Nnennaya Kanu
@nnennayakanu.bsky.social
Chief Scientific Officer, CRUK Lung Cancer Centre of Excellence
Reposted by Nnennaya Kanu
Scientists at the Crick, @ucl.ac.uk , @uclh.bsky.social and Personalis have found that a test to detect circulating tumour DNA can help predict the outcome of lung cancer treatments 🧪
First authors: James Black, Gabor Bartha
Senior author: @charlesswanton.bsky.social
www.crick.ac.uk/news-and-rep...
First authors: James Black, Gabor Bartha
Senior author: @charlesswanton.bsky.social
www.crick.ac.uk/news-and-rep...
Tumour DNA in the blood can predict lung cancer outcome
Scientists from the Francis Crick Institute, UCL, UCLH and Personalis have found that a test to detect circulating tumour DNA can predict lung cancer outcome in a Cancer Research UK-funded study.
www.crick.ac.uk
January 13, 2025 at 11:36 AM
Scientists at the Crick, @ucl.ac.uk , @uclh.bsky.social and Personalis have found that a test to detect circulating tumour DNA can help predict the outcome of lung cancer treatments 🧪
First authors: James Black, Gabor Bartha
Senior author: @charlesswanton.bsky.social
www.crick.ac.uk/news-and-rep...
First authors: James Black, Gabor Bartha
Senior author: @charlesswanton.bsky.social
www.crick.ac.uk/news-and-rep...
Reposted by Nnennaya Kanu
And lots of cool cancer genomics/genetics this week in Nature too, www.nature.com/articles/s41... 🧪
Complex rearrangements fuel ER+ and HER2+ breast tumours - Nature
A study identifies three dominant genomic archetypes of breast cancer induced by discrete mutational processes, describing a continuum of genomic profiles and detailing the mechanisms underlying the p...
www.nature.com
January 9, 2025 at 7:53 PM
And lots of cool cancer genomics/genetics this week in Nature too, www.nature.com/articles/s41... 🧪
Reposted by Nnennaya Kanu
New pre-print alert 🚨 Interested in what @ikafetzo.bsky.social learned about DNA hypomethylation in cancer from investigating surprising gains DNA methylation in DNMT1 KO cells? Read all about it here: www.biorxiv.org/content/10.1...
For a quick summary see this 🧵 1/8 #epigenetics
For a quick summary see this 🧵 1/8 #epigenetics
DNMT1 loss leads to hypermethylation of a subset of late replicating domains by DNMT3A
Loss of DNA methylation is a hallmark of cancer that is proposed to promote carcinogenesis through gene expression alterations, retrotransposon activation and induction of genomic instability. Cancer-...
www.biorxiv.org
January 9, 2025 at 4:53 PM
New pre-print alert 🚨 Interested in what @ikafetzo.bsky.social learned about DNA hypomethylation in cancer from investigating surprising gains DNA methylation in DNMT1 KO cells? Read all about it here: www.biorxiv.org/content/10.1...
For a quick summary see this 🧵 1/8 #epigenetics
For a quick summary see this 🧵 1/8 #epigenetics
Reposted by Nnennaya Kanu
We hope this is useful for the field. Our paper can be found here:
www.nature.com/articles/s41...
Or the readcube link below:
rdcu.be/d5gAe
Finally we wish everyone a happy new year!!! 14/end
www.nature.com/articles/s41...
Or the readcube link below:
rdcu.be/d5gAe
Finally we wish everyone a happy new year!!! 14/end
TRACERx analysis identifies a role for FAT1 in regulating chromosomal instability and whole-genome doubling via Hippo signalling - Nature Cell Biology
Lu et al. perform systematic functional analyses using data from the TRACERx cohort of patients with non-small-cell lung cancer and delineate how FAT1 regulates homologous recombination repair, chromo...
www.nature.com
January 3, 2025 at 11:24 AM
We hope this is useful for the field. Our paper can be found here:
www.nature.com/articles/s41...
Or the readcube link below:
rdcu.be/d5gAe
Finally we wish everyone a happy new year!!! 14/end
www.nature.com/articles/s41...
Or the readcube link below:
rdcu.be/d5gAe
Finally we wish everyone a happy new year!!! 14/end
Reposted by Nnennaya Kanu
Finally, a huge thank you to all our funders without which our work would not be possible @crick.ac.uk, Genomics England, @cancerresearchuk.org, @uclh.bsky.social @bcrfcure.bsky.social, Danish Cancer Society, UCL Cancer Institute and @cruk-cityoflondon.bsky.social. 13/14
January 3, 2025 at 11:24 AM
Finally, a huge thank you to all our funders without which our work would not be possible @crick.ac.uk, Genomics England, @cancerresearchuk.org, @uclh.bsky.social @bcrfcure.bsky.social, Danish Cancer Society, UCL Cancer Institute and @cruk-cityoflondon.bsky.social. 13/14
Reposted by Nnennaya Kanu
I am happy to see that our paper is out just before the new year!!! We have a lab tweetorial out for anyone interested! Got to say it was an exciting journey working with CharlesSwanton, the wider TRACERx and PEACE team, and @nnennayakanu.bsky.social Jiri Bartek labs. 🧵1/14
💫NEW by Lu, Bartek, Kanu & Swanton & co: analyses of data from the TRACERx cohort of #LungCancer patients delineate how FAT1 regulates homologous recombination repair, chromosomal instability & whole-genome doubling with distinct mechanisms.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
TRACERx analysis identifies a role for FAT1 in regulating chromosomal instability and whole-genome doubling via Hippo signalling - Nature Cell Biology
Lu et al. perform systematic functional analyses using data from the TRACERx cohort of patients with non-small-cell lung cancer and delineate how FAT1 regulates homologous recombination repair, chromo...
www.nature.com
January 3, 2025 at 11:24 AM
I am happy to see that our paper is out just before the new year!!! We have a lab tweetorial out for anyone interested! Got to say it was an exciting journey working with CharlesSwanton, the wider TRACERx and PEACE team, and @nnennayakanu.bsky.social Jiri Bartek labs. 🧵1/14
Reposted by Nnennaya Kanu
