Alex Meraz
@nephroguy.bsky.social
Academic Nephrologist in Winnipeg 🇨🇦. Onconeph and Critical care neph FTW!
@hswapnil.medsky.social @kidneyboy.bsky.social
What’s the name of the nephrology song you play at the end of the podcast?
What’s the name of the nephrology song you play at the end of the podcast?
November 14, 2025 at 4:02 PM
@hswapnil.medsky.social @kidneyboy.bsky.social
What’s the name of the nephrology song you play at the end of the podcast?
What’s the name of the nephrology song you play at the end of the podcast?
Reposted by Alex Meraz
The second sibeprenlimab paper in @nejm.org
(At least we gave it an oral at #KidneyWk unlike the poster for the phase 2 data in 2023!)
www.nejm.org/doi/full/10....
(At least we gave it an oral at #KidneyWk unlike the poster for the phase 2 data in 2023!)
www.nejm.org/doi/full/10....
Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial | NEJM
The cytokine A proliferation-inducing ligand (APRIL) is considered a key driver of
the pathogenesis of IgA nephropathy. Sibeprenlimab, a humanized IgG2 monoclonal antibody,
selectively binds to and...
www.nejm.org
November 8, 2025 at 5:03 PM
The second sibeprenlimab paper in @nejm.org
(At least we gave it an oral at #KidneyWk unlike the poster for the phase 2 data in 2023!)
www.nejm.org/doi/full/10....
(At least we gave it an oral at #KidneyWk unlike the poster for the phase 2 data in 2023!)
www.nejm.org/doi/full/10....
Reposted by Alex Meraz
And it’s live
Iptacopan in C3GN makes it to @thelancet.com
www.thelancet.com/journals/lan...
#NephSky
Iptacopan in C3GN makes it to @thelancet.com
www.thelancet.com/journals/lan...
#NephSky
September 26, 2025 at 9:37 AM
And it’s live
Iptacopan in C3GN makes it to @thelancet.com
www.thelancet.com/journals/lan...
#NephSky
Iptacopan in C3GN makes it to @thelancet.com
www.thelancet.com/journals/lan...
#NephSky
Reposted by Alex Meraz
Amazing to me that a seemingly acute event is either
A) has long-term sequellae despite being apparently resolving or
B) a dramatic and early presentation of profound endothelial disease
A) has long-term sequellae despite being apparently resolving or
B) a dramatic and early presentation of profound endothelial disease
Effect of losartan on endothelial function in women with history of #preeclampsia
🔗 academic.oup.com/ajh/article/... 🔓
#OpenAccess #Free
🔗 academic.oup.com/ajh/article/... 🔓
#OpenAccess #Free
July 14, 2025 at 11:35 AM
Amazing to me that a seemingly acute event is either
A) has long-term sequellae despite being apparently resolving or
B) a dramatic and early presentation of profound endothelial disease
A) has long-term sequellae despite being apparently resolving or
B) a dramatic and early presentation of profound endothelial disease
Reposted by Alex Meraz
June 14, 2025 at 7:59 PM
Reposted by Alex Meraz
June 5, 2025 at 9:54 AM
Reposted by Alex Meraz
The first #ERA25 simultaneous pub
CONFIDENCE trial of empagliflozin + finerenone in N = 579
Greater reduction in ACR and BP
Note the impressive GFR dip
www.nejm.org/doi/full/10....
CONFIDENCE trial of empagliflozin + finerenone in N = 579
Greater reduction in ACR and BP
Note the impressive GFR dip
www.nejm.org/doi/full/10....
June 5, 2025 at 9:54 AM
The first #ERA25 simultaneous pub
CONFIDENCE trial of empagliflozin + finerenone in N = 579
Greater reduction in ACR and BP
Note the impressive GFR dip
www.nejm.org/doi/full/10....
CONFIDENCE trial of empagliflozin + finerenone in N = 579
Greater reduction in ACR and BP
Note the impressive GFR dip
www.nejm.org/doi/full/10....
Reposted by Alex Meraz
In the CONFIDENCE trial in persons with chronic kidney disease and type 2 diabetes, combination therapy with finerenone and empagliflozin led to a greater reduction in the urinary albumin-to-creatinine ratio than either drug alone. Full trial results: nej.md/4jEVbbk
#ERA25 #MedSky #Nephrology
#ERA25 #MedSky #Nephrology
June 5, 2025 at 9:45 AM
In the CONFIDENCE trial in persons with chronic kidney disease and type 2 diabetes, combination therapy with finerenone and empagliflozin led to a greater reduction in the urinary albumin-to-creatinine ratio than either drug alone. Full trial results: nej.md/4jEVbbk
#ERA25 #MedSky #Nephrology
#ERA25 #MedSky #Nephrology
@kevinyau.bsky.social GLP1 agonist master Jedi presenting at #ERA25.
💉GLP1 agonist reduce ED visits and hospitalizations!!!
📉Awesome methods. Best of the session:
💊DDP4 for comparison, IPTW, ICES data. Ticking all the right boxes (EPI nerd).
💊Only 40% on SGLT2i!!! We should flozinate more!!!
💉GLP1 agonist reduce ED visits and hospitalizations!!!
📉Awesome methods. Best of the session:
💊DDP4 for comparison, IPTW, ICES data. Ticking all the right boxes (EPI nerd).
💊Only 40% on SGLT2i!!! We should flozinate more!!!
June 5, 2025 at 9:49 AM
@kevinyau.bsky.social GLP1 agonist master Jedi presenting at #ERA25.
💉GLP1 agonist reduce ED visits and hospitalizations!!!
📉Awesome methods. Best of the session:
💊DDP4 for comparison, IPTW, ICES data. Ticking all the right boxes (EPI nerd).
💊Only 40% on SGLT2i!!! We should flozinate more!!!
💉GLP1 agonist reduce ED visits and hospitalizations!!!
📉Awesome methods. Best of the session:
💊DDP4 for comparison, IPTW, ICES data. Ticking all the right boxes (EPI nerd).
💊Only 40% on SGLT2i!!! We should flozinate more!!!
Reposted by Alex Meraz
Experiential Evidence of Systemic Racism for Indigenous Peoples Navigating Transplantation in Canada - in @kireports.bsky.social
www.kireports.org/article/S246...
#NephSky
www.kireports.org/article/S246...
#NephSky
June 3, 2025 at 10:30 AM
Experiential Evidence of Systemic Racism for Indigenous Peoples Navigating Transplantation in Canada - in @kireports.bsky.social
www.kireports.org/article/S246...
#NephSky
www.kireports.org/article/S246...
#NephSky
Reposted by Alex Meraz
The US spends billions of dollars on binders every year
We are doing the RCT to get you the answer - more than 3000 enrolled
ajkdblog.org/2021/06/16/c... and www.nephjc.com/news/2021/2/...
We are doing the RCT to get you the answer - more than 3000 enrolled
ajkdblog.org/2021/06/16/c... and www.nephjc.com/news/2021/2/...
Could High Be Better Than Low? Targeting Phosphate in Trials
Phosphate is bad, right? As kidney function declines, phosphate excretion goes down. Serum phosphate levels rise, causing parathyroid hormone (PTH) to increase and bring phosphate down. Phosphate h…
ajkdblog.org
June 3, 2025 at 11:17 AM
The US spends billions of dollars on binders every year
We are doing the RCT to get you the answer - more than 3000 enrolled
ajkdblog.org/2021/06/16/c... and www.nephjc.com/news/2021/2/...
We are doing the RCT to get you the answer - more than 3000 enrolled
ajkdblog.org/2021/06/16/c... and www.nephjc.com/news/2021/2/...
Reposted by Alex Meraz
Torsemide is proposed to have clinically important pharmacokinetic and pharmacodynamic advantages over furosemide. This study found no meaningful pharmacokinetic/pharmacodynamic advantages for torsemide versus furosemide. bit.ly/JASN0481
January 15, 2025 at 4:04 PM
Torsemide is proposed to have clinically important pharmacokinetic and pharmacodynamic advantages over furosemide. This study found no meaningful pharmacokinetic/pharmacodynamic advantages for torsemide versus furosemide. bit.ly/JASN0481
Reposted by Alex Meraz
Dapagliflozin improves diabetic kidney disease by inhibiting ferroptosis through β-hydroxybutyrate production
#Nephrology #endocrinology #Diabetes #SGLT2i #NephSky
www.tandfonline.com/doi/full/10....
#Nephrology #endocrinology #Diabetes #SGLT2i #NephSky
www.tandfonline.com/doi/full/10....
Dapagliflozin improves diabetic kidney disease by inhibiting ferroptosis through β-hydroxybutyrate production
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. Sodium-glucose cotransporter protein 2 inhibitors (SGLT2i) are antihyperglycemic agents that provide additional renal-...
www.tandfonline.com
January 5, 2025 at 4:25 PM
Dapagliflozin improves diabetic kidney disease by inhibiting ferroptosis through β-hydroxybutyrate production
#Nephrology #endocrinology #Diabetes #SGLT2i #NephSky
www.tandfonline.com/doi/full/10....
#Nephrology #endocrinology #Diabetes #SGLT2i #NephSky
www.tandfonline.com/doi/full/10....
Reposted by Alex Meraz
Case report:
Daratumumab for Bortezomib-Refractory Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits in Kidney Allograft: A Case Report
https://buff.ly/3P5dsSc
Daratumumab for Bortezomib-Refractory Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits in Kidney Allograft: A Case Report
https://buff.ly/3P5dsSc
December 22, 2024 at 5:54 PM
Case report:
Daratumumab for Bortezomib-Refractory Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits in Kidney Allograft: A Case Report
https://buff.ly/3P5dsSc
Daratumumab for Bortezomib-Refractory Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits in Kidney Allograft: A Case Report
https://buff.ly/3P5dsSc
Reposted by Alex Meraz
💡 Kidney stone patients not meeting their fluid intake goals? Try this one weird trick!
Sprinkle a little Carolina reaper powder on their food a couple times a day and 💦🆙 they'll be drinking so much water you'll be looking up the latest #NephJC on hyponatremia correction rates! GI docs hate him!
Sprinkle a little Carolina reaper powder on their food a couple times a day and 💦🆙 they'll be drinking so much water you'll be looking up the latest #NephJC on hyponatremia correction rates! GI docs hate him!
December 18, 2024 at 10:58 PM
💡 Kidney stone patients not meeting their fluid intake goals? Try this one weird trick!
Sprinkle a little Carolina reaper powder on their food a couple times a day and 💦🆙 they'll be drinking so much water you'll be looking up the latest #NephJC on hyponatremia correction rates! GI docs hate him!
Sprinkle a little Carolina reaper powder on their food a couple times a day and 💦🆙 they'll be drinking so much water you'll be looking up the latest #NephJC on hyponatremia correction rates! GI docs hate him!
Reposted by Alex Meraz
December 17, 2024 at 11:00 PM
Reposted by Alex Meraz
Nope we use the patients usual dwell volume
December 14, 2024 at 1:25 AM
Nope we use the patients usual dwell volume
December 13, 2024 at 4:42 PM
Reposted by Alex Meraz
Prevent kidney failure to reduce carbon emissions ♻️ 🍃 🏭
Our new analysis of CREDENCE assessing environmental impacts from ⬇️ hospitalisations & dialysis 🏥 with SGLT2i
SGLT2i ⬇️ greenhouse gas emissions from inpatient bed days & dialysis by 20% (39 kg CO2e per yr)
www.thelancet.com/journals/lan...
Our new analysis of CREDENCE assessing environmental impacts from ⬇️ hospitalisations & dialysis 🏥 with SGLT2i
SGLT2i ⬇️ greenhouse gas emissions from inpatient bed days & dialysis by 20% (39 kg CO2e per yr)
www.thelancet.com/journals/lan...
December 12, 2024 at 12:45 AM
Prevent kidney failure to reduce carbon emissions ♻️ 🍃 🏭
Our new analysis of CREDENCE assessing environmental impacts from ⬇️ hospitalisations & dialysis 🏥 with SGLT2i
SGLT2i ⬇️ greenhouse gas emissions from inpatient bed days & dialysis by 20% (39 kg CO2e per yr)
www.thelancet.com/journals/lan...
Our new analysis of CREDENCE assessing environmental impacts from ⬇️ hospitalisations & dialysis 🏥 with SGLT2i
SGLT2i ⬇️ greenhouse gas emissions from inpatient bed days & dialysis by 20% (39 kg CO2e per yr)
www.thelancet.com/journals/lan...
Kidney biopsy on aspirin, nay or yay? I am interested in your type 1, blink of an eye, kind of reasoning. Is Dr Glassock yet in Blue Sky? #askrenal #nephsky @kidneyboy.bsky.social
December 9, 2024 at 8:39 PM
Kidney biopsy on aspirin, nay or yay? I am interested in your type 1, blink of an eye, kind of reasoning. Is Dr Glassock yet in Blue Sky? #askrenal #nephsky @kidneyboy.bsky.social
Reposted by Alex Meraz
💊 Hydralazine (Hz) was first introduced to the market in 1951.
The first case of Hz autoimmunity was in 1953, and the first series of Hz induced ANCA vasculitis overlapping with lupus was in 1984!
But, who is really at high risk and what are the outcomes? #nephsky #nephtwitter
The first case of Hz autoimmunity was in 1953, and the first series of Hz induced ANCA vasculitis overlapping with lupus was in 1984!
But, who is really at high risk and what are the outcomes? #nephsky #nephtwitter
December 2, 2024 at 3:27 AM
💊 Hydralazine (Hz) was first introduced to the market in 1951.
The first case of Hz autoimmunity was in 1953, and the first series of Hz induced ANCA vasculitis overlapping with lupus was in 1984!
But, who is really at high risk and what are the outcomes? #nephsky #nephtwitter
The first case of Hz autoimmunity was in 1953, and the first series of Hz induced ANCA vasculitis overlapping with lupus was in 1984!
But, who is really at high risk and what are the outcomes? #nephsky #nephtwitter