Farid Moussavi-Harami, MD
@moussavi-harami.bsky.social
Physician-scientist and cardiologist at the University of Washington
Studying biomechanics and all things sarcomere!
U of Iowa Graduate and Hawkeye Fan!
Opinions are my own.
Studying biomechanics and all things sarcomere!
U of Iowa Graduate and Hawkeye Fan!
Opinions are my own.
Reposted by Farid Moussavi-Harami, MD
Work from Patrick Boyle at University of Washington shows population-based computational simulations elucidate mechanisms of focal arrhythmia following stem cell injection
Read more: doi.org/10.1016/j.yj...
Read more: doi.org/10.1016/j.yj...
July 15, 2025 at 8:42 PM
Work from Patrick Boyle at University of Washington shows population-based computational simulations elucidate mechanisms of focal arrhythmia following stem cell injection
Read more: doi.org/10.1016/j.yj...
Read more: doi.org/10.1016/j.yj...
Great new study with collaboration from the Regnier lab @uwbioe.bsky.social and the Kad lab at the University of Kent in the UK! Very cool spatially resolved single-molecule imaging. @ctmr-uw.bsky.social
Single-molecule imaging provides a high spatial resolution of fluorescent ATP binding to myosin within cardiac myofibrils. Pilagov, Steczina, Naim, et al. of the Kad lab @kent.ac.uk study PKA phosphorylation and a haploinsufficiency-causing mutation from human tissue. rupress.org/jgp/article/...
July 8, 2025 at 2:39 PM
Great new study with collaboration from the Regnier lab @uwbioe.bsky.social and the Kad lab at the University of Kent in the UK! Very cool spatially resolved single-molecule imaging. @ctmr-uw.bsky.social
Reposted by Farid Moussavi-Harami, MD
Excited to see this published: rdcu.be/egHer
Common- and rare-variant genetic analyses of heart failure in >2 million individuals
🔘 Dozens of new common variant loci
🔘 Confirmation of rare damaging variation in "definitive" cardiomyopathy genes
🔘 A PRS modifies penetrance of TTNtv
Common- and rare-variant genetic analyses of heart failure in >2 million individuals
🔘 Dozens of new common variant loci
🔘 Confirmation of rare damaging variation in "definitive" cardiomyopathy genes
🔘 A PRS modifies penetrance of TTNtv
Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum
Nature Genetics - Common-variant and rare-variant association analyses combining datasets from multiple populations yield insights into the genetic architecture of all-cause heart failure across...
rdcu.be
April 8, 2025 at 11:44 AM
Excited to see this published: rdcu.be/egHer
Common- and rare-variant genetic analyses of heart failure in >2 million individuals
🔘 Dozens of new common variant loci
🔘 Confirmation of rare damaging variation in "definitive" cardiomyopathy genes
🔘 A PRS modifies penetrance of TTNtv
Common- and rare-variant genetic analyses of heart failure in >2 million individuals
🔘 Dozens of new common variant loci
🔘 Confirmation of rare damaging variation in "definitive" cardiomyopathy genes
🔘 A PRS modifies penetrance of TTNtv
Happy Persian New Year!
March 20, 2025 at 5:51 AM
Happy Persian New Year!
Reposted by Farid Moussavi-Harami, MD
Regulation of TTN as a mechanism of and treatment for heart failure: buff.ly/4b9AEZy
Dominic E. Fullenkamp comments on Yuri Kim et al. (buff.ly/3X7mW3Y)
Dominic E. Fullenkamp comments on Yuri Kim et al. (buff.ly/3X7mW3Y)
February 28, 2025 at 7:20 PM
Regulation of TTN as a mechanism of and treatment for heart failure: buff.ly/4b9AEZy
Dominic E. Fullenkamp comments on Yuri Kim et al. (buff.ly/3X7mW3Y)
Dominic E. Fullenkamp comments on Yuri Kim et al. (buff.ly/3X7mW3Y)
Reposted by Farid Moussavi-Harami, MD
Our paper led by J. Shin & A. Small evaluating the longitudinal penetrance of HCM alleles in the Mass General Brigham Biobank www.sciencedirect.com/science/arti... @jaccjournals.bsky.social #JACCAdv @broadinstitute.org @cgm-mgh.bsky.social @mgbresearch.bsky.social
February 5, 2025 at 3:57 PM
Our paper led by J. Shin & A. Small evaluating the longitudinal penetrance of HCM alleles in the Mass General Brigham Biobank www.sciencedirect.com/science/arti... @jaccjournals.bsky.social #JACCAdv @broadinstitute.org @cgm-mgh.bsky.social @mgbresearch.bsky.social
Exciting work from my brother!
SHP1 keeps lungs afloat in a sea of inflammation: https://www.jci.org/articles/view/183161
S. Farshid Moussavi-Harami & team show that Shp1 activation reduces lung inflammation in mouse models of acute lung injury.
S. Farshid Moussavi-Harami & team show that Shp1 activation reduces lung inflammation in mouse models of acute lung injury.
December 30, 2024 at 4:15 PM
Exciting work from my brother!
Reposted by Farid Moussavi-Harami, MD
A coding variant in BAG3 protects against dilated cardiomyopathy but increases risk for hypertrophic cardiomyopathy and is found to modify the effects of pathogenic TTN variants
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Bidirectional Risk Modulator Along the DCM-HCM Spectrum
This cross-sectional study evaluates the association of BAG3 genetic variation with penetrance and longitudinal outcomes of dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM).
jamanetwork.com
December 26, 2024 at 5:27 PM
A coding variant in BAG3 protects against dilated cardiomyopathy but increases risk for hypertrophic cardiomyopathy and is found to modify the effects of pathogenic TTN variants
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...