Nan Zhang
@nanzhangwistar.bsky.social
Aiming to cure #OvarianCancer #PeritonealCarcinomatosis #PeritonealMetastasis by manipulating #Macrophage #MyeloidCell #Microenvironment.
https://www.wistar.org/our-scientists/nan-zhang/
https://www.wistar.org/our-scientists/nan-zhang/
Reposted by Nan Zhang
We have developed a new workflow to map in 3D at single-cell resolution whole human organs.
Prof. Rong Fan (Yale) mapped out immune cell populations in the vicinity of ovarian precancerous lesions in healthy women and found no enrichment.
More here: www.biorxiv.org/content/10.1...
Prof. Rong Fan (Yale) mapped out immune cell populations in the vicinity of ovarian precancerous lesions in healthy women and found no enrichment.
More here: www.biorxiv.org/content/10.1...
October 1, 2025 at 12:42 PM
We have developed a new workflow to map in 3D at single-cell resolution whole human organs.
Prof. Rong Fan (Yale) mapped out immune cell populations in the vicinity of ovarian precancerous lesions in healthy women and found no enrichment.
More here: www.biorxiv.org/content/10.1...
Prof. Rong Fan (Yale) mapped out immune cell populations in the vicinity of ovarian precancerous lesions in healthy women and found no enrichment.
More here: www.biorxiv.org/content/10.1...
Reposted by Nan Zhang
Peritumoral macrophages recruit eosinophils to promote antitumor immune responses in breast cancer | PNAS www.pnas.org/doi/abs/10.1...
congratulations to Joe Saglimbeni and Boris Reizis lab!
congratulations to Joe Saglimbeni and Boris Reizis lab!
Peritumoral macrophages recruit eosinophils to promote antitumor immune responses in breast cancer | PNAS
Breast tumors harbor dynamic microenvironments, with multiple immune cell types playing
opposing roles during tumor progression and/or response to ...
www.pnas.org
September 20, 2025 at 11:10 PM
Peritumoral macrophages recruit eosinophils to promote antitumor immune responses in breast cancer | PNAS www.pnas.org/doi/abs/10.1...
congratulations to Joe Saglimbeni and Boris Reizis lab!
congratulations to Joe Saglimbeni and Boris Reizis lab!
Reposted by Nan Zhang
The National Institutes of Health’s budget, and structure, would be preserved under a Senate bill for the 2026 fiscal year.
With boost to NIH budget, Senate panel rejects Trump’s plan to slash agency
Republicans on spending committee push back against proposed reorganization and overhead cuts
scim.ag
July 31, 2025 at 9:37 PM
The National Institutes of Health’s budget, and structure, would be preserved under a Senate bill for the 2026 fiscal year.
Reposted by Nan Zhang
This just in…
FY’26 Bill Highlights:
National Institutes of Health: $48.7 billion for biomedical investments in research.
Cancer: $7.4 billion for the National Cancer Institute, including $28 million for the Childhood Cancer STAR Act.
www.statnews.com/2025/07/31/n...
FY’26 Bill Highlights:
National Institutes of Health: $48.7 billion for biomedical investments in research.
Cancer: $7.4 billion for the National Cancer Institute, including $28 million for the Childhood Cancer STAR Act.
www.statnews.com/2025/07/31/n...
Senate committee endorses NIH budget increase, rebuking Trump administration’s proposed 40% cut
Senators from both parties endorsed a $400 million increase to the budget of the National Institutes of Health on Thursday
www.statnews.com
July 31, 2025 at 10:36 PM
This just in…
FY’26 Bill Highlights:
National Institutes of Health: $48.7 billion for biomedical investments in research.
Cancer: $7.4 billion for the National Cancer Institute, including $28 million for the Childhood Cancer STAR Act.
www.statnews.com/2025/07/31/n...
FY’26 Bill Highlights:
National Institutes of Health: $48.7 billion for biomedical investments in research.
Cancer: $7.4 billion for the National Cancer Institute, including $28 million for the Childhood Cancer STAR Act.
www.statnews.com/2025/07/31/n...
Cautious optimistic! Was there a streamed hearing? What’s the source?
The NIH budget will INCREASE by $400 million — not slashed by 40%, as Trump proposed — according to a proposal by Senate appropriators, says Sen Murray.
"Some have asked if there will even be an NIH by [2029]. The commmittee's resounding message is yes—Congress has your back", she says.
"Some have asked if there will even be an NIH by [2029]. The commmittee's resounding message is yes—Congress has your back", she says.
July 31, 2025 at 10:52 PM
Cautious optimistic! Was there a streamed hearing? What’s the source?
Reposted by Nan Zhang
Nowosad Lab will be recruiting postdocs soon. Reach out if you are interested!
July 22, 2025 at 11:34 PM
Nowosad Lab will be recruiting postdocs soon. Reach out if you are interested!
Reposted by Nan Zhang
#MicrobiotaPower via #Exercise! Phelps, Meisel &co show @cp-cell.bsky.social that exercise drives formate from microbiota that in turns activates NRF2 in CD8 T cells driving STAT1/IRF8 programs that potentiate immune checkpoint inhibitor efficacy against #melanoma! dlvr.it/TLqLW7
Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing
microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker
of melanoma suppression.
dlvr.it
July 9, 2025 at 3:56 PM
#MicrobiotaPower via #Exercise! Phelps, Meisel &co show @cp-cell.bsky.social that exercise drives formate from microbiota that in turns activates NRF2 in CD8 T cells driving STAT1/IRF8 programs that potentiate immune checkpoint inhibitor efficacy against #melanoma! dlvr.it/TLqLW7
We are hiring! Please help spread the words. Thank you!
Post-Doctoral Fellow - Zhang Lab - Philadelphia, Pennsylvania (US) job with The Wistar Institute | 12841397
The Wistar Institute has an opening for an ambitious and productive Post-Doctoral Fellow to join the laboratory of Dr. Nan Zhang.
www.nature.com
July 9, 2025 at 3:30 PM
We are hiring! Please help spread the words. Thank you!
Reposted by Nan Zhang
Abstract deadline extended to Monday, June 30! And travel grants are still available to student and post-doc members. Don't miss out - REPOST to share the info with others.
Don't forget 📆 Abstract deadline for poster or oral presentations is June 18. Please repost to your network to spread the word! More info or register at seattle.cytokinesociety.org
June 25, 2025 at 6:59 PM
Abstract deadline extended to Monday, June 30! And travel grants are still available to student and post-doc members. Don't miss out - REPOST to share the info with others.
Reposted by Nan Zhang
Last week was big for IL-12 engineering @cytokinesociety.bsky.social : Membrane-IL12 adjuvant mRNA vaccine polarizes pre-effector T cells for optimized tumor control url:https://rupress.org/jem/article-abstract/222/9/e20241454/278038/Membrane-IL12-adjuvant-mRNA-vaccine-polarizes-pre
June 16, 2025 at 11:44 AM
Last week was big for IL-12 engineering @cytokinesociety.bsky.social : Membrane-IL12 adjuvant mRNA vaccine polarizes pre-effector T cells for optimized tumor control url:https://rupress.org/jem/article-abstract/222/9/e20241454/278038/Membrane-IL12-adjuvant-mRNA-vaccine-polarizes-pre
Reposted by Nan Zhang
Happy to be part of @kingofpathogens.bsky.social study showing mRNAs encoding IL-12 enhance CD8 T cell responses to co-administered HA mRNA vaccines. Study led by Emily Aunins and Anthony Phan from the Hunter lab @upenn.edu
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
An Il12 mRNA-LNP adjuvant enhances mRNA vaccine–induced CD8 T cell responses
IL-12 is dispensable for CD8 T cell responses to mRNA vaccination, but an Il12 mRNA-LNP enhances CD8 T cell memory and protection.
www.science.org
June 6, 2025 at 9:26 PM
Happy to be part of @kingofpathogens.bsky.social study showing mRNAs encoding IL-12 enhance CD8 T cell responses to co-administered HA mRNA vaccines. Study led by Emily Aunins and Anthony Phan from the Hunter lab @upenn.edu
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Nan Zhang
188 PhD/graduate fellowships from private foundations, federal agencies and international organizations.
Database can be downloaded here: research.jhu.edu/rdt/funding-...
Database can be downloaded here: research.jhu.edu/rdt/funding-...
May 9, 2025 at 7:44 PM
188 PhD/graduate fellowships from private foundations, federal agencies and international organizations.
Database can be downloaded here: research.jhu.edu/rdt/funding-...
Database can be downloaded here: research.jhu.edu/rdt/funding-...
A few quotes I love from this article about writing: "There’s no such thing as thinking", "Writing. Is. Thinking.", "Without writing there is no thinking and no real opportunity for exchange in the marketplace of ideas."
An open letter to graduate students and other procrastinators: it's time to write - PubMed
An open letter to graduate students and other procrastinators: it's time to write
pubmed.ncbi.nlm.nih.gov
April 7, 2025 at 1:41 AM
A few quotes I love from this article about writing: "There’s no such thing as thinking", "Writing. Is. Thinking.", "Without writing there is no thinking and no real opportunity for exchange in the marketplace of ideas."
Reposted by Nan Zhang
#MustRead. For #TumorImminologyLovers & more, check this fantastic review @ostunilab.bsky.social &co @cp-trendsimmuno.bsky.social all about #IL1 from #macrophages & pathogenic #inflammation in #cancer. #ScienceMatters dlvr.it/TJslPb
IL-1β+ macrophages and the control of pathogenic inflammation in cancer
While highlighting the complexity and heterogeneity of tumor immune microenvironments,
the application of single-cell analyses in human cancers has identified recurrent
subsets of tumor-associated mac...
dlvr.it
April 1, 2025 at 1:22 AM
#MustRead. For #TumorImminologyLovers & more, check this fantastic review @ostunilab.bsky.social &co @cp-trendsimmuno.bsky.social all about #IL1 from #macrophages & pathogenic #inflammation in #cancer. #ScienceMatters dlvr.it/TJslPb
Reposted by Nan Zhang
#TickTock⏰! Udeehardt, LaiGuan NG, @drusqui.bsky.social &co show @nature.com that skin #neutrophils produce in a circadian manner extracellular matrix potentiating skin barrier & that after injury they create TGFb-dependent rings of matrix shielding pathogens & foreign molecules!
Matrix-producing neutrophils populate and shield the skin - Nature
A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of pathogens.
www.nature.com
March 19, 2025 at 7:36 PM
#TickTock⏰! Udeehardt, LaiGuan NG, @drusqui.bsky.social &co show @nature.com that skin #neutrophils produce in a circadian manner extracellular matrix potentiating skin barrier & that after injury they create TGFb-dependent rings of matrix shielding pathogens & foreign molecules!
Beautiful work by Ed Thorp’s team. We did a journal club on this paper and learned a lot about the crosstalk between resident macrophages and cardiomyocytes through thromoxane signaling and efferocytosis.
www.cell.com/immunity/abs...
www.cell.com/immunity/abs...
Early-age efferocytosis directs macrophage arachidonic acid metabolism for tissue regeneration
Mechanisms that differentiate the capacity of newborn immune cells to orchestrate
tissue regeneration are inadequately understood. Lantz et al. discover that in response
to dying cells, neonatal macro...
www.cell.com
March 12, 2025 at 11:19 PM
Beautiful work by Ed Thorp’s team. We did a journal club on this paper and learned a lot about the crosstalk between resident macrophages and cardiomyocytes through thromoxane signaling and efferocytosis.
www.cell.com/immunity/abs...
www.cell.com/immunity/abs...
Reposted by Nan Zhang
Happy to share our new study on the functional reprogramming of neutrophils in the brain tumor microenvironment by hypoxia-driven lactylation
@theaacr.bsky.social
@wistar.org
@moffittnews.bsky.social
@theaacr.bsky.social
@wistar.org
@moffittnews.bsky.social
March 2, 2025 at 3:24 PM
Happy to share our new study on the functional reprogramming of neutrophils in the brain tumor microenvironment by hypoxia-driven lactylation
@theaacr.bsky.social
@wistar.org
@moffittnews.bsky.social
@theaacr.bsky.social
@wistar.org
@moffittnews.bsky.social
March 7, 2025 at 4:27 PM
Congratulations, Jie, Xiaoqin, and the team! Beautiful work!
#InterferonFriendOrFoe?! Joe Sun, Xiaoqin Wei &co show @science.org that lung macrophage peroxisomes instruct repair programs after virus infections favoring AT2 cell renewal & recovery! IFNgamma drives pexophagy, increasing mitochondrial ROS & activating inflammasomes driving KRT8 cells & fibrosis!
Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae
Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolutio...
www.science.org
March 7, 2025 at 3:26 PM
Congratulations, Jie, Xiaoqin, and the team! Beautiful work!
Just noticed that the study section meeting was rescheduled to 4/10/2025 🤞
My R01 was scheduled to be reviewed tomorrow, but the meeting (TIR) got cancelled just now with a yet-to-be-determined future date. 😥
March 3, 2025 at 2:27 PM
Just noticed that the study section meeting was rescheduled to 4/10/2025 🤞
Reposted by Nan Zhang
Neutrophil extracellular traps promote pre-metastatic niche formation in the omentum by expanding innate-like B cells that express IL-10: Cancer Cell www.cell.com/cancer-cell/...
Neutrophil extracellular traps promote pre-metastatic niche formation in the omentum by expanding innate-like B cells that express IL-10
Lee et al. show that neutrophil extracellular traps (NETs) establish the pre-metastatic
niche in the omentum by recruiting innate-like B cells and eliciting IL-10 production
in these cells through ina...
www.cell.com
February 28, 2025 at 10:13 PM
Neutrophil extracellular traps promote pre-metastatic niche formation in the omentum by expanding innate-like B cells that express IL-10: Cancer Cell www.cell.com/cancer-cell/...
Reposted by Nan Zhang
Reposted by Nan Zhang
This is the first movement from Sen. Fetterman, please fill out immediately if you have been impacted. Please circulate Penn, Pitt, PSU, Temple etc @cbartman.bsky.social
🚨PA colleagues:
"Senator Fetterman wants to hear from you about how the federal funding freeze is affecting Pennsylvania."
"If your project has been impacted, please fill out our constituent impact form:" forms.office.com/g/mFv2JAPxpC
Get out your Other Support and share that info!
"Senator Fetterman wants to hear from you about how the federal funding freeze is affecting Pennsylvania."
"If your project has been impacted, please fill out our constituent impact form:" forms.office.com/g/mFv2JAPxpC
Get out your Other Support and share that info!
Microsoft Forms
forms.office.com
February 22, 2025 at 8:52 PM
This is the first movement from Sen. Fetterman, please fill out immediately if you have been impacted. Please circulate Penn, Pitt, PSU, Temple etc @cbartman.bsky.social
Reposted by Nan Zhang
U.S. early-career researchers struggling amid chaos www.science.org/content/arti... #research #science
U.S. early-career researchers struggling amid chaos
Uncertain funding, government firings, and distressed universities hit vulnerable groups especially hard
www.science.org
February 22, 2025 at 4:08 PM
U.S. early-career researchers struggling amid chaos www.science.org/content/arti... #research #science
Reposted by Nan Zhang
