Karolin Luger
@nucleosomepolice.bsky.social
Chromatin and cryoEM afficionada. Still a fan of crystallography. Avid Colorado hiker. Will call out ugly nucleosome cartoons. Come for the science, stay for the mountain pictures and snark. Opinions and snark are my own.
Pinned
Histone PARylation factor 1: a review of its role in the DNA damage response
Abstract. Although poly-(ADP ribose) polymerase 1 (PARP1) and PARylation of histones have been known for over 50 years and have been successfully targeted
academic.oup.com
Beautiful review from J. Rudolph on Histone PARylation factor 1: a review of its role in the DNA damage response url: academic.oup.com/nar/article/...
add my WTF to the collective. WTF.
The former oil executive/DOE official who held the all-staff meeting announcing the change repeatedly told the scientists who work on clean energy that she "hates" clean energy.
'A Collective WTF': National Renewable Energy Laboratory Gets a Trumpian Name Change
NREL employees, many of whom joined the lab specifically to work toward its clean energy mission, are not happy about the oil-soaked leadership's moves.
www.gravityisgone.com
December 2, 2025 at 10:29 PM
add my WTF to the collective. WTF.
if y'all arent follwing @frwildflowers.bsky.social you are missing out on fantastic #plant pictures native to #colorado.
Oenothera caespitosa, our Tufted Evening Primrose, blooming with spider in Boulder Canyon #nativeplants
#FallBackFlowers #FallBack to June 2 🌿
#FallBackFlowers #FallBack to June 2 🌿
December 2, 2025 at 5:34 PM
if y'all arent follwing @frwildflowers.bsky.social you are missing out on fantastic #plant pictures native to #colorado.
you go girls! Austrian nuns raise a ruckus. www.npr.org/2025/12/01/g...
Austria's rebel nuns refuse to give up Instagram to stay in their convent
The trio of octogenarian nuns gained global fame after fleeing their care home and breaking into their former convent. Now their superior has asked the Vatican to intercede in the dispute.
www.npr.org
December 2, 2025 at 5:15 PM
you go girls! Austrian nuns raise a ruckus. www.npr.org/2025/12/01/g...
Reposted by Karolin Luger
Yesterday was #WorldAIDSDay. It's the first time since its inception in 1988 that the US has not formally recognized it.
December 2, 2025 at 4:55 PM
Yesterday was #WorldAIDSDay. It's the first time since its inception in 1988 that the US has not formally recognized it.
Reposted by Karolin Luger
Oenothera caespitosa, our Tufted Evening Primrose, blooming with spider in Boulder Canyon #nativeplants
#FallBackFlowers #FallBack to June 2 🌿
#FallBackFlowers #FallBack to June 2 🌿
December 2, 2025 at 3:23 PM
Oenothera caespitosa, our Tufted Evening Primrose, blooming with spider in Boulder Canyon #nativeplants
#FallBackFlowers #FallBack to June 2 🌿
#FallBackFlowers #FallBack to June 2 🌿
immigrants... get the job done!
Electronic engineer Joy Lim Arthur was born 90 years ago today in Manila, traveling to the United States in the 1950s for college. After graduation, she spent her career working for the US Army on methods to protect soldiers from electronic warfare.
#WomenInSTEM #Engineering 🧪🔌
#WomenInSTEM #Engineering 🧪🔌
December 2, 2025 at 3:05 PM
immigrants... get the job done!
Reposted by Karolin Luger
New York Times article on science funding with some depressing but familiar curves with interactive graphics.
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
The U.S. Is Funding Fewer Grants in Every Area of Science and Medicine (Gift Article)
A quiet policy change means the government is making fewer bets on long-term science.
www.nytimes.com
December 2, 2025 at 11:57 AM
New York Times article on science funding with some depressing but familiar curves with interactive graphics.
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
Question to y'all #protein experts: we used to do limited proteolysis, then N-terminal sequencing to see where domains are in proteins. no more N-terminal sequencing. 1) why doesnt anyone do Edman any more? 2) what is the most accurate / feasible / cost effective way to do this now?
December 1, 2025 at 1:40 PM
Question to y'all #protein experts: we used to do limited proteolysis, then N-terminal sequencing to see where domains are in proteins. no more N-terminal sequencing. 1) why doesnt anyone do Edman any more? 2) what is the most accurate / feasible / cost effective way to do this now?
Reposted by Karolin Luger
The world has lost a giant of virology, molecular biology and science advocacy
David Baltimore’s obituary by Stephen Goff www.nature.com/articles/d41...
David Baltimore’s obituary by Stephen Goff www.nature.com/articles/d41...
David Baltimore obituary: virologist whose enzyme discovery transformed understanding of cancer and HIV/AIDS
The protein, reverse transcriptase, has become an essential tool for making DNA copies of RNA.
www.nature.com
December 1, 2025 at 1:25 PM
The world has lost a giant of virology, molecular biology and science advocacy
David Baltimore’s obituary by Stephen Goff www.nature.com/articles/d41...
David Baltimore’s obituary by Stephen Goff www.nature.com/articles/d41...
Reposted by Karolin Luger
And now confirmation of the liquid nature of viral factories for poxviridae.
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Poxvirus H5 mediates the formation of liquid-liquid phase separation condensates which promote virus factory assembly
Author summary In this study, we investigate the role of a protein called H5 from the vaccinia virus in the formation of structures inside infected cells known as viral factories. These viral factorie...
journals.plos.org
November 21, 2025 at 6:00 AM
And now confirmation of the liquid nature of viral factories for poxviridae.
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
i am here for this
November 30, 2025 at 3:52 PM
i am here for this
Reposted by Karolin Luger
Here’s this year’s Books We Love—but thanks to lots of work by lots of people, you can also look over all the Books We Love years back to 2013. It’s a remarkable project, and I can say that because I have nothing to do with it. (/fin)
Books We Love
Here are 380+ great reads from 2025 handpicked just for you by NPR staffers and trusted critics.
apps.npr.org
November 30, 2025 at 1:54 PM
Here’s this year’s Books We Love—but thanks to lots of work by lots of people, you can also look over all the Books We Love years back to 2013. It’s a remarkable project, and I can say that because I have nothing to do with it. (/fin)
Reposted by Karolin Luger
It’s officially Denver’s first snow of the season!
A whopping 0.2” at DIA = we’re on the board. First measurable snow since April 18 (225 days).
❄️ 2nd-latest first snow of the season (12/10/21).
❄️ 225 snowless days = T-3rd-longest snowless on record for Denver.
#COwx
A whopping 0.2” at DIA = we’re on the board. First measurable snow since April 18 (225 days).
❄️ 2nd-latest first snow of the season (12/10/21).
❄️ 225 snowless days = T-3rd-longest snowless on record for Denver.
#COwx
November 29, 2025 at 2:51 PM
It’s officially Denver’s first snow of the season!
A whopping 0.2” at DIA = we’re on the board. First measurable snow since April 18 (225 days).
❄️ 2nd-latest first snow of the season (12/10/21).
❄️ 225 snowless days = T-3rd-longest snowless on record for Denver.
#COwx
A whopping 0.2” at DIA = we’re on the board. First measurable snow since April 18 (225 days).
❄️ 2nd-latest first snow of the season (12/10/21).
❄️ 225 snowless days = T-3rd-longest snowless on record for Denver.
#COwx
Reposted by Karolin Luger
This!!!!
I was one of those immigrants, and we commit fewer crimes than people born here.
“Trump says he wants to “permanently pause migration” from poorer nations and is promising to seek to expel millions of immigrants from the US by revoking their legal status.”
apnews.com/article/trum...
“Trump says he wants to “permanently pause migration” from poorer nations and is promising to seek to expel millions of immigrants from the US by revoking their legal status.”
apnews.com/article/trum...
Trump says he wants to 'permanently pause' migration to the US from poorer countries
President Donald Trump says he wants to “permanently pause migration” from poorer nations and is promising to seek to expel millions of immigrants from the United States by revoking their legal status...
apnews.com
November 28, 2025 at 3:28 PM
This!!!!
Reposted by Karolin Luger
An #Amazon#dart#frogsits on the end of a plant amongst the damp undergrowth of the #forest.Its #vibrantcolours mask how small this #creatureis. Shot using #UKNikon#macro.See more #photographyvia www.darrensmith.org.uk #animalphotography#amphibian#macrophotography
November 27, 2025 at 8:00 PM
An #Amazon#dart#frogsits on the end of a plant amongst the damp undergrowth of the #forest.Its #vibrantcolours mask how small this #creatureis. Shot using #UKNikon#macro.See more #photographyvia www.darrensmith.org.uk #animalphotography#amphibian#macrophotography
Reposted by Karolin Luger
Thats 216 biomedical PhD students for their whole degree, or 140 2 year R21 grants, or 30 5 year R01 grants, or one fired football coach...
FIFTY FOUR MILLION DOLLARS, to fire a football coach at a state university
SOURCE: LSU has given Brian Kelly formal written notice that he has been terminated without cause and that it will fulfill the obligation of his nearly $54 million buyout.
November 27, 2025 at 3:45 AM
Thats 216 biomedical PhD students for their whole degree, or 140 2 year R21 grants, or 30 5 year R01 grants, or one fired football coach...
Reposted by Karolin Luger
just awful
This is so tragic. Faith brought many other women into the political arena, training them and mentoring them on a local to national level.
Horrible news tonight...
Colorado state senator killed in multi-vehicle crash south of Denver coloradosun.com/2025/11/26/f... #copolitics #coleg
Colorado state senator killed in multi-vehicle crash south of Denver coloradosun.com/2025/11/26/f... #copolitics #coleg
November 27, 2025 at 2:15 PM
just awful
Reposted by Karolin Luger
This is so tragic. Faith brought many other women into the political arena, training them and mentoring them on a local to national level.
Horrible news tonight...
Colorado state senator killed in multi-vehicle crash south of Denver coloradosun.com/2025/11/26/f... #copolitics #coleg
Colorado state senator killed in multi-vehicle crash south of Denver coloradosun.com/2025/11/26/f... #copolitics #coleg
Colorado state senator killed in multi-vehicle crash south of Denver
Faith Winter, a Broomfield Democrat, was a fierce advocate for transit. She was entering her 12th and final year as a state lawmaker.
coloradosun.com
November 27, 2025 at 2:05 PM
This is so tragic. Faith brought many other women into the political arena, training them and mentoring them on a local to national level.
Reposted by Karolin Luger
Hi Bluesky! I’m a molecular virologist studying how innate immune defences restrict cross-species transmission and shape disease severity.
I just joined, so reposts appreciated to help me reconnect with virology, immunology, and host–pathogen interaction folks.
(whiteboard art from Zhuonan Li)
I just joined, so reposts appreciated to help me reconnect with virology, immunology, and host–pathogen interaction folks.
(whiteboard art from Zhuonan Li)
November 26, 2025 at 5:12 PM
Hi Bluesky! I’m a molecular virologist studying how innate immune defences restrict cross-species transmission and shape disease severity.
I just joined, so reposts appreciated to help me reconnect with virology, immunology, and host–pathogen interaction folks.
(whiteboard art from Zhuonan Li)
I just joined, so reposts appreciated to help me reconnect with virology, immunology, and host–pathogen interaction folks.
(whiteboard art from Zhuonan Li)
Reposted by Karolin Luger
Identification of Previously Unknown DNA-Binding Proteins Using DNA Affinity/Pull-Down Methods Followed by Mass Spectrometry
Jutras, Babb, Jusufovic, Krusenstjerna, Saylor, Verma, and Stevenson
Current Protocols 2025, 5:e70264
doi: 10.1002/cpz1.70264
#MicroSky
Jutras, Babb, Jusufovic, Krusenstjerna, Saylor, Verma, and Stevenson
Current Protocols 2025, 5:e70264
doi: 10.1002/cpz1.70264
#MicroSky
November 26, 2025 at 4:00 PM
Identification of Previously Unknown DNA-Binding Proteins Using DNA Affinity/Pull-Down Methods Followed by Mass Spectrometry
Jutras, Babb, Jusufovic, Krusenstjerna, Saylor, Verma, and Stevenson
Current Protocols 2025, 5:e70264
doi: 10.1002/cpz1.70264
#MicroSky
Jutras, Babb, Jusufovic, Krusenstjerna, Saylor, Verma, and Stevenson
Current Protocols 2025, 5:e70264
doi: 10.1002/cpz1.70264
#MicroSky
Will you look at this. The world is shite but then there are azalea...
November 27, 2025 at 3:22 AM
Will you look at this. The world is shite but then there are azalea...
i'd gladly wear nice clothes when flying if airplanes werent as filthy and crowded. As long as there is a high probability that I sit in a seat where somebody has parked their street shoes, and my neighbor who sits 1 inch away from me spills their OJ on me, i wont put on my finery.
Sorry, Sean Duffy, the age of suits was not the golden age of airplane civility. To restore order in the skies, we need to look even further back, @petridishes.bsky.social writes:
The Biggest Problem With Air Travel: Pajamas?
The transportation secretary seems to think fashion will solve flying’s problems.
bit.ly
November 26, 2025 at 11:29 PM
i'd gladly wear nice clothes when flying if airplanes werent as filthy and crowded. As long as there is a high probability that I sit in a seat where somebody has parked their street shoes, and my neighbor who sits 1 inch away from me spills their OJ on me, i wont put on my finery.