Nneka Ufere, MD MSCE
@nnekauferemd.bsky.social
Transplant Hepatologist at Massachusetts General Hospital. My mission statement: Increase healthcare system empathy for patients with cirrhosis #LiverPal #palliativehepatology #geripal
#hpm #hapc #medsky #LiverSky
#hpm #hapc #medsky #LiverSky
Today we enrolled our 100th patient into our LiverPal RCT assessing whether longitudinal inpatient palliative care can improve outcomes for hospitalized patients with liver disease and their families. What a Good Friday! #palliativehepatology #livertwitter #liversky
April 18, 2025 at 6:06 PM
Today we enrolled our 100th patient into our LiverPal RCT assessing whether longitudinal inpatient palliative care can improve outcomes for hospitalized patients with liver disease and their families. What a Good Friday! #palliativehepatology #livertwitter #liversky
Reposted by Nneka Ufere, MD MSCE
Harvard redid its whole homepage to push back against the administration’s demands. I mean, this is just a website but I think it’s kind of a great PR move: www.harvard.edu
Harvard University
Harvard University is devoted to excellence in teaching, learning, and research, and to developing leaders who make a difference globally.
www.harvard.edu
April 14, 2025 at 7:10 PM
Harvard redid its whole homepage to push back against the administration’s demands. I mean, this is just a website but I think it’s kind of a great PR move: www.harvard.edu
Reposted by Nneka Ufere, MD MSCE
How many hospitalized patients need care in the ICU? How many of them survive? What interventions do they receive there?
These are some of the questions I had two years ago while trying to write the "background" section for my masters thesis. But I couldn't find the answers... they did not exist.
These are some of the questions I had two years ago while trying to write the "background" section for my masters thesis. But I couldn't find the answers... they did not exist.
Following pandemic-era changes, many ICU outcome measures returned to prior levels.
The rates of mechanical ventilation have declined even further, while vasopressor use remained elevated above 2010s rates.
#MedSky https://ja.ma/42Jl3NO
The rates of mechanical ventilation have declined even further, while vasopressor use remained elevated above 2010s rates.
#MedSky https://ja.ma/42Jl3NO
Life Support and Outcomes Among ICU Patients
This cohort study uses data from US health systems continuously contributing to the Epic Cosmos database from 2014-2023 to characterize changes in intensive care unit (ICU) outcomes (ICU length of stay; use of mechanical ventilation or vasopressors; in-hospital mortality) and use of life support...
ja.ma
April 14, 2025 at 9:41 PM
How many hospitalized patients need care in the ICU? How many of them survive? What interventions do they receive there?
These are some of the questions I had two years ago while trying to write the "background" section for my masters thesis. But I couldn't find the answers... they did not exist.
These are some of the questions I had two years ago while trying to write the "background" section for my masters thesis. But I couldn't find the answers... they did not exist.
As hepatologists, there are few things more devastating and very preventable that we see than HBV reactivation. If you are about to start your patient on an immunosuppressant, please keep this figure in mind. #LiverSky #MedSky
https://buff.ly/4gaKqf7
https://buff.ly/4gaKqf7
January 23, 2025 at 3:33 PM
As hepatologists, there are few things more devastating and very preventable that we see than HBV reactivation. If you are about to start your patient on an immunosuppressant, please keep this figure in mind. #LiverSky #MedSky
https://buff.ly/4gaKqf7
https://buff.ly/4gaKqf7
Reposted by Nneka Ufere, MD MSCE
January 17, 2025 at 1:28 PM
Reposted by Nneka Ufere, MD MSCE
Albumin is the closest thing to a "universal remedy" in cirrhosis
We use it to treat different complications, with good evidence but also with debatable or negative evidence
Excellent analysis by Jonel Trebicka & @ggarciatsao.bsky.social
doi.org/10.1097/hep.0000000000000521
#LiverSky
We use it to treat different complications, with good evidence but also with debatable or negative evidence
Excellent analysis by Jonel Trebicka & @ggarciatsao.bsky.social
doi.org/10.1097/hep.0000000000000521
#LiverSky
January 4, 2025 at 11:11 AM
Albumin is the closest thing to a "universal remedy" in cirrhosis
We use it to treat different complications, with good evidence but also with debatable or negative evidence
Excellent analysis by Jonel Trebicka & @ggarciatsao.bsky.social
doi.org/10.1097/hep.0000000000000521
#LiverSky
We use it to treat different complications, with good evidence but also with debatable or negative evidence
Excellent analysis by Jonel Trebicka & @ggarciatsao.bsky.social
doi.org/10.1097/hep.0000000000000521
#LiverSky
Just created a document titled "R01 SA page".
So it begins. Both nervous but also really excited to think big.
Advice, thoughts, prayers, etc. welcome!
#LiverSky
So it begins. Both nervous but also really excited to think big.
Advice, thoughts, prayers, etc. welcome!
#LiverSky
January 3, 2025 at 6:43 PM
Just created a document titled "R01 SA page".
So it begins. Both nervous but also really excited to think big.
Advice, thoughts, prayers, etc. welcome!
#LiverSky
So it begins. Both nervous but also really excited to think big.
Advice, thoughts, prayers, etc. welcome!
#LiverSky
Reposted by Nneka Ufere, MD MSCE
“A donor wanted to give $2 million to my lab, but only wanted to allow a maximum 10 percent to go to indirect cost recovery. And the school declined to receive the $2 million because they wanted at minimum, I believe it was 20 percent.”
www.harvardmagazine.com/2025/01/harv...
www.harvardmagazine.com/2025/01/harv...
Harvard Professors Leaving for Private Sector Research | Harvard Magazine
Three distinguished scientists on leaving academia to advance biomedical research
www.harvardmagazine.com
December 25, 2024 at 12:19 PM
“A donor wanted to give $2 million to my lab, but only wanted to allow a maximum 10 percent to go to indirect cost recovery. And the school declined to receive the $2 million because they wanted at minimum, I believe it was 20 percent.”
www.harvardmagazine.com/2025/01/harv...
www.harvardmagazine.com/2025/01/harv...
It is rare that an editorial will make me give a standing ovation to the authors - this one recently published in JAMA Internal Medicine by Kieran Quinn and colleagues did: https://buff.ly/4ggq9FS
@kencovinsky.bsky.social
#palliativehepatology #liversky #hapc
@kencovinsky.bsky.social
#palliativehepatology #liversky #hapc
buff.ly
December 17, 2024 at 1:12 PM
It is rare that an editorial will make me give a standing ovation to the authors - this one recently published in JAMA Internal Medicine by Kieran Quinn and colleagues did: https://buff.ly/4ggq9FS
@kencovinsky.bsky.social
#palliativehepatology #liversky #hapc
@kencovinsky.bsky.social
#palliativehepatology #liversky #hapc
Reposted by Nneka Ufere, MD MSCE
How do we apply the new SLD definitions in research? To study outcomes and implement trials for different SLD subtypes, we first need to be able to accurately identify each clinical entity using medical records/registry data.
www.cghjournal.org/article/S154...
@amergastroassn.bsky.social
www.cghjournal.org/article/S154...
@amergastroassn.bsky.social
December 16, 2024 at 1:07 PM
How do we apply the new SLD definitions in research? To study outcomes and implement trials for different SLD subtypes, we first need to be able to accurately identify each clinical entity using medical records/registry data.
www.cghjournal.org/article/S154...
@amergastroassn.bsky.social
www.cghjournal.org/article/S154...
@amergastroassn.bsky.social
Reposted by Nneka Ufere, MD MSCE
@j-palliativemed.bsky.social Daniel Shalev et al respond to Susan Block's Special Report: Realizing the Imperative: The Future of Mental Health and Palliative Care Integration www.liebertpub.com/doi/10.1089/...
Realizing the Imperative: The Future of Mental Health and Palliative Care Integration | Journal of Palliative Medicine
Journal of Palliative Medicine
www.liebertpub.com
December 13, 2024 at 9:07 PM
@j-palliativemed.bsky.social Daniel Shalev et al respond to Susan Block's Special Report: Realizing the Imperative: The Future of Mental Health and Palliative Care Integration www.liebertpub.com/doi/10.1089/...
Reposted by Nneka Ufere, MD MSCE
Everything you want to know about the management of depression and anxiety in #cirrhosis
From Zimbrean (@YalePsych) and Jakab (@YaleDigestive)
journals.lww.com/hepcomm/full...
#liversky
From Zimbrean (@YalePsych) and Jakab (@YaleDigestive)
journals.lww.com/hepcomm/full...
#liversky
Depression and anxiety management in cirrhosis : Hepatology Communications
nd depression are linked to lower health-related quality of life, more severe symptoms (eg, fatigue), and poorer response to medical treatment. Screening instruments for depression and anxiety have sh...
journals.lww.com
December 16, 2024 at 1:11 AM
Everything you want to know about the management of depression and anxiety in #cirrhosis
From Zimbrean (@YalePsych) and Jakab (@YaleDigestive)
journals.lww.com/hepcomm/full...
#liversky
From Zimbrean (@YalePsych) and Jakab (@YaleDigestive)
journals.lww.com/hepcomm/full...
#liversky
Reposted by Nneka Ufere, MD MSCE
Wonderful 1st day of @amcollegegastro.bsky.social #DEI Scholar Adjoa Anyane-Yeboa MD MPH in Department of Medicine at Tufts Medical Center
Grand Rounds tomorrow:
Leveling the Playing Field: Colorectal Cancer Screening in Historically Marginalize Populations
Grand Rounds tomorrow:
Leveling the Playing Field: Colorectal Cancer Screening in Historically Marginalize Populations
December 13, 2024 at 3:42 AM
Wonderful 1st day of @amcollegegastro.bsky.social #DEI Scholar Adjoa Anyane-Yeboa MD MPH in Department of Medicine at Tufts Medical Center
Grand Rounds tomorrow:
Leveling the Playing Field: Colorectal Cancer Screening in Historically Marginalize Populations
Grand Rounds tomorrow:
Leveling the Playing Field: Colorectal Cancer Screening in Historically Marginalize Populations
Reposted by Nneka Ufere, MD MSCE
The always-thoughtful Derek Angus, master of the large randomized trial, calls for “a qualitative assessment of [the clinical team’s] experience [to] provide insight on how the intervention worked and on features considered unhelpful”
The future of RCTs includes qual
jamanetwork.com/journals/jam...
The future of RCTs includes qual
jamanetwork.com/journals/jam...
Do Sepsis Alerts Help?
A great hope of moving from paper to electronic health records (EHRs) is that health data could be scanned in real-time, alerting the care team of potential gaps in care before untoward consequences o...
jamanetwork.com
December 12, 2024 at 1:29 PM
The always-thoughtful Derek Angus, master of the large randomized trial, calls for “a qualitative assessment of [the clinical team’s] experience [to] provide insight on how the intervention worked and on features considered unhelpful”
The future of RCTs includes qual
jamanetwork.com/journals/jam...
The future of RCTs includes qual
jamanetwork.com/journals/jam...
Reposted by Nneka Ufere, MD MSCE
+1. Incredibly proud of the hard work that went into this comprehensive review on sudden cardiac arrest in athletes. Understanding these events in athletes has implications that echo far beyond the field and touches the health of all young adults.
Full Text Link: bit.ly/3B1TxjT
Full Text Link: bit.ly/3B1TxjT
December 4, 2024 at 4:22 PM
+1. Incredibly proud of the hard work that went into this comprehensive review on sudden cardiac arrest in athletes. Understanding these events in athletes has implications that echo far beyond the field and touches the health of all young adults.
Full Text Link: bit.ly/3B1TxjT
Full Text Link: bit.ly/3B1TxjT
Reposted by Nneka Ufere, MD MSCE
Great summary of evidence for safety of naltrexone in liver disease 👇
Things We Do for No Reason™: Avoiding naltrexone for alcohol use disorder in liver disease
Hospitalizations related to alcohol use disorder (AUD) are common. Yet, few patients receive pharmacotherapy consistent with guideline recommendations. Previous concerns over the potential hepatotoxi...
shmpublications.onlinelibrary.wiley.com
December 11, 2024 at 3:31 PM
Great summary of evidence for safety of naltrexone in liver disease 👇
Reposted by Nneka Ufere, MD MSCE
Great question to ask our patients during a clinical encounter:
"If we could help you with only one thing today, what would you want it to be?"
Recommend this wise essay
www.nejm.org/doi/full/10....
"If we could help you with only one thing today, what would you want it to be?"
Recommend this wise essay
www.nejm.org/doi/full/10....
A Good Day | NEJM
Shared decision making takes time that most clinicians don’t have. So one medical
team developed some shortcuts for eliciting essential input from patients with multiple
complex problems.
www.nejm.org
December 12, 2024 at 1:31 AM
Great question to ask our patients during a clinical encounter:
"If we could help you with only one thing today, what would you want it to be?"
Recommend this wise essay
www.nejm.org/doi/full/10....
"If we could help you with only one thing today, what would you want it to be?"
Recommend this wise essay
www.nejm.org/doi/full/10....
Continually inspired by Dan Shalev's work @pallipsych.bsky.social and excited for ongoing collaborations at intersection of mental health, palliative care, and cirrhosis/transplant care. #pallipsych #palliativehepatology
Got to collaborate with friends and colleagues in the #hapc #psychiatry #psychology #socialwork #pallipsych space to respond to Susan Block's inspiring call to improve mental health components of #hapc 1/?
www.liebertpub.com/doi/10.1089/...
www.liebertpub.com/doi/10.1089/...
Realizing the Imperative: The Future of Mental Health and Palliative Care Integration | Journal of Palliative Medicine
Journal of Palliative Medicine
www.liebertpub.com
December 10, 2024 at 7:34 PM
Continually inspired by Dan Shalev's work @pallipsych.bsky.social and excited for ongoing collaborations at intersection of mental health, palliative care, and cirrhosis/transplant care. #pallipsych #palliativehepatology
Reposted by Nneka Ufere, MD MSCE
Let me tell you a story – one of the more haunting I’ve seen in 20 years of journalism. It’s about greed, death and denial. It took two years to unravel one doctor’s myth, a hospital’s complicity in creating it, and a documented trail of suspicious deaths…🧵
December 7, 2024 at 3:52 PM
Let me tell you a story – one of the more haunting I’ve seen in 20 years of journalism. It’s about greed, death and denial. It took two years to unravel one doctor’s myth, a hospital’s complicity in creating it, and a documented trail of suspicious deaths…🧵
Reposted by Nneka Ufere, MD MSCE
December 6, 2024 at 4:58 PM
Reposted by Nneka Ufere, MD MSCE
Two stages of writing:
1) This shouldn't take too long
2) Oh no
1) This shouldn't take too long
2) Oh no
December 4, 2024 at 7:36 PM
Two stages of writing:
1) This shouldn't take too long
2) Oh no
1) This shouldn't take too long
2) Oh no
Reposted by Nneka Ufere, MD MSCE
Do conversations about prognosis (defined as "conversation with your hepatologist about the likely outcome of your liver disease over time") cause patients w/ cirrhosis to lose hope?
Simple answer: No
Work led by🌟@donlan_john in CGH @amergastroassn.bsky.social https://buff.ly/4i1R6OM #LiverSky
Simple answer: No
Work led by🌟@donlan_john in CGH @amergastroassn.bsky.social https://buff.ly/4i1R6OM #LiverSky
November 24, 2024 at 2:57 PM
Do conversations about prognosis (defined as "conversation with your hepatologist about the likely outcome of your liver disease over time") cause patients w/ cirrhosis to lose hope?
Simple answer: No
Work led by🌟@donlan_john in CGH @amergastroassn.bsky.social https://buff.ly/4i1R6OM #LiverSky
Simple answer: No
Work led by🌟@donlan_john in CGH @amergastroassn.bsky.social https://buff.ly/4i1R6OM #LiverSky
Do conversations about prognosis (defined as "conversation with your hepatologist about the likely outcome of your liver disease over time") cause patients w/ cirrhosis to lose hope?
Simple answer: No
Work led by🌟@donlan_john in CGH @amergastroassn.bsky.social https://buff.ly/4i1R6OM #LiverSky
Simple answer: No
Work led by🌟@donlan_john in CGH @amergastroassn.bsky.social https://buff.ly/4i1R6OM #LiverSky
November 24, 2024 at 2:57 PM
Do conversations about prognosis (defined as "conversation with your hepatologist about the likely outcome of your liver disease over time") cause patients w/ cirrhosis to lose hope?
Simple answer: No
Work led by🌟@donlan_john in CGH @amergastroassn.bsky.social https://buff.ly/4i1R6OM #LiverSky
Simple answer: No
Work led by🌟@donlan_john in CGH @amergastroassn.bsky.social https://buff.ly/4i1R6OM #LiverSky