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morgs6942.bsky.social
Morgs
@morgs6942.bsky.social
18 followers 53 following 17 posts
ME/CFS since Sept 92.
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Reposted by Morgs
emec.bsky.social
1) The European Commission has several funding opportunities for NGO’s, which might also be relevant for ME/CFS organizations.

We wanted to share some of these programs.
commission.europa.eu/funding-tend...
Funding opportunities for NGOs
NGOs can benefit from a number of funding opportunities.
commission.europa.eu
July 4, 2025 at 8:23 AM
Reposted by Morgs
bhanlon15.bsky.social
Healthspan: 'The Mitochondrial Signature of Long COVID: What PRDX3 Is Trying to Tell Us—And How We Might Reverse It'

'One of the most compelling new biomarkers...is peroxiredoxin-3 (PRDX3), a mitochondrial antioxidant enzyme found at elevated levels..'

gethealthspan.com/science/arti...
Healthspan Research Review | The Mitochondrial Signature of Long COVID: What PRDX3 Is Trying to Tell Us—And How We Might Reverse It
Long COVID presents with a complex constellation of persistent symptoms—fatigue, brain fog, muscle weakness—that often occur despite unremarkable findings on conventional tests. Emerging evidence sugg...
gethealthspan.com
June 2, 2025 at 2:03 AM
morgs6942.bsky.social
medicalxpress.com/news/2025-05... #longcovid #MECFS
Targeting the epipharynx to disrupt the residual triggers of COVID-19 in patients with long COVID
The COVID-19 pandemic had a profound effect on the world, resulting in a dramatic loss of human lives. While the situation is now largely under control, there are patients who still suffer from the di...
medicalxpress.com
May 27, 2025 at 8:37 PM
Reposted by Morgs
monzamayhem.bsky.social
Exciting new ME/CFS research by Prof. Klaus Wirth.

youtu.be/6FkenaYkz3c?...
The Man Trying to Cure ME/CFS & Long Covid: Prof. Klaus Wirth on Mitodicure
YouTube video by Understanding ME-CFS
youtu.be
May 15, 2025 at 5:04 AM
morgs6942.bsky.social
medicalxpress.com/news/2025-04... #MECFS #longcovid
A cocktail of drugs may work against a whole family of viruses
Enteroviruses are a group of viruses that cause everything from the common cold to meningitis, polio, type 1 diabetes, and much more. Over 100 different types have been described by researchers, and m...
medicalxpress.com
April 15, 2025 at 3:38 PM
morgs6942.bsky.social
medicalxpress.com/news/2025-04... #MECFS #longcovid
Discovery of PZL-A molecule brings treatment for mitochondrial diseases within reach
A medical breakthrough could result in the first treatment for rare but serious diseases in which genetic defects disrupt cellular energy production. Researchers at the University of Gothenburg have i...
medicalxpress.com
April 9, 2025 at 8:00 PM
morgs6942.bsky.social
medicalxpress.com/news/2025-04... #MECFS #longcovid
Organoid model integrates microglia to study inflammation in brain
Organoids have revolutionized science and medicine, providing platforms for disease modeling, drug testing, and understanding developmental processes. While not exact replicas of human organs, they of...
medicalxpress.com
April 3, 2025 at 5:42 PM
morgs6942.bsky.social
newatlas.com/medical-tech... #MECFS #longcovid
Bioinspired sensor monitors your metabolism in real time
Researchers at University of California, Los Angeles (UCLA) have developed a tiny sensor that can help keep tabs on metabolites – substances produced or used when your body breaks down food, medicatio...
newatlas.com
March 31, 2025 at 3:32 PM
morgs6942.bsky.social
medicalxpress.com/news/2025-03... #MECFS #longcovid
New PET radiotracer provides first look at inflammation biomarker in human brain
A novel PET imaging approach can effectively quantify a key enzyme associated with brain inflammation, according to research published in the March issue of The Journal of Nuclear Medicine. The first-...
medicalxpress.com
March 28, 2025 at 4:44 PM
Reposted by Morgs
atranscendedman.bsky.social
Hisar, India researchers show that SB431542, a TGF-β inhibitor, blocks SARS-CoV-2 by targeting three steps at once—entry, assembly, and release.

No resistance emerged after 50 viral generations, making it a promising broad-spectrum antiviral.

www.biorxiv.org/content/10.1...
TGF-β inhibitor SB431542 suppresses coronavirus replication through multistep inhibition
The COVID-19 pandemic highlighted the critical need for broad-spectrum antivirals with high resistance barriers. Here, we demonstrate that SB431542, a selective TGF-β receptor I (ALK5) inhibitor, exhi...
www.biorxiv.org
March 22, 2025 at 1:14 PM
morgs6942.bsky.social
www.bbc.co.uk/news/article... #longcovid #MECFS
Long Covid: Young people describe 'battle' to access NHS care
Kaylee, 17, who experiences dizziness and shortness of breath, says she has not seen an NHS specialist for two years.
www.bbc.co.uk
March 22, 2025 at 8:57 AM
morgs6942.bsky.social
medicalxpress.com/news/2025-03... #longcovid #MECFS
Long COVID could be costing U.S. between $2 billion and $6.5 billion annually
The current number of long COVID-19 cases may already be costing the U.S. $2.01–6.56 billion dollars per year, according to a study recently published in the Journal of Infectious Diseases.
medicalxpress.com
March 19, 2025 at 8:18 PM
morgs6942.bsky.social
medicalxpress.com/news/2025-03... #MECFS #longcovid
Cause of post-COVID inflammatory shock in children identified
MIS-C is a serious inflammatory shock that affects children. It can occur several weeks after a COVID infection and can be life-threatening. Until now, however, the precise cause of the condition was ...
medicalxpress.com
March 12, 2025 at 4:48 PM
Reposted by Morgs
emergeaustralia.bsky.social
#mecfs #healthcare #disability #chronicillness #research #podcast
March 11, 2025 at 5:00 AM
Reposted by Morgs
atranscendedman.bsky.social
Researchers found that IL6 suppresses mitochondrial function via the JAK1/STAT1/3-HIF1α/ERRα pathway.

When PGC1 levels are low, IL6 stabilizes HIF1α, which inhibits ERRα, reducing mitochondrial activity.

Boosting PGC1 reverses this effect.

www.cell.com/cell-reports...
The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axis
Xu et al. show that IL6, not TNF-α, suppresses mitochondrial function. When PGC1 is low, IL6 increases HIF1A transcription and stabilizes HIF1α protein via ERRα. HIF1α reciprocally suppresses ERRα, co...
www.cell.com
March 8, 2025 at 12:25 AM
Reposted by Morgs
precisionlife.bsky.social
🔬 𝗟𝗮𝗻𝗱𝗺𝗮𝗿𝗸 𝗟𝗼𝗻𝗴 𝗖𝗢𝗩𝗜𝗗 𝗦𝘁𝘂𝗱𝘆 𝗖𝗼𝗻𝗳𝗶𝗿𝗺𝘀 𝗞𝗲𝘆 𝗚𝗲𝗻𝗲𝘁𝗶𝗰 𝗔𝘀𝘀𝗼𝗰𝗶𝗮𝘁𝗶𝗼𝗻𝘀 𝗔𝗰𝗿𝗼𝘀𝘀 𝗗𝗶𝘃𝗲𝗿𝘀𝗲 𝗣𝗼𝗽𝘂𝗹𝗮𝘁𝗶𝗼𝗻𝘀: 𝗣𝗮𝘃𝗶𝗻𝗴 𝘁𝗵𝗲 𝗪𝗮𝘆 𝗳𝗼𝗿 𝗣𝗿𝗲𝗰𝗶𝘀𝗶𝗼𝗻 𝗗𝗶𝗮𝗴𝗻𝗼𝘀𝘁𝗶𝗰𝘀 & 𝗧𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁𝘀

We’re excited to share a major breakthrough in 𝗹𝗼𝗻𝗴 𝗖𝗢𝗩𝗜𝗗 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵.

🔍 Read the full press release: precisionlife.com/news-and-eve...
February 26, 2025 at 3:23 PM
Reposted by Morgs
renegaderesearch.bsky.social
Accelerate research & care for #MECFS and #LongCOVID

Renegade Research (RR) is a non-profit 501c3 decentralized organization pioneering #patient & #caregiver led #research with a focus on ME/CFS, Long COVID (LC) & other infection associated chronic illnesses #IACI...

www.zeffy.com/en-US/fundra...
Accelerate research and care for ME/CFS & Long COVID
Renegade Research (RR) is a non-profit, 501c3 decentralized organization pioneering patient and caregiver-led research with a focus on ME/CFS, Long COVID (LC) and other infection associated chronic il...
www.zeffy.com
February 28, 2025 at 9:17 AM
morgs6942.bsky.social
medicalxpress.com/news/2025-02... #MECFS #longcovid
MRI study uncovers enlarged hippocampus in long COVID and ME/CFS patients
Striking brain similarities have been detected in patients who experience long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), in particular, a larger than normal hippocampus.
medicalxpress.com
February 11, 2025 at 4:50 PM
morgs6942.bsky.social
medicalxpress.com/news/2025-02... possible implications for #MECFS #longcovid?
Researchers discover a major driver of inflammatory pathology in autoimmune and chronic inflammatory diseases
Our immune system is armed with an array of defenses designed to detect and eliminate harmful threats. One of its most powerful defense mechanisms is the complement system—a group of proteins that pat...
medicalxpress.com
February 6, 2025 at 5:10 PM
Reposted by Morgs
tomkindlon.bsky.social
New US poster abstract from a long-term ME/CFS expert, John Chia:

Efficacy Of SARS–CoV-2 Specific Antiviral Therapy for Enteroviral Myalgic Encephalomyelitis/ChronicFatigue Syndrome

academic.oup.com/ofid/article...

#MEcfs #CFS
Abstract Background Etiology remains elusive for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), and no treatment exists. Antivirals had no efficacy in randomized clinical trials (RCT) for Epstein-Barr Virus and HHV-6. Enteroviruses (EV) have been implicated, but no antivirals are available. Many patients who received SARS–CoV-2-specific antiviral drugs for acute Covid-19 (COV19) infection experienced significant improvement of prior ME/CFS symptoms. This study summarizes their responses to antivirals for SARS-Cov-2. Methods Neutralizing Antibody (NA) for Coxsackievirus B (CVB)1-6 and Echovirus 6, 7, 9, 11, 30 were done by ARUP lab. Enterovirus Protein (EVP) of Peripheral Blood Leukocytes (PBL) was determined by Western Blot. ME/CFS patients fulfilled Canadian consensus criteria, and had either elevated NA for enteroviruses and/or positive EVP in PBL. ME/CFS patients hospitalized for acute COV19 infection and patients without COV19, were given 5-10 days of IV Remdesivir (Rem) +/- immune modulators. Controls: 20 ME/CFS patients seen concurrently without Remdesivir treatment. Other ME/CFS patients (non-COV19) were given Nirmaltrelvir/Ritonavir (PAX) daily for 10 days +/- one repeat. The energy index (EI) was monitored by the patients before, during and after treatment. Significant improvement was defined as > 30%. Results 15/20 (75%) ME/CFS patients – 10/12 hospitalized, 5/8 non-COV19 patients – responded to IV Rem 2-6 weeks after infusions; remission lasted 6-8 weeks to 6-9 months before relapse. Of Controls: 2/20 had mild improvement (< 0.001, X 2 ). 104/200 (52%) of PAX-treated ME/CFS patients improved, often within 2-3 days; all relapsed within days to weeks after treatment. 66%, 33% and 44% of CVB4+, CVB3+, non-CVB3,4+ patients responded to treatment, respectively. EVP decreased and increased with clinical response and relapse. Conclusion Rem and PAX demonstrated clinical efficacy in ME/CFS patients with chronic enterovirus infections. Placebo-c…
February 1, 2025 at 12:25 AM
Reposted by Morgs
lucibee.bsky.social
This is from a summary of the Ciba Foundation conference in May 1992 of Sharpe's chapter presentation and the discussion that followed.

His trial reported "an unexpectedly high rate of improvement in the comparison [treatment as usual] group."
katybrc.bsky.social Katy B @katybrc.bsky.social · Jan 28
"Non pharmaceutical treatment of CFS"
"Sharpe admits there was no scientific foundation for his promotion of CBT as a treatment for #ME #MEcfs
Ignoring all evidence of pathology, he aimed to merely change the beliefs of #pwME.
It was hidden away as part of the 'Secret Files'."
👇
January 28, 2025 at 6:16 PM
morgs6942.bsky.social
medicalxpress.com/news/2025-01... #MECFS #longcovid
Mitochondria may be a promising therapeutic target for inflammatory diseases
Scientists in the laboratory of Navdeep Chandel, Ph.D., the David W. Cugell, MD, Professor of Medicine in the Division of Pulmonary and Critical Care, have discovered how mitochondria influence the bo...
medicalxpress.com
January 23, 2025 at 4:51 PM
Reposted by Morgs
openmedf.bsky.social
In this project, they developed an algorithm that can identify ME/CFS from a panel of metabolic markers and survey data with good specificity.

Read more about this study👉 ow.ly/Hker50UL3zJ.
Discriminating ME/CFS and Comorbid Conditions Using NMR Metabolomics in UK Biobank - Open Medicine Foundation
Explore new publication from the OMF Melbourne ME/CFS Collaboration: Discriminating ME/CFS and Comorbid Conditions Using NMR Metabolomics in UK Biobank.
ow.ly
January 22, 2025 at 3:14 PM
morgs6942.bsky.social
medicalxpress.com/news/2025-01... #MECFS #longcovid
Exercise-activated PanK4 could aid in treating metabolic disorders
Physical activity is not only important for fitness but also for overall health. This is confirmed by a new study, which identified PanK4 as a key regulator of energy metabolism in skeletal muscle, re...
medicalxpress.com
January 22, 2025 at 5:04 PM