsky.social.
We think/hope we can use it to turn arbitrary proteins (including drugs!) on and off in opaque creatures (including humans!).
bsky.app/profile/addg...
November 22, 2024 at 12:06 AM
MagLOV!
MagLOV is a fluorescent protein you can "turn off" with a handheld magnet, engineered by @mariaingaramo.bsky.social.
We think/hope we can use it to turn arbitrary proteins (including drugs!) on and off in opaque creatures (including humans!).
bsky.app/profile/addg...
MagLOV is a fluorescent protein you can "turn off" with a handheld magnet, engineered by @mariaingaramo.bsky.social.
We think/hope we can use it to turn arbitrary proteins (including drugs!) on and off in opaque creatures (including humans!).
bsky.app/profile/addg...
Reposted by Oliver Grant
We have a new preprint on the receptor specificity of 2.3.4.4 H5 viruses. We introduced the hallmark Q226L mutation in several antigenic backgrounds and observed different phenotypes. #H5N1 #glycotime www.biorxiv.org/content/10.1...
The Q226L mutation can convert a highly pathogenic H5 2.3.4.4e virus to bind human-type receptors
H5Nx viruses continue to wreak havoc in avian and mammalian species worldwide. The virus distinguishes itself by the ability to replicate to high titers and transmit efficiently in a wide variety of h...
www.biorxiv.org
January 13, 2025 at 10:46 AM
We have a new preprint on the receptor specificity of 2.3.4.4 H5 viruses. We introduced the hallmark Q226L mutation in several antigenic backgrounds and observed different phenotypes. #H5N1 #glycotime www.biorxiv.org/content/10.1...
Figure 3 needs a strobe effect warning. I find deducing carbohydrate structure from ChemDraw images hard enough, I don't need this!
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Surface Structures of Group B Streptococcus Important in Human Immunity | Microbiology Spectrum
ABSTRACTThe surface of the Gram-positive opportunistic pathogen Streptococcus agalactiae,
or group B Streptococcus (GBS), harbors several carbohydrate and protein antigens
with the potential to be eff...
journals.asm.org
December 18, 2024 at 2:19 PM
Figure 3 needs a strobe effect warning. I find deducing carbohydrate structure from ChemDraw images hard enough, I don't need this!
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...