OHSU-MMI
@ohsummi.bsky.social
The Department for Molecular Microbiology and Immunology at Oregon Health and Science University
Reposted by OHSU-MMI
Can we improve peer review? We think we can! Check out an experiment I helped with as part of @solvingforsci.bsky.social 's mission to make science better.
And if you don't want to read the whole bioRxiv manuscript, here's an overview of the main findings:
solvingfor.org/news-posts-d...
And if you don't want to read the whole bioRxiv manuscript, here's an overview of the main findings:
solvingfor.org/news-posts-d...
November 5, 2025 at 11:25 PM
Can we improve peer review? We think we can! Check out an experiment I helped with as part of @solvingforsci.bsky.social 's mission to make science better.
And if you don't want to read the whole bioRxiv manuscript, here's an overview of the main findings:
solvingfor.org/news-posts-d...
And if you don't want to read the whole bioRxiv manuscript, here's an overview of the main findings:
solvingfor.org/news-posts-d...
Congratulations to the Rauch lab @rauchlab.bsky.social on their newest publication!
Check out our new publication, a collaboration with Giovanni Luchetti and Vishva Dixit @ Genentech.
We show that the E.coli effector NleL inhibits intestinal epithelial cell extrusion after #inflammasome activation via degrading the kinases ROCK1 and 2!!
www.nature.com/articles/s41...
Explainer 1/8
We show that the E.coli effector NleL inhibits intestinal epithelial cell extrusion after #inflammasome activation via degrading the kinases ROCK1 and 2!!
www.nature.com/articles/s41...
Explainer 1/8
Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion - Nature
The bacterial ubiquitin ligase NleL evades host defence mechanisms both by inhibiting pyroptosis and by preventing infected intestinal epithelial cells from being extruded into the lumen and expelled ...
www.nature.com
October 22, 2025 at 10:49 PM
Congratulations to the Rauch lab @rauchlab.bsky.social on their newest publication!
Last week we had another amazing department retreat, expertly organized by @laurenrodda.bsky.social and @jnpruneda.bsky.social . Thank you to our fantastic invited speaker @harmitmalik.bsky.social and all the trainees for a day of wonderful science discussions.
September 15, 2025 at 5:34 PM
Last week we had another amazing department retreat, expertly organized by @laurenrodda.bsky.social and @jnpruneda.bsky.social . Thank you to our fantastic invited speaker @harmitmalik.bsky.social and all the trainees for a day of wonderful science discussions.
Reposted by OHSU-MMI
Join us at the amazing Midwinter Conference of Immunologists in January 2025 in beautiful Asilomar!
🚨There is a travel grant for underrepresented trainees, apply now! www.cvent.com/c/abstracts/...
#blackinImmuno #BlackinMicro #Sacnas
🚨There is a travel grant for underrepresented trainees, apply now! www.cvent.com/c/abstracts/...
#blackinImmuno #BlackinMicro #Sacnas
September 8, 2025 at 3:59 PM
Join us at the amazing Midwinter Conference of Immunologists in January 2025 in beautiful Asilomar!
🚨There is a travel grant for underrepresented trainees, apply now! www.cvent.com/c/abstracts/...
#blackinImmuno #BlackinMicro #Sacnas
🚨There is a travel grant for underrepresented trainees, apply now! www.cvent.com/c/abstracts/...
#blackinImmuno #BlackinMicro #Sacnas
Reposted by OHSU-MMI
The Trump admin is erasing critical federal data - including climate trends, water quality, wildfire risk, public health stats, and pollution monitoring.
When the data goes dark, the American lives are at risk.
This is how To Sabatoge A Nation👇
zurl.co/slECM
When the data goes dark, the American lives are at risk.
This is how To Sabatoge A Nation👇
zurl.co/slECM
Trump’s Cuts Are Making Federal Data Disappear
Online tools that professionals use for everything from diagnosing diseases to calculating insurance payouts are going dark.
zurl.co
July 18, 2025 at 5:33 PM
The Trump admin is erasing critical federal data - including climate trends, water quality, wildfire risk, public health stats, and pollution monitoring.
When the data goes dark, the American lives are at risk.
This is how To Sabatoge A Nation👇
zurl.co/slECM
When the data goes dark, the American lives are at risk.
This is how To Sabatoge A Nation👇
zurl.co/slECM
Congratulations to Bahareh Ajami and her lab @baharehajami.bsky.social ! Dr. Ajami and her team of 6 are studying one of the most promising theories in ALS immunology today. alsnorthwest.org/research-app...
July 15, 2025 at 8:22 PM
Congratulations to Bahareh Ajami and her lab @baharehajami.bsky.social ! Dr. Ajami and her team of 6 are studying one of the most promising theories in ALS immunology today. alsnorthwest.org/research-app...
Congratulations to @tafesselab.bsky.social for promotion to Full Professor with tenure!!! Well deserved!
July 2, 2025 at 8:10 PM
Congratulations to @tafesselab.bsky.social for promotion to Full Professor with tenure!!! Well deserved!
Check out the mucosal Immunology podcast episode with MMI faculty member @rauchlab.bsky.social
It’s #MucosalMonday and the June episode of the Mucosal Immunology Podcast is out with @rauchlab.bsky.social @marionbrunck.bsky.social, @ashu-mangalam.bsky.social, @kknoop.bsky.social and more! Subscribe and follow on your favorite podcast platform. open.spotify.com/episode/5H1k...
Inflammasomes and Tuft Cells
Mucosal Immunology Podcast · Episode
open.spotify.com
June 30, 2025 at 4:51 PM
Check out the mucosal Immunology podcast episode with MMI faculty member @rauchlab.bsky.social
Reposted by OHSU-MMI
It’s finally out!
Started this project as a PhD student in the @holthuislab.bsky.social lab & finished by my PhD student. Full-circle moment and the end of an era. 😊
Thanks to Gaelen and everyone who made this happen. @ohsummi.bsky.social @ohsunews.bsky.social
pubmed.ncbi.nlm.nih.gov/40473211/
Started this project as a PhD student in the @holthuislab.bsky.social lab & finished by my PhD student. Full-circle moment and the end of an era. 😊
Thanks to Gaelen and everyone who made this happen. @ohsummi.bsky.social @ohsunews.bsky.social
pubmed.ncbi.nlm.nih.gov/40473211/
Characterization of C. elegans sphingomyelin synthases through heterologous expression - PubMed
Sphingomyelin (SM) is a major component of mammalian cell membranes and particularly abundant in the myelin sheath that surrounds nerve fibers. Its production is catalyzed by SM synthases SMS1 and SMS...
pubmed.ncbi.nlm.nih.gov
June 10, 2025 at 2:20 AM
It’s finally out!
Started this project as a PhD student in the @holthuislab.bsky.social lab & finished by my PhD student. Full-circle moment and the end of an era. 😊
Thanks to Gaelen and everyone who made this happen. @ohsummi.bsky.social @ohsunews.bsky.social
pubmed.ncbi.nlm.nih.gov/40473211/
Started this project as a PhD student in the @holthuislab.bsky.social lab & finished by my PhD student. Full-circle moment and the end of an era. 😊
Thanks to Gaelen and everyone who made this happen. @ohsummi.bsky.social @ohsunews.bsky.social
pubmed.ncbi.nlm.nih.gov/40473211/
Reposted by OHSU-MMI
Excited to share our latest preprint! Using integrated global lipidomics and proteomics, we show that SARS-CoV-2 variants induce conserved changes in host lipid metabolism pathways. Congrats to Scotty for leading the work. @ohsummi.bsky.social @ohsunews.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Multi-Omic Profiling Identifies Conserved Metabolic Pathways Critical for SARS-CoV-2 Variants Infection
The rapid evolution of SARS-CoV-2 has led to the emergence of numerous variants with en-hanced transmissibility and immune evasion. Despite widespread vaccination, infections persist, and the mechanis...
www.biorxiv.org
June 4, 2025 at 3:45 PM
Excited to share our latest preprint! Using integrated global lipidomics and proteomics, we show that SARS-CoV-2 variants induce conserved changes in host lipid metabolism pathways. Congrats to Scotty for leading the work. @ohsummi.bsky.social @ohsunews.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
This cool study on compounds that can kill Plasmodium inside mosquitoes and can be applied to bed-nets was contributed to by the Riscoe lab at MMI!
Excellent new study from the Catteruccia lab, co-led by Alexandra Probst and Douglas Paton www.nature.com/articles/s41...
In vivo screen of Plasmodium targets for mosquito-based malaria control - Nature
An in vivo screen of small-molecule compounds to inhibit the mosquito-stage development of Plasmodium identified hits that can be incorporated into bed nets and led to effective parasite killing in th...
www.nature.com
May 23, 2025 at 11:40 PM
This cool study on compounds that can kill Plasmodium inside mosquitoes and can be applied to bed-nets was contributed to by the Riscoe lab at MMI!
Congratulations to the Tafesse lab on their recent publication on the effects on timing in repeat vaccinations!
Have you ever wondered how repeated vaccination shapes our immune responses, and whether timing between doses matters? Check out our latest work!
@ohsunews.bsky.social @ohsummi.bsky.social
www.nature.com/articles/s43...
@ohsunews.bsky.social @ohsummi.bsky.social
www.nature.com/articles/s43...
Immune imprinting and vaccine interval determine antibody responses to monovalent XBB.1.5 COVID-19 vaccination - Communications Medicine
Wrynla et al. assess humoral immunity elicited by the monovalent XBB.1.5 COVID-19 vaccine in participants who did or did not previously receive the bivalent Wuhan-Hu-1/BA.4-5 vaccine. They find that i...
www.nature.com
May 19, 2025 at 11:41 PM
Congratulations to the Tafesse lab on their recent publication on the effects on timing in repeat vaccinations!
Congratulations to the groups of Eric Barklis and @tafesselab.bsky.social for reporting an analysis of factors that regulate HIV-1 fusion in reverse pmc.ncbi.nlm.nih.gov/articles/PMC...
Analysis of Factors That Regulate HIV-1 Fusion in Reverse
Based on observations that HIV-1 envelope (Env) proteins on the surfaces of cells have the capacity to fuse with neighboring cells or enveloped viruses that express CD4 receptors and CXCR4 co-receptor...
pmc.ncbi.nlm.nih.gov
April 30, 2025 at 2:25 PM
Congratulations to the groups of Eric Barklis and @tafesselab.bsky.social for reporting an analysis of factors that regulate HIV-1 fusion in reverse pmc.ncbi.nlm.nih.gov/articles/PMC...
Reposted by OHSU-MMI
Excitement plus!! The full program is online for the upcoming GRC Salmonella Biology and Pathogenesis meeting. There is still some room in the schedule for short talks, which will be chosen from submitted abstracts. Submit your abstract, if you haven't done so already.
www.grc.org/salmonella-b...
www.grc.org/salmonella-b...
kermit the frog from the muppet show is standing in front of a red curtain .
ALT: kermit the frog from the muppet show is standing in front of a red curtain .
media.tenor.com
April 4, 2025 at 2:35 PM
Excitement plus!! The full program is online for the upcoming GRC Salmonella Biology and Pathogenesis meeting. There is still some room in the schedule for short talks, which will be chosen from submitted abstracts. Submit your abstract, if you haven't done so already.
www.grc.org/salmonella-b...
www.grc.org/salmonella-b...
Reposted by OHSU-MMI
Federal funding of biomedical research has been a remarkably successful partnership, with benefits that are so intertwined in our daily lives that they can be easy to take for granted.
So what will we lose if the U.S. continues to defund research?
theconversation.com/cuts-to-scie...
So what will we lose if the U.S. continues to defund research?
theconversation.com/cuts-to-scie...
Cuts to science research funding cut American lives short − federal support is essential for medical breakthroughs
The National Institutes of Health has been integral to scientific progress in treating countless human diseases. Without its support, patients will ultimately pay the price.
theconversation.com
March 28, 2025 at 4:08 PM
Federal funding of biomedical research has been a remarkably successful partnership, with benefits that are so intertwined in our daily lives that they can be easy to take for granted.
So what will we lose if the U.S. continues to defund research?
theconversation.com/cuts-to-scie...
So what will we lose if the U.S. continues to defund research?
theconversation.com/cuts-to-scie...
Thank you to Adair Borges @adairb.bsky.social for giving a great talk about her exciting science at @arcadiascience.com and for discussing careers in biotech with our trainees!
March 25, 2025 at 5:01 PM
Thank you to Adair Borges @adairb.bsky.social for giving a great talk about her exciting science at @arcadiascience.com and for discussing careers in biotech with our trainees!
New research from the @jnpruneda.bsky.social and @michaelnadbio.bsky.social labs:
In this collaborative work, the groups show that ubiquitin is directly linked to mono-ADP-ribose modifications on proteins, a process called “MARUbylation".
www.embopress.org/doi/full/10....
In this collaborative work, the groups show that ubiquitin is directly linked to mono-ADP-ribose modifications on proteins, a process called “MARUbylation".
www.embopress.org/doi/full/10....
Ubiquitin is directly linked via an ester to protein-conjugated mono-ADP-ribose | The EMBO Journal
imageimageCertain E3 ligases have been found to ubiquitylate hydroxyl groups on free NAD+ and
ADP-ribose in vitro, but the in vivo occurrence of this dual post-translational modification
has remained ...
www.embopress.org
March 20, 2025 at 8:49 PM
New research from the @jnpruneda.bsky.social and @michaelnadbio.bsky.social labs:
In this collaborative work, the groups show that ubiquitin is directly linked to mono-ADP-ribose modifications on proteins, a process called “MARUbylation".
www.embopress.org/doi/full/10....
In this collaborative work, the groups show that ubiquitin is directly linked to mono-ADP-ribose modifications on proteins, a process called “MARUbylation".
www.embopress.org/doi/full/10....
New publication out of the @rauchlab.bsky.social at OHSU MMI
First authors Madeline Churchill and Ankit Pandeya @nkeet50.bsky.social from @rauchlab.bsky.social show that tuft cells, known for their role in anti-parasite defenses, can also contribute to anti-bacterial responses in the small intestine. rupress.org/jem/article/...
#InfectiousDisease
#InfectiousDisease
March 14, 2025 at 9:56 PM
New publication out of the @rauchlab.bsky.social at OHSU MMI
Reposted by OHSU-MMI
@laurenrodda.bsky.social, @nicelab.bsky.social , @jnpruneda.bsky.social and I wrote an OpEd on the impacts of NIH cuts on Oregon: www.bizjournals.com/portland/new...
It was signed by over 450 OHSU researchers!
It’s unfortunately paywalled, DM me if you’d like a gift link or a pdf of it.
It was signed by over 450 OHSU researchers!
It’s unfortunately paywalled, DM me if you’d like a gift link or a pdf of it.
Opinion: Scientists on how NIH cuts will hurt all Oregonians. - Portland Business Journal
"These cuts will cripple biomedical research and drug development in the U.S. We should be investing more in science, not less."
www.bizjournals.com
March 4, 2025 at 9:24 PM
@laurenrodda.bsky.social, @nicelab.bsky.social , @jnpruneda.bsky.social and I wrote an OpEd on the impacts of NIH cuts on Oregon: www.bizjournals.com/portland/new...
It was signed by over 450 OHSU researchers!
It’s unfortunately paywalled, DM me if you’d like a gift link or a pdf of it.
It was signed by over 450 OHSU researchers!
It’s unfortunately paywalled, DM me if you’d like a gift link or a pdf of it.
Reposted by OHSU-MMI
Come join us! No excuses!!!
Only 1 week until the Stand Up For Science rally at the OR capitol! We'll be hearing from Rep. Andrea Salinas and at least 4 renowned scientists. Rally with me to defend science from censorship and cuts! Let's make this big! #sciencenotsilence #standupforscience2025 @standupforscience.bsky.social
February 28, 2025 at 3:53 AM
Come join us! No excuses!!!
Reposted by OHSU-MMI
NIH funding freeze stalls $1.5 billion in medical research grant funding : Shots - Health News www.npr.org/sections/sho...
NIH funding freeze stalls applications on $1.5 billion in medical research funds
The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.
www.npr.org
February 22, 2025 at 6:05 PM
NIH funding freeze stalls $1.5 billion in medical research grant funding : Shots - Health News www.npr.org/sections/sho...
Reposted by OHSU-MMI
Join me in standing up for science on March 7. in Salem, Oregon!
Tell your friends and bring them too!! This is a nation wide event, with every state having at least one gathering. We need to show up strong!!!
standupforscience2025.org
Tell your friends and bring them too!! This is a nation wide event, with every state having at least one gathering. We need to show up strong!!!
standupforscience2025.org
February 21, 2025 at 1:23 AM
Join me in standing up for science on March 7. in Salem, Oregon!
Tell your friends and bring them too!! This is a nation wide event, with every state having at least one gathering. We need to show up strong!!!
standupforscience2025.org
Tell your friends and bring them too!! This is a nation wide event, with every state having at least one gathering. We need to show up strong!!!
standupforscience2025.org
Congratulations Ankit!!
Huge gratulations to Ankit @nkeet50.bsky.social , postdoc in the lab, for receiving the IRACDA fellowship, a fantastic mechanism that rewards scientific excellence and teaching potential.
My trainees are crushing it, 3/4 of them are self-funded! I wish that would rub off on my grant applications...😬
My trainees are crushing it, 3/4 of them are self-funded! I wish that would rub off on my grant applications...😬
February 12, 2025 at 6:09 PM
Congratulations Ankit!!
@laurenrodda.bsky.social and her trainee @georgecelis.bsky.social from our department, together with @joshuamoreau.bsky.social , Rashi Yadav and Abrar Samiea from @ohsuknight.bsky.social wrote a review on B-cells, check it out!
NEW Review: B cells in non-lymphoid tissues
by Abrar Samiea @georgecelis.bsky.social Rashi Yadav @laurenrodda.bsky.social @joshuamoreau.bsky.social
Highlighting new insights into mechanisms of tissue B cell function and immunotherapeutic targets
#immunology #immunosky
by Abrar Samiea @georgecelis.bsky.social Rashi Yadav @laurenrodda.bsky.social @joshuamoreau.bsky.social
Highlighting new insights into mechanisms of tissue B cell function and immunotherapeutic targets
#immunology #immunosky
B cells in non-lymphoid tissues - Nature Reviews Immunology
B cells are major drivers of systemic immunity, but they also act locally in non-lymphoid organs. This Review highlights new insights into mechanisms of tissue B cell function as well as efforts to le...
www.nature.com
February 6, 2025 at 9:03 PM
@laurenrodda.bsky.social and her trainee @georgecelis.bsky.social from our department, together with @joshuamoreau.bsky.social , Rashi Yadav and Abrar Samiea from @ohsuknight.bsky.social wrote a review on B-cells, check it out!
Reposted by OHSU-MMI
If you are female PhD faculty in #GIresearch ( #basicscience or #translational), we invite you to join WINGS, Women Innovating in Gastrointestinal Science, a community for career development, mentorship & networking. Please fill out the form on our website and RT! bit.ly/4fHBWfj #GISky #Gastrosky
WINGS | edelblumlab
Women Innovating in Gastrointestinal Science is a group of basic & translational GI researchers that provides a community to connect, empower and inspire female faculty.
www.edelblumlab.com
January 6, 2025 at 9:29 PM
If you are female PhD faculty in #GIresearch ( #basicscience or #translational), we invite you to join WINGS, Women Innovating in Gastrointestinal Science, a community for career development, mentorship & networking. Please fill out the form on our website and RT! bit.ly/4fHBWfj #GISky #Gastrosky